{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:27:34Z","timestamp":1755793654482,"version":"3.44.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"am","delay-in-days":304,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R00 ES030405","P30 ES036084"],"award-info":[{"award-number":["R00 ES030405","P30 ES036084"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.taap.2025.117463","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:05:58Z","timestamp":1752642358000},"page":"117463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolism disrupting effects in human pre-adipocytes: Influence of donor sex and body composition"],"prefix":"10.1016","volume":"503","author":[{"given":"Praneeth","family":"Goli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Kocarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Kassotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117463_bb0005","doi-asserted-by":"crossref","first-page":"162587","DOI":"10.1016\/j.scitotenv.2023.162587","article-title":"Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures","volume":"876","author":"B\u00e9rub\u00e9","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"3\u20135","key":"10.1016\/j.taap.2025.117463_bb0010","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jsbmb.2007.09.001","article-title":"Androgens and body fat distribution","volume":"108","author":"Blouin","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"5","key":"10.1016\/j.taap.2025.117463_bb0015","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/s-0028-1093403","article-title":"Specific weight loss in hyperthyroidism","volume":"10","author":"Bratusch-Marrain","year":"1978","journal-title":"Horm. Metab. Res."},{"issue":"8","key":"10.1016\/j.taap.2025.117463_bb0020","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1101\/gad.10.8.974","article-title":"Differential activation of adipogenesis by multiple PPAR isoforms","volume":"10","author":"Brun","year":"1996","journal-title":"Genes Dev."},{"issue":"3\u20135","key":"10.1016\/j.taap.2025.117463_bb0025","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jsbmb.2008.06.010","article-title":"Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141","volume":"111","author":"Bryzgalova","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"9","key":"10.1016\/j.taap.2025.117463_bb0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11892-018-1031-3","article-title":"Gender and sex differences in adipose tissue","volume":"18","author":"Chang","year":"2018","journal-title":"Curr. Diab. Rep."},{"issue":"6","key":"10.1016\/j.taap.2025.117463_bb0035","doi-asserted-by":"crossref","first-page":"bqae050","DOI":"10.1210\/endocr\/bqae050","article-title":"Molecular assessment of pro-adipogenic effects for common-use contraceptives and their mixtures","volume":"165","author":"Chiang","year":"2024","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.taap.2025.117463_bb0040","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1177\/1535370214566565","article-title":"Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells","volume":"240","author":"Contador","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"2","key":"10.1016\/j.taap.2025.117463_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2265.2001.01329.x","article-title":"Weight gain following treatment of hyperthyroidism","volume":"55","author":"Dale","year":"2001","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"1","key":"10.1016\/j.taap.2025.117463_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/79111","article-title":"Failure of adipocyte differentiation causes type II diabetes mellitus?","volume":"26","author":"Danforth","year":"2000","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.taap.2025.117463_bb0060","doi-asserted-by":"crossref","first-page":"57005","DOI":"10.1289\/EHP6779","article-title":"On the utility of ToxCast-based predictive models to evaluate potential metabolic disruption by environmental chemicals","volume":"130","author":"Filer","year":"2022","journal-title":"Environ. Health Perspect."},{"issue":"6 Suppl","key":"10.1016\/j.taap.2025.117463_bb0065","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1210\/en.2005-1129","article-title":"Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling","volume":"147","author":"Grun","year":"2006","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.taap.2025.117463_bb0070","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1210\/me.2005-0367","article-title":"Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates","volume":"20","author":"Grun","year":"2006","journal-title":"Mol. Endocrinol."},{"issue":"24","key":"10.1016\/j.taap.2025.117463_bb0075","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/eurheartj\/ehn387","article-title":"Adipose tissue dysfunction in obesity, diabetes, and vascular diseases","volume":"29","author":"Hajer","year":"2008","journal-title":"Eur. Heart J."},{"year":"2017","series-title":"Prevalence of Obesity among Adults and Youth: United States, 2015\u20132016","author":"Hales","key":"10.1016\/j.taap.2025.117463_bb0080"},{"key":"10.1016\/j.taap.2025.117463_bb0085","series-title":"NCHS Data Brief","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017\u20132018","volume":"360","author":"Hales","year":"2020"},{"issue":"8","key":"10.1016\/j.taap.2025.117463_bb0090","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.ijo.0802314","article-title":"Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women","volume":"27","author":"van Harmelen","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.taap.2025.117463_bb0095","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12940-015-0042-7","article-title":"Parma consensus statement on metabolic disruptors","volume":"14","author":"Heindel","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.taap.2025.117463_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.taap.2025.117463_bb0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jsbmb.2011.01.005","article-title":"Minireview: PPAR\u03b3 as the target of Obesogens","volume":"127","author":"Janesick","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"5","key":"10.1016\/j.taap.2025.117463_bb0110","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ajog.2016.01.182","article-title":"Obesogens: an emerging threat to public health","volume":"214","author":"Janesick","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.taap.2025.117463_bb0115","doi-asserted-by":"crossref","first-page":"R1772","DOI":"10.1152\/ajpregu.2001.280.6.R1772","article-title":"Altered expression of C\/EBP family members results in decreased adipogenesis with aging","volume":"280","author":"Karagiannides","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.taap.2025.117463_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2042-6410-3-13","article-title":"Sex differences in human adipose tissues \u2013 the biology of pear shape","volume":"3","author":"Karastergiou","year":"2012","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.taap.2025.117463_bb0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fendo.2019.00039","article-title":"Endocrine-mediated mechanisms of metabolic disruption and new approaches to examine the public health threat","volume":"10","author":"Kassotis","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.taap.2025.117463_bb0130","doi-asserted-by":"crossref","first-page":"42104","DOI":"10.1038\/srep42104","article-title":"Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: implications for reproducibility based on cell source and handling","volume":"7","author":"Kassotis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117463_bb0135","doi-asserted-by":"crossref","first-page":"42104","DOI":"10.1038\/srep42104","article-title":"Characterization of adipogenic chemicals in three different cell culture systems: implications for reproducibility based on cell source and handling","volume":"7","author":"Kassotis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117463_bb0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.scitotenv.2019.02.273","article-title":"Thyroid receptor antagonism as a contributory mechanism for Adipogenesis induced by environmental mixtures in 3T3-L1 cells","volume":"666","author":"Kassotis","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117463_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152900","article-title":"Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: an interlaboratory study","volume":"461","author":"Kassotis","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2025.117463_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143707","article-title":"Characterization of adipogenic, PPARgamma, and TRbeta activities in house dust extracts and their associations with organic contaminants","volume":"758","author":"Kassotis","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117463_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115014","article-title":"Obesity III: Obesogen assays: limitations, strengths, and new directions","volume":"199","author":"Kassotis","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.taap.2025.117463_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10020099","article-title":"Nonylphenol Polyethoxylates enhance adipose deposition in developmentally exposed zebrafish","volume":"10","author":"Kassotis","year":"2022","journal-title":"Toxics"},{"issue":"3","key":"10.1016\/j.taap.2025.117463_bb0170","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbrc.2018.04.136","article-title":"Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1","volume":"500","author":"Khanh","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.taap.2025.117463_bb0175","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bone.2005.01.017","article-title":"Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors","volume":"36","author":"Kindblom","year":"2005","journal-title":"Bone"},{"issue":"20","key":"10.1016\/j.taap.2025.117463_bb0180","first-page":"11857","article-title":"Chemical mixtures isolated from house dust disrupt thyroid receptor \u03b2 (TR\u03b2) signaling","volume":"52","author":"Kollitz","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"38","key":"10.1016\/j.taap.2025.117463_bb0185","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1024\/1661-8157.96.38.1411","article-title":"Hypothyroidism. Main symptoms: fatigue, weight gain, depression, myalgia, edema","volume":"96","author":"Kolyvanos Naumann","year":"2007","journal-title":"Praxis (Bern 1994)"},{"issue":"9","key":"10.1016\/j.taap.2025.117463_bb0190","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ijo.2014.6","article-title":"The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine production in human adipocytes","volume":"38","author":"Lee","year":"2014","journal-title":"Int. J. Obes. (Lond)"},{"issue":"3","key":"10.1016\/j.taap.2025.117463_bb0195","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/metabo13030359","article-title":"Cetyl alcohol Polyethoxylates disrupt metabolic health in developmentally exposed zebrafish","volume":"13","author":"LeFauve","year":"2023","journal-title":"Metabolites"},{"issue":"1\u20132","key":"10.1016\/j.taap.2025.117463_bb0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jsbmb.2011.03.012","article-title":"The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes","volume":"127","author":"Li","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"12","key":"10.1016\/j.taap.2025.117463_bb0205","first-page":"4269","article-title":"Body weight and body composition changes after treatment of hyperthyroidism","volume":"83","author":"Lonn","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.taap.2025.117463_bb0210","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1677\/JME-09-0107","article-title":"Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors","volume":"44","author":"Lu","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.taap.2025.117463_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115012","article-title":"Obesity I: overview and molecular and biochemical mechanisms","volume":"199","author":"Lustig","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2025.117463_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2015.00001","article-title":"Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy","volume":"6","author":"Ma","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.taap.2025.117463_bb0225","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/embor.2009.8","article-title":"Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors","volume":"10","author":"le Maire","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.taap.2025.117463_bb0230","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fendo.2019.00137","article-title":"The impact of aging on adipose function and Adipokine synthesis","volume":"10","author":"Mancuso","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.taap.2025.117463_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/thy.2007.0254","article-title":"Thyroid hormone and adipocyte differentiation","volume":"18","author":"Obregon","year":"2008","journal-title":"Thyroid"},{"issue":"10","key":"10.1016\/j.taap.2025.117463_bb0240","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1091\/mbc.e08-04-0420","article-title":"Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro","volume":"19","author":"Pantoja","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"7","key":"10.1016\/j.taap.2025.117463_bb0245","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/oby.2009.419","article-title":"Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation","volume":"18","author":"Sargis","year":"2010","journal-title":"Obesity (Silver Spring)"},{"issue":"12","key":"10.1016\/j.taap.2025.117463_bb0250","doi-asserted-by":"crossref","first-page":"7354","DOI":"10.1073\/pnas.1131854100","article-title":"Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking","volume":"100","author":"Schapira","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.taap.2025.117463_bb0255","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1056\/NEJMra043590","article-title":"Retinoid x receptor heterodimers in the metabolic syndrome","volume":"353","author":"Shulman","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.taap.2025.117463_bb0260","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-3459","article-title":"Prevalence of obesity and severe obesity in US children, 1999-2016","volume":"141","author":"Skinner","year":"2018","journal-title":"Pediatrics"},{"issue":"10","key":"10.1016\/j.taap.2025.117463_bb0265","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/oby.2010.56","article-title":"Sex- and depot-dependent differences in adipogenesis in normal-weight humans","volume":"18","author":"Tchoukalova","year":"2010","journal-title":"Obesity (Silver Spring)"},{"issue":"9","key":"10.1016\/j.taap.2025.117463_bb0270","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1124\/dmd.123.001311","article-title":"Adipocyte-derived PXR signaling is dispensable for diet-induced obesity and metabolic disorders in mice","volume":"51","author":"Wang","year":"2023","journal-title":"Drug Metab. Dispos."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2500239X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2500239X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:44:53Z","timestamp":1755236693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2500239X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":52,"alternative-id":["S0041008X2500239X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117463","relation":{},"ISSN":["0041-008X"],"issn-type":[{"type":"print","value":"0041-008X"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolism disrupting effects in human pre-adipocytes: Influence of donor sex and body composition","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117463"}}