{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:01:31Z","timestamp":1793120491723,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023915","name":"Faculty of Dentistry, Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.taap.2025.117307","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T17:04:46Z","timestamp":1742403886000},"page":"117307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Paricalcitol, an active vitamin D analog, mitigates dexamethasone-induced hepatic injury: Role of autophagy, pyroptosis, and PERK\/Nrf2\/HO-1 signaling pathway"],"prefix":"10.1016","volume":"498","author":[{"given":"Aamal G.","family":"El-Waseif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Elshal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia H.","family":"El-Kashef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa M.","family":"Abu-Elsaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117307_bb0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.21608\/asmj.2021.192511","article-title":"Potential Role of Vitamin D Receptor Agonist in Acetaminophen-Induced Hepatic Injury: Role of Caspase-1","volume":"72","author":"Abood","year":"2021","journal-title":"Ain Shams Med. J."},{"key":"10.1016\/j.taap.2025.117307_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43088-019-0021-0","article-title":"Thymus vulgaris extract modulates dexamethasone induced liver injury and restores the hepatic antioxidant redox system","volume":"8","author":"Abou-Seif","year":"2019","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0015","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.3390\/ijms25094901","article-title":"Vitamin D and metabolic dysfunction-associated steatotic liver disease (MASLD): novel mechanistic insights","volume":"25","author":"Aggeletopoulou","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0020","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/1574885514666191007094424","article-title":"Effect of Canagliflozin, an SGLT2 inhibitor, in comparison with atorvastatin on dexamethasone-induced hepatic steatosis in albino rats","volume":"15","author":"Ahmed","year":"2020","journal-title":"Curr. Drug Ther."},{"key":"10.1016\/j.taap.2025.117307_bb0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s40360-024-00820-z","article-title":"L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis","volume":"25","author":"Amer","year":"2024","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2025.117307_bb0030","series-title":"Theory and Practice of Histo-logical Techniques ed 2 Churchill-Livingstone","author":"Bancroft","year":"1982"},{"key":"10.1016\/j.taap.2025.117307_bb0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/2231-4040.157981","article-title":"Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats","volume":"6","author":"Bhat","year":"2015","journal-title":"J. adv. Pharm. Technol. Res."},{"key":"10.1016\/j.taap.2025.117307_bb0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejim.2021.10.035","article-title":"Drug-induced liver injury: pathogenesis, epidemiology, clinical features, and practical management","volume":"97","author":"Bj\u00f6rnsson","year":"2022","journal-title":"Euro. J. Intern. Med."},{"key":"10.1016\/j.taap.2025.117307_bb0045","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2025.117307_bb0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2025.117307_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116657","article-title":"Embryonic dexamethasone exposure exacerbates hepatic steatosis and APAP-mediated liver injury in zebrafish","volume":"282","author":"Chang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2025.117307_bb0060","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biocel.2005.09.018","article-title":"Coordination of ER and oxidative stress signaling: the PERK\/Nrf2 signaling pathway","volume":"38","author":"Cullinan","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2025.117307_bb0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/njecp.njecp_11_22","article-title":"Dexamethasone-induced derangement in some liver function parameters: Hepatoprotective effect of L-Citrulline","volume":"10","author":"Danboyi","year":"2022","journal-title":"Nigerian J. Exp. Clin. Biosci."},{"key":"10.1016\/j.taap.2025.117307_bb0070","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"De","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117307_bb0075","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/JOE-14-0437","article-title":"Autophagy in diabetic nephropathy","volume":"224","author":"Ding","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.taap.2025.117307_bb0080","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2025.117307_bb0085","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","article-title":"The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation","volume":"14","author":"Fernandes-Alnemri","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.taap.2025.117307_bb0090","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tem.2012.06.003","article-title":"New insights into ER stress-induced insulin resistance","volume":"23","author":"Flamment","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.taap.2025.117307_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.211","article-title":"Role of endoplasmic reticulum stress in drug\u2010induced toxicity","volume":"4","author":"Foufelle","year":"2016","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.taap.2025.117307_bb0100","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/cas.12550","article-title":"Final safety and efficacy of erlotinib in the phase 4 POLARSTAR surveillance study of 10 708 Japanese patients with non\u2010small\u2010cell lung cancer","volume":"105","author":"Gemma","year":"2014","journal-title":"Cancer Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0105","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2019.01.021","article-title":"Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation","volume":"163","author":"He","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2025.117307_bb0115","first-page":"59","article-title":"Oxidative stress and dysfunction of the intracellular proteolytic machinery: A pathological hallmark of nonalcoholic fatty liver disease","author":"Homma","year":"2019","journal-title":"Diet. interv. Liver Dis."},{"key":"10.1016\/j.taap.2025.117307_bb0120","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.metabol.2008.07.030","article-title":"Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia","volume":"57","author":"Hyogo","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.taap.2025.117307_bb0125","article-title":"Drug-induced liver injury associated with liraglutide use: A systematic review of detection, severity, causality assessment, and clinical outcomes","volume":"9","author":"Inayat","year":"2023","journal-title":"J. Clin. Trans. Res"},{"key":"10.1016\/j.taap.2025.117307_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2369-13-159","article-title":"Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients","volume":"13","author":"Izquierdo","year":"2012","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.taap.2025.117307_bb0135","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2021.04.019","article-title":"Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice","volume":"169","author":"Jia","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2025.117307_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105789","article-title":"Vitamin D\/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3\/Caspase-1\/GSDMD pyroptosis pathway","volume":"206","author":"Jiang","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2025.117307_bb0145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4161\/auto.3269","article-title":"Role of autophagy in cancer: management of metabolic stress","volume":"3","author":"Jin","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2025.117307_bb0150","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/cells8111389","article-title":"The role of inflammasome-dependent and inflammasome-independent NLRP3 in the kidney","volume":"8","author":"Kim","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.taap.2025.117307_bb0155","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2025.117307_bb0160","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/15548627.2021.1962681","article-title":"Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway","volume":"18","author":"Li","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2025.117307_bb0165","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ptr.6206","article-title":"Berberine ameliorates lipopolysaccharide\u2010induced acute lung injury via the PERK\u2010mediated Nrf2\/HO\u20101 signaling axis","volume":"33","author":"Liang","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2025.117307_bb0170","first-page":"432","article-title":"Supersaturated solutions of fat stains in dilute isopropanol for demonstration of acute fatty degeneration not shown by Herxheimer\u2019s technique","volume":"36","author":"Lillie","year":"1943","journal-title":"Arch. Pathol."},{"key":"10.1016\/j.taap.2025.117307_bb0175","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1080\/14728222.2023.2274099","article-title":"Vitamin D\/vitamin D receptor pathway in non-alcoholic fatty liver disease","volume":"27","author":"Liu","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.taap.2025.117307_bb0180","first-page":"345","article-title":"Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats","volume":"45","author":"Mahendran","year":"2001","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2025.117307_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105484","article-title":"Coriander essential oil attenuates dexamethasone-induced acute liver injury through potentiating Nrf2\/HO-1 and ameliorating apoptotic signaling","volume":"103","author":"Mahmoud","year":"2023","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.taap.2025.117307_bb0190","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2025.117307_bb0195","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2025.117307_bb0200","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.1073\/pnas.0809677105","article-title":"Antioxidants reduce endoplasmic reticulum stress and improve protein secretion","volume":"105","author":"Malhotra","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111299","article-title":"Paricalcitol attenuates oxidative stress and inflammatory response in the liver of NAFLD rats by regulating FOXO3a and NF\u03baB acetylation","volume":"121","author":"Malladi","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.taap.2025.117307_bb0210","first-page":"695","article-title":"Colchicine alleviates steroid-induced hyperglycemia and dyslipidemia: targeting pyroptosis and oxidative stress","volume":"31","author":"Nageeb","year":"2025","journal-title":"Zagazig University Medical Journal"},{"key":"10.1016\/j.taap.2025.117307_bb0215","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s40264-022-01224-w","article-title":"Therapeutic management of idiosyncratic drug-induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review","volume":"45","author":"Niu","year":"2022","journal-title":"Drug Saf."},{"key":"10.1016\/j.taap.2025.117307_bb0220","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2025.117307_bb0225","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/cancers15020445","article-title":"Dexamethasone-induced fatty acid oxidation and autophagy\/mitophagy are essential for T-ALL glucocorticoid resistance","volume":"15","author":"Olivas-Aguirre","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.taap.2025.117307_bb0230","first-page":"233","article-title":"Drug-induced hepatotoxicity: a review","author":"Pandit","year":"2012","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100973","article-title":"Autophagy in liver diseases: a review","volume":"82","author":"Qian","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.taap.2025.117307_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/761264","article-title":"Oxidative stress, prooxidants, and antioxidants: the interplay","volume":"2014","author":"Rahal","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2025.117307_bb0245","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2147\/DMSO.S247379","article-title":"Glucocorticoid-induced fatty liver disease","author":"Rahimi","year":"2020","journal-title":"Diab. Metab. Syndrome Obes."},{"key":"10.1016\/j.taap.2025.117307_bb0250","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2165\/00003495-200565040-00008","article-title":"Paricalcitol: a review of its use in the management of secondary hyperparathyroidism","volume":"65","author":"Robinson","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2025.117307_bb0255","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bbamcr.2007.12.011","article-title":"Ero1 and redox homeostasis in the endoplasmic reticulum","volume":"1783","author":"Sevier","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2025.117307_bb0260","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/0253-7613.28209","article-title":"Prevention of dexamethasone-and fructose-induced insulin resistance in rats by SH-01D, a herbal preparation","volume":"38","author":"Shalam","year":"2006","journal-title":"Indian J. Pharm."},{"key":"10.1016\/j.taap.2025.117307_bb0265","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.taap.2025.117307_bb0270","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1080\/0886022X.2022.2063744","article-title":"Vitamin D\/vitamin D receptor\/Atg16L1 axis maintains podocyte autophagy and survival in diabetic kidney disease","volume":"44","author":"Shi","year":"2022","journal-title":"Ren. Fail."},{"key":"10.1016\/j.taap.2025.117307_bb0275","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/ars.2016.6776","article-title":"Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis","volume":"26","author":"Spahis","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2025.117307_bb0280","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/hep.31699","article-title":"Vitamin D\u2014liver disease association: Biological basis and mechanisms of action","volume":"74","author":"Triantos","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117307_bb0285","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.4161\/cc.29272","article-title":"Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance","volume":"13","author":"Troncoso","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.taap.2025.117307_bb0290","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3390\/ijms24020969","article-title":"Paricalcitol ameliorates acute kidney injury in mice by suppressing oxidative stress and inflammation via Nrf2\/HO-1 signaling","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110877","article-title":"PPAR \u03b3 activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement","volume":"390","author":"Wu","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2025.117307_bb0300","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2337\/db11-1199","article-title":"Mapping autophagy on to your metabolic radar","volume":"61","author":"Yamada","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2025.117307_bb0305","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117307_bb0310","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00018-017-2639-1","article-title":"Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential","volume":"75","author":"Yang","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2025.117307_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-015-0536-7","article-title":"Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells","volume":"13","author":"Zhang","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2025.117307_bb0320","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jcmgh.2022.10.011","article-title":"Vitamin D receptor activation targets ROS-mediated crosstalk between autophagy and apoptosis in hepatocytes in cholestasic mice","volume":"15","author":"Zheng","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2025.117307_bb0325","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hep.30887","article-title":"Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117307_bb0330","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.biopha.2018.04.073","article-title":"Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice","volume":"103","author":"Zhu","year":"2018","journal-title":"Biomed. Pharmacother."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25000833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25000833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:37:38Z","timestamp":1744151858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25000833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":66,"alternative-id":["S0041008X25000833"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117307","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paricalcitol, an active vitamin D analog, mitigates dexamethasone-induced hepatic injury: Role of autophagy, pyroptosis, and PERK\/Nrf2\/HO-1 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117307"}}