{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:56:33Z","timestamp":1793706993720,"version":"4.6.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900485"],"award-info":[{"award-number":["31900485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371322"],"award-info":[{"award-number":["32371322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271329"],"award-info":[{"award-number":["32271329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["24B0052"],"award-info":[{"award-number":["24B0052"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["24A0059"],"award-info":[{"award-number":["24A0059"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1304900"],"award-info":[{"award-number":["2023YFF1304900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80158"],"award-info":[{"award-number":["2025JJ80158"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.taap.2025.117374","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:20:42Z","timestamp":1746710442000},"page":"117374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Isolation and identification of toxins inhibiting Shal potassium channels from the venom of Ornithoctonus hainana spider"],"prefix":"10.1016","volume":"500","author":[{"given":"Minzhi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117374_bb0005","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2022.0166","article-title":"Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models","volume":"378","author":"Alrabghi","year":"2023","journal-title":"Biol. Sci."},{"key":"10.1016\/j.taap.2025.117374_bb0010","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fphar.2019.00058","article-title":"Venom-derived peptide modulators of cation-selective channels: friend, foe or frenemy","volume":"10","author":"Bajaj","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2025.117374_bb0015","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/physrev.00039.2003","article-title":"Structure and function of Kv4-family transient potassium channels","volume":"84","author":"Birnbaum","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2025.117374_bb0020","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.peptides.2014.09.005","article-title":"Mapping the interaction site for the tarantula toxin hainantoxin-IV (\u03b2-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels","volume":"68","author":"Cai","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.taap.2025.117374_bb0025","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1038\/ncomms3602","article-title":"The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods","volume":"4","author":"Cao","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2025.117374_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","article-title":"Complex cocktails: the evolutionary novelty of venoms","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.taap.2025.117374_bb0035","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1523\/JNEUROSCI.21-17-06626.2001","article-title":"Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy","volume":"21","author":"Castro","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2025.117374_bb0040","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.bbabio.2016.03.011","article-title":"Physiology of intracellular potassium channels: a unifying role as mediators of counterion fluxes?","volume":"1857","author":"Checchetto","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2025.117374_bb0045","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1007\/s11064-008-9650-8","article-title":"The neuronal Kv4 channel complex","volume":"33","author":"Covarrubias","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2025.117374_bb0050","article-title":"Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao","volume":"26","author":"Deng","year":"2020","journal-title":"J. Venom. Anim. Toxins Including Trop. Dis."},{"key":"10.1016\/j.taap.2025.117374_bb0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.bjp.0702283","article-title":"Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis","volume":"126","author":"Diochot","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2025.117374_bb0060","article-title":"Nocturnal atrial fibrillation caused by mutation in KCND2, encoding pore-forming (\u03b1) subunit of the cardiac Kv4.2 Potassium Channel","volume":"11","author":"Drabkin","year":"2018","journal-title":"Circul. Genom. Precis. Med."},{"key":"10.1016\/j.taap.2025.117374_bb0065","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.hrthm.2011.02.021","article-title":"Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome","volume":"8","author":"Giudicessi","year":"2011","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.taap.2025.117374_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29010035","article-title":"Spider-venom peptides: structure, bioactivity, strategy, and research applications","volume":"29","author":"Guo","year":"2023","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.taap.2025.117374_bb0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuron.2006.03.010","article-title":"The kv4.2 potassium channel subunit is required for pain plasticity","volume":"50","author":"Hu","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.taap.2025.117374_bb0080","doi-asserted-by":"crossref","first-page":"9182","DOI":"10.1523\/JNEUROSCI.0339-14.2014","article-title":"Inhibition of A-type potassium current by the peptide toxin SNX-482","volume":"34","author":"Kimm","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2025.117374_bb0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41586-021-03935-z","article-title":"Structural basis of gating modulation of Kv4 channel complexes","volume":"599","author":"Kise","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.taap.2025.117374_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11100611","article-title":"Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses","volume":"11","author":"Langenegger","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.taap.2025.117374_bb0095","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0014-5793(03)01303-6","article-title":"Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana","volume":"555","author":"Li","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2025.117374_bb0100","doi-asserted-by":"crossref","first-page":"20392","DOI":"10.1074\/jbc.M112.426627","article-title":"Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana","volume":"288","author":"Liu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2025.117374_bb0105","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1073\/pnas.1714760115","article-title":"Centipedes subdue giant prey by blocking KCNQ channels","volume":"115","author":"Luo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"42","key":"10.1016\/j.taap.2025.117374_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202406656","article-title":"Optimizing Nav1.7-targeted analgesics: revealing off-target effects of spider venom-derived peptide toxins and engineering strategies for improvement","volume":"11","author":"Luo","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.taap.2025.117374_bb0115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.toxicon.2012.11.022","article-title":"The venom optimization hypothesis revisited","volume":"63","author":"Morgenstern","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.taap.2025.117374_bb0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yjmcc.2009.07.013","article-title":"Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation","volume":"48","author":"Niwa","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2025.117374_bb0125","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/cvr\/cvt028","article-title":"A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation","volume":"98","author":"Olesen","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.taap.2025.117374_bb0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.toxicon.2016.06.014","article-title":"Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in\u00a0vivo","volume":"119","author":"Pucca","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.taap.2025.117374_bb0135","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0026-895X(24)13491-8","article-title":"Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels","volume":"51","author":"Sanguinetti","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2025.117374_bb0140","first-page":"1","article-title":"Control of action potential afterdepolarizations in the inferior olive by inactivating A-type currents through K(V)4 channels","volume":"0","author":"Sultan","year":"2024","journal-title":"J. Physiol."},{"key":"10.1016\/j.taap.2025.117374_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk3870","article-title":"Venom trade-off shapes interspecific interactions, physiology, and reproduction","volume":"10","author":"Surm","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.taap.2025.117374_bb0150","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1021\/pr1000016","article-title":"Molecular diversification of peptide toxins from the tarantula Haplopelma hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses","volume":"9","author":"Tang","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.taap.2025.117374_bb0155","doi-asserted-by":"crossref","first-page":"517","DOI":"10.17219\/acem\/22339","article-title":"Voltage-gated potassium channels Kv1.3--potentially new molecular target in cancer diagnostics and therapy","volume":"24","author":"Teisseyre","year":"2015","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.taap.2025.117374_bb0160","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0041-0101(01)00277-X","article-title":"The venom optimisation hypothesis: a spider injects large venom quantities only into difficult prey types","volume":"40","author":"Wigger","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.taap.2025.117374_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.692076","article-title":"Variation of two S3b residues in K(V)4.1-4.3 channels underlies their different modulations by spider toxin \u03ba-LhTx-1","volume":"12","author":"Xiao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2025.117374_bb0170","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1074\/mcp.M112.018853","article-title":"Chemical punch packed in venoms makes centipedes excellent predators","volume":"11","author":"Yang","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.taap.2025.117374_bb0175","article-title":"Target switch of centipede toxins for antagonistic switch","volume":"6","author":"Yang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.taap.2025.117374_bb0180","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.molcel.2022.04.032","article-title":"Activation and closed-state inactivation mechanisms of the human voltage-gated K(V)4 channel complexes","volume":"82","author":"Ye","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2025.117374_bb0185","doi-asserted-by":"crossref","first-page":"14192","DOI":"10.1074\/jbc.M114.635458","article-title":"Structural and functional diversity of peptide toxins from tarantula Haplopelma hainanum (Ornithoctonus hainana) venom revealed by transcriptomic, Peptidomic, and patch clamp approaches","volume":"290","author":"Zhang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2025.117374_bb0190","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1038\/s41467-020-16210-y","article-title":"Spider venom-derived peptide induces hyperalgesia in Na(v)1.7 knockout mice by activating Na(v)1.9 channels","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25001504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25001504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:27:29Z","timestamp":1778473649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25001504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"alternative-id":["S0041008X25001504"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117374","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation and identification of toxins inhibiting Shal potassium channels from the venom of Ornithoctonus hainana spider","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117374"}}