{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:29:20Z","timestamp":1770679760332,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.taap.2024.117116","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T17:15:33Z","timestamp":1727716533000},"page":"117116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Ameliorative effect of Schisandrol B against Diosbulbin B-induced hepatotoxicity via inhibiting CYP3A4-mediated bioactivation"],"prefix":"10.1016","volume":"492","author":[{"given":"Dongju","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bufan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2024.117116_bb0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cbi.2011.03.016","article-title":"Herbal bioactivation, molecular targets and the toxicity relevance","volume":"192","author":"Chen","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2024.117116_bb0010","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.fitote.2014.06.014","article-title":"The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms","volume":"97","author":"Chun","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.taap.2024.117116_bb0015","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1002\/jssc.201900222","article-title":"Exploration and optimization of conditions for quantitative analysis of lignans in Schisandra chinensis by an online supercritical fluid extraction with supercritical fluid chromatography system","volume":"42","author":"Dai","year":"2019","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.taap.2024.117116_bb0020","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.biopha.2018.05.073","article-title":"Dioscorea bulbifera induced apoptosis through inhibition of ERK 1\/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells","volume":"104","author":"Fadhlurrahman","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2024.117116_bb0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chemphyslip.2019.03.003","article-title":"Comprehensive analysis of the phospholipids and phytosterols in Schisandra chinensis oil by UPLC-Q\/TOF- MSE","volume":"221","author":"Gao","year":"2019","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.taap.2024.117116_bb0030","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11101-017-9505-5","article-title":"Bioactivity, toxicity and detoxification assessment of Dioscorea bulbifera L.: a comprehensive review","volume":"16","author":"Guan","year":"2017","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.taap.2024.117116_bb0035","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.3390\/ijms23094485","article-title":"Examination of the impact of CYP3A4\/5 on drug-drug interaction between schizandrol A\/schizandrol B and tacrolimus (FK-506): a physiologically based pharmacokinetic modeling approach","volume":"23","author":"He","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117116_bb0040","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/molecules22101617","article-title":"A network pharmacologybased study on the hepatoprotective effect of fructus schisandrae","volume":"22","author":"Hong","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2024.117116_bb0045","first-page":"36","article-title":"Dioscorea bulbifera decoction in the treatment of thyroid nodules on random parallel control","volume":"24","author":"Huang","year":"2013","journal-title":"J. Pract. Tradit. Chin. Intern. Med."},{"key":"10.1016\/j.taap.2024.117116_bb0050","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jep.2016.03.021","article-title":"Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress","volume":"185","author":"Jang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2024.117116_bb0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/toxsci\/kfu216","article-title":"Schisandrol B protects against acetaminophen induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration","volume":"143","author":"Jiang","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2024.117116_bb0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cbi.2015.02.022","article-title":"Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation","volume":"231","author":"Jiang","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2024.117116_bb0065","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/aps.2015.120","article-title":"Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2\/ARE signaling pathway","volume":"37","author":"Jiang","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2024.117116_bb0070","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/bdd.705","article-title":"Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats","volume":"31","author":"Jin","year":"2010","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.taap.2024.117116_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2006.06.015","article-title":"Gomisin A improves scopolamine-induced memory impairment in mice","volume":"542","author":"Kim","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2024.117116_bb0080","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1254\/jphs.FP0071738","article-title":"Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice","volume":"106","author":"Kim","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.taap.2024.117116_bb0085","first-page":"61","article-title":"Steroids from tuber of Dioscorea bulbifera L","volume":"8","author":"Li","year":"1999","journal-title":"J. Plant Resour. Environ."},{"key":"10.1016\/j.taap.2024.117116_bb0090","first-page":"52","article-title":"Advances in modern research on Dioscorea bulbifera","volume":"11","author":"Li","year":"2013","journal-title":"Guide China Med."},{"key":"10.1016\/j.taap.2024.117116_bb0095","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00204-015-1495-8","article-title":"Metabolic activation of the furan moiety makes diosbulbin B hepatotoxic","volume":"90","author":"Li","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2024.117116_bb0100","first-page":"175","article-title":"Advances in studies on Dioscorea bulbifera","volume":"33","author":"Lin","year":"2002","journal-title":"Chin. Tradit. Herb. Drug"},{"key":"10.1016\/j.taap.2024.117116_bb0105","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1124\/dmd.114.059261","article-title":"Cytochrome P450-mediated metabolic activation of diosbulbin B","volume":"42","author":"Lin","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2024.117116_bb0110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1021\/acs.chemrestox.8b00071","article-title":"In vitro DNA adduction resulting from metabolic activation of diosbulbin B and 8-epidiosbulbin E acetate","volume":"32","author":"Lin","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2024.117116_bb0115","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3109\/13880209.2014.890232","article-title":"The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy","volume":"52","author":"Lu","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.taap.2024.117116_bb0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1389450118666170125144557","article-title":"Cytochrome P450 structure, function and clinical significance: a review","volume":"19","author":"Manikandan","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.taap.2024.117116_bb0125","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jep.2010.01.061","article-title":"Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K+ channel activation","volume":"128","author":"Nguelefack","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2024.117116_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113254","article-title":"Rapid analysis of nine lignans in Schisandra chinensis by supercritical fluid chromatography using diode array and mass spectrometric detection","volume":"185","author":"Onay","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.taap.2024.117116_bb0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/jcpt.13058","article-title":"Clinically relevant drug interactions between statins and antidepressants","volume":"45","author":"Palleria","year":"2020","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.taap.2024.117116_bb0140","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2008.04.020","article-title":"Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine","volume":"118","author":"Panossian","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2024.117116_bb0145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/jmf.2013.2849","article-title":"Schisandra chinensis prevents alcohol-induced fatty liver disease in rats","volume":"17","author":"Park","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.taap.2024.117116_bb0150","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/161062","article-title":"Correlation between antistress and hepatoprotective effects of schisandra lignans was related with its antioxidative actions in liver cells","volume":"2012","author":"Pu","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2024.117116_bb0155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/dmd.113.053892","article-title":"In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A\/P-glycoprotein-mediated absorption and metabolism of tacrolimus","volume":"42","author":"Qin","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2024.117116_bb0160","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.phymed.2013.12.006","article-title":"Effect of tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp","volume":"21","author":"Qin","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2024.117116_bb0165","first-page":"394","article-title":"Determination of diosbulbin B in Dioscorea bulbifera L. from different regions","volume":"34","author":"Shen","year":"2015","journal-title":"Herald Med."},{"key":"10.1016\/j.taap.2024.117116_bb0170","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ijantimicag.2008.05.013","article-title":"A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria","volume":"32","author":"Shriram","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.taap.2024.117116_bb0175","first-page":"26","article-title":"Research progress on chemical constituents from Kadsura genus and its pharmacological activities and clinical application","volume":"49","author":"Su","year":"2024","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.taap.2024.117116_bb0185","series-title":"Chinese Materia Medica","volume":"8","author":"The Editorial Committee of Chinese Herbals","year":"1999"},{"key":"10.1016\/j.taap.2024.117116_bb0190","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1248\/cpb.57.625","article-title":"Two new furanoid norditerpenes from Dioscorea bulbifera","volume":"57","author":"Wang","year":"2009","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.taap.2024.117116_bb0195","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/toxins9080249","article-title":"Chemical identity of interaction of protein with reactive metabolite of Diosbulbin B in vitro and in vivo","volume":"9","author":"Wang","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.taap.2024.117116_bb0200","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2010.06.038","article-title":"Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers","volume":"131","author":"Xie","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2024.117116_bb0205","first-page":"29","article-title":"Study on the effect of the Schisandra chinensis (Turcz.) Baill on the hepanic and renal toxicity of Dioscorea bulbifera L","volume":"6","author":"Yang","year":"2008","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.taap.2024.117116_bb0210","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/bph.13729","article-title":"Schisandrol B protects against cholestatic liver injury through pregnane X receptors","volume":"174","author":"Zeng","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2024.117116_bb0215","first-page":"147","article-title":"Pharmacological research and clinical progress of Rhizoma Dioscorea bulbiferae","volume":"35","author":"Zhao","year":"2012","journal-title":"Drug Eval. Res."},{"key":"10.1016\/j.taap.2024.117116_bb0220","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fct.2013.04.053","article-title":"Inhibitory effects of astaxanthin, \u03b2-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities","volume":"59","author":"Zheng","year":"2013","journal-title":"Food Chem. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T09:11:58Z","timestamp":1731402718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24003156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":43,"alternative-id":["S0041008X24003156"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117116","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ameliorative effect of Schisandrol B against Diosbulbin B-induced hepatotoxicity via inhibiting CYP3A4-mediated bioactivation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117116"}}