{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:48:46Z","timestamp":1787597326927,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.taap.2024.117203","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:29:45Z","timestamp":1734481785000},"page":"117203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Chronic cadmium exposure to minimal-risk doses causes dysfunction of epididymal adipose tissue and metabolic disorders"],"prefix":"10.1016","volume":"495","author":[{"given":"Victor Enrique","family":"Sarmiento-Ortega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Issac","family":"Alc\u00e1ntara-Jara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Moroni-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n Antonio","family":"V\u00e1zquez-Roque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Brambila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Trevi\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2024.117203_bb0005","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2337\/dc09-1825","article-title":"Visceral adiposity IndexA reliable indicator of visceral fat function associated with cardiometabolic risk","volume":"33","author":"Amato","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.taap.2024.117203_bb0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnins.2013.00051","article-title":"The role of leptin in the control of insulin-glucose axis","volume":"7","author":"Amitani","year":"2013","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.taap.2024.117203_bb0015","series-title":"Toxicological Profile for Cadmium. Agency for Toxic Substances and Disease Registry, Public Health Service- U.S","first-page":"1","author":"ATSDR","year":"2012"},{"issue":"1","key":"10.1016\/j.taap.2024.117203_bb0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12403-021-00427-3","article-title":"Cadmium: an emerging role in adipose tissue dysfunction","volume":"14","author":"Attia","year":"2021","journal-title":"Expo. Health"},{"key":"10.1016\/j.taap.2024.117203_bb0025","doi-asserted-by":"crossref","first-page":"1010817","DOI":"10.3389\/fphar.2022.1010817","article-title":"White adipose tissue as a target for cadmium toxicity","volume":"13","author":"Attia","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2024.117203_bb0030","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1007\/s12011-020-02502-3","article-title":"Serum cadmium levels and risk of metabolic syndrome: a cross-sectional study","volume":"199","author":"Ayoub","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2024.117203_bb0035","doi-asserted-by":"crossref","first-page":"1003118","DOI":"10.3389\/fcell.2022.1003118","article-title":"Of mice and men: pinpointing species differences in adipose tissue biology","volume":"10","author":"B\u00f6rgeson","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2024.117203_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10050630","article-title":"The role of toxic metals and metalloids in Nrf2 signaling","volume":"10","author":"Buha","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.taap.2024.117203_bb0045","first-page":"1","article-title":"Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus","volume":"9","author":"Burhans","year":"2019","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.taap.2024.117203_bb0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fcvm.2020.00022","article-title":"Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease","volume":"7","author":"Chait","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.taap.2024.117203_bb0055","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.scitotenv.2019.03.114","article-title":"Levels and determinants of adipose tissue cadmium concentrations in an adult cohort from southern Spain","volume":"670","author":"Echeverr\u00eda","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2024.117203_bb0060","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1039\/C9MT00178F","article-title":"Chemical imaging and assessment of cadmium distribution in the human body","volume":"11","author":"Egger","year":"2019","journal-title":"Metallomics"},{"key":"10.1016\/j.taap.2024.117203_bb0065","series-title":"Adiponectin-Leptin Ratio: A Promising Index to Estimate Adipose Tissue Dysfunction. Relation with Obesity-Associated Cardiometabolic Risk","author":"Fr\u00fchbeck","year":"2018"},{"key":"10.1016\/j.taap.2024.117203_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103264","article-title":"Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: a mechanistic case-control and a population-based cohort study","volume":"65","author":"Fryk","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.taap.2024.117203_bb0075","article-title":"Replication of integrative data analysis for adipose tissue dysfunction, low-grade inflammation, postprandial responses and OMICs signatures in symptom-free adults","volume":"10","author":"Gallegos-Cabriales","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.taap.2024.117203_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153153","article-title":"Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes","volume":"470","author":"Gasser","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2024.117203_bb0085","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1152\/physrev.00034.2017","article-title":"Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity","volume":"98","author":"Hammarstedt","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2024.117203_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0003-9861(03)00120-6","article-title":"Cadmium induces impaired glucose tolerance in rat by down-regulating GLUT4 expression in adipocytes","volume":"413","author":"Han","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2024.117203_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/nu15153445","article-title":"Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity\u2014the case of BBS obesity","volume":"15","author":"Horwitz","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2024.117203_bb0100","doi-asserted-by":"crossref","DOI":"10.1080\/08923973.2019.1697284","article-title":"The effects of cadmium exposure in the induction of inflammation","author":"Hossein-Khannazer","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.taap.2024.117203_bb0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tox.2009.07.022","article-title":"Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1\/Mest in adipose tissue","volume":"267","author":"Kawakami","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2024.117203_bb0110","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.taap.2013.07.015","article-title":"Cadmium modulates adipocyte functions in metallothionein-null mice","volume":"272","author":"Kawakami","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2024.117203_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jscs.2022.101569","article-title":"Cadmium sources, toxicity, resistance and removal by microorganisms-a potential strategy for cadmium eradication","volume":"26","author":"Khan","year":"2022","journal-title":"J. Saudi Chem. Soc."},{"key":"10.1016\/j.taap.2024.117203_bb0120","article-title":"Mechanisms of adiponectin action: implication of adiponectin receptor agonism in diabetic kidney disease","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117203_bb0125","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/CIRCRESAHA.121.318093","article-title":"Obesity, adipose tissue and vascular dysfunction","volume":"128","author":"Koenen","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2024.117203_bb0130","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s00044-020-02539-y","article-title":"Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction","volume":"29","author":"Lee","year":"2020","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.taap.2024.117203_bb0135","doi-asserted-by":"crossref","first-page":"1003219","DOI":"10.3389\/fcell.2022.1003219","article-title":"The regulation of adipocyte growth in white adipose tissue","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2024.117203_bb0140","article-title":"Cadmium induces acute liver injury by inhibiting Nrf2 and the role of NF-\u03baB, NLRP3, and MAPKS signaling pathway","volume":"17","author":"Liu","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.taap.2024.117203_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092358","article-title":"Adipose tissue dysfunction as determinant of obesity-associated metabolic complications","volume":"20","author":"Longo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117203_bb0150","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1021\/acs.jafc.9b02434","article-title":"Antiobesity effect of flaxseed polysaccharide via inducing satiety due to leptin resistance removal and promoting lipid metabolism through the AMP-activated protein kinase (AMPK) signaling pathway","volume":"67","author":"Luo","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.taap.2024.117203_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21176039","article-title":"There and Back again: leptin actions in white adipose tissue","volume":"21","author":"Mart\u00ednez-S\u00e1nchez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117203_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/570650","article-title":"Immunohistochemical study of Nrf2-antioxidant response element as Indicator of oxidative stress induced by cadmium in developing rats","volume":"2015","author":"Montes","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2024.117203_bb0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/toxics11030223","article-title":"Pancreas\u2013liver\u2013adipose Axis: target of environmental cadmium exposure linked to metabolic diseases","volume":"11","author":"Moroni-Gonz\u00e1lez","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2024.117203_bb0170","article-title":"Pancreatic Antioxidative defense and heat shock proteins prevent islet of Langerhans cell death after chronic Oral exposure to cadmium LOAEL dose","author":"Moroni-Gonz\u00e1lez","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2024.117203_bb0175","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/antiox10040622","article-title":"Contribution of adipose tissue oxidative stress to obesity-associated diabetes risk and ethnic differences: focus on women of African ancestry","volume":"10","author":"Nono Nankam","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.taap.2024.117203_bb0180","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrn.2017.168","article-title":"Leptin and the maintenance of elevated body weight","volume":"19","author":"Pan","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.taap.2024.117203_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.06577","article-title":"The toxic effect of environmental cadmium on visceral adipose tissue","volume":"34","author":"Prabhu","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2024.117203_bb0190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/21623945.2020.1743116","article-title":"Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study","volume":"9","author":"Rodriguez-Ayala","year":"2020","journal-title":"Adipocyte"},{"key":"10.1016\/j.taap.2024.117203_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146359","article-title":"Adipose tissue cadmium concentrations as a potential risk factor for insulin resistance and future type 2 diabetes mellitus in GraMo adult cohort","volume":"780","author":"Salcedo-Bellido","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2024.117203_bb0200","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.abb.2017.10.003","article-title":"Changes on serum and hepatic lipidome after a chronic cadmium exposure in Wistar rats","volume":"635","author":"Sarmiento-Ortega","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2024.117203_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/toxics6030055","article-title":"The NOAEL metformin dose is ineffective against metabolic disruption induced by chronic cadmium exposure in Wistar rats","volume":"6","author":"Sarmiento-Ortega","year":"2018","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2024.117203_bb0210","article-title":"Oral subacute exposure to cadmium LOAEL dose induces insulin resistance and impairment of the hormonal and metabolic liver-adipose Axis in Wistar rats","author":"Sarmiento-Ortega","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2024.117203_bb0215","doi-asserted-by":"crossref","DOI":"10.1007\/s10534-020-00276-8","article-title":"Sodium metavanadate treatment improves glycogen levels in multiple tissues in a model of metabolic syndrome caused by chronic cadmium exposure in Wistar rats","author":"Sarmiento-Ortega","year":"2021","journal-title":"BioMetals"},{"key":"10.1016\/j.taap.2024.117203_bib301","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-024-04314-1","article-title":"Curcumin Treatment Ameliorates Hepatic Insulin Resistance Induced by Sub-chronic Oral Exposure to Cadmium LOAEL Dose via NF-\u03baB and Nrf2 Pathways","author":"Sarmiento-Ortega","year":"2024","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.taap.2024.117203_bb0220","article-title":"ROS and ERK pathway mechanistic approach on hepatic insulin resistance after chronic Oral exposure to cadmium NOAEL dose","volume":"1\u201316","author":"Sarmiento-Ortega","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2024.117203_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/toxics6010015","article-title":"Dietary cadmium intake and its effects on kidneys","volume":"6","author":"Satarug","year":"2018","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2024.117203_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11090755","article-title":"Estimation of the cadmium nephrotoxicity threshold from loss of glomerular filtration rate and albuminuria","volume":"11","author":"Satarug","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2024.117203_bb0235","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.5551\/jat.ED083","article-title":"Leptin resistance and lipolysis of white adipose tissue: an implication to ectopic fat disposition and its consequences","volume":"24","author":"Shimabukuro","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.taap.2024.117203_bb0240","doi-asserted-by":"crossref","first-page":"28660","DOI":"10.1074\/jbc.M114.595496","article-title":"Nrf2\/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis","volume":"289","author":"Son","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2024.117203_bb0245","article-title":"Insulin action, glucose homeostasis and free fatty acid metabolism: insights from a novel model","volume":"12","author":"Stefanovski","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.taap.2024.117203_bb0250","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1515\/jpem-2018-0378","article-title":"Adiponectin, leptin and high sensitivity C-reactive protein values in obese children - important markers for metabolic syndrome?","volume":"32","author":"Stroescu","year":"2019","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2024.117203_bb0255","author":"Substance Priority List"},{"key":"10.1016\/j.taap.2024.117203_bb0260","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.scitotenv.2017.05.224","article-title":"The role of cadmium in obesity and diabetes","volume":"601\u2013602","author":"Tinkov","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2024.117203_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20122863","article-title":"Adipose tissue, obesity and adiponectin: role in endocrine Cancer risk","volume":"20","author":"Tumminia","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2024.117203_bb0270","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-012-2598-x","article-title":"Adiponectin: mechanistic insights and clinical implications","author":"Turer","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.taap.2024.117203_bb0275","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12997","article-title":"Adipokine dysregulation and adipose tissue inflammation in human obesity","volume":"48","author":"Unamuno","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.taap.2024.117203_bb0280","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2018.06.003","article-title":"Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane","volume":"353","author":"Wang","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2024.117203_bb0285","doi-asserted-by":"crossref","first-page":"116057","DOI":"10.1016\/j.taap.2022.116057","article-title":"A novel chronic in vivo oral cadmium exposure-washout mouse model for studying cadmium toxicity and complex diabetogenic effects","volume":"447","author":"Wong","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2024.117203_bb0290","article-title":"Epigenetic therapeutics targeting NRF2\/KEAP1 signaling in Cancer oxidative stress","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2024.117203_bb0295","article-title":"The Nrf2 pathway in liver diseases","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2024.117203_bb0300","doi-asserted-by":"crossref","first-page":"1101399","DOI":"10.3389\/fendo.2023.1101399","article-title":"Leptin\/adiponectin ratio as a prognostic factor for increased weight gain in girls with central precocious puberty","volume":"14","author":"Zurita-Cruz","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24004022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24004022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T20:45:46Z","timestamp":1738615546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24004022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":61,"alternative-id":["S0041008X24004022"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117203","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic cadmium exposure to minimal-risk doses causes dysfunction of epididymal adipose tissue and metabolic disorders","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117203"}}