{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T21:25:04Z","timestamp":1779225904743,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.taap.2025.117240","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T22:37:47Z","timestamp":1737931067000},"page":"117240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Sex differences in aristolochic acid I-induced nephrotoxicity in mice and the effect of estradiol"],"prefix":"10.1016","volume":"496","author":[{"given":"Qianru","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuwen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Shui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie Shiliu","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibing","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117240_bb0005","article-title":"The protective role of estrogen and its receptors in gentamicin-induced acute kidney injury in rats","volume":"239","author":"Abd","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2025.117240_bb0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/ndt\/18.1.54","article-title":"Estradiol is nephroprotective in the rat remnant kidney","volume":"18","author":"Antus","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.taap.2025.117240_bb0015","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41581-019-0208-6","article-title":"Sex and the kidneys: current understanding and research opportunities","volume":"15","author":"Bairey","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.taap.2025.117240_bb0020","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1124\/dmd.32.6.620","article-title":"Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels","volume":"32","author":"Buist","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2025.117240_bb0025","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95978","article-title":"Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity","volume":"2","author":"Chang","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.taap.2025.117240_bb0030","article-title":"Gender and renal insufficiency: opportunities for their therapeutic management?","volume":"11","author":"Ciarambino","year":"2022","journal-title":"Cells-Basel."},{"key":"10.1016\/j.taap.2025.117240_bb0035","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1124\/dmd.111.044461","article-title":"Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice","volume":"40","author":"Fu","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2025.117240_bb0040","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1681\/ASN.2015070741","article-title":"Adjusting the 17beta-estradiol-to-androgen ratio ameliorates diabetic nephropathy","volume":"27","author":"Inada","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2025.117240_bb0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.clim.2015.04.009","article-title":"17beta estradiol regulates adhesion molecule expression in mesangial cells during glomerulonephritis","volume":"159","author":"Jog","year":"2015","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.taap.2025.117240_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15020118","article-title":"The presence of testis determines Aristolochic acid-induced nephrotoxicity in mice","volume":"15","author":"Li","year":"2023","journal-title":"Toxins"},{"key":"10.1016\/j.taap.2025.117240_bb0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tox.2015.01.019","article-title":"Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A","volume":"331","author":"Lingappan","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2025.117240_bb0060","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/dmd.105.003780","article-title":"Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice","volume":"33","author":"Maher","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2025.117240_bb0065","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/em.22321","article-title":"Bioactivation mechanisms of N-hydroxyaristolactams: nitroreduction metabolites of aristolochic acids","volume":"60","author":"Okuno","year":"2019","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.taap.2025.117240_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21101391","article-title":"Renal protective effects of 17beta-estradiol on mice with acute aristolochic acid nephropathy","volume":"21","author":"Shi","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2025.117240_bb0075","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/carcin\/bgu095","article-title":"Bioactivation of the human carcinogen aristolochic acid","volume":"35","author":"Sidorenko","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2025.117240_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-018-3427-4","article-title":"Estradiol attenuates ischemia reperfusion-induced acute kidney injury through PPAR-gamma stimulated eNOS activation in rats","volume":"453","author":"Singh","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2025.117240_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102144","article-title":"DNA adducts formed by Aristolochic acid are unique biomarkers of exposure and explain the initiation phase of upper urothelial cancer","volume":"18","author":"Stiborova","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117240_bb0090","author":"United States Renal Data System"},{"key":"10.1016\/j.taap.2025.117240_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011171","article-title":"Early diagnosis and treatment of kidney injury: a focus on urine protein","volume":"25","author":"Zeng","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117240_bb0100","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/465690a","article-title":"Males still dominate animal studies","volume":"465","author":"Zucker","year":"2010","journal-title":"Nature"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2500016X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2500016X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:38:22Z","timestamp":1740055102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2500016X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":20,"alternative-id":["S0041008X2500016X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117240","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in aristolochic acid I-induced nephrotoxicity in mice and the effect of estradiol","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117240"}}