{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:51:43Z","timestamp":1768254703512,"version":"3.49.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.taap.2024.117110","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T21:19:11Z","timestamp":1727126351000},"page":"117110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Protective effects of alpinetin against interleukin-1\u03b2-exposed nucleus pulposus cells: Involvement of the TLR4\/MyD88 pathway in a cellular model of intervertebral disc degeneration"],"prefix":"10.1016","volume":"492","author":[{"given":"Junfeng","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2024.117110_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121561","article-title":"Cardioprotective and renoprotective effects of venlafaxine on cisplatin-induced cardiotoxicity and nephrotoxicity in rats","volume":"320","author":"Ali","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0010","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/13880209.2022.2035773","article-title":"Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2\/STAT3 signal pathway in vitro and in vivo","volume":"60","author":"Bai","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.taap.2024.117110_bb0015","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1007\/s11033-023-08390-9","article-title":"Overloaded axial stress activates the Wnt\/\u03b2-catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration","volume":"50","author":"Cai","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.taap.2024.117110_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3224","article-title":"Intervertebral disc degeneration: a focus on obesity and type 2 diabetes","volume":"36","author":"Cannata","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.taap.2024.117110_bb0025","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2024.117110_bb0030","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1002\/ptr.7767","article-title":"Inhibiting mitochondrial inflammation through Drp1\/HK1\/NLRP3 pathway: a mechanism of alpinetin attenuated aging-associated cognitive impairment","volume":"37","author":"Chen","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2024.117110_bb0035","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3765173","article-title":"High glucose-induced oxidative stress mediates apoptosis and extracellular matrix metabolic imbalances possibly via p38 MAPK activation in rat nucleus pulposus cells","volume":"2016","author":"Cheng","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.taap.2024.117110_bb0040","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101567R","article-title":"Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: requirement of GSk3\u03b2\/Fyn-dependent Nrf2 activation","volume":"36","author":"Dong","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2024.117110_bb0045","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1177\/09603271211003311","article-title":"Bone marrow mesenchymal stem cells-derived exosomes reduce apoptosis and inflammatory response during spinal cord injury by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"40","author":"Fan","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.taap.2024.117110_bb0050","first-page":"1347","article-title":"Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway","volume":"17","author":"Ge","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2024.117110_bb0055","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1007\/s12010-022-03960-2","article-title":"Alpinetin: a dietary flavonoid with diverse anticancer effects","volume":"194","author":"Gul","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.taap.2024.117110_bb0060","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3855\/jidc.18877","article-title":"Expression of norA, norB and norC efflux pump genes mediating fluoroquinolones resistance in MRSA isolates","volume":"18","author":"Hamady","year":"2024","journal-title":"J. Infect. Dev. Ctries."},{"key":"10.1016\/j.taap.2024.117110_bb0065","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13677","article-title":"p300 arrests intervertebral disc degeneration by regulating the FOXO3\/Sirt1\/Wnt\/\u03b2-catenin axis","volume":"21","author":"Hao","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.taap.2024.117110_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116556","article-title":"Caffeic acid alleviates skeletal muscle atrophy in 5\/6 nephrectomy rats through the TLR4\/MYD88\/NF-kB pathway","volume":"174","author":"He","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2024.117110_bb0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lfs.2018.03.020","article-title":"Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells","volume":"199","author":"He","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0080","doi-asserted-by":"crossref","first-page":"28370","DOI":"10.1038\/srep28370","article-title":"Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis","volume":"6","author":"He","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2024.117110_bb0085","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/08820139.2023.2205884","article-title":"Ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of NLRP3 inflammasome","volume":"52","author":"Hu","year":"2023","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.taap.2024.117110_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18510","article-title":"Mecp2 promotes the anti-inflammatory effect of alpinetin via epigenetic modification crosstalk","volume":"28","author":"Hu","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2024.117110_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122008","article-title":"Stattic ameliorates the cecal ligation and puncture-induced cardiac injury in septic mice via IL-6-gp130-STAT3 signaling pathway","volume":"330","author":"Imbaby","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0100","doi-asserted-by":"crossref","first-page":"19232","DOI":"10.1038\/s41598-020-75301-4","article-title":"Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation","volume":"10","author":"Katare","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2024.117110_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117015","article-title":"Effect of mesenchymal stem cells and melatonin on experimentally induced peripheral nerve injury in rats","volume":"177","author":"Khodir","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2024.117110_bb0110","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.wneu.2021.09.066","article-title":"Fundamentals of intervertebral disc degeneration","volume":"157","author":"Kirnaz","year":"2022","journal-title":"World Neurosurg."},{"key":"10.1016\/j.taap.2024.117110_bb0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12016-020-08791-9","article-title":"Anti-inflammatory action of statins in cardiovascular disease: the role of inflammasome and toll-like receptor pathways","volume":"60","author":"Koushki","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.taap.2024.117110_bb0120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/vaccines5040034","article-title":"TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.taap.2024.117110_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.787020","article-title":"Establishment of an ex vivo inflammatory osteoarthritis model with human osteochondral explants","volume":"9","author":"Li","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.taap.2024.117110_bb0130","article-title":"Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2024.117110_bb0135","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/ijms23031715","article-title":"The proteolysis of ecm in intervertebral disc degeneration","volume":"23","author":"Liang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0140","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.7150\/thno.33638","article-title":"Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo","volume":"9","author":"Liao","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.taap.2024.117110_bb0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jos.2021.09.010","article-title":"Oxidative stress as a critical factor might involve in intervertebral disc degeneration via regulating NOXs\/FOXOs","volume":"28","author":"Liu","year":"2023","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0150","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.63.5.6","article-title":"Melatonin attenuates LPS-induced proinflammatory cytokine response and lipogenesis in human meibomian gland epithelial cells via MAPK\/NF-\u03baB pathway","volume":"63","author":"Liu","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.micpath.2018.11.007","article-title":"Protective effects of alpinetin on lipopolysaccharide\/d-Galactosamine-induced liver injury through inhibiting inflammatory and oxidative responses","volume":"126","author":"Liu","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.taap.2024.117110_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9998517","article-title":"Alpinetin attenuates persistent inflammation, immune suppression, and catabolism syndrome in a septic mouse model","volume":"2021","author":"Liu","year":"2021","journal-title":"J Immunol Res"},{"key":"10.1016\/j.taap.2024.117110_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6670497","article-title":"Ferroportin-dependent iron homeostasis protects against oxidative stress-induced nucleus pulposus cell ferroptosis and ameliorates intervertebral disc degeneration in vivo","volume":"2021","author":"Lu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2024.117110_bb0170","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1039\/D2FO00100D","article-title":"Dual effects of cardamonin\/alpinetin and their acrolein adducts on scavenging acrolein and the anti-bacterial activity from Alpinia katsumadai Hayata as a spice in roasted meat","volume":"13","author":"Lu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2024.117110_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108671","article-title":"SIRT1 alleviates IL-1\u03b2 induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration","volume":"107","author":"Ma","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2024.117110_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114772","article-title":"Alpinetin improves intestinal barrier homeostasis via regulating AhR\/suv39h1\/TSC2\/mTORC1\/autophagy pathway","volume":"384","author":"Miao","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2024.117110_bb0185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/ijms24010208","article-title":"Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0190","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/0363546517737497","article-title":"Autologous chondrocyte implantation in osteoarthritic surroundings: TNF\u03b1 and its inhibition by adalimumab in a knee-specific bioreactor","volume":"46","author":"Ossendorff","year":"2018","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.taap.2024.117110_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107527","article-title":"Alpinetin protects against hepatic ischemia\/reperfusion injury in mice by inhibiting the NF-\u03baB\/MAPK signaling pathways","volume":"95","author":"Pan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2024.117110_bb0200","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1039\/D0FO02335C","article-title":"Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4\/NF-\u03baB signal pathway","volume":"12","author":"Qi","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2024.117110_bb0205","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3892\/etm.2016.3425","article-title":"MyD88-dependent toll-like receptor 4 signal pathway in intervertebral disc degeneration","volume":"12","author":"Qin","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.taap.2024.117110_bb0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arr.2017.02.004","article-title":"Targeting the TLR4 signaling pathway by polyphenols: a novel therapeutic strategy for neuroinflammation","volume":"36","author":"Rahimifard","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.taap.2024.117110_bb0215","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/BRS.0b013e31826b71f4","article-title":"Toll-like receptor 4 (TLR4) expression and stimulation in a model of intervertebral disc inflammation and degeneration","volume":"38","author":"Rajan","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.taap.2024.117110_bb0220","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/ijms22041579","article-title":"Genetic therapy for intervertebral disc degeneration","volume":"22","author":"Roh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0225","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6684147","article-title":"Tea polyphenol attenuates oxidative stress-induced degeneration of intervertebral discs by regulating the Keap1\/Nrf2\/ARE pathway","volume":"2021","author":"Song","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2024.117110_bb0230","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1002\/fsn3.1952","article-title":"Protective effect of Alpinetin on rats with chronic obstructive pulmonary disease","volume":"8","author":"Su","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.taap.2024.117110_bb0235","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.amjms.2018.01.002","article-title":"Effects of alpinetin on intestinal barrier function, inflammation and oxidative stress in dextran sulfate sodium-induced ulcerative colitis mice","volume":"355","author":"Tan","year":"2018","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.taap.2024.117110_bb0240","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/13880209.2022.2147548","article-title":"Effects of puerarin on the intervertebral disc degeneration and biological characteristics of nucleus pulposus cells","volume":"61","author":"Tang","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.taap.2024.117110_bb0245","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s13018-022-03438-1","article-title":"Astragaloside IV attenuates IL-1\u03b2-induced intervertebral disc degeneration through inhibition of the NF-\u03baB pathway","volume":"17","author":"Tian","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.taap.2024.117110_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110660","article-title":"The role of IL-1\u03b2 and TNF-\u03b1 in intervertebral disc degeneration","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2024.117110_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106400","article-title":"Alpinetin ameliorates bone loss in LPS-induced inflammation osteolysis via ROS mediated P38\/PI3K signaling pathway","volume":"184","author":"Wei","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2024.117110_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1052878","article-title":"The role of ageing and oxidative stress in intervertebral disc degeneration","volume":"9","author":"Wen","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.taap.2024.117110_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108537","article-title":"Mesenchymal stromal\/stem cells and their exosomes application in the treatment of intervertebral disc disease: a promising frontier","volume":"105","author":"Widjaja","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2024.117110_bb0270","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.3390\/ijms21062135","article-title":"Intervertebral disc diseases PART 2: a review of the current diagnostic and treatment strategies for intervertebral disc disease","volume":"21","author":"Wu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0275","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/cns.14085","article-title":"Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2\/STAT3 signaling pathway in spinal cord injury","volume":"29","author":"Xiao","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.taap.2024.117110_bb0280","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3892\/etm.2023.11999","article-title":"Proanthocyanidins: a novel approach to Henoch-Schonlein purpura through balancing immunity and arresting oxidative stress via TLR4\/MyD88\/NF-\u03baB signaling pathway (review)","volume":"25","author":"Xie","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.taap.2024.117110_bb0285","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/os.13254","article-title":"Treatment of intervertebral disc degeneration","volume":"14","author":"Xin","year":"2022","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.taap.2024.117110_bb0290","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1002\/jcp.30039","article-title":"Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis","volume":"236","author":"Yang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2024.117110_bb0295","first-page":"6016","article-title":"Sparstolonin B attenuates spinal cord injury-induced inflammation in rats by modulating TLR4-trafficking","volume":"17","author":"Yuan","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2024.117110_bb0300","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ptr.7610","article-title":"Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA\/mTOR\/ULK1 signaling","volume":"37","author":"Zeng","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2024.117110_bb0305","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.18632\/oncotarget.23299","article-title":"Dysregulation of YAP by the hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence","volume":"9","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2024.117110_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102305","article-title":"Alpinetin alleviates LPS-induced lung epithelial cell injury by inhibiting p38 and ERK1\/2 signaling via aquaporin-1","volume":"87","author":"Zhang","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.taap.2024.117110_bb0315","first-page":"5427","article-title":"Andrographolide mitigates IL-1\u03b2-induced human nucleus pulposus cells degeneration through the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"18","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2024.117110_bb0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10863-022-09932-9","article-title":"Circ-LRP1B functions as a competing endogenous RNA to regulate proliferation, apoptosis and oxidative stress of LPS-induced human C28\/I2 chondrocytes","volume":"54","author":"Zhang","year":"2022","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.taap.2024.117110_bb0325","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.7150\/ijms.59171","article-title":"Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy","volume":"18","author":"Zhang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.taap.2024.117110_bb0330","doi-asserted-by":"crossref","first-page":"10499","DOI":"10.18632\/aging.102472","article-title":"Melatonin modulates IL-1\u03b2-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation","volume":"11","author":"Zhang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.taap.2024.117110_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22608","article-title":"Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC-133 through the inhibition of STAT\/JAK signaling pathway","volume":"35","author":"Zhang","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.taap.2024.117110_bb0340","article-title":"Alpinetin: a review of its pharmacology and pharmacokinetics","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2024.117110_bb0345","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12941","article-title":"Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration","volume":"54","author":"Zhao","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.taap.2024.117110_bb0350","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6082377","article-title":"Mesenchymal stem cells may alleviate the intervertebral disc degeneration by reducing the oxidative stress in nucleus pulposus cells","volume":"2022","author":"Zhao","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.taap.2024.117110_bb0355","article-title":"Inappropriate activation of TLR4\/NF-\u03baB is a cause of heart failure","volume":"7","author":"Zhou","year":"2022","journal-title":"Cardiovasc. Innov. Appl."},{"key":"10.1016\/j.taap.2024.117110_bb0360","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.biopha.2017.10.035","article-title":"Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism","volume":"97","author":"Zhou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2024.117110_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107660","article-title":"Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis","volume":"96","author":"Zhu","year":"2021","journal-title":"Int. Immunopharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T09:11:46Z","timestamp":1731402706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24003090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":73,"alternative-id":["S0041008X24003090"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117110","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of alpinetin against interleukin-1\u03b2-exposed nucleus pulposus cells: Involvement of the TLR4\/MyD88 pathway in a cellular model of intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117110"}}