{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T05:54:26Z","timestamp":1746770066436,"version":"3.37.3"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021570","name":"Ministerie van Defensie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.taap.2024.117137","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T10:50:41Z","timestamp":1730285441000},"page":"117137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Synergistic polytherapy for the broad-spectrum treatment of chemically-induced seizures in rats"],"prefix":"10.1016","volume":"493","author":[{"given":"Alex S.","family":"Cornelissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland M.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelle C.","family":"de Koning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P.","family":"Langenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth C.M.","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marloes J.A.","family":"Joosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.taap.2024.117137_bb0005","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1081\/CLT-120026523","article-title":"Status epilepticus from an illegally imported Chinese rodenticide: \u201ctetramine\u201d","volume":"41","author":"Barrueto","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0010","first-page":"1051","article-title":"Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat","volume":"283","author":"Bol","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0015","first-page":"347","article-title":"Quantification of pharmacodynamic interactions between dexmedetomidine and midazolam in the rat","volume":"294","author":"Bol","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.taap.2024.117137_bb0020","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.seizure.2011.01.004","article-title":"Combining antiepileptic drugs - Rational polytherapy?","volume":"20","author":"Brodie","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.taap.2024.117137_bb0025","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuropharm.2015.03.035","article-title":"Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures","volume":"95","author":"Bruun","year":"2015","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0030","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/00000542-199406000-00008","article-title":"Dexmedetomidine decreases thiopental dose requirement and alters distribution pharmacokinetics","volume":"80","author":"B\u00fchrer","year":"1994","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0035","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11064-021-03445-4","article-title":"The Anticonvulsant Effects of Alpha-2 Adrenoceptor Agonist Dexmedetomidine on Pentylenetetrazole-Induced Seizures in Rats","volume":"47","author":"Cetindag Ciltas","year":"2022","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0040","first-page":"511","article-title":"Tetramine poisoning","volume":"11","author":"Chau","year":"2005","journal-title":"Hong Kong Medical J. = Xianggang Yi Xue Za Zhi"},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12871-018-0562-0","article-title":"Efficacy of different doses of dexmedetomidine as a rapid bolus for children: A double-blind, prospective, randomized study","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Anesthesiol."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/bja\/aex086","article-title":"Dexmedetomidine pharmacodynamics in healthy volunteers: 2. Haemodynamic profile","volume":"119","author":"Colin","year":"2017","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0055","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/bja\/aex085","article-title":"Dexmedetomidine pharmacokinetic\u2013pharmacodynamic modelling in healthy volunteers: 1. Influence of arousal on bispectral index and sedation","volume":"119","author":"Colin","year":"2017","journal-title":"BJA: British J. Anaesthes."},{"issue":"11","key":"10.1016\/j.taap.2024.117137_bb0060","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s12630-020-01753-x","article-title":"The effect of dexmedetomidine on status epilepticus in a patient with anti-NMDA receptor encephalitis","volume":"67","author":"Coluzzi","year":"2020","journal-title":"Can. J. Anesth.\/J. Can. Anesth."},{"issue":"5\u20136","key":"10.1016\/j.taap.2024.117137_bb0065","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1159\/000096473","article-title":"Sequential Hemoperfusion and Continuous Venovenous Hemofiltration in Treatment of Severe Tetramine Poisoning","volume":"24","author":"Dehua","year":"2006","journal-title":"Blood Purif."},{"key":"10.1016\/j.taap.2024.117137_bb0070","series-title":"Chapter 36 - Models of Chemically-Induced Acute Seizures and Epilepsy: Toxic Compounds and Drugs of Addiction","first-page":"529","author":"Dorandeu","year":"2017"},{"issue":"4","key":"10.1016\/j.taap.2024.117137_bb0075","first-page":"146","article-title":"The pathophysiology of organophosphorus pesticide self-poisoning is not so simple","volume":"66","author":"Eddleston","year":"2008","journal-title":"Neth. J. Med."},{"issue":"9612","key":"10.1016\/j.taap.2024.117137_bb0080","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0140-6736(07)61202-1","article-title":"Management of acute organophosphorus pesticide poisoning","volume":"371","author":"Eddleston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2024.117137_bb0085","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fnmol.2018.00217","article-title":"Kainate Receptors: Role in Epilepsy","volume":"11","author":"Falc\u00f3n-Moya","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-2999(88)90688-7","article-title":"A proconvulsant action of selective alpha 2-adrenoceptor antagonists","volume":"151","author":"Fletcher","year":"1988","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/glia.23763","article-title":"Activation of alpha-2 adrenergic receptors stimulates GABA release by astrocytes","volume":"68","author":"Gaidin","year":"2020","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0100","first-page":"403","article-title":"[Study on the effect using hemoperfusion to treat tetramine poisoned patients]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases","volume":"20","author":"Ge","year":"2002"},{"key":"10.1016\/j.taap.2024.117137_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110171","article-title":"Midazolam - A diazepam replacement for the management of nerve agent-induced seizures","volume":"261","author":"Gorecki","year":"2024","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.taap.2024.117137_bb0110","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1213\/ANE.0000000000000931","article-title":"Dexmedetomidine as a rapid bolus for treatment and prophylactic prevention of emergence agitation in anesthetized children","volume":"121","author":"Hauber","year":"2015","journal-title":"Anesth. Analg."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0115","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1213\/ane.0b013e31817b859e","article-title":"Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility","volume":"107","author":"Hendrickx","year":"2008","journal-title":"Anesth. Analg."},{"issue":"5","key":"10.1016\/j.taap.2024.117137_bb0120","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/ALN.0b013e3182700ab9","article-title":"Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine \u03b2-hydroxylase knockout mice","volume":"117","author":"Hu","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.taap.2024.117137_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vascn.2019.02.006","article-title":"Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital","volume":"97","author":"Jackson","year":"2019","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00204-010-0571-3","article-title":"Treatment efficacy in a soman-poisoned guinea pig model: Added value of physostigmine?","volume":"85","author":"Joosen","year":"2011","journal-title":"Arch. Toxicol."},{"year":"2011","series-title":"Organophosphate toxicity relating to exposure route and type of agent","author":"Joosen","key":"10.1016\/j.taap.2024.117137_bb0135"},{"key":"10.1016\/j.taap.2024.117137_bb0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2013.03.036","article-title":"Anticonvulsant effect of dexmedetomidine in a rat model of self-sustaining status epilepticus with prolonged amygdala stimulation","volume":"543","author":"Kan","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0145","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/00000542-199109000-00020","article-title":"Influence of Dexmedetomidine and Clonidine on Human Liver Microsomal Alfentanil Metabolism","volume":"75","author":"Kharasch","year":"1991","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.taap.2024.117137_bb0150","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.14336\/AD.2021.0302","article-title":"Super-refractory status epilepticus: Prognosis and recent advances in management","volume":"12","author":"Kirmani","year":"2021","journal-title":"Aging Dis."},{"issue":"4","key":"10.1016\/j.taap.2024.117137_bb0155","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.braindev.2012.05.011","article-title":"Epileptic seizures induced by dexmedetomidine in a neonate","volume":"35","author":"Kubota","year":"2013","journal-title":"Brain Dev."},{"issue":"14","key":"10.1016\/j.taap.2024.117137_bb0160","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2165\/00003495-200666140-00004","article-title":"Combination Therapy in Epilepsy","volume":"66","author":"Kwan","year":"2006","journal-title":"Drugs"},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s002040050595","article-title":"Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support","volume":"73","author":"Lallement","year":"1999","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.taap.2024.117137_bb0170","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/10915818211040483","article-title":"Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms","volume":"40","author":"Larson","year":"2021","journal-title":"Int. J. Toxicol."},{"issue":"4","key":"10.1016\/j.taap.2024.117137_bb0175","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/dneu.22582","article-title":"Developmental and sex differences in tetramethylenedisulfotetramine (TMDT)-induced syndrome in rats","volume":"78","author":"Laukov\u00e1","year":"2018","journal-title":"Developm. Neurobiol."},{"issue":"March 2019","key":"10.1016\/j.taap.2024.117137_bb0180","article-title":"Tetramethylenedisulfotetramine neurotoxicity: What have we learned in the past 70\u00a0years?","volume":"133","author":"Laukov\u00e1","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0185","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuro.2011.10.008","article-title":"Tetramethylenedisulfotetramine intoxication presenting with de novo Status Epilepticus: a case series","volume":"33","author":"Li","year":"2012","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0190","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/WNF.0b013e3180d09983","article-title":"Nongenetic cause of epileptic seizures in 2 otherwise healthy Chinese families: tetramine--case presentation and literature survey","volume":"31","author":"Lu","year":"2008","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.taap.2024.117137_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2019.104629","article-title":"Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats","volume":"27","author":"Lumley","year":"2019","journal-title":"Data in Brief"},{"issue":"October 2020","key":"10.1016\/j.taap.2024.117137_bb0200","article-title":"Treatment of acetylcholinesterase inhibitor-induced seizures with polytherapy targeting GABA and glutamate receptors","volume":"185","author":"Lumley","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.taap.2024.117137_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107229","article-title":"Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice","volume":"111","author":"Marrero-Rosado","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.taap.2024.117137_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2018.01.010","article-title":"Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus","volume":"141","author":"McCarren","year":"2018","journal-title":"Epilepsy Res."},{"issue":"8","key":"10.1016\/j.taap.2024.117137_bb0215","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s002040050637","article-title":"Comparative evaluation of benzodiazepines for control of soman-induced seizures","volume":"73","author":"McDonough","year":"1999","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0220","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0149-7634(05)80151-4","article-title":"Pharmacological modulation of soman-induced seizures","volume":"17","author":"McDonough","year":"1993","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.taap.2024.117137_bb0225","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0149-7634(96)00050-4","article-title":"Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology","volume":"21","author":"McDonough","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0230","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/01480540903483417","article-title":"Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs","volume":"33","author":"McDonough","year":"2010","journal-title":"Drug Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0235","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1001\/archneur.1973.00490190028002","article-title":"Prolonged Epileptic Seizures in Primates: Ischemic Cell Change and Its Relation to Ictal Physiological Events","volume":"28","author":"Meldrum","year":"1973","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0240","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0003-9861(67)90006-9","article-title":"Ageing and dealkylation of Soman (pinacolylmethylphosphonofluoridate)-inactivated eel cholinesterase","volume":"121","author":"Michel","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2024.117137_bb0245","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuro.2019.08.004","article-title":"Survey of drug therapies against acute oral tetramethylenedisulfotetramine poisoning in a rat voluntary consumption model","volume":"74","author":"Moffett","year":"2019","journal-title":"Neurotoxicology"},{"issue":"10","key":"10.1016\/j.taap.2024.117137_bb0250","article-title":"Dexmedetomidine in current anaesthesia practice- a review","volume":"8","author":"Naaz","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"year":"2018","series-title":"AMedP-7.1: Medical Management of CBRN Casualties (Edition A)","author":"NATO Standardization Office (NSO)","key":"10.1016\/j.taap.2024.117137_bb0255"},{"issue":"S1","key":"10.1016\/j.taap.2024.117137_bb0260","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1002\/epi4.12718","article-title":"In the fast lane: Receptor trafficking during status epilepticus","volume":"8","author":"Naylor","year":"2023","journal-title":"Epileps. Open"},{"key":"10.1016\/j.taap.2024.117137_bb0265","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2017.04.019","article-title":"Simultaneous triple therapy for the treatment of status epilepticus","volume":"104","author":"Niquet","year":"2017","journal-title":"Neurobiol. Dis."},{"issue":"March 2019","key":"10.1016\/j.taap.2024.117137_bb0270","article-title":"Rational polytherapy in the treatment of cholinergic seizures","volume":"133","author":"Niquet","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"S1","key":"10.1016\/j.taap.2024.117137_bb0275","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1002\/epi4.12713","article-title":"Treatment of cholinergic-induced status epilepticus with polytherapy targeting GABA and glutamate receptors","volume":"8","author":"Niquet","year":"2023","journal-title":"Epileps. Open"},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0280","first-page":"1","article-title":"Dexmedetomidine administration in a patient with status epilepticus under color density spectral array monitoring","volume":"5","author":"Obara","year":"2019","journal-title":"JA Clin. Report."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/toxics6030051","article-title":"Tetramethylenedisulfotetramine: A Health Risk Compound and a Potential Chemical Warfare Agent","volume":"6","author":"Patocka","year":"2018","journal-title":"Toxics"},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0290","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00204-020-02728-z","article-title":"Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice","volume":"94","author":"Pressly","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0295","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2885.2012.01383.x","article-title":"Effect of dexmedetomidine on its clearance: a pharmacokinetic model","volume":"36","author":"Pypendop","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0300","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/epi.12989","article-title":"Midazolam as an anticonvulsant antidote for organophosphate intoxication - A pharmacotherapeutic appraisal","volume":"56","author":"Reddy","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.taap.2024.117137_bb0305","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuro.2017.08.009","article-title":"Behavioral intoxication following voluntary oral ingestion of tetramethylenedisulfotetramine: Dose-dependent onset, severity, survival, and recovery","volume":"63","author":"Rice","year":"2017","journal-title":"NeuroToxicology"},{"issue":"1\u20132","key":"10.1016\/j.taap.2024.117137_bb0310","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02245313","article-title":"Dexmedetomidine synergism with midazolam in the elevated plus-maze test in rats","volume":"108","author":"Salonen","year":"1992","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0315","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/00000542-199206000-00022","article-title":"Synergistic interaction between alpha 2-adrenergic agonists and benzodiazepines in rats","volume":"76","author":"Salonen","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.taap.2024.117137_bb0320","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-2885.1995.tb00599.x","article-title":"Atipamezole increases medetomidine clearance in the dog: an agonist-antagonist interaction","volume":"18","author":"Salonen","year":"1995","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0325","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.taap.2012.01.017","article-title":"The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: Synergism with the benzodiazepine diazepam","volume":"259","author":"Schultz","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0330","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.taap.2012.08.037","article-title":"Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABA(A) receptors","volume":"265","author":"Shakarjian","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2024.117137_bb0335","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuro.2015.03.007","article-title":"Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice","volume":"48","author":"Shakarjian","year":"2015","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0340","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/nyas.13120","article-title":"Tetramethylenedisulfotetramine: pest control gone awry","volume":"1378","author":"Shakarjian","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2024.117137_bb0345","series-title":"Journal of the Royal Society of Medicine","first-page":"114","article-title":"Nicotinic antagonists in the treatment of nerve agent intoxication","volume":"98, Issue 3","author":"Sheridan","year":"2005"},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0350","first-page":"86","article-title":"Anticonvulsants for soman-induced seizure activity","volume":"6","author":"Shih","year":"1999","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0355","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0041-008X(03)00019-X","article-title":"Control of nerve agent-induced seizures is critical for neuroprotection and survival","volume":"188","author":"Shih","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"40","key":"10.1016\/j.taap.2024.117137_bb0360","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1021\/jp307790v","article-title":"Aging mechanism of soman inhibited acetylcholinesterase","volume":"116","author":"Sirin","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.taap.2024.117137_bb0365","article-title":"Alpha2 Adrenergic Modulation of Spike-Wave Epilepsy: Experimental Study of Pro-Epileptic and Sedative Effects of Dexmedetomidine. In","volume":"24, Issue 11","author":"Sitnikova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021477","article-title":"Alpha2-Adrenergic Receptors as a Pharmacological Target for Spike-Wave Epilepsy","volume":"24","author":"Sitnikova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0375","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0736-4679(90)90013-L","article-title":"Strychnine poisoning","volume":"8","author":"Smith","year":"1990","journal-title":"J. Emergen. Med."},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0380","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/seiz.2002.0711","article-title":"Seizure freedom with more than one antiepileptic drug","volume":"11","author":"Stephen","year":"2002","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0773.1980.tb02411.x","article-title":"Toxicity of soman after repetitive injection of sublethal doses in rat","volume":"46","author":"Sterri","year":"1980","journal-title":"Acta Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2024.117137_bb0390","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/petr.12618","article-title":"Tacrolimus interaction with dexmedetomidine--a case report","volume":"20","author":"Stiehl","year":"2016","journal-title":"Pediatr. Transplant."},{"issue":"3","key":"10.1016\/j.taap.2024.117137_bb0395","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/ANA.0b013e318060d281","article-title":"Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy","volume":"19","author":"Talke","year":"2007","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"10.1016\/j.taap.2024.117137_bb0400","series-title":"The Treatment of Epilepsy","first-page":"398","article-title":"Benzodiazepines Used in the Treatment of Epilepsy","author":"Trinka","year":"2015"},{"issue":"42","key":"10.1016\/j.taap.2024.117137_bb0405","doi-asserted-by":"crossref","first-page":"26954","DOI":"10.18632\/oncotarget.25485","article-title":"Astroglial role in the pathophysiology of status epilepticus: an overview","volume":"9","author":"Vargas-S\u00e1nchez","year":"2018","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.taap.2024.117137_bb0410","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/cc712","article-title":"Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care","volume":"4","author":"Venn","year":"2000","journal-title":"Critic. Care (London, England)"},{"issue":"2","key":"10.1016\/j.taap.2024.117137_bb0415","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.taap.2014.10.001","article-title":"Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication","volume":"281","author":"Vito","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Suppl. 8","key":"10.1016\/j.taap.2024.117137_bb0420","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1528-1167.2011.03243.x","article-title":"Rational polytherapy in the treatment of acute seizures and status epilepticus","volume":"52","author":"Wasterlain","year":"2011","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.taap.2024.117137_bb0425","first-page":"481","article-title":"Comparison of ketamine-xylazine and ketamine-dexmedetomidine anesthesia and intraperitoneal tolerance in rats","volume":"52","author":"Wellington","year":"2013","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"issue":"6","key":"10.1016\/j.taap.2024.117137_bb0430","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.annemergmed.2004.09.009","article-title":"Tetramethylenedisulfotetramine: old agent and new terror","volume":"45","author":"Whitlow","year":"2005","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.taap.2024.117137_bb0435","series-title":"Handbook of Toxicology of Chemical Warfare Agents","first-page":"97","article-title":"Chapter 8 - Organophosphate nerve agents","author":"Young","year":"2020"},{"key":"10.1016\/j.taap.2024.117137_bb0440","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"8607","article-title":"GABAA receptor target of tetramethylenedisulfotetramine","volume":"111(23)","author":"Zhao","year":"2014"},{"key":"10.1016\/j.taap.2024.117137_bb0445","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.2147\/DDDT.S254055","article-title":"Effects of dexmedetomidine on the pharmacokinetics of dezocine, midazolam and its metabolite 1-hydroxymidazolam in beagles by UPLC-MS\/MS","volume":"14","author":"Zhou","year":"2020","journal-title":"Drug Design, Developm. Therap."},{"issue":"7","key":"10.1016\/j.taap.2024.117137_bb0450","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00204-021-03053-9","article-title":"Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam","volume":"95","author":"Zolkowska","year":"2021","journal-title":"Arch. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T01:36:43Z","timestamp":1732585003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24003363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":90,"alternative-id":["S0041008X24003363"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117137","relation":{},"ISSN":["0041-008X"],"issn-type":[{"type":"print","value":"0041-008X"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic polytherapy for the broad-spectrum treatment of chemically-induced seizures in rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117137"}}