{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:54:49Z","timestamp":1792630489507,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY22H040010"],"award-info":[{"award-number":["LY22H040010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20220387"],"award-info":[{"award-number":["Y20220387"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371610"],"award-info":[{"award-number":["82371610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301892"],"award-info":[{"award-number":["82301892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.taap.2025.117480","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T23:11:55Z","timestamp":1752880315000},"page":"117480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Significant enhancement of inhibitory strength of bisphenol A analogs against human and rat 5\u03b1-reductase 1 upon halogenation of the benzene ring: Potentially disrupting neurosteroid biosynthesis"],"prefix":"10.1016","volume":"503","author":[{"given":"Shihan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfen","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-shan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117480_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125236","article-title":"Simultaneous determination of bisphenol a and its chlorinated derivatives in human plasma: development, validation and application of a UHPLC-MS\/MS method","volume":"242","author":"Cambien","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2025.117480_bb0010","doi-asserted-by":"crossref","first-page":"100552","DOI":"10.1007\/s11356-023-29426-4","article-title":"The association of bisphenol a and paraben exposure with sensorineural hearing loss in children","volume":"30","author":"Chang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.taap.2025.117480_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116632","article-title":"Phthalates, adipates, BPA, and pesticides in school meals","volume":"236","author":"Cohen","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2025.117480_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110987","article-title":"Carbon-chain length determines the binding affinity and inhibitory strength of per- and polyfluoroalkyl substances on human and rat steroid 5alpha-reductase 1 activity","volume":"394","author":"Cui","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2025.117480_bb0025","doi-asserted-by":"crossref","first-page":"1272368","DOI":"10.3389\/ftox.2023.1272368","article-title":"A systematic review of the evaluation of endocrine-disrupting chemicals in the Japanese medaka (Oryzias latipes) fish","volume":"5","author":"Dasmahapatra","year":"2023","journal-title":"Front Toxicol"},{"key":"10.1016\/j.taap.2025.117480_bb0030","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/j.scitotenv.2009.08.037","article-title":"Brominated flame retardants in the Arctic environment--trends and new candidates","volume":"408","author":"de Wit","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117480_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170989","article-title":"Ecotoxicological responses of juvenile Sparus aurata to BDE-99 and BPA exposure: a multi-biomarker approach integrating immune, endocrine and oxidative endpoints","volume":"920","author":"Dias","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117480_bb0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1527-3458.2006.00053.x","article-title":"A new look at the 5alpha-reductase inhibitor finasteride","volume":"12","author":"Finn","year":"2006","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.taap.2025.117480_bb0045","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1210\/endo.139.9.6183","article-title":"Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells","volume":"139","author":"Ge","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2025.117480_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132355","article-title":"Unveiling the occurrence, distribution, removal, and environmental impacts of 65 emerging contaminants in neglected fresh leachate from municipal solid waste incineration plants","volume":"460","author":"Gong","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2025.117480_bb0055","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1897\/06-308R.1","article-title":"Quantitative structure-activity relationship modeling on in vitro endocrine effects and metabolic stability involving 26 selected brominated flame retardants","volume":"26","author":"Harju","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.taap.2025.117480_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","article-title":"ZINC--a free database of commercially available compounds for virtual screening","volume":"45","author":"Irwin","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.taap.2025.117480_bb0065","article-title":"Demethoxylation of curcumin enhances its inhibition on human and rat 17beta-hydroxysteroid dehydrogenase 3: QSAR structure-activity relationship and in silico docking analysis","volume":"186","author":"Ji","year":"2024","journal-title":"Food Chemi. Toxicol. : Int. J. Published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.taap.2025.117480_bb0070","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fendo.2020.00447","article-title":"Bisphenols and Leydig cell development and function","volume":"11","author":"Li","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.taap.2025.117480_bb0075","doi-asserted-by":"crossref","first-page":"13222","DOI":"10.1021\/acs.est.2c03452","article-title":"Per- and Polyfluoroalkyl substances (PFASs) impair lipid metabolism in Rana nigromaculata: a field investigation and laboratory study","volume":"56","author":"Lin","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2025.117480_bb0080","article-title":"Assessing the hepatotoxicity of PFOA, PFOS, and 6:2 cl-PFESA in black-spotted frogs (Rana nigromaculata) and elucidating potential association with gut microbiota","volume":"312","author":"Lin","year":"2022","journal-title":"Environment. Pollut. (Barking, Essex\u202f: 1987)"},{"key":"10.1016\/j.taap.2025.117480_bb0085","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1210\/en.2016-1508","article-title":"5\u03b1-Androstane-3\u03b1,17\u03b2-diol inhibits neurotoxicity in SH-SY5Y human neuroblastoma cells and mouse primary cortical neurons","volume":"157","author":"Mendell","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2025.117480_bb0090","series-title":"Physiology, Testosterone","author":"Nassar","year":"2021"},{"key":"10.1016\/j.taap.2025.117480_bb0095","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.3390\/molecules27196338","article-title":"Homology modeling, molecular docking, molecular dynamic simulation, and drug-likeness of the modified alpha-Mangostin against the beta-tubulin protein of Acanthamoeba keratitis","volume":"27","author":"Ongtanasup","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2025.117480_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106547","article-title":"An overview of the literature on emerging pollutants: chlorinated derivatives of bisphenol a (ClxBPA)","volume":"153","author":"Plattard","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2025.117480_bb0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-444-53630-3.00008-7","article-title":"Neurosteroids: endogenous role in the human brain and therapeutic potentials","volume":"186","author":"Reddy","year":"2010","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.taap.2025.117480_bb0110","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0167-4838(87)90015-X","article-title":"Kinetics of amino acid esterification catalyzed by hydrophobic derivatives of alpha-chymotrypsin","volume":"911","author":"Remy","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2025.117480_bb0115","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-033509","article-title":"Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis","volume":"10","author":"Ribeiro","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.taap.2025.117480_bb0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/toxsci\/kfj132","article-title":"Toxicokinetics of tetrabromobisphenol a in humans and rats after oral administration","volume":"91","author":"Schauer","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2025.117480_bb0125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.placenta.2019.10.008","article-title":"Environmental pollutant induced cellular injury is reflected in exosomes from placental explants","volume":"89","author":"Sheller-Miller","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.taap.2025.117480_bb0130","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/eje.0.1450669","article-title":"Neurosteroid metabolism in the human brain","volume":"145","author":"Stoffel-Wagner","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.taap.2025.117480_bb0135","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1021\/ci010368v","article-title":"Prediction of n-octanol\/water partition coefficients from PHYSPROP database using artificial neural networks and E-state indices","volume":"41","author":"Tetko","year":"2001","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.taap.2025.117480_bb0140","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1021\/acs.jcim.3c00301","article-title":"Screening and biological evaluation of soluble epoxide hydrolase inhibitors: assessing the role of hydrophobicity in the pharmacophore-guided search of novel hits","volume":"63","author":"V\u00e1zquez","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.taap.2025.117480_bb0145","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1021\/acs.chemrestox.8b00404","article-title":"Flurbiprofen inhibits androgen productions in rat immature Leydig cells","volume":"32","author":"Wang","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2025.117480_bb0150","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1002\/tox.24124","article-title":"Halogenated bisphenol a derivatives potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase 1: structure-activity relationship and molecular docking","volume":"39","author":"Wang","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2025.117480_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116406","article-title":"Aqueous photodecomposition of the emerging brominated flame retardant tetrabromobisphenol S (TBBPS)","volume":"271","author":"Xu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2025.117480_bb0160","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.3390\/molecules16129983","article-title":"Inhibitors of testosterone biosynthetic and metabolic activation enzymes","volume":"16","author":"Ye","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2025.117480_bb0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2023.09.002","article-title":"Halogenated bisphenol a derivatives potently inhibit human, rat, and mouse gonadal 3beta-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis","volume":"386","author":"Yu","year":"2023","journal-title":"Toxicol. Lett."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2500256X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2500256X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T01:50:27Z","timestamp":1762221027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2500256X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":33,"alternative-id":["S0041008X2500256X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117480","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Significant enhancement of inhibitory strength of bisphenol A analogs against human and rat 5\u03b1-reductase 1 upon halogenation of the benzene ring: Potentially disrupting neurosteroid biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117480"}}