{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:30:56Z","timestamp":1776774656800,"version":"3.51.2"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085MH257"],"award-info":[{"award-number":["2008085MH257"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072687"],"award-info":[{"award-number":["82072687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.taap.2024.117117","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T23:17:07Z","timestamp":1727824627000},"page":"117117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Alcohol promotes hepatocyte injury via ER stress sensor XBP1s mediated regulation of autophagy and lysosomal activity"],"prefix":"10.1016","volume":"492","author":[{"given":"Yong","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuojiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiatao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2024.117117_bb0005","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0168-8278(05)80498-2","article-title":"Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver","volume":"20","author":"Baroni","year":"1994","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2024.117117_bb0010","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ni.3225","article-title":"The transcription factor XBP1 is selectively required for eosinophil differentiation","volume":"16","author":"Bettigole","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.taap.2024.117117_bb0015","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1042\/BCJ20170678","article-title":"The inositol-requiring enzyme 1 (IRE1\u03b1) RNAse inhibitor, 4\u03bc8C, is also a potent cellular antioxidant","volume":"475","author":"Chan","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2024.117117_bb0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.apha.2019.01.008","article-title":"Role and mechanisms of autophagy in alcohol-induced liver injury","volume":"85","author":"Chao","year":"2019","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.taap.2024.117117_bb0025","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1053\/j.gastro.2018.05.027","article-title":"Impaired TFEB-mediated lysosome biogenesis and autophagy promote chronic ethanol-induced liver injury and steatosis in mice","volume":"155","author":"Chao","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117117_bb0030","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1080\/15548627.2018.1489170","article-title":"Insufficient autophagy: a novel autophagic flux scenario uncovered by impaired liver TFEB-mediated lysosomal biogenesis from chronic alcohol-drinking mice","volume":"14","author":"Chao","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2024.117117_bb0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.apsb.2022.06.015","article-title":"Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation","volume":"13","author":"Che","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.taap.2024.117117_bb0040","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/hep.22837","article-title":"Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver","volume":"49","author":"Cohen","year":"2009","journal-title":"Hepatology"},{"issue":"664\u2013674","key":"10.1016\/j.taap.2024.117117_bb0045","first-page":"674","article-title":"Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice","volume":"139","author":"Cohen","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117117_bb0050","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4161\/auto.25063","article-title":"Functions of autophagy in normal and diseased liver","volume":"9","author":"Czaja","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2024.117117_bb0055","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1053\/j.gastro.2020.06.031","article-title":"IRE1A stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis","volume":"159","author":"Dasgupta","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117117_bb0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4331\/wjbc.v1.i1.3","article-title":"Role of autophagy in liver physiology and pathophysiology","volume":"1","author":"Ding","year":"2010","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.taap.2024.117117_bb0065","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.taap.2024.117117_bb0070","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s42255-024-01063-2","article-title":"Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption","volume":"6","author":"Fu","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.taap.2024.117117_bb0075","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117117_bb0080","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1136\/gutjnl-2014-308506","article-title":"PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury","volume":"65","author":"Han","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.taap.2024.117117_bb0085","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.2147\/OTT.S194770","article-title":"Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment","volume":"12","author":"He","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.taap.2024.117117_bb0090","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1039\/D2FO01042A","article-title":"Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver injury in mice","volume":"13","author":"He","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2024.117117_bb0095","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0016-5085(03)00276-2","article-title":"Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice","volume":"124","author":"Ji","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117117_bb0100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1055\/s-2007-991513","article-title":"Endoplasmic reticulum stress and liver injury","volume":"27","author":"Kaplowitz","year":"2007","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2024.117117_bb0105","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.4161\/cc.10.9.15291","article-title":"Regulation of the autophagy initiating kinase ULK1 by nutrients: roles of mTORC1 and AMPK","volume":"10","author":"Kim","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.taap.2024.117117_bb0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2024.117117_bb0115","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nm.2449","article-title":"p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis","volume":"17","author":"Lee","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2024.117117_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/479348","article-title":"Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease","volume":"2012","author":"Longato","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2024.117117_bb0125","first-page":"134","article-title":"Alcohol-associated liver disease","author":"Mackowiak","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2024.117117_bb0130","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/j.gastro.2016.02.035","article-title":"Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes","volume":"150","author":"Nagy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117117_bb0135","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: a matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2024.117117_bb0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/glia.24082","article-title":"The role of endoplasmic reticulum stress in astrocytes","volume":"70","author":"Sims","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.taap.2024.117117_bb0145","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2024.117117_bb0150","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2018.10.041","article-title":"Alcohol-related liver disease: areas of consensus, unmet needs and opportunities for further study","volume":"70","author":"Thursz","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2024.117117_bb0155","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCULATIONAHA.118.038924","article-title":"Spliced X-box binding protein 1 stimulates adaptive growth through activation of mTOR","volume":"140","author":"Wang","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2024.117117_bb0160","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jhep.2022.02.031","article-title":"Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis","volume":"77","author":"Wang","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2024.117117_bb0165","doi-asserted-by":"crossref","first-page":"12908","DOI":"10.3748\/wjg.v20.i36.12908","article-title":"New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases","volume":"20","author":"Williams","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2024.117117_bb0170","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.7150\/ijbs.67852","article-title":"Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases","volume":"18","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2024.117117_bb0175","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.taap.2024.117117_bb0180","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1158\/1541-7786.MCR-17-0307","article-title":"A human genome-wide RNAi screen reveals diverse modulators that mediate IRE1\u03b1-XBP1 activation","volume":"16","author":"Yang","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.taap.2024.117117_bb0185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41419-022-04580-8","article-title":"Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy","volume":"13","author":"Ye","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2024.117117_bb0190","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/hep.22146","article-title":"Autophagy in the liver","volume":"47","author":"Yin","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2024.117117_bb0195","article-title":"Hepatotoxicity induced by isoniazid-lipopolysaccharide through endoplasmic reticulum stress, autophagy, and apoptosis pathways in zebrafish","volume":"63","author":"Zhang","year":"2019","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:50:56Z","timestamp":1731545456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24003168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":39,"alternative-id":["S0041008X24003168"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117117","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol promotes hepatocyte injury via ER stress sensor XBP1s mediated regulation of autophagy and lysosomal activity","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117117"}}