{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:48:06Z","timestamp":1788248886549,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005481","name":"New York University Grossman School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.taap.2023.116661","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:51:27Z","timestamp":1692705087000},"page":"116661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Isorhapontigenin (ISO) inhibits malignant cell transformation, migration, and invasion through MEG3\/NEDD9 signaling in Cr(VI)-transformed cells"],"prefix":"10.1016","volume":"476","author":[{"given":"Sophia","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huailu","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costa","family":"Max","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2023.116661_bb0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/biom8040169","article-title":"Clinical significance of serum NEDD9 levels in patients with pancreatic Cancer","volume":"8","author":"Afsar","year":"2018","journal-title":"Biomolecules."},{"key":"10.1016\/j.taap.2023.116661_bb0015","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/sj.bjc.6602478","article-title":"Epigenetic alteration at the DLK1\u2013GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms\u2019 tumour","volume":"92","author":"Astuti","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2023.116661_bb0020","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/physiolgenomics.00062.2014","article-title":"Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer","volume":"46","author":"Beck","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.taap.2023.116661_bb0025","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3816\/CLM.2008.n.021","article-title":"Promoter hypermethylation of the MEG3 (DLK1\/MEG3) imprinted gene in multiple myeloma","volume":"8","author":"Benetatos","year":"2008","journal-title":"Clin. Lymphoma Myeloma"},{"key":"10.1016\/j.taap.2023.116661_bb0030","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"0","author":"Beurel","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2023.116661_bb0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1158\/1940-6207.CAPR-08-0160","article-title":"Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials","volume":"2","author":"Bishayee","year":"2009","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.taap.2023.116661_bb0040","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3892\/etm.2012.693","article-title":"Role of NEDD9 in invasion and metastasis of lung adenocarcinoma","volume":"4","author":"Chang","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.taap.2023.116661_bb0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.7754\/Clin.Lab.2016.160812","article-title":"Comprehensive analysis of lncRNA and mRNA expression profiles in lung cancer","volume":"63","author":"Chen","year":"2017","journal-title":"Clin. Lab."},{"key":"10.1016\/j.taap.2023.116661_bb0055","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.taap.2017.06.014","article-title":"Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis","volume":"331","author":"Dai","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116661_bb0060","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2023.116661_bb0065","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.foodchem.2012.05.086","article-title":"Isorhapontigenin: a novel bioactive stilbene from wine grapes","volume":"135","author":"Fernandez-Marin","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.taap.2023.116661_bb0070","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12967-017-1372-8","article-title":"Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma","volume":"15","author":"Gao","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2023.116661_bb0075","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/hep.510260307","article-title":"Ki-67 expression during rat liver regeneration after partial hepatectomy","volume":"26","author":"Gerlach","year":"1997","journal-title":"Hepatology."},{"key":"10.1016\/j.taap.2023.116661_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2217\/epi.14.80","article-title":"Genetic alterations of DNA methylation machinery in human diseases","volume":"7","author":"Hamidi","year":"2015","journal-title":"Epigenomics."},{"key":"10.1016\/j.taap.2023.116661_bb0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell."},{"key":"10.1016\/j.taap.2023.116661_bb0090","doi-asserted-by":"crossref","first-page":"73282","DOI":"10.18632\/oncotarget.19931","article-title":"Potential applications of MEG3 in cancer diagnosis and prognosis","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.taap.2023.116661_bb0095","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1158\/0008-5472.CAN-12-4008","article-title":"NEDD9 depletion destabilizes Aurora a kinase and heightens the efficacy of Aurora a inhibitors: implications for treatment of metastatic solid tumors","volume":"73","author":"Ice","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2023.116661_bb0100","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1158\/0008-5472.CAN-09-0795","article-title":"NEDD9 promotes oncogenic signaling in mammary tumor development","volume":"69","author":"Izumchenko","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2023.116661_bb0105","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06030","article-title":"LKB1 modulates lung cancer differentiation and metastasis","volume":"448","author":"Ji","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.taap.2023.116661_bib256","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/ijc.28568","article-title":"NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition","volume":"134","author":"Jin","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.taap.2023.116661_bb0110","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/mnfr.201100117","article-title":"Enhancing the bioavailability of resveratrol by combining it with piperine","volume":"55","author":"Johnson","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2023.116661_bb0115","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0959-437X(00)00120-9","article-title":"GSK3, a master switch regulating cell-fate specification and tumorigenesis","volume":"10","author":"Kim","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.taap.2023.116661_bb0120","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.06.008","article-title":"Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene","volume":"125","author":"Kim","year":"2006","journal-title":"Cell."},{"key":"10.1016\/j.taap.2023.116661_bb0125","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1074\/jbc.M114.619783","article-title":"Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development","volume":"290","author":"Kim","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2023.116661_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022666","article-title":"NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer","volume":"6","author":"Kong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2023.116661_bb0135","doi-asserted-by":"crossref","first-page":"2633e2643","DOI":"10.1038\/onc.2010.632","article-title":"HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression","volume":"30","author":"Li","year":"2011","journal-title":"Oncogene."},{"key":"10.1016\/j.taap.2023.116661_bb0140","article-title":"The long noncoding RNA MEG3 contributes to cisplatin resistance of human lung adenocarcinoma","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2023.116661_bb0145","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/carcin\/bgw048","article-title":"Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity","volume":"37","author":"Lubecka","year":"2016","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.taap.2023.116661_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037045","article-title":"Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells","volume":"7","author":"Medan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2023.116661_bb0155","first-page":"4022","article-title":"NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK\/EMT","volume":"18","author":"Meng","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.taap.2023.116661_bb0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12253-012-9580-2","article-title":"Overexpression of NEDD9 is associated with altered expression of E-cadherin, \u03b2-catenin and N-cadherin and predictive of poor prognosis in non-small cell lung cancer","volume":"19","author":"Miao","year":"2013","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.taap.2023.116661_bb0165","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial mesenchymal transition in tumor metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.taap.2023.116661_bb0170","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/pros.22809","article-title":"NEDD9 crucially regulates TGF-beta-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: involvement in cancer progressiveness","volume":"74","author":"Morimoto","year":"2014","journal-title":"Prostate."},{"key":"10.1016\/j.taap.2023.116661_bb0175","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/sj.onc.1209199","article-title":"HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells","volume":"25","author":"Natarajan","year":"2006","journal-title":"Oncogene."},{"key":"10.1016\/j.taap.2023.116661_bb0180","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3892\/etm.2015.2895","article-title":"Bioavailability and safety study of resveratrol 500 mg tablets in healthy male and female volunteers","volume":"11","author":"Sergides","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.taap.2023.116661_bb0185","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5487\/TR.2010.26.4.245","article-title":"Epithelial-mesenchymal transition and cell invasion","volume":"26","author":"Son","year":"2010","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.taap.2023.116661_bb0190","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3390\/cancers11121947","article-title":"A Stilbenoid Isorhapontigenin as a potential anti-Cancer agent against breast Cancer through inhibiting sphingosine kinases\/tubulin stabilization","volume":"11","author":"Subedi","year":"2019","journal-title":"Cancers."},{"key":"10.1016\/j.taap.2023.116661_bb0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/15384101.2019.1706903","article-title":"The double dealing of cyclin D1","volume":"19","author":"Tchakarskaa","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.taap.2023.116661_bb0205","first-page":"2307","article-title":"Loss of MEG3 contributes to the enhanced migration and invasion in arsenic-induced carcinogenesis through NQO1\/FSCN1 pathway","volume":"13","author":"Tu","year":"2023","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.taap.2023.116661_bb0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1254\/jjp.87.61","article-title":"Antioxidative activity of natural isorhapontigenin","volume":"87","author":"Wang","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.taap.2023.116661_bb0215","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/mnfr.200500010","article-title":"Metabolism and bioavailability of trans-resveratrol","volume":"49","author":"Wenzel","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2023.116661_bb0220","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.3892\/mmr.2015.3897","article-title":"Downregulation of Meg3 enhances cisplatin resistance of lung cancer cells through activation of the WNT\/\u03b2-catenin signaling pathway","volume":"12","author":"Xia","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2023.116661_bb0225","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/bph.13803","article-title":"Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism","volume":"174","author":"Yeo","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2023.116661_bb0230","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1007\/s13277-015-3139-2","article-title":"Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer","volume":"36","author":"Yin","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.taap.2023.116661_bb0235","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.taap.2023.116661_bb0240","article-title":"Overexpression of long non-coding RNA MEG3 suppresses breast cancer cell proliferation, invasion, and angiogenesis through AKT pathway","volume":"39","author":"Zhang","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.taap.2023.116661_bb0245","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.canlet.2021.07.041","article-title":"Isorhapontigenin (ISO) inhibits EMT through FOXO3A\/METTL14\/VIMENTIN pathway in bladder cancer cells","volume":"520","author":"Zhang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2023.116661_bb0250","article-title":"Loss of MEG3 and upregulation of miR-145 play an important role in the invasion and migration of Cr(VI)-transformed cells","volume":"8","author":"Zhang","year":"2022","journal-title":"Heliyon."},{"key":"10.1016\/j.taap.2023.116661_bb0255","first-page":"808","article-title":"Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP response element (CRE) in the MEG3 proximal promoter region","volume":"381","author":"Zhao","year":"2006","journal-title":"Int. J. Biol. Cell Biol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23003009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23003009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:02:53Z","timestamp":1758574973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X23003009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":49,"alternative-id":["S0041008X23003009"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2023.116661","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isorhapontigenin (ISO) inhibits malignant cell transformation, migration, and invasion through MEG3\/NEDD9 signaling in Cr(VI)-transformed cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2023.116661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116661"}}