{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:03:08Z","timestamp":1786863788615,"version":"build-2736575974"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008047","name":"Hebei University","doi-asserted-by":"publisher","award":["20567605H"],"award-info":[{"award-number":["20567605H"]}],"id":[{"id":"10.13039\/501100008047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2024201028"],"award-info":[{"award-number":["H2024201028"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.taap.2025.117297","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:03:33Z","timestamp":1741694613000},"page":"117297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments"],"prefix":"10.1016","volume":"498","author":[{"given":"Gaotao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhuang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duqiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117297_bb0005","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.biopha.2017.07.068","article-title":"Baicalein: a review of its anti-cancer effects and mechanisms in hepatocellular carcinoma","volume":"93","author":"Bie","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2025.117297_bb0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/bcr55","article-title":"Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer","volume":"2","author":"Biscardi","year":"2000","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.taap.2025.117297_bb0015","first-page":"121","article-title":"Regulation, substrates and functions of src","volume":"1287","author":"Brown","year":"1996","journal-title":"BBA"},{"key":"10.1016\/j.taap.2025.117297_bb0020","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.annonc.2020.09.010","article-title":"Fifth ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)","volume":"31","author":"Cardoso","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.taap.2025.117297_bb0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/mutage\/geu045","article-title":"The expanding role of mTOR in cancer cell growth and proliferation","volume":"30","author":"Cargnello","year":"2015","journal-title":"Mutagenesis"},{"key":"10.1016\/j.taap.2025.117297_bb0030","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400769R","article-title":"Cell cycle machinery in oncology: a comprehensive review of therapeutic targets","volume":"38","author":"Cavalu","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2025.117297_bb0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.48095\/ccrvch2024247","article-title":"Current trends in breast cancer surgery","volume":"103","author":"Chaloupkov\u00e1","year":"2024","journal-title":"Rozhl. Chir."},{"key":"10.1016\/j.taap.2025.117297_bb0040","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/sj.onc.1208445","article-title":"The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1","volume":"24","author":"Chan","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2025.117297_bb0045","article-title":"The intention of utilization and experience toward traditional Chinese medicine among breast cancer patients in the early and late stages: a qualitative study","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Complement. Med."},{"key":"10.1016\/j.taap.2025.117297_bb0050","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1002\/cncr.28376","article-title":"The symptom burden of cancer: evidence for a core set of cancer-related and treatment-related symptoms from the eastern cooperative oncology group symptom outcomes and practice patterns study","volume":"119","author":"Cleeland","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.taap.2025.117297_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/bst0310025","article-title":"Isolation of novel Src substrates","volume":"31","author":"Courtneidge","year":"2003","journal-title":"Biochem. Soc. T"},{"key":"10.1016\/j.taap.2025.117297_bb0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41573-020-0070-z","article-title":"Targeting the hippo pathway in cancer, fibrosis, wound healing and regenerative medicine","volume":"19","author":"Dey","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2025.117297_bb0065","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/mc.23724","article-title":"Baicalein promotes KDM4E to induce BICD1 and inhibit triple-negative breast cancer progression by blocking PAR1 signaling","volume":"63","author":"Dong","year":"2024","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.taap.2025.117297_bb0070","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s13304-023-01569-6","article-title":"Precision surgery for breast cancer: current trends and future perspectives","volume":"75","author":"Franceschini","year":"2023","journal-title":"Updat. Surg."},{"key":"10.1016\/j.taap.2025.117297_bb0075","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1021\/acs.jmedchem.6b00065","article-title":"Rapid discovery and structure-activity relationships of Pyrazolopyrimidines that potently suppress breast cancer cell growth via SRC kinase inhibition with exceptional selectivity over ABL kinase","volume":"59","author":"Fraser","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2025.117297_bb0080","first-page":"3413","article-title":"Triptolide induces autophagy and apoptosis through ERK activation in human breast cancer MCF-7 cells","volume":"15","author":"Gao","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.taap.2025.117297_bb0085","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1074\/jbc.M709037200","article-title":"Tumor suppressor LATS1 is a negative regulator of oncogene YAP","volume":"283","author":"Hao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2025.117297_bb0090","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(03)00557-9","article-title":"The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis","volume":"114","author":"Harvey","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.taap.2025.117297_bb0095","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrc3458","article-title":"The hippo pathway and human cancer","volume":"13","author":"Harvey","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2025.117297_bb0100","first-page":"862","article-title":"Cancer therapy by cyclin-dependent kinase inhibitors (CDKIs): bench to bedside","volume":"23","author":"Hassanzadeh","year":"2024","journal-title":"EXCLI J."},{"key":"10.1016\/j.taap.2025.117297_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77980-9","article-title":"Down-regulation of ESRP2 inhibits breast cancer cell proliferation via inhibiting cyclinD1","volume":"14","author":"He","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117297_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113262","article-title":"Preliminary investigation on the mechanism of baicalein regulating the effects of Nischarin on invasion and apoptosis of human breast cancer cells MCF-7 through Wnt3\u03b1\/\u03b2-catenin pathway","volume":"143","author":"He","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2025.117297_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e40809","article-title":"Exploring baicalein: a natural flavonoid for enhancing cancer prevention and treatment","volume":"10","author":"Hegde","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.taap.2025.117297_bb0120","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1021\/acs.jchemed.6b00555","article-title":"Demonstration of AutoDock as an educational tool for drug discovery","volume":"94","author":"Helgren","year":"2017","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.taap.2025.117297_bb0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.stem.2017.03.023","article-title":"An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice","volume":"21","author":"Hu","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.taap.2025.117297_bb0130","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1128\/MCB.00311-16","article-title":"Role of Src family kinases in regulation of intestinal epithelial homeostasis","volume":"36","author":"Imada","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2025.117297_bb0135","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1038\/sj.onc.1203912","article-title":"Role of Src expression and activation in human cancer","volume":"19","author":"Irby","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2025.117297_bb0140","first-page":"625","article-title":"Association between cellular immune response and spleen weight in mice with hepatocellular carcinoma","volume":"22","author":"Jiang","year":"2021","journal-title":"Noco Lett."},{"key":"10.1016\/j.taap.2025.117297_bb0145","first-page":"1","article-title":"Harnessing network pharmacology in drug discovery: an integrated approach","author":"Joshi","year":"2024","journal-title":"N-S Arch Pharmacol."},{"key":"10.1016\/j.taap.2025.117297_bb0150","first-page":"21","article-title":"Effects of chemotherapy(Anthracyclin, cyclophosphamide following docetaxel regimen) on sleep, anxiety, depression and quality of life in patients with breast cancer","volume":"1\u201311","author":"Ju","year":"2025","journal-title":"Oncology"},{"key":"10.1016\/j.taap.2025.117297_bb0155","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.trecan.2020.04.004","article-title":"The hippo pathway as a driver of select human cancers","volume":"6","author":"Kulkarni","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.taap.2025.117297_bb0160","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1074\/jbc.RA118.004364","article-title":"SRC tyrosine kinase activates the YAP\/TAZ axis and thereby drives tumor growth and metastasis","volume":"294","author":"Lamar","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2025.117297_bb0165","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1128\/MCB.01874-07","article-title":"TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway","volume":"28","author":"Lei","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2025.117297_bb0170","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/cac2.12207","article-title":"Global patterns of breast cancer incidence and mortality: a population-based cancer registry data analysis from 2000 to 2020","volume":"41","author":"Lei","year":"2021","journal-title":"Cancer Commun."},{"key":"10.1016\/j.taap.2025.117297_bb0175","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1570-0232(04)00545-8","article-title":"Separation methods used for Scutellaria baicalensis active components","volume":"812","author":"Li","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.taap.2025.117297_bb0180","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.274951.115","article-title":"Alpha E-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of hippo signaling pathway","volume":"30","author":"Li","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2025.117297_bb0185","article-title":"Potential mechanisms of traditional Chinese medicine in treating insomnia: a network pharmacology, GEO validation, and molecular-docking study","volume":"103","author":"Liu","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.taap.2025.117297_bb0190","article-title":"Mechanisms of multi-omics and network pharmacology to explain traditional chinese medicine for vascular cognitive impairment: a narrative review","volume":"123","author":"Lv","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2025.117297_bb0195","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1017\/erm.2015.12","article-title":"The hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications","volume":"17","author":"Maugeri-Sacc\u00e0","year":"2015","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.taap.2025.117297_bb0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2017.11.011","article-title":"Splenomegaly: pathophysiological bases and therapeutic options","volume":"94","author":"McKenzie","year":"2018","journal-title":"Int. J. Biochem. Cell B"},{"key":"10.1016\/j.taap.2025.117297_bb0205","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.cell.2016.11.005","article-title":"The hippo pathway kinases LATS1\/2 suppress cancer immunity","volume":"167","author":"Moroishi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.taap.2025.117297_bb0210","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1038\/s41388-019-0894-3","article-title":"Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence","volume":"38","author":"Ou","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2025.117297_bb0215","first-page":"1","article-title":"Cyclin-dependent kinase (CDK) inhibitors in solid tumors: a review of clinical trials","volume":"24","author":"Panagiotou","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.taap.2025.117297_bb0220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.blre.2008.10.001","article-title":"Splenomegaly: investigation, diagnosis and management","volume":"23","author":"Pozo","year":"2008","journal-title":"Blood Rev."},{"key":"10.1016\/j.taap.2025.117297_bb0225","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/jnci\/djr485","article-title":"Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival","volume":"103","author":"Quinten","year":"2011","journal-title":"J. Natl. Cancer Lett."},{"key":"10.1016\/j.taap.2025.117297_bb0230","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2015.01.003","article-title":"Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors","volume":"94","author":"Roskoski","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2025.117297_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-79688-2","article-title":"LATS2 and FAT4 as key candidate genes of hippo pathway associated with the risk and progression of breast cancer: an in-silico approach","volume":"14","author":"Sadaf","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117297_bb0240","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.3390\/molecules25235677","article-title":"The biological activities and therapeutic potentials of Baicalein extracted from Oroxylum indicum: a systematic review","volume":"25","author":"Salleh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2025.117297_bb0245","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic signaling pathways in the cancer genome atlas","volume":"173","author":"Sanchez","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.taap.2025.117297_bb0250","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1158\/1078-0432.CCR-15-0411","article-title":"Molecular pathways: hippo signaling, a critical tumor suppressor","volume":"21","author":"Sebio","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2025.117297_bb0255","article-title":"Baicalin and Baicalein enhance cytotoxicity, Proapoptotic activity, and genotoxicity of doxorubicin and docetaxel in MCF-7 breast cancer cells","volume":"29","author":"Slomczewska","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2025.117297_bb0260","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcb.26246","article-title":"Platelet-derived growth factor regulates YAP transcriptional activity via Src family kinase dependent tyrosine phosphorylation","volume":"119","author":"Smoot","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2025.117297_bb0265","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.taap.2025.117297_bb0270","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0092-8674(02)00824-3","article-title":"Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines","volume":"110","author":"Tapon","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.taap.2025.117297_bb0275","first-page":"303","article-title":"The differential roles of caspase family members in mediating PF4-induced breast cancer apoptosis","volume":"40","author":"Tengku","year":"2018","journal-title":"Malays. J. Pathol."},{"key":"10.1016\/j.taap.2025.117297_bb0280","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1211\/0022357055380","article-title":"Pharmacokinetic advantage of intraperitoneal injection of docetaxel in the treatment for peritoneal dissemination of cancer in mice","volume":"57","author":"Tsutomu","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.taap.2025.117297_bb0285","article-title":"Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment","volume":"11","author":"Wan","year":"2024","journal-title":"Front. Nut."},{"key":"10.1016\/j.taap.2025.117297_bb0290","first-page":"1","article-title":"TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches","volume":"19","author":"Wang","year":"2021","journal-title":"CJNM"},{"key":"10.1016\/j.taap.2025.117297_bb0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3390\/cancers10040115","article-title":"YAP\/TAZ activation as a target for treating metastatic cancer","volume":"10","author":"Warren","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.taap.2025.117297_bb0300","first-page":"479","article-title":"Integration strategy of network pharmacology in traditional Chinese medicine: a narrative review","volume":"42","author":"Wu","year":"2022","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.taap.2025.117297_bb0305","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.2147\/DDDT.S181939","article-title":"Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K\/AKT pathway in vivo and vitro","volume":"12","author":"Yan","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.taap.2025.117297_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113249","article-title":"The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer","volume":"264","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2025.117297_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312868","article-title":"The hippo pathway in breast cancer: the extracellular matrix and hypoxia","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117297_bb0320","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Yin","year":"2023","journal-title":"PLoS ONE"},{"key":"10.1016\/j.taap.2025.117297_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113144","article-title":"Hippo signaling pathway: a comprehensive gene expression profile analysis in breast cancer","volume":"151","author":"Yousefi","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2025.117297_bb0330","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/ijc.29293","article-title":"The hippo pathway in chemotherapeutic drug resistance","volume":"137","author":"Zhao","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2025.117297_bb0335","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2025.117297_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113926","article-title":"The hippo signaling pathway in development and regeneration","volume":"43","author":"Zhong","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.taap.2025.117297_bb0345","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2025.117297_bb0350","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1646905","article-title":"Applications of network pharmacology in traditional Chinese medicine research","volume":"2020","author":"Zhou","year":"2020","journal-title":"Evid. Based Compl. Alt."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25000730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25000730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:49:05Z","timestamp":1762220945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25000730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":70,"alternative-id":["S0041008X25000730"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117297","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117297"}}