{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:30:25Z","timestamp":1784547025997,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"publisher","award":["Mu-phra-21-19"],"award-info":[{"award-number":["Mu-phra-21-19"]}],"id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"publisher","award":["Mu-phar-21-19"],"award-info":[{"award-number":["Mu-phar-21-19"]}],"id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.taap.2024.117202","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T11:30:39Z","timestamp":1733916639000},"page":"117202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Desloratadine mitigates hepatocellular carcinoma in rats: Possible contribution of TLR4\/MYD88\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"495","author":[{"given":"Heba A.","family":"Bahriz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania R.","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia H.","family":"El-Kashef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2024.117202_bb0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/scipharm90020022","article-title":"Cinnamaldehyde relieves induced hepatocellular carcinoma in rat model via targeting Wnt\/&beta;-catenin pathway","volume":"90","author":"Abd El Salam","year":"2022","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.taap.2024.117202_bb0010","article-title":"Andrographis paniculata leaf extract prevents thioacetamide-induced liver cirrhosis in rats","volume":"9","author":"Abdulaziz BARDI","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2024.117202_bb0015","first-page":"9895485","article-title":"Protective effects of garlic and cinnamon oils on hepatocellular carcinoma in albino rats","volume":"2019","author":"Aly","year":"2019","journal-title":"Anal. Cell. Pathol. (Amst.)"},{"key":"10.1016\/j.taap.2024.117202_bb0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/0394632017694898","article-title":"Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: biochemical and histological study","volume":"30","author":"Amer","year":"2017","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0030","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.taap.2024.117202_bb0035","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-4632.2006.02467.x","article-title":"Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria","volume":"45","author":"Cassano","year":"2006","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.taap.2024.117202_bb0040","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.3892\/ol.2017.6815","article-title":"Combining thioridazine and loratadine for the treatment of gastrointestinal tumor","volume":"14","author":"Chen","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.taap.2024.117202_bb0045","doi-asserted-by":"crossref","first-page":"23265","DOI":"10.18632\/oncotarget.15575","article-title":"Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma","volume":"8","author":"Cheng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2024.117202_bb0050","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2024.117202_bb0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2165\/00003088-200847040-00001","article-title":"Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine\u202f: a comparative review","volume":"47","author":"Devillier","year":"2008","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.taap.2024.117202_bb0060","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00432-017-2364-z","article-title":"Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine","volume":"143","author":"Ding","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.taap.2024.117202_bb0065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fphar.2019.00389","article-title":"Baishouwu extract suppresses the development of hepatocellular carcinoma via TLR4\/MyD88\/NF-\u03baB pathway","volume":"10","author":"Ding","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0070","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1517\/14656566.6.14.2511","article-title":"Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders","volume":"6","author":"Dubuske","year":"2005","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.taap.2024.117202_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216301","article-title":"Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: up regulation of hepatic cAMP, and modulation of inflammatory, oxidative stress and apoptotic biomarkers","volume":"14","author":"EL Awdan","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2024.117202_bb0080","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.lfs.2019.05.019","article-title":"Sitagliptin ameliorates thioacetamide-induced acute liver injury via modulating TLR4\/NF-KB signaling pathway in mice","volume":"228","author":"EL-Kashef","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104093","article-title":"Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models","volume":"99","author":"Ezhilarasan","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lfs.2016.12.008","article-title":"Antihistamines as promising drugs in cancer therapy","volume":"172","author":"Faustino-RochA","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0095","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/all.14273","article-title":"Desloratadine and loratadine use associated with improved melanoma survival","volume":"75","author":"Fritz","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.taap.2024.117202_bb0100","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1080\/0284186X.2020.1769185","article-title":"Desloratadine and loratadine stand out among common H(1)-antihistamines for association with improved breast cancer survival","volume":"59","author":"Fritz","year":"2020","journal-title":"Acta Oncol."},{"key":"10.1016\/j.taap.2024.117202_bb0105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2174\/187152011795347513","article-title":"Astemizole: an old anti-histamine as a new promising anti-cancer drug","volume":"11","author":"Garc\u00eda-Quiroz","year":"2011","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.taap.2024.117202_bb0110","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1158\/0008-5472.CAN-14-0243","article-title":"Transforming growth factor-\u03b2 as a therapeutic target in hepatocellular carcinoma","volume":"74","author":"Giannelli","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2024.117202_bb0115","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","article-title":"NF-kappaB activation by reactive oxygen species: fifteen years later","volume":"72","author":"Gloire","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0120","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1021\/tx3002719","article-title":"Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes","volume":"25","author":"Hajovsky","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2024.117202_bb0125","first-page":"350","article-title":"Adamantane-linked isothiourea derivatives suppress the growth of experimental hepatocellular carcinoma via inhibition of TLR4-MyD88-NF-\u03baB signaling","volume":"11","author":"Hassan","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.taap.2024.117202_bb0130","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2024.117202_bb0140","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0676.1990.tb00428.x","article-title":"Sirius red histophotometry and spectrophotometry of sections in the assessment of the collagen content of liver tissue and its application in growing rat liver","volume":"10","author":"James","year":"1990","journal-title":"Liver"},{"key":"10.1016\/j.taap.2024.117202_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101250","article-title":"USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-\u03baB activation and autophagy induction by TLR4","volume":"15","author":"Kim","year":"2022","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.taap.2024.117202_bb0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/0886022X.2020.1769656","article-title":"The effect of desloratadine on ischemia reperfusion induced oxidative and inflammatory renal injury in rats","volume":"42","author":"Kocaturk","year":"2020","journal-title":"Ren. Fail."},{"key":"10.1016\/j.taap.2024.117202_bb0165","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.taap.2024.117202_bb0170","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.toxlet.2010.01.021","article-title":"The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells","volume":"194","author":"Lee","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2024.117202_bb0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12935-016-0352-z","article-title":"Relationship between TRAF6 and deterioration of HCC: an immunohistochemical and in vitro study","volume":"16","author":"Li","year":"2016","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.taap.2024.117202_bb0185","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.taap.2024.117202_bb0190","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-\u03baB in the liver--linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0195","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117202_bb0200","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820926591","article-title":"Desloratadine, a novel antigrowth reagent for bladder Cancer","volume":"19","author":"Ma","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.taap.2024.117202_bb0205","first-page":"1840","article-title":"Study on the effects of desloratadine citrate disodium on the postoperative complications and inflammatory response in patients with chronic sinusitis undergoing endoscopic sinus surgery","volume":"13","author":"Ma","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.taap.2024.117202_bb0210","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/gut.2008.156307","article-title":"Toll-like receptors as targets in chronic liver diseases","volume":"58","author":"Mencin","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.taap.2024.117202_bb0215","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1053\/j.gastro.2017.07.014","article-title":"Transforming growth factor-\u03b2 promotes liver tumorigenesis in mice via up-regulation of snail","volume":"153","author":"Moon","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117202_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103240","article-title":"Targeting p 53\/TRAIL\/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats","volume":"72","author":"Nazmy","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0225","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1111\/jgh.13318","article-title":"Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease","volume":"31","author":"Nishida","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0230","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: A review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2024.117202_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00535-013-0931-x","article-title":"TAK1 regulates hepatic cell survival and carcinogenesis","volume":"49","author":"Roh","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.taap.2024.117202_bb0240","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1365-2222.2008.02990.x","article-title":"Histamine H1-receptor antagonists inhibit nuclear factor-kappaB and activator protein-1 activities via H1-receptor-dependent and -independent mechanisms","volume":"38","author":"Roumestan","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.taap.2024.117202_bb0245","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.etap.2010.05.001","article-title":"Protective effect of desloratadine against oxidative stress in human erythrocytes in vitro","volume":"30","author":"Sadowska-Woda","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116933","article-title":"Beyond its antioxidant properties: quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats","volume":"236","author":"Salama","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0255","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317695923","article-title":"Animal models as a tool in hepatocellular carcinoma research: A review","volume":"39","author":"Santos","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.taap.2024.117202_bb0260","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2024.117202_bb0265","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2024.117202_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121441","article-title":"Ameliorative effect of desloratadine against cisplatin-induced renal and testicular toxicity in rats: attention to TLR4\/NLRP3 inflammasome signaling pathway","volume":"316","author":"Shaaban","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0275","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.lfs.2018.07.019","article-title":"Agmatine attenuates rhabdomyolysis-induced acute kidney injury in rats in a dose dependent manner","volume":"208","author":"Sharawy","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0280","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ijc.31029","article-title":"The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice","volume":"142","author":"Song","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2024.117202_bb0285","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4254\/wjh.v7.i7.968","article-title":"Control of oxidative stress in hepatocellular carcinoma: helpful or harmful?","volume":"7","author":"Takaki","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2022.100671","article-title":"Caffeine mitigates experimental nonalcoholic steatohepatitis and the progression of thioacetamide-induced liver fibrosis by blocking the MAPK and TGF-\u03b2\/Smad3 signaling pathways","volume":"27","author":"Vargas-Pozada","year":"2022","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0295","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/cld.578","article-title":"The transition from inflammation to cancer in the liver","volume":"8","author":"Villanueva","year":"2016","journal-title":"Clin. Liver Dis. (Hoboken)"},{"key":"10.1016\/j.taap.2024.117202_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153609","article-title":"Schisantherin A ameliorates liver fibrosis through TGF-\u03b21mediated activation of TAK1\/MAPK and NF-\u03baB pathways in vitro and in vivo","volume":"88","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2024.117202_bb0305","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000082325","article-title":"Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-\u03baB activity consistent with inverse Agonism at the histamine H1 receptor","volume":"135","author":"Wu","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.taap.2024.117202_bb0310","doi-asserted-by":"crossref","first-page":"7924199","DOI":"10.1155\/2022\/7924199","article-title":"Toll-like receptor 4: A promising therapeutic target for Alzheimer\u2019s disease","volume":"2022","author":"Wu","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.taap.2024.117202_bb0315","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/240365","article-title":"Current views of toll-like receptor signaling pathways","volume":"2010","author":"Yamamoto","year":"2010","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.taap.2024.117202_bb0320","first-page":"11","article-title":"Emerging role of toll-like receptor 4 in hepatocellular carcinoma","volume":"2","author":"Yang","year":"2015","journal-title":"J. Hepatocell Carcinoma"},{"key":"10.1016\/j.taap.2024.117202_bb0325","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2024.117202_bb0330","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ejphar.2014.11.008","article-title":"Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma","volume":"746","author":"Zaghloul","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2024.117202_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120410","article-title":"Hepatoprotective effect of Baicalin against thioacetamide-induced cirrhosis in rats: targeting NOX4\/NF-\u03baB\/NLRP3 inflammasome signaling pathways","volume":"295","author":"Zaghloul","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118458","article-title":"Niclosamide-loaded polymeric micelles ameliorate hepatocellular carcinoma in vivo through targeting Wnt and notch pathways","volume":"261","author":"Zeyada","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2024.117202_bb0345","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.taap.2024.117202_bb0350","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 years of NF-\u03baB: A blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24004010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24004010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:06:18Z","timestamp":1778659578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24004010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":67,"alternative-id":["S0041008X24004010"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117202","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Desloratadine mitigates hepatocellular carcinoma in rats: Possible contribution of TLR4\/MYD88\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117202"}}