{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:08:09Z","timestamp":1791313689374,"version":"4.3.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.taap.2024.116991","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T14:14:09Z","timestamp":1718201649000},"page":"116991","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Dapagliflozin dampens liver fibrosis induced by common bile duct ligation in rats associated with the augmentation of the hepatic Sirt1\/AMPK\/PGC1\u03b1\/FoxO1 axis"],"prefix":"10.1016","volume":"489","author":[{"given":"Heba A.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahitab M.","family":"Nageeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba Osama","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa","family":"Samy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Fawzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rofaida","family":"Afifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha A.T.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0005","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1053\/j.gastro.2007.01.033","article-title":"The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells","volume":"132","author":"Adachi","year":"2007","journal-title":"Gastroenterology"},{"issue":"C","key":"10.1016\/j.taap.2024.116991_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12565-019-00488-0","article-title":"Histological and biochemical changes induced by gibberellic acid in the livers of pregnant albino rats and their offspring: ameliorative effect of nigella sativa","volume":"94","author":"Alsemeh","year":"2019","journal-title":"Anat. Sci. Int."},{"issue":"7","key":"10.1016\/j.taap.2024.116991_bb0020","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1089\/ars.2013.5697","article-title":"Extracellular matrix and liver disease","volume":"21","author":"Arriazu","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2024.116991_bb0025","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques,The Hematoxylin and Eosin, Connective and Mesenchymal Tissues with Their Stains","author":"Bancroft","year":"2013"},{"issue":"5","key":"10.1016\/j.taap.2024.116991_bb0030","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1159\/000459586","article-title":"Colorimetric determination of alkaline phosphatase activity","volume":"12","author":"Belfield","year":"1971","journal-title":"Enzyme"},{"issue":"2","key":"10.1016\/j.taap.2024.116991_bb0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10557-018-6778-x","article-title":"Combined SGLT2 and DPP4 inhibition reduces the activation of the Nlrp3\/ASC inflammasome and attenuates the development of diabetic nephropathy in mice with type 2 diabetes","volume":"32","author":"Birnbaum","year":"2018","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.taap.2024.116991_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The Sir2 family of protein deacetylases","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2024.116991_bib346","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0003-2697(73)90316-3","article-title":"A quick and specific assay for hydroxyproline","volume":"55","author":"Blumenkrantz","year":"1973","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0045","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/gast.2002.35953","article-title":"Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis","volume":"123","author":"Canbay","year":"2002","journal-title":"Gastroenterology"},{"issue":"7241","key":"10.1016\/j.taap.2024.116991_bb0050","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.taap.2024.116991_bb0055","first-page":"12","article-title":"The nurse administrator in transition: reflections and future perspectives","volume":"58","author":"Chang","year":"2011","journal-title":"J. Nurs."},{"key":"10.1016\/j.taap.2024.116991_bb0060","doi-asserted-by":"crossref","DOI":"10.1007\/s10238-022-00799-z","article-title":"Liver biopsy for assessment of chronic liver diseases: a synopsis","author":"Chowdhury","year":"2022","journal-title":"Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.taap.2024.116991_bb0070","first-page":"411","article-title":"Development of hepatic fibrosis occurs normally in AMPK-deficient mice","volume":"118","author":"da Silva","year":"2009","journal-title":"Clin. Sci."},{"issue":"23","key":"10.1016\/j.taap.2024.116991_bb0080","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.3748\/wjg.v20.i23.7260","article-title":"Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: an update","volume":"20","author":"Elpek","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2024.116991_bb0085","first-page":"8765954","article-title":"SIRT1 modulators in experimentally induced liver injury","author":"Farghali","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.taap.2024.116991_bb0090","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/1440-1681.13638","article-title":"Dapagliflozin attenuates high glucose-induced endothelial cell apoptosis and inflammation through AMPK\/SIRT1 activation","volume":"49","author":"Faridvand","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2613.2008.00597.x","article-title":"Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation","volume":"89","author":"Geerts","year":"2008","journal-title":"Int. J. Exp. Pathol."},{"issue":"5","key":"10.1016\/j.taap.2024.116991_bb0100","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.6050","article-title":"Characterization of time-related changes after experimental bile duct ligation","volume":"95","author":"Georgiev","year":"2008","journal-title":"Br. J. Surg."},{"issue":"1","key":"10.1016\/j.taap.2024.116991_bb0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.taap.2010.11.016","article-title":"Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice","volume":"251","author":"Ghatak","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2024.116991_bb0110","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.2337\/db07-1472","article-title":"Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats","volume":"57","author":"Han","year":"2008","journal-title":"Diabetes"},{"issue":"November","key":"10.1016\/j.taap.2024.116991_bb0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"10.1016\/j.taap.2024.116991_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073875","article-title":"Regulation of FOXOs and P53 by SIRT1 modulators under oxidative stress","volume":"8","author":"Hori","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.taap.2024.116991_bb0130","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00109-019-01746-4","article-title":"AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model","volume":"97","author":"Hu","year":"2019","journal-title":"J. Mol. Med."},{"issue":"29","key":"10.1016\/j.taap.2024.116991_bb0135","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-Activated Protein Kinase (AMPK) Action in Skeletal Muscle via Direct Phosphorylation of PGC-1alpha","volume":"104","author":"J\u00e4ger","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.taap.2024.116991_bb0140","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1159\/000487783","article-title":"Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in Db\/Db Mice","volume":"45","author":"Jia","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.taap.2024.116991_bb0145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/TP.0000000000000194","article-title":"Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion","volume":"98","author":"Khader","year":"2014","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0150","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/10715760410001665262","article-title":"Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells","volume":"38","author":"Lee","year":"2004","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.taap.2024.116991_bb0155","series-title":"Biliary Disease. Scheuer\u2019s Liver Biopsy Interpretation","author":"Lefkowitch","year":"2021"},{"issue":"1\u20132","key":"10.1016\/j.taap.2024.116991_bb0160","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11010-018-3324-x","article-title":"Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1\/FOXO1 signaling pathway","volume":"448","author":"Li","year":"2018","journal-title":"Mol. Cell. Biochem."},{"issue":"37","key":"10.1016\/j.taap.2024.116991_bb0165","doi-asserted-by":"crossref","first-page":"62780","DOI":"10.18632\/oncotarget.19376","article-title":"AMPK: a novel target for treating hepatic fibrosis","volume":"8","author":"Liang","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.taap.2024.116991_bb0170","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jcp.22824","article-title":"AMP-activated protein kinase inhibits TGF-\u03b2-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300","volume":"227","author":"Lim","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2024.116991_bb0175","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1038\/ncomms5451","article-title":"GIV\/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis","volume":"5","author":"Lopez-Sanchez","year":"2014","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.taap.2024.116991_bb0180","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2174\/1568026615666150610125715","article-title":"Longevity pathways (MTOR, SIRT, Insulin\/IGF-1) as key modulatory targets on aging and neurodegeneration","volume":"15","author":"Mazucanti","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"issue":"7","key":"10.1016\/j.taap.2024.116991_bb0185","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s11011-020-00597-0","article-title":"Calorie restriction promotes remyelination in a cuprizone-induced demyelination mouse model of multiple sclerosis","volume":"35","author":"Mojaverrostami","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.taap.2024.116991_bb0190","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.biopha.2018.10.100","article-title":"Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats","volume":"109","author":"Oraby","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2024.116991_bb0195","first-page":"13","article-title":"Physiology of the liver cite this paper physiology of the liver","volume":"4","author":"Ozougwu","year":"2017","journal-title":"Int. J. Res. Pharm. Biosci."},{"issue":"1","key":"10.1016\/j.taap.2024.116991_bb0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.hbpd.2018.01.008","article-title":"Pathophysiological consequences of obstructive jaundice and perioperative management","volume":"17","author":"Pavlidis","year":"2018","journal-title":"Hepatob. Pancreatic Dis. Int."},{"issue":"3","key":"10.1016\/j.taap.2024.116991_bib347","first-page":"255","article-title":"A simplified method for the analysis of hydroxyproline in biological tissue","volume":"29","author":"Reddy","year":"1996","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2024.116991_bb0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s13300-014-0053-3","article-title":"Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus","volume":"5","author":"Reilly","year":"2014","journal-title":"Diabetes Ther."},{"issue":"1","key":"10.1016\/j.taap.2024.116991_bb0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"issue":"7","key":"10.1016\/j.taap.2024.116991_bb0220","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/s41401-021-00805-2","article-title":"Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress","volume":"43","author":"Ren","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0225","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a long-standing partnership?","volume":"298","author":"Ruderman","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.taap.2024.116991_bb0230","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrgastro.2009.46","article-title":"Secondary sclerosing cholangitis","volume":"6","author":"Ruemmele","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2024.116991_bib348","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-3-642-21631-2_7","article-title":"The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity","volume":"206","author":"Satoh","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"issue":"7","key":"10.1016\/j.taap.2024.116991_bb0235","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.taap.2024.116991_bb0240","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/ajh\/hpz016","article-title":"Dapagliflozin attenuates cardiac remodeling in mice model of cardiac pressure overload","volume":"32","author":"Shi","year":"2019","journal-title":"Am. J. Hypertens."},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0245","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11130-016-0574-1","article-title":"Phytosterols and dementia","volume":"71","author":"Shuang","year":"2016","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.taap.2024.116991_bb0250","doi-asserted-by":"crossref","unstructured":"Stoica R, Rusu CM, Staicu CE, Burlacu AE, Radu M, and Radu BM. \u2018Chapter Two - Ca2+ Homeostasis in Brain Microvascular Endothelial Cells\u2019. In Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, edited by Saverio Marchi and Lorenzo Galluzzi, 2021; 362:55\u2013110. International Review of Cell and Molecular Biology. Academic Press. doi: https:\/\/doi.org\/10.1016\/bs.ircmb.2021.01.001.","DOI":"10.1016\/bs.ircmb.2021.01.001"},{"key":"10.1016\/j.taap.2024.116991_bb0255","first-page":"1","article-title":"Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis","volume":"96","author":"Tag","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.taap.2024.116991_bb0260","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0023677214567748","article-title":"Induction of experimental obstructive cholestasis in mice","volume":"49","author":"Tag","year":"2015","journal-title":"Lab. Anim."},{"issue":"5","key":"10.1016\/j.taap.2024.116991_bb0265","doi-asserted-by":"crossref","first-page":"E563","DOI":"10.1152\/ajpendo.00086.2017","article-title":"Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes","volume":"313","author":"Tang","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"16","key":"10.1016\/j.taap.2024.116991_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16162965","article-title":"SGLT2 inhibitors: a review of their antidiabetic and cardioprotective effects","volume":"16","author":"Tentolouris","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"16","key":"10.1016\/j.taap.2024.116991_bb0275","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1111\/jcmm.16601","article-title":"Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK\u03b1\/TGF-\u03b2\/Smad signalling in type 2 diabetic rats","volume":"25","author":"Tian","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"16","key":"10.1016\/j.taap.2024.116991_bb0280","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1111\/jcmm.16601","article-title":"Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK\u03b1\/TGF-\u03b2\/Smad signalling in Type 2 diabetic rats","volume":"25","author":"Tian","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"10.1016\/j.taap.2024.116991_bb0285","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jhep.2010.04.025","article-title":"Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells","volume":"53","author":"Trebicka","year":"2010","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.taap.2024.116991_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-021-00547-y","article-title":"Dapagliflozin attenuates hypoxia\/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK","volume":"11","author":"Tsai","year":"2021","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.taap.2024.116991_bb0305","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0026-265X(70)90045-7","article-title":"An ultramicromethod for the determination of conjugated and total bilirubin in serum or plasma","volume":"15","author":"Walter and Gerade","year":"1970","journal-title":"Microchem. J."},{"key":"10.1016\/j.taap.2024.116991_bb0310","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.arr.2017.11.002","article-title":"FOXO1\/3: potential suppressors of fibrosis","volume":"41","author":"Xin","year":"2018","journal-title":"Ageing Res. Rev."},{"issue":"July","key":"10.1016\/j.taap.2024.116991_bb0315","first-page":"1","article-title":"A SGLT2 inhibitor dapagliflozin alleviates diabetic cardiomyopathy by suppressing high glucose-induced oxidative stress in vivo and in vitro","volume":"12","author":"Xing","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2024.116991_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109272","article-title":"Therapeutic efficacy of dapagliflozin on diabetic kidney disease in rats","volume":"113","author":"Yang","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.taap.2024.116991_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247234","article-title":"Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells","volume":"16","author":"Zaibi","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.taap.2024.116991_bb0330","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/liv.13591","article-title":"Complications, symptoms, quality of life and pregnancy in cholestatic liver disease","volume":"38","author":"Zakharia","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2024.116991_bb0335","doi-asserted-by":"crossref","first-page":"1095487","DOI":"10.3389\/fphar.2023.1095487","article-title":"Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-\u03b21\/MAPK mediated mitochondrial damage","volume":"14","author":"Zeng","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"48","key":"10.1016\/j.taap.2024.116991_bb0340","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"20","key":"10.1016\/j.taap.2024.116991_bb0345","doi-asserted-by":"crossref","first-page":"12572","DOI":"10.3390\/ijms232012572","article-title":"The molecular mechanisms of liver fibrosis and its potential therapy in application","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24001893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24001893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T16:57:14Z","timestamp":1720544234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24001893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":66,"alternative-id":["S0041008X24001893"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.116991","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dapagliflozin dampens liver fibrosis induced by common bile duct ligation in rats associated with the augmentation of the hepatic Sirt1\/AMPK\/PGC1\u03b1\/FoxO1 axis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.116991","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116991"}}