{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:12:50Z","timestamp":1793337170071,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471191"],"award-info":[{"award-number":["82471191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302655"],"award-info":[{"award-number":["82302655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.taap.2025.117494","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T16:15:23Z","timestamp":1753805723000},"page":"117494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Muscone ameliorates osteoarthritis progression by inhibiting M1 macrophages polarization via Nrf2\/NF-\u03baB axis and protecting chondrocytes"],"prefix":"10.1016","volume":"503","author":[{"given":"Zhuang","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangwei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117494_bb0005","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/annrheumdis-2014-205894","article-title":"Synovitis in knee osteoarthritis: a precursor of disease?","volume":"75","author":"Atukorala","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.taap.2025.117494_bb0010","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.joca.2019.10.011","article-title":"Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization","volume":"28","author":"Barreto","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.taap.2025.117494_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122007","article-title":"The crosstalk between Nrf2 and NF-kappaB pathways in coronary artery disease: can it be regulated by SIRT6?","volume":"330","author":"Casper","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2025.117494_bb0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/med.21925","article-title":"KEAP1-NRF2 protein-protein interaction inhibitors: design, pharmacological properties and therapeutic potential","volume":"43","author":"Crisman","year":"2023","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.taap.2025.117494_bb0025","first-page":"4235","article-title":"Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-kappaB and NLRP3 inflammasome","volume":"10","author":"Du","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.taap.2025.117494_bb0030","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"Suppl. 3","key":"10.1016\/j.taap.2025.117494_bb0035","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.taap.2025.117494_bb0040","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2025.117494_bb0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1142\/S0192415X20500287","article-title":"Muscone ameliorates LPS-induced depressive-like behaviors and inhibits neuroinflammation in prefrontal cortex of mice","volume":"48","author":"He","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.taap.2025.117494_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2025.117494_bb0055","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.taap.2025.117494_bb0060","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41584-020-00518-6","article-title":"Emerging pharmaceutical therapies for osteoarthritis","volume":"16","author":"Latourte","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.taap.2025.117494_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149628","article-title":"Muscone inhibits the progression of atherosclerotic plaques in mice aorta by inhibiting the NF-kappaB\/p65 pathway","volume":"702","author":"Li","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2025.117494_bb0070","first-page":"356","article-title":"T cells in osteoarthritis: alterations and beyond","volume":"8","author":"Li","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2025.117494_bb0075","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1007\/s11999-009-1079-0","article-title":"Muscone protects vertebral end-plate degeneration by antiinflammatory property","volume":"468","author":"Liang","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.taap.2025.117494_bb0080","article-title":"Macrophage membrane-biomimetic multi-layered nanoparticles targeting synovial angiogenesis for osteoarthritis therapy","volume":"14","author":"Liao","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.taap.2025.117494_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11033-023-08916-1","article-title":"Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-beta\/SMAD signaling pathways","volume":"51","author":"Liu","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.taap.2025.117494_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114799","article-title":"Chemical compositions and pharmacological activities of natural musk (Moschus) and artificial musk: a review","volume":"284","author":"Lv","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2025.117494_bb0095","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.joca.2019.10.010","article-title":"Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization","volume":"28","author":"Mahon","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.taap.2025.117494_bb0100","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-kappaB signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.taap.2025.117494_bb0105","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1016\/j.cell.2022.10.007","article-title":"Macrophages in health and disease","volume":"185","author":"Park","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.taap.2025.117494_bb0110","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13523","article-title":"Muscone improves hypoxia\/reoxygenation (H\/R)-induced neuronal injury by blocking HMGB1\/TLR4\/NF-kappaB pathway via modulating microRNA-142","volume":"10","author":"Ren","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.taap.2025.117494_bb0115","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.taap.2025.117494_bb0120","article-title":"Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2025.117494_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106355","article-title":"Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4\/JAK2-STAT3 pathway and NLRP3 inflammasome","volume":"82","author":"Yu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2025.117494_bb0130","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.taap.2025.117494_bb0135","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jnc.15011","article-title":"Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1-dependent mitochondrial fission","volume":"155","author":"Zhou","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2025.117494_bb0140","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1007\/s12035-022-02948-7","article-title":"Muscone can improve spinal cord injury by activating the Angiogenin\/Plexin-B2 Axis","volume":"59","author":"Zhou","year":"2022","journal-title":"Mol. Neurobiol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25002704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25002704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:44:46Z","timestamp":1755236686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25002704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"alternative-id":["S0041008X25002704"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117494","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Muscone ameliorates osteoarthritis progression by inhibiting M1 macrophages polarization via Nrf2\/NF-\u03baB axis and protecting chondrocytes","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117494","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117494"}}