{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:23:22Z","timestamp":1780417402310,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012269","name":"Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province","doi-asserted-by":"publisher","award":["19H05770"],"award-info":[{"award-number":["19H05770"]}],"id":[{"id":"10.13039\/501100012269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016981","name":"Pharmaceutical Society of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06592"],"award-info":[{"award-number":["22K06592"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.taap.2024.117171","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T16:00:06Z","timestamp":1732464006000},"page":"117171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cisplatin caused highly delayed cytotoxicity in the immortalized cells derived from S3 segment of mouse kidney proximal tubules"],"prefix":"10.1016","volume":"494","author":[{"given":"Hiroki","family":"Taguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Sumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2024.117171_bb0005","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1073\/pnas.1615327114","article-title":"Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity","volume":"114","author":"Awuah","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.taap.2024.117171_bb0010","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1021\/acs.analchem.8b01429","article-title":"Quantitative bioimaging of platinum via online isotope dilution-laser ablation-inductively coupled plasma mass spectrometry","volume":"90","author":"Bauer","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2024.117171_bb0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-021-01355-1","article-title":"Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin","volume":"20","author":"Cheng","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.taap.2024.117171_bb0020","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0002-9440(10)61234-5","article-title":"Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2","volume":"167","author":"Ciarimboli","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2024.117171_bb0025","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2024.117171_bb0030","first-page":"551","article-title":"Mechanism of cis-platinum nephrotoxicity: II. Morphologic observations","volume":"213","author":"Dobyan","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2024.117171_bb0035","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/clpt.2009.139","article-title":"Contribution of Organic Cation Transporter 2 (OCT2) to cisplatin-induced nephrotoxicity","volume":"86","author":"Filipski","year":"2009","journal-title":"Clin. Pharmacol. Ther. (St. Louis, MO, U. S.)"},{"key":"10.1016\/j.taap.2024.117171_bb0040","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1039\/c1mt00020a","article-title":"High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8","volume":"3","author":"Fujishiro","year":"2011","journal-title":"Metallomics"},{"key":"10.1016\/j.taap.2024.117171_bb0045","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2131\/jts.44.611","article-title":"Segment-specific and direction-dependent transport of cadmium and manganese in immortalized S1, S2, and S3 cells derived from mouse kidney proximal tubules","volume":"44","author":"Fujishiro","year":"2019","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2024.117171_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105179","article-title":"Comparisons of segment-specific toxicity of platinum-based agents and cadmium using S1, S2, and S3 cells derived from mouse kidney proximal tubules","volume":"75","author":"Fujishiro","year":"2021","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2024.117171_bb0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/oxfordjournals.ndt.a027066","article-title":"Cisplatin nephrotoxicity and protection by silibinin","volume":"11","author":"Gaedeke","year":"1996","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.taap.2024.117171_bb0060","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1200\/JCO.2014.56.0896","article-title":"Testicular cancer: a reflection on 50 years of discovery","volume":"32","author":"Hanna","year":"2014","journal-title":"JCO"},{"key":"10.1016\/j.taap.2024.117171_bb0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tox.2016.06.011","article-title":"Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma","volume":"359\u2013360","author":"Hosohata","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2024.117171_bb0070","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.taap.2024.117171_bb0075","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1021\/cr980421n","article-title":"Structure, recognition, and processing of cisplatin-DNA adducts","volume":"99","author":"Jamieson","year":"1999","journal-title":"Chem. Rev."},{"key":"10.1016\/j.taap.2024.117171_bb0080","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2215\/CJN.08070715","article-title":"Long\u2013term renal outcomes after cisplatin treatment","volume":"11","author":"Latcha","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2024.117171_bb0085","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.3390\/cancers13071572","article-title":"Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations","volume":"13","author":"McSweeney","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.taap.2024.117171_bb0090","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.taap.2024.117171_bb0095","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2147\/OTT.S86743","article-title":"Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury","volume":"8","author":"Mizuno","year":"2015","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.taap.2024.117171_bb0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5049\/EBP.2014.12.2.55","article-title":"Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies","volume":"12","author":"Oh","year":"2014","journal-title":"Electrolyte Blood Press"},{"key":"10.1016\/j.taap.2024.117171_bb0105","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2024.117171_bb0110","doi-asserted-by":"crossref","first-page":"F505","DOI":"10.1152\/ajprenal.90545.2008","article-title":"The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity","volume":"296","author":"Pabla","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.taap.2024.117171_bb0115","doi-asserted-by":"crossref","first-page":"45597","DOI":"10.18632\/oncotarget.17316","article-title":"Enhanced antitumor efficacy of cisplatin for treating ovarian cancer in vitro and in vivo via transferrin binding","volume":"8","author":"Peng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2024.117171_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1462802","article-title":"Cisplatin-induced rodent model of kidney injury: characteristics and challenges","volume":"2018","author":"Per\u0161e","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2024.117171_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.15171\/jnp.2017.28","article-title":"Time course of cisplatin-induced nephrotoxicity and hepatotoxicity","volume":"6","author":"Pezeshki","year":"2017","journal-title":"J. Nephropathol."},{"key":"10.1016\/j.taap.2024.117171_bb0130","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1039\/c3mt00147d","article-title":"Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS","volume":"5","author":"Reifschneider","year":"2013","journal-title":"Metallomics"},{"key":"10.1016\/j.taap.2024.117171_bb0135","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1158\/1535-7163.1543.3.12","article-title":"Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells","volume":"3","author":"Song","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2024.117171_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153840","article-title":"Ferroptosis is involved in cisplatin sensitivity of the S3 segment of immortalized proximal tubule cells","volume":"506","author":"Taguchi","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2024.117171_bb0145","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1177\/0192623312444765","article-title":"Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats","volume":"40","author":"Vinken","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2024.117171_bb0150","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular processing of platinum anticancer drugs","volume":"4","author":"Wang","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2024.117171_bb0155","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.ajpath.2014.01.025","article-title":"Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice","volume":"184","author":"Wen","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2024.117171_bb0160","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00204-015-1633-3","article-title":"DNA damage response in cisplatin-induced nephrotoxicity","volume":"89","author":"Zhu","year":"2015","journal-title":"Arch. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24003703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T09:53:04Z","timestamp":1733997184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24003703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":32,"alternative-id":["S0041008X24003703"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117171","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cisplatin caused highly delayed cytotoxicity in the immortalized cells derived from S3 segment of mouse kidney proximal tubules","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117171"}}