{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:14:52Z","timestamp":1792239292045,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC81773391"],"award-info":[{"award-number":["NSFC81773391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["ZCLQN25H2601"],"award-info":[{"award-number":["ZCLQN25H2601"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.taap.2025.117347","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:44:09Z","timestamp":1744803849000},"page":"117347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["H3K9\/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells"],"prefix":"10.1016","volume":"499","author":[{"given":"Xiaomin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quekun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daimin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanshu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.taap.2025.117347_bb0005","doi-asserted-by":"crossref","first-page":"9139","DOI":"10.1039\/D2RA00378C","article-title":"A comprehensive review on the sources, essentiality and toxicological profile of nickel","volume":"12","author":"Begum","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.taap.2025.117347_bb0010","article-title":"Histone hypoacetylation contributes to neurotoxicity induced by chronic nickel exposure in vivo and in vitro","volume":"783","author":"Ca","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"27","key":"10.1016\/j.taap.2025.117347_bb0015","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1038\/onc.2017.14","article-title":"LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1\u03b1 translation","volume":"36","author":"Cb","year":"2017","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.taap.2025.117347_bb0020","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/carcin\/bgq197","article-title":"Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells","volume":"31","author":"Chen","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2025.117347_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216285","article-title":"NUSAP1-LDHA-glycolysis-lactate feedforward loop promotes Warburg effect and metastasis in pancreatic ductal adenocarcinoma","volume":"567","author":"Chen","year":"2023","journal-title":"Cancer Lett."},{"issue":"13","key":"10.1016\/j.taap.2025.117347_bb0030","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.febslet.2010.11.010","article-title":"Histone arginine methylation","volume":"585","author":"Di Lorenzo","year":"2011","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1186\/s12967-023-04403-0","article-title":"Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis","volume":"21","author":"Duan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"12","key":"10.1016\/j.taap.2025.117347_bb0040","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1002\/cam4.1820","article-title":"Lactate dehydrogenase a: a key player in carcinogenesis and potential target in cancer therapy","volume":"7","author":"Feng","year":"2018","journal-title":"Cancer Med."},{"issue":"24","key":"10.1016\/j.taap.2025.117347_bb0045","doi-asserted-by":"crossref","first-page":"16062","DOI":"10.3390\/ijms232416062","article-title":"Effect of LDHA inhibition on TNF-\u03b1-induced cell migration in esophageal cancers","volume":"23","author":"Forkasiewicz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2025.117347_bb0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/ijerph17030679","article-title":"nickel: human health and environmental toxicology","volume":"17","author":"Genchi","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.taap.2025.117347_bb0055","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.omtn.2018.05.017","article-title":"ISO, via upregulating MiR-137 transcription, inhibits GSK3\u03b2-HSP70-MMP-2 axis, resulting in attenuating urothelial cancer invasion","volume":"12","author":"Guo","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"19","key":"10.1016\/j.taap.2025.117347_bb0060","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.3390\/ijms20194690","article-title":"Nickel carcinogenesis mechanism: DNA damage","volume":"20","author":"Guo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.taap.2025.117347_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002666","article-title":"KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation","volume":"22","author":"Hou","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.taap.2025.117347_bb0070","doi-asserted-by":"crossref","first-page":"1388999","DOI":"10.3389\/fonc.2024.1388999","article-title":"Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target","volume":"14","author":"Hu","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.taap.2025.117347_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuro.2020.08.005","article-title":"Epigenetic influence of environmentally neurotoxic metals","volume":"81","author":"Ijomone","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2025.117347_bb0080","article-title":"Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer","volume":"11","author":"Jiang","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13072-019-0324-3","article-title":"Nickel-induced transcriptional changes persist post exposure through epigenetic reprogramming","volume":"12","author":"Jose","year":"2019","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0090","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/15548627.2023.2249762","article-title":"Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer","volume":"20","author":"Li","year":"2024","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.taap.2025.117347_bb0095","doi-asserted-by":"crossref","first-page":"e0140339","DOI":"10.1371\/journal.pone.0140339","article-title":"Histone methylation in nickel-smelting industrial workers","volume":"10","author":"Ma","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2025.117347_bb0100","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbrc.2022.05.028","article-title":"LDHA promotes osteoblast differentiation through histone lactylation","volume":"615","author":"Nian","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0105","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/taap.1996.8075","article-title":"Carcinogenicity assessment of selected nickel compounds","volume":"143","author":"Oller","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2025.117347_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106270","article-title":"Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells","volume":"181","author":"Pan","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0115","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s42003-024-06543-5","article-title":"Histone lactylation-ROS loop contributes to light exposure-exacerbated neutrophil recruitment in zebrafish","volume":"7","author":"Qiu","year":"2024","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.repbio.2019.11.005","article-title":"Nickel toxicology with reference to male molecular reproductive physiology","volume":"20","author":"Rizvi","year":"2020","journal-title":"Reprod. Biol."},{"issue":"2","key":"10.1016\/j.taap.2025.117347_bb0125","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.taap.2025.117347_bb0130","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/bgx038","article-title":"Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells","volume":"38","author":"Scanlon","year":"2017","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0135","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1038\/s41467-023-42025-8","article-title":"Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.taap.2025.117347_bb0140","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cmet.2014.03.014","article-title":"Lysine glutarylation is a protein posttranslational modification regulated by SIRT5","volume":"19","author":"Tan","year":"2014","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.taap.2025.117347_bb0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrm3931","article-title":"50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond","volume":"16","author":"Verdin","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"Database issue","key":"10.1016\/j.taap.2025.117347_bb0150","article-title":"PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s11658-024-00541-5","article-title":"Ubiquitous protein lactylation in health and diseases","volume":"29","author":"Wang","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"12","key":"10.1016\/j.taap.2025.117347_bb0160","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/bph.16332","article-title":"Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification","volume":"181","author":"Wang","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2025.117347_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110047","article-title":"Mitochondria-targeted catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28\/miR-200b\/PP2A-C\u03b1 axis","volume":"758","author":"Wen","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"issue":"31","key":"10.1016\/j.taap.2025.117347_bb0170","article-title":"Endothelial cell-derived lactate triggers bone mesenchymal stem cell histone lactylation to attenuate osteoporosis","volume":"10","author":"Wu","year":"2023","journal-title":"Adv Sci (Weinh)."},{"issue":"5","key":"10.1016\/j.taap.2025.117347_bb0175","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1074\/mcp.M111.015875","article-title":"Lysine succinylation and lysine malonylation in histones","volume":"11","author":"Xie","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.taap.2025.117347_bb0180","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinforma."},{"issue":"3","key":"10.1016\/j.taap.2025.117347_bb0185","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1039\/C7MT00346C","article-title":"Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells","volume":"10","author":"Yin","year":"2018","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.taap.2025.117347_bb0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","article-title":"Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma","volume":"22","author":"Yu","year":"2021","journal-title":"Genome Biol."},{"issue":"19","key":"10.1016\/j.taap.2025.117347_bb0195","article-title":"Histone H3K9 lactylation confers temozolomide resistance in glioblastoma via LUC7L2-mediated MLH1 intron retention","volume":"11","author":"Yue","year":"2024","journal-title":"Adv Sci (Weinh)."},{"issue":"7","key":"10.1016\/j.taap.2025.117347_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110188","article-title":"Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma","volume":"27","author":"Zang","year":"2024","journal-title":"iScience"},{"issue":"7779","key":"10.1016\/j.taap.2025.117347_bb0205","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.taap.2025.117347_bb0210","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1158\/0008-5472.CAN-23-3513","article-title":"H3K18 Lactylation potentiates immune escape of non-small cell lung Cancer","volume":"84","author":"Zhang","year":"2024","journal-title":"Cancer Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25001231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25001231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:49:46Z","timestamp":1762220986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25001231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":42,"alternative-id":["S0041008X25001231"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117347","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H3K9\/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117347"}}