{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:27:22Z","timestamp":1787657242230,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1464400"],"award-info":[{"award-number":["21ZR1464400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1460500"],"award-info":[{"award-number":["23ZR1460500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22377087"],"award-info":[{"award-number":["22377087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303818"],"award-info":[{"award-number":["82303818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373317"],"award-info":[{"award-number":["82373317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["882374085"],"award-info":[{"award-number":["882374085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16DZ2280100"],"award-info":[{"award-number":["16DZ2280100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20S11902200"],"award-info":[{"award-number":["20S11902200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.taap.2023.116729","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:00:08Z","timestamp":1697630408000},"page":"116729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Carnosol analogue WK-63 alleviated cancer cachexia by inhibiting NF-\u03baB and activating AKT pathways in muscle while inhibiting NF-\u03baB and AMPK pathways in adipocyte"],"prefix":"10.1016","volume":"479","author":[{"given":"Xiaojuan","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunru","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2023.116729_bb0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41577-021-00624-w","article-title":"The interplay of immunology and cachexia in infection and cancer","volume":"22","author":"Baazim","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2023.116729_bb0010","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s11864-022-01028-1","article-title":"Understanding cancer cachexia and its implications in upper gastrointestinal cancers","volume":"23","author":"Brown","year":"2022","journal-title":"Curr. Treat. Options in Oncol."},{"key":"10.1016\/j.taap.2023.116729_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094501","article-title":"Biomarkers for cancer cachexia: a mini review","volume":"22","author":"Cao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2023.116729_bb0020","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bcp.2012.05.022","article-title":"Fenofibrate lowers lipid accumulation in myotubes by modulating the PPAR\u03b1\/AMPK\/FoxO1\/ATGL pathway","volume":"84","author":"Chen","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"1594\u20131608","key":"10.1016\/j.taap.2023.116729_bb0025","article-title":"Renal NF-kappaB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting","volume":"55","author":"Chen","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2023.116729_bb0030","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ptr.7676","article-title":"Saikosaponin D alleviates cancer cachexia by directly inhibiting STAT3","volume":"37","author":"Chen","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2023.116729_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14215262","article-title":"Inflammation as a therapeutic target in Cancer Cachexia","volume":"14","author":"Clamon","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.taap.2023.116729_bb0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","article-title":"Adipose triglyceride lipase contributes to cancer-associated cachexia","volume":"333","author":"Das","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.taap.2023.116729_bb0045","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/cncr.21013","article-title":"Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones","volume":"103","author":"Fouladiun","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.taap.2023.116729_bb0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jpen.2287","article-title":"Nutrition challenges of cancer cachexia","volume":"45","author":"Gaafer","year":"2021","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"10.1016\/j.taap.2023.116729_bb0055","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s11010-022-04398-0","article-title":"The burning furnace: alteration in lipid metabolism in cancer-associated cachexia","volume":"477","author":"Joshi","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2023.116729_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15051407","article-title":"Unveiling the role of the proton gateway, uncoupling proteins (UCPs), in Cancer Cachexia","volume":"15","author":"Joshi","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.taap.2023.116729_bb0065","article-title":"Carnosic acid and carnosol display antioxidant and anti-prion properties in in vitro and cell-free models of prion diseases","volume":"11","author":"Karagianni","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.taap.2023.116729_bb0070","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/MCB.00244-16","article-title":"AMPK phosphorylates desnutrin\/ATGL and hormone-sensitive lipase to regulate lipolysis and fatty acid oxidation within adipose tissue","volume":"36","author":"Kim","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2023.116729_bb0075","first-page":"1069","article-title":"NF-kappaB is important for TNF-alpha-induced lipolysis in human adipocytes","volume":"48","author":"Laurencikiene","year":"2007"},{"key":"10.1016\/j.taap.2023.116729_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101612","article-title":"Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia","volume":"66","author":"Lemecha","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.taap.2023.116729_bb0085","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jcsm.12710","article-title":"Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia","volume":"12","author":"Lu","year":"2021","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.taap.2023.116729_bb0090","first-page":"1","article-title":"Cancer cachexia and chronic inflammation: an unbreakable bond","author":"Maccio","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2023.116729_bb0095","doi-asserted-by":"crossref","first-page":"12450","DOI":"10.1096\/fj.202000164R","article-title":"The novel non-steroidal MR antagonist finerenone improves metabolic parameters in high-fat diet-fed mice and activates brown adipose tissue via AMPK-ATGL pathway","volume":"34","author":"Marzolla","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2023.116729_bb0100","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3389\/fphar.2017.00915","article-title":"Pyrrolidine dithiocarbamate (PDTC) attenuates cancer cachexia by affecting muscle atrophy and fat lipolysis","volume":"8","author":"Miao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2023.116729_bb0105","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcsm.12912","article-title":"A systematic review examining the relationship between cytokines and cachexia in incurable cancer","volume":"13","author":"Paval","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.taap.2023.116729_bb0110","first-page":"428","article-title":"Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-\u03baB and the lipolytic PKA activation in 3T3-L1 adipocytes","volume":"91","author":"Purohit","year":"2013"},{"key":"10.1016\/j.taap.2023.116729_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14174258","article-title":"Cancer cachexia: signaling and transcriptional regulation of muscle catabolic genes","volume":"14","author":"Rao","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.taap.2023.116729_bb0120","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2023.116729_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153858","article-title":"Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway","volume":"95","author":"Shen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2023.116729_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154563","article-title":"Curcumin treatment suppresses cachexia-associated adipose wasting in mice by blocking the cAMP\/PKA\/CREB signaling pathway","volume":"109","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2023.116729_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.848394","article-title":"Metabolic reprogramming in adipose tissue during cancer cachexia","volume":"12","author":"Weber","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.taap.2023.116729_bb0140","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/jcsm.13028","article-title":"Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia","volume":"13","author":"Wu","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.taap.2023.116729_bb0145","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153746","article-title":"Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia","volume":"23","author":"Wyart","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.taap.2023.116729_bb0150","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00011-022-01626-7","article-title":"Comprehensive comparison of the prognostic value of systemic inflammation biomarkers for cancer cachexia: a multicenter prospective study","volume":"71","author":"Xie","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.taap.2023.116729_bb0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s12276-022-00752-w","article-title":"Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia","volume":"54","author":"Yeom","year":"2022","journal-title":"Exp. Mol. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2300368X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2300368X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:04:06Z","timestamp":1758575046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2300368X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":31,"alternative-id":["S0041008X2300368X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2023.116729","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carnosol analogue WK-63 alleviated cancer cachexia by inhibiting NF-\u03baB and activating AKT pathways in muscle while inhibiting NF-\u03baB and AMPK pathways in adipocyte","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2023.116729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116729"}}