{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:22:45Z","timestamp":1787235765882,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.taap.2023.116752","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T02:47:59Z","timestamp":1699670879000},"page":"116752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell"],"prefix":"10.1016","volume":"481","author":[{"given":"Yuto","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Arakida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Enoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2023.116752_bb0005","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/bip.1977.360161203","article-title":"Binding of azide ion to methemoglobin at elevated temperatures and the reality of the \u201ccompensation\u201d temperature","volume":"16","author":"Anusiem","year":"1977","journal-title":"Biopolymers"},{"key":"10.1016\/j.taap.2023.116752_bb0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-2836(83)80329-5","article-title":"Spectral properties and reactivity towards azide of Dicrocoelium dendriticum met-hemoglobin","volume":"168","author":"Ascenzi","year":"1983","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.taap.2023.116752_bb0015","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1182\/bloodadvances.2022007977","article-title":"First-in-human phase 1 trial of hemoglobin vesicles as artificial red blood cells developed for use as a transfusion alternative","volume":"6","author":"Azuma","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.taap.2023.116752_bb0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1432-1033.1973.tb02594.x","article-title":"Cooperative ligand binding by ferrihemoglobin","volume":"32","author":"Banerjee","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.taap.2023.116752_bb0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.emc.2014.09.014","article-title":"Asphyxiants","volume":"33","author":"Borron","year":"2015","journal-title":"Emerg. Med. Clin. North Am."},{"key":"10.1016\/j.taap.2023.116752_bb0030","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.1021\/acs.jpcb.6b06686","article-title":"Access and binding of H2S to hemeproteins: the case of HbI of Lucina pectinata","volume":"120","author":"Boubeta","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.taap.2023.116752_bb0035","series-title":"Nanobiotherapeutic Based Blood Substitutes, Regenerative Medicine, Artificial Cells and Nanomedicine","doi-asserted-by":"crossref","DOI":"10.1142\/12054","author":"Chang","year":"2022"},{"key":"10.1016\/j.taap.2023.116752_bb0040","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/0006-291X(77)90618-0","article-title":"Evidence for a quaternary structure change in the cooperative binding of cyanide to ferrihemoglobin a","volume":"74","author":"Coleman","year":"1977","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2023.116752_bb0045","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/acs.chemrestox.9b00422","article-title":"A comparison of potential azide antidotes in a mouse model","volume":"33","author":"Frawley","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2023.116752_bb0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/nyas.13015","article-title":"Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations","volume":"1374","author":"Haouzi","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2023.116752_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jinorgbio.2018.02.007","article-title":"Reactions of ferric hemoglobin and myoglobin with hydrogen sulfide under physiological conditions","volume":"182","author":"Jensen","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.taap.2023.116752_bb0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-291X(78)91123-3","article-title":"15N NMR studies of the binding of 15N-labeled cyanide to various hemoglobins in intact erythrocyte","volume":"80","author":"Morishima","year":"1978","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2023.116752_bb0065","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ccc.2005.06.002","article-title":"Cyanides","volume":"21","author":"Morocco","year":"2005","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.taap.2023.116752_bb0070","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1021\/bi00707a027","article-title":"Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin","volume":"13","author":"Perutz","year":"1974","journal-title":"Biochemistry"},{"key":"10.1016\/j.taap.2023.116752_bb0075","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5662\/wjm.v5.i2.88","article-title":"Past, present and future of cyanide antagonism research: from the early remedies to the current therapies","volume":"5","author":"Petrikovics","year":"2015","journal-title":"World J. Methodol."},{"key":"10.1016\/j.taap.2023.116752_bb0080","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1074\/jbc.M707660200","article-title":"Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier","volume":"283","author":"Sakai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2023.116752_bb0085","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbapap.2008.03.007","article-title":"NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers","volume":"1784","author":"Sakai","year":"2008","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.taap.2023.116752_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmedt.2022.1048951","article-title":"Research of storable and ready-to-use artificial red blood cells (hemoglobin vesicles) for emergency medicine and other clinical applications","volume":"4","author":"Sakai","year":"2022","journal-title":"Front. Med. Technol."},{"key":"10.1016\/j.taap.2023.116752_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121260","article-title":"Long-term pharmaceutical stability of liposome-encapsulated methemoglobin as an antidote for cyanide poisoning","volume":"610","author":"Suzuki","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.taap.2023.116752_bb0100","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jconrel.2021.07.015","article-title":"Liposome-encapsulated methemoglobin as an antidote against cyanide poisoning","volume":"337","author":"Suzuki","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.taap.2023.116752_bb0105","article-title":"Oxidized liposomal artificial red blood cells rescue azide-poisoned mice from lethal toxidrome by recovering cytochrome c oxidase activity","volume":"71","author":"Suzuki","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.taap.2023.116752_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116159","article-title":"Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning","volume":"450","author":"Suzuki","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116752_bb0115","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jconrel.2022.07.001","article-title":"Methemoglobin-albumin clusters for the treatment of hydrogen sulfide intoxication","volume":"349","author":"Suzuki","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.taap.2023.116752_bb0120","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00232-013-9591-2","article-title":"The effect of fatal carbon monoxide poisoning on the surface charge of blood cells","volume":"246","author":"Szeremeta","year":"2013","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.taap.2023.116752_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005828","article-title":"Altered membrane structure and surface potential in homozygous hemoglobin C erythrocytes","volume":"4","author":"Tokumasu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2023.116752_bb0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.exppara.2012.03.005","article-title":"Modifications in erythrocyte membrane zeta potential by plasmodium falciparum infection","volume":"131","author":"Tokumasu","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.taap.2023.116752_bb0135","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/jat\/25.4.228","article-title":"Rapid determination of cyanide and azide in beverages by microdiffusion spectrophotometric method","volume":"25","author":"Tsuge","year":"2001","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.taap.2023.116752_bb0140","first-page":"116","article-title":"An azide-methemoglobin method for hemoglobin determination in blood","volume":"67","author":"Vanzetti","year":"1966","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.taap.2023.116752_bb0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.pa.24.040184.002315","article-title":"Cyanide intoxication and its mechanism of antagonism","volume":"24","author":"Way","year":"1984","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2023.116752_bb0150","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/acschembio.7b00174","article-title":"Hidden antioxidative functions of reduced nicotinamide adenine dinucleotide coexisting with hemoglobin","volume":"12","author":"Yamada","year":"2017","journal-title":"ACS Chem. Biol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23003915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23003915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:03:13Z","timestamp":1758574993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X23003915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":30,"alternative-id":["S0041008X23003915"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2023.116752","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2023.116752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116752"}}