{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:13:36Z","timestamp":1787588016303,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.taap.2024.117212","type":"journal-article","created":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T06:40:20Z","timestamp":1734849620000},"page":"117212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Dehydrodiisoeugenol inhibits PDGF-BB-induced proliferation and migration of human pulmonary artery smooth muscle cells via the mTOR\/HIF1-\u03b1\/HK2 signaling pathway"],"prefix":"10.1016","volume":"495","author":[{"given":"Shishun","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.taap.2024.117212_bb0005","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3390\/ijms22042144","article-title":"mTOR signaling in pulmonary vascular disease: pathogenic role and therapeutic target[J]","volume":"22","author":"Babicheva","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.taap.2024.117212_bb0010","first-page":"4984","article-title":"Formononetin attenuates monocrotaline-induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats[J]","volume":"20","author":"Cai","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.taap.2024.117212_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41419-020-2336-0","article-title":"Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a\/HIF-1\u03b1\/HK2[J]","volume":"11","author":"Cao","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2024.117212_bb0020","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12967-023-04233-0","article-title":"Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation[J]","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.taap.2024.117212_bb0025","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01325-2024","article-title":"Treatment algorithm for pulmonary arterial hypertension[J]","volume":"64","author":"Chin","year":"2024","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0030","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1038\/s41467-019-10044-z","article-title":"A RASSF1A-HIF1\u03b1 loop drives Warburg effect in cancer and pulmonary hypertension[J]","volume":"10","author":"Dabral","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0035","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1038\/s41467-018-06376-x","article-title":"Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway[J]","volume":"9","author":"Dai","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2024.117212_bb0040","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.biopha.2018.04.112","article-title":"CTRP6 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration[J]","volume":"103","author":"Dong","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.taap.2024.117212_bb0045","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/ph15111351","article-title":"Synthesis and biological activities of dehydrodiisoeugenol: a review[J]","volume":"15","author":"God\u00ednez-Chaparro","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.taap.2024.117212_bb0050","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1096\/fj.12-222224","article-title":"mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects[J]","volume":"27","author":"Goncharova","year":"2013","journal-title":"FASEB J."},{"issue":"11","key":"10.1016\/j.taap.2024.117212_bb0055","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s12272-020-01285-4","article-title":"Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review[J]","volume":"43","author":"Ha","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2024.117212_bb0060","article-title":"Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia[J]","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0065","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension[J]","volume":"61","author":"Humbert","year":"2023","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0070","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s13046-019-1351-4","article-title":"Cardamonin inhibits breast cancer growth by repressing HIF-1\u03b1-dependent metabolic reprogramming[J]","volume":"38","author":"Jin","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.taap.2024.117212_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121201","article-title":"LPA\/LPAR1 signaling induces PGAM1 expression via AKT\/mTOR\/HIF-1\u03b1 pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation[J]","volume":"311","author":"Kim","year":"2022","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.taap.2024.117212_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001783","article-title":"Blind spots on western blots: assessment of common problems in western blot figures and methods reporting with recommendations to improve them[J]","volume":"20","author":"Kroon","year":"2022","journal-title":"PLoS Biol."},{"issue":"3","key":"10.1016\/j.taap.2024.117212_bb0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4161\/cc.8.3.7555","article-title":"PI3K\/mTORC1 activation in hamartoma syndromes: Therapeutic prospects[J]","volume":"8","author":"Krymskaya","year":"2009","journal-title":"Cell Cycle"},{"issue":"10","key":"10.1016\/j.taap.2024.117212_bb0090","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/abbs\/gmab103","article-title":"Small-molecule inhibitor LF3 restrains the development of pulmonary hypertension through the Wnt\/\u03b2-catenin pathway[J]","volume":"53","author":"Lei","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13046-021-01915-9","article-title":"Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways[J]","volume":"40","author":"Li","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/CM9.0000000000000577","article-title":"3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation[J]","volume":"133","author":"Liu","year":"2020","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.taap.2024.117212_bb0105","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.redox.2017.11.012","article-title":"Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS\/NF\u03baB\/mTOR\/P70S6K signaling cascade[J]","volume":"14","author":"Lu","year":"2018","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.taap.2024.117212_bb0110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control[J]","volume":"10","author":"Ma","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.taap.2024.117212_bb0115","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCRESAHA.111.263848","article-title":"Dynamin-related protein 1\u2013mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension[J]","volume":"110","author":"Marsboom","year":"2012","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-023-00486-7","article-title":"Pulmonary hypertension[J]","volume":"10","author":"Mocumbi","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"12","key":"10.1016\/j.taap.2024.117212_bb0125","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41568-018-0074-8","article-title":"mTOR signalling and cellular metabolism are mutual determinants in cancer[J]","volume":"18","author":"Mossmann","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.taap.2024.117212_bb0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.abb.2004.11.013","article-title":"Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages[J]","volume":"434","author":"Murakami","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/rccm.200707-1037OC","article-title":"Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension[J]","volume":"178","author":"Perros","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"14","key":"10.1016\/j.taap.2024.117212_bb0140","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jama.2022.4402","article-title":"Diagnosis and treatment of pulmonary arterial hypertension: a review[J]","volume":"327","author":"Ruopp","year":"2022","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.taap.2024.117212_bb0145","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease[J]","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.taap.2024.117212_bb0150","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1172\/JCI24838","article-title":"Reversal of experimental pulmonary hypertension by PDGF inhibition[J]","volume":"115","author":"Schermuly","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.taap.2024.117212_bb0155","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.3390\/ijms24065850","article-title":"New drugs and therapies in pulmonary arterial hypertension[J]","volume":"24","author":"Shah","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2024.117212_bb0160","doi-asserted-by":"crossref","first-page":"H613","DOI":"10.1152\/ajpheart.00220.2020","article-title":"Metabolism of vascular smooth muscle cells in vascular diseases[J]","volume":"319","author":"Shi","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molmed.2016.11.005","article-title":"Targeting vascular remodeling to treat pulmonary arterial hypertension[J]","volume":"23","author":"Thompson","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"7","key":"10.1016\/j.taap.2024.117212_bb0170","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.62347\/MZGO7330","article-title":"Exploring the therapeutic effect of core components in Xuanshen Yishen mixture on hypertension through network pharmacology[J]","volume":"16","author":"Wang","year":"2024","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0175","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/08916934.2021.1998895","article-title":"LncRNA RP5-857K21.7 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells through the miR-508-3p\/PI3K\/AKT\/mTOR axis[J]","volume":"55","author":"Wang","year":"2022","journal-title":"Autoimmunity"},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0180","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40659-023-00480-z","article-title":"The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension[J]","volume":"56","author":"Wu","year":"2023","journal-title":"Biol. Res."},{"issue":"4","key":"10.1016\/j.taap.2024.117212_bb0185","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1159\/000479401","article-title":"PDGF promotes the warburg effect in pulmonary arterial smooth muscle cells via activation of the PI3K\/AKT\/mTOR\/HIF-1\u03b1 signaling pathway[J]","volume":"42","author":"Xiao","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2024.117212_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108186","article-title":"The role of hypoxia-inducible factors in cardiovascular diseases[J]","volume":"238","author":"Yu","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.taap.2024.117212_bb0195","doi-asserted-by":"crossref","first-page":"681","DOI":"10.7150\/ijms.69289","article-title":"Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK\/NF-\u03baB pathways[J]","volume":"19","author":"Yu","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.taap.2024.117212_bb0200","article-title":"Exploring the effect of Gupi Xiaoji Prescription on hepatitis B virus-related liver cancer through network pharmacology and in vitro experiments[J]","volume":"139","author":"Yu","year":"2021","journal-title":"Biomed. Pharmacother. = Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.taap.2024.117212_bb0205","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1002\/jcp.29763","article-title":"NLRC3 inhibits PDGF-induced PASMCs proliferation via PI3K-mTOR pathway[J]","volume":"235","author":"Zha","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.taap.2024.117212_bb0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10565-024-09849-6","article-title":"Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension[J]","volume":"40","author":"Zhou","year":"2024","journal-title":"Cell Biol. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24004113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X24004113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T20:45:55Z","timestamp":1738615555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X24004113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":42,"alternative-id":["S0041008X24004113"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2024.117212","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dehydrodiisoeugenol inhibits PDGF-BB-induced proliferation and migration of human pulmonary artery smooth muscle cells via the mTOR\/HIF1-\u03b1\/HK2 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2024.117212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117212"}}