{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:29:23Z","timestamp":1792801763185,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A5A2021242"],"award-info":[{"award-number":["2018R1A5A2021242"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["13182MFDS988"],"award-info":[{"award-number":["13182MFDS988"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.taap.2025.117341","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:54:49Z","timestamp":1744199689000},"page":"117341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The lipidome landscape of amiodarone toxicity: An in vivo lipid-centric multi-omics study"],"prefix":"10.1016","volume":"499","author":[{"given":"Nguyen Quang","family":"Thu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hwa","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Tran Nam","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Myo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Hai","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Ky","family":"Phat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Minh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Truong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc Ninh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokjoo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Phuoc","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117341_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100574","article-title":"The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis","volume":"65","author":"Abe","year":"2024","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2025.117341_bb0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10565-020-09537-1","article-title":"Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity","volume":"37","author":"Allard","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.taap.2025.117341_bb0015","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1016\/j.febslet.2006.08.061","article-title":"Drug-induced phospholipidosis","volume":"580","author":"Anderson","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2025.117341_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311810","article-title":"Combining metabolomics and machine learning to discover biomarkers for early-stage breast cancer diagnosis","volume":"19","author":"Anh","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2025.117341_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.263","article-title":"Generation and quality control of lipidomics data for the alzheimer\u2019s disease neuroimaging initiative cohort","volume":"5","author":"Barupal","year":"2018","journal-title":"Sci. Data"},{"key":"10.1016\/j.taap.2025.117341_bb0030","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2025.117341_bb0035","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0016-5085(98)70590-6","article-title":"Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes","volume":"114","author":"Berson","year":"1998","journal-title":"Gastroenterol"},{"key":"10.1016\/j.taap.2025.117341_bb0040","series-title":"EnhancedVolcano: Publication-ready volcano plots with enhanced colouring and labeling. R package version 1.16.0","author":"Blighe","year":"2022"},{"key":"10.1016\/j.taap.2025.117341_bb0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1515\/hsz-2019-0270","article-title":"Emerging mechanisms of drug-induced phospholipidosis","volume":"401","author":"Breiden","year":"2020","journal-title":"Biol. Chem."},{"key":"10.1016\/j.taap.2025.117341_bb0050","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/ijms24031987","article-title":"Optimization of mobile phase modifiers for fast LC-MS-based untargeted metabolomics and lipidomics","volume":"24","author":"Cajka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117341_bb0055","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00204-020-02656-y","article-title":"Prospects and challenges of multi-omics data integration in toxicology","volume":"94","author":"Canzler","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2025.117341_bb0060","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tem.2015.07.006","article-title":"Ceramides \u2013 lipotoxic inducers of metabolic disorders","volume":"26","author":"Chaurasia","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.taap.2025.117341_bb0065","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehad655.491","article-title":"Amiodarone is associated with increased mortality compared with other antiarrhythmic drugs in female patients with atrial fibrillation","volume":"44","author":"Choi","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.taap.2025.117341_bb0070","first-page":"552","article-title":"Adverse reactions of amiodarone","volume":"16","author":"Colunga Biancatelli","year":"2019","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.taap.2025.117341_bb0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/biomedicines10010194","article-title":"Detailed molecular mechanisms involved in drug-induced non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: an update","volume":"10","author":"Di Pasqua","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.taap.2025.117341_bb0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/toxsci\/kfx143","article-title":"Hepatic amiodarone lipotoxicity is ameliorated by genetic and pharmacological inhibition of endoplasmatic reticulum stress","volume":"159","author":"Erez","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2025.117341_bb0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.taap.2025.117341_bb0090","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/ajcp\/aqab142","article-title":"Development of a scoring system to differentiate amiodarone-induced liver injury from alcoholic steatohepatitis","volume":"157","author":"Gonz\u00e1lez","year":"2021","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.taap.2025.117341_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.43","article-title":"Complex heatmap visualization","volume":"1","author":"Gu","year":"2022","journal-title":"iMeta"},{"key":"10.1016\/j.taap.2025.117341_bb0100","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s00018-008-8030-5","article-title":"Cardiolipin, the heart of mitochondrial metabolism","volume":"65","author":"Houtkooper","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2025.117341_bb0105","doi-asserted-by":"crossref","first-page":"G298","DOI":"10.1152\/ajpgi.00458.2020","article-title":"Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation","volume":"321","author":"Hubel","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2025.117341_bb0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12944-017-0473-y","article-title":"Perilipins: a diversity of intracellular lipid droplet proteins","volume":"16","author":"Itabe","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.taap.2025.117341_bb0115","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/jat.3960","article-title":"Increased hepatic acylcarnitines after oral administration of amiodarone in rats","volume":"40","author":"Kim","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.taap.2025.117341_bb0120","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nmeth.2551","article-title":"LipidBlast in silico tandem mass spectrometry database for lipid identification","volume":"10","author":"Kind","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.taap.2025.117341_bb0125","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12944-020-01390-9","article-title":"Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma","volume":"19","author":"Li","year":"2020","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.taap.2025.117341_bb0130","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1038\/s41467-023-38785-y","article-title":"ExpressAnalyst: a unified platform for RNA-sequencing analysis in non-model species","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2025.117341_bb0135","doi-asserted-by":"crossref","first-page":"W390","DOI":"10.1093\/nar\/gkae335","article-title":"LipidSig 2.0: integrating lipid characteristic insights into advanced lipidomics data analysis","volume":"52","author":"Liu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2025.117341_bb0140","doi-asserted-by":"crossref","first-page":"13395","DOI":"10.1038\/s41598-022-17521-4","article-title":"Comprehensive lipid and lipid-related gene investigations of host immune responses to characterize metabolism-centric biomarkers for pulmonary tuberculosis","volume":"12","author":"Long","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117341_bb0145","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1038\/s41467-021-27279-4","article-title":"AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway","volume":"12","author":"Mak","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2025.117341_bb0150","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.rmed.2014.01.014","article-title":"Initial characteristics and outcome of hospitalized patients with amiodarone pulmonary toxicity","volume":"108","author":"Mankikian","year":"2014","journal-title":"Respir. Med."},{"key":"10.1016\/j.taap.2025.117341_bb0155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/0192623311432290","article-title":"Phospholipidosis in rats treated with amiodarone: serum biochemistry and whole genome micro-array analysis supporting the lipid traffic jam hypothesis and the subsequent rise of the biomarker BMP","volume":"40","author":"Mesens","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2025.117341_bb0160","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz061","article-title":"LION\/web: a web-based ontology enrichment tool for lipidomic data analysis","volume":"8","author":"Molenaar","year":"2019","journal-title":"Gigascience"},{"key":"10.1016\/j.taap.2025.117341_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104521","article-title":"The role of amiodarone in contemporary management of complex cardiac arrhythmias","volume":"151","author":"Mujovi\u0107","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2025.117341_bb0170","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40170-020-00237-2","article-title":"The diversity and breadth of cancer cell fatty acid metabolism","volume":"9","author":"Nagarajan","year":"2021","journal-title":"Cancer Metab."},{"key":"10.1016\/j.taap.2025.117341_bb0175","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/15569543.2020.1818105","article-title":"Toxins mechanism in instigating hepatotoxicity","volume":"40","author":"Nithiyanandam","year":"2021","journal-title":"Toxin Rev."},{"key":"10.1016\/j.taap.2025.117341_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108519","article-title":"Liver lipidome signature and metabolic pathways in nonalcoholic fatty liver disease induced by a high-sugar diet","volume":"87","author":"Oliveira","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.taap.2025.117341_bb0185","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2025.117341_bb0190","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2025.117341_bb0195","series-title":"R: A Language and Environment for Statistial Computing","author":"R Core Team","year":"2023"},{"key":"10.1016\/j.taap.2025.117341_bb0200","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biochi.2020.07.005","article-title":"Bis(monoacylglycero)phosphate, a new lipid signature of endosome-derived extracellular vesicles","volume":"178","author":"Rabia","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.taap.2025.117341_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12258","article-title":"Population-level incidence and monitoring of adverse drug reactions with long-term amiodarone therapy","volume":"35","author":"Rankin","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.taap.2025.117341_bb0210","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plipres.2017.01.002","article-title":"Sphingolipids and glycerophospholipids \u2013 the \u201cying and yang\u201d of lipotoxicity in metabolic diseases","volume":"66","author":"Rodriguez-Cuenca","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.taap.2025.117341_bb0215","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.amjcard.2019.09.008","article-title":"Meta-analysis comparing the relative risk of adverse events for amiodarone versus placebo","volume":"124","author":"Ruzieh","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.taap.2025.117341_bb0220","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2131\/jts.42.589","article-title":"Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver","volume":"42","author":"Sanoh","year":"2017","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2025.117341_bb0225","doi-asserted-by":"crossref","first-page":"11179","DOI":"10.1073\/pnas.94.21.11179","article-title":"Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site1","volume":"94","author":"Scheek","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.taap.2025.117341_bb0230","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.freeradbiomed.2011.09.004","article-title":"Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration","volume":"51","author":"Serviddio","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2025.117341_bb0235","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbalip.2012.08.013","article-title":"Drug induced phospholipidosis: an acquired lysosomal storage disorder","volume":"1831","author":"Shayman","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.taap.2025.117341_bb0240","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/joim.13095","article-title":"Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase","volume":"288","author":"Simonen","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.taap.2025.117341_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111415","article-title":"De novo sphingolipid biosynthesis necessitates detoxification in cancer cells","volume":"40","author":"Spears","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.taap.2025.117341_bb0250","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.toxlet.2012.07.013","article-title":"Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats","volume":"213","author":"Thompson","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2025.117341_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116652","article-title":"An exploratory multi-omics study reveals distinct molecular signatures of ulcerative colitis and Crohn's disease and their correlation with disease activity","volume":"255","author":"Tien","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.taap.2025.117341_bb0260","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41587-020-0531-2","article-title":"A lipidome atlas in MS-DIAL 4","volume":"38","author":"Tsugawa","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.taap.2025.117341_bb0265","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.taap.2025.117341_bb0270","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1007\/s00204-020-02837-9","article-title":"Autophagy alleviates amiodarone-induced hepatotoxicity","volume":"94","author":"Wandrer","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2025.117341_bb0275","article-title":"Amiodarone pulmonary toxicity","volume":"16","author":"Wolkove","year":"2009","journal-title":"Can. Respir. J."},{"key":"10.1016\/j.taap.2025.117341_bb0280","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.atv.0000125703.20434.4d","article-title":"Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein","volume":"24","author":"Worgall","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2025.117341_bb0285","article-title":"Screening of lipid metabolism-related gene diagnostic signature for patients with dilated cardiomyopathy","volume":"9","author":"Xu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.taap.2025.117341_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100337","article-title":"Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro","volume":"64","author":"Xu","year":"2023","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2025.117341_bb0295","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biochi.2023.04.009","article-title":"Multimodal plasma metabolomics and lipidomics in elucidating metabolic perturbations in tuberculosis patients with concurrent type 2 diabetes","volume":"211","author":"Yen","year":"2023","journal-title":"Biochimie"},{"key":"10.1016\/j.taap.2025.117341_bb0300","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1021\/acs.jproteome.9b00234","article-title":"Systemic and local metabolic alterations in sleep-deprivation-induced stress: a multiplatform mass-spectrometry-based lipidomics and metabolomics approach","volume":"18","author":"Yoon","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.taap.2025.117341_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.839441","article-title":"Amiodarone-induced multi-systemic toxicity involving the liver, lungs, thyroid, and eyes: a case report","volume":"9","author":"You","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.taap.2025.117341_bb0310","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1038\/s41467-021-27244-1","article-title":"The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25001176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25001176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:49:41Z","timestamp":1762220981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25001176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":62,"alternative-id":["S0041008X25001176"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117341","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.21.633980","asserted-by":"object"}]},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The lipidome landscape of amiodarone toxicity: An in vivo lipid-centric multi-omics study","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117341","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117341"}}