{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:19:47Z","timestamp":1792531187552,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["2023\/50\/E\/NZ3\/00172"],"award-info":[{"award-number":["2023\/50\/E\/NZ3\/00172"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014420","name":"John Paul II University in Biala Podlaska","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014420","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010621","name":"Uniwersytet Medyczny w Lublinie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004442","name":"Narodowym Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["DS449"],"award-info":[{"award-number":["DS449"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.taap.2025.117499","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:47:41Z","timestamp":1754549261000},"page":"117499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The hepatic and developmental toxicity of chronic morphine and disulfiram co-treatment for pain relief - a comprehensive in vitro and in vivo assessment"],"prefix":"10.1016","volume":"504","author":[{"given":"Zuzanna","family":"Zelazewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Lazarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Paszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Marszalek-Grabska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Gawel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Nawrocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Andrzejuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Sacharczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lesniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117499_bb0005","series-title":"EC50 Calculator, pp","author":"A.B.","year":"2024"},{"key":"10.1016\/j.taap.2025.117499_bb0010","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/19345798251336731","article-title":"The effect of morphine in the development of neonatal cholestasis in extremely preterm neonates","volume":"18","author":"Abdelwahab","year":"2025","journal-title":"J. Neonatal-Perinatal Med."},{"key":"10.1016\/j.taap.2025.117499_bb0015","article-title":"Prescribing medications in patients with decompensated liver cirrhosis","volume":"2011","author":"Amarapurkar","year":"2011","journal-title":"Int J Hepatol"},{"key":"10.1016\/j.taap.2025.117499_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/biom9080375","article-title":"Inactivation of aldehyde dehydrogenase by disulfiram in the presence and absence of lipoic acid or Dihydrolipoic acid: an in vitro study","volume":"9","author":"Bilska-Wilkosz","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.taap.2025.117499_bb0025","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jhep.2005.12.016","article-title":"Clinical characteristics and prognostic markers in disulfiram-induced liver injury","volume":"44","author":"Bj\u00f6rnsson","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2025.117499_bb0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2165\/00002018-199920050-00003","article-title":"Safety issues concerning the use of disulfiram in treating alcohol dependence","volume":"20","author":"Chick","year":"1999","journal-title":"Drug Saf."},{"key":"10.1016\/j.taap.2025.117499_bb0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.taap.2025.117499_bb0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/FBP.0000000000000376","article-title":"Disulfiram attenuates morphine or methadone withdrawal syndrome in mice","volume":"29","author":"de Cord\u00e9","year":"2018","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.taap.2025.117499_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084057","article-title":"Disulfiram abrogates morphine tolerance-a possible role of \u03bc-opioid receptor-related G-protein activation in the striatum","volume":"22","author":"de Corde-Skurska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117499_bb0050","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1021\/acsmedchemlett.3c00450","article-title":"The promiscuity of disulfiram in medicinal research","volume":"14","author":"Cvek","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.taap.2025.117499_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.714918","article-title":"Comparative toxicity assessment of kratom decoction, mitragynine and speciociliatine versus morphine on zebrafish (Danio rerio) embryos","volume":"12","author":"Damodaran","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2025.117499_bb0060","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.taap.2025.117499_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13010029","article-title":"The positive and negative outcome of morphine and disulfiram subacute co-administration in rats in the absence of ethanol challenge","volume":"13","author":"Fr\u0105czek","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.taap.2025.117499_bb0070","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1365-2125.2002.01522.x","article-title":"Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects","volume":"53","author":"Frye","year":"2002","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.taap.2025.117499_bb0075","article-title":"\"Repurposing\" Disulfiram in the Treatment of Lyme Disease and Babesiosis: Retrospective Review of First 3 Years' Experience in One Medical Practice","volume":"9","author":"Gao","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.taap.2025.117499_bb0080","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s40265-022-01675-6","article-title":"Pharmacologic Management of Persistent Pain in Cancer survivors","volume":"82","author":"Glare","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2025.117499_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2172-13-31","article-title":"Tgf\u03b2 signaling plays a critical role in promoting alternative macrophage activation","volume":"13","author":"Gong","year":"2012","journal-title":"BMC Immunol."},{"key":"10.1016\/j.taap.2025.117499_bb0090","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1089\/jpm.2019.0171","article-title":"Managing Cancer pain, monitoring for Cancer recurrence, and mitigating risk of opioid use disorders: a team-based, interdisciplinary approach to Cancer survivorship","volume":"22","author":"Goodlev","year":"2019","journal-title":"J. Palliat. Med."},{"key":"10.1016\/j.taap.2025.117499_bb0095","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1080\/10520295.2023.2261367","article-title":"Disulfiram ameliorates bleomycin induced pulmonary inflammation and fibrosis in rats","volume":"98","author":"Hamidi","year":"2023","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.taap.2025.117499_bb0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2007-994688","article-title":"First trimester disulfiram exposure: report of two cases","volume":"10","author":"Helmbrecht","year":"1993","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.taap.2025.117499_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2021.05.030","article-title":"The glutathionylation agent disulfiram augments superoxide\/hydrogen peroxide production when liver mitochondria are oxidizing ubiquinone pool-linked and branched chain amino acid substrates","volume":"172","author":"Hirschenson","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2025.117499_bb0110","series-title":"Drug-Induced Liver Disease (Third Edition)","first-page":"725","article-title":"Chapter 40 - LiverTox: A website on drug-induced liver injury","author":"Hoofnagle","year":"2013"},{"key":"10.1016\/j.taap.2025.117499_bb0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0014-2999(77)90046-2","article-title":"Disulfiram inhibition of development of tolerance to analgesia induced by central gray stimulation in humans","volume":"43","author":"Hosobuchi","year":"1977","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2025.117499_bb0120","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1111\/febs.15669","article-title":"Alveolar epithelial cell-derived sonic hedgehog promotes pulmonary fibrosis through OPN-dependent alternative macrophage activation","volume":"288","author":"Hou","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.taap.2025.117499_bb0125","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ijrobp.2024.05.009","article-title":"A phase 1\/2 study of disulfiram and copper with concurrent radiation therapy and Temozolomide for patients with newly diagnosed glioblastoma","volume":"120","author":"Huang","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.taap.2025.117499_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122701","article-title":"A strategy of \u201cadding fuel to the flames\u201d enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy","volume":"311","author":"Huang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.taap.2025.117499_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106382","article-title":"Disulfiram reduces the severity of mouse acute pancreatitis by inhibiting RIPK1-dependent acinar cell necrosis","volume":"133","author":"Huang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.taap.2025.117499_bb0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00000542-200307000-00025","article-title":"Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans","volume":"99","author":"Koppert","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.taap.2025.117499_bb0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13227-017-0090-x","article-title":"Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate","volume":"9","author":"Kremnyov","year":"2018","journal-title":"EvoDevo"},{"key":"10.1016\/j.taap.2025.117499_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133955","article-title":"Disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site","volume":"276","author":"Kuan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2025.117499_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics12030524","article-title":"Disulfiram: mechanisms, applications, and challenges","volume":"12","author":"Lanz","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.taap.2025.117499_bb0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1051\/fopen\/2022011","article-title":"Rampant proteolysis at the intersection of therapy-induced hypoalbuminemia and acute pancreatitis","volume":"5","author":"Leonard","year":"2022","journal-title":"4open"},{"key":"10.1016\/j.taap.2025.117499_bb0165","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/jcmm.13334","article-title":"Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-kappaB and TGF-beta pathways","volume":"22","author":"Li","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2025.117499_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1498204","article-title":"Safety assessment of disulfiram: real-world adverse event analysis based on FAERS database","volume":"15","author":"Luo","year":"2024","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.taap.2025.117499_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/biom14091148","article-title":"The effects of kynurenic acid in zebrafish embryos and adult rainbow trout","volume":"14","author":"Marszalek-Grabska","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.taap.2025.117499_bb0180","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1248\/bpb.b22-00531","article-title":"Activation of HSP90\/HSF1 signaling as an adaptive response to an electrophilic metabolite of morphine","volume":"46","author":"Matsuo","year":"2023","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.taap.2025.117499_bb0185","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1248\/bpb.b22-00543","article-title":"Activation of the Keap1\/Nrf2 pathway as an adaptive response to an electrophilic metabolite of morphine","volume":"46","author":"Matsuo","year":"2023","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.taap.2025.117499_bb0190","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s10637-022-01271-1","article-title":"Phase II study of disulfiram and cisplatin in refractory germ cell tumors. The GCT-SK-006 phase II trial","volume":"40","author":"Mego","year":"2022","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.taap.2025.117499_bb0195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"10.1016\/j.taap.2025.117499_bb0200","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2131\/jts.15.63","article-title":"Loss of viability after disulfiram treatment without preceding depletion of intracellular GSH","volume":"15","author":"Ohno","year":"1990","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2025.117499_bb0205","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.lfs.2006.05.008","article-title":"Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver","volume":"79","author":"Payabvash","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2025.117499_bb0210","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.taap.2025.117499_bb0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3164\/jcbn.20.55","article-title":"Biochemical observations on rat intestine during chronic administration of morphine","volume":"20","author":"Siva","year":"1996","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.taap.2025.117499_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087366","article-title":"Disulfiram efficacy in the treatment of alcohol dependence: a meta-analysis","volume":"9","author":"Skinner","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2025.117499_bb0225","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1038\/s41598-019-41187-0","article-title":"Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation","volume":"9","author":"Spillier","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117499_bb0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2013.01.023","article-title":"Cartilage and bone malformations in the head of zebrafish (Danio rerio) embryos following exposure to disulfiram and acetic acid hydrazide","volume":"268","author":"Strecker","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2025.117499_bb0235","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.3390\/cells10123294","article-title":"Benefits and toxicity of disulfiram in preclinical models of nephropathic Cystinosis","volume":"10","author":"Taranta","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.taap.2025.117499_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032371","article-title":"Effect of disulfiram on the reproductive capacity of female mice","volume":"24","author":"Teng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117499_bb0245","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jhep.2018.03.018","article-title":"EASL clinical practice guidelines: management of alcohol-related liver disease","volume":"69","author":"Thursz","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2025.117499_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019683","article-title":"Regulation of zebrafish hatching by tetraspanin cd63","volume":"6","author":"Trikic","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2025.117499_bb0255","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.4149","article-title":"Effect of disulfiram and copper plus chemotherapy vs chemotherapy alone on survival in patients with recurrent glioblastoma: a randomized clinical trial","volume":"6","author":"Werlenius","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.taap.2025.117499_bb0260","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.tiv.2007.05.014","article-title":"Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells","volume":"21","author":"Westerink","year":"2007","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2025.117499_bb0265","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2217\/pmt-2020-0105","article-title":"Mechanisms, diagnosis, prevention and management of perioperative opioid-induced hyperalgesia","volume":"11","author":"Wilson","year":"2021","journal-title":"Pain Manag"},{"key":"10.1016\/j.taap.2025.117499_bb0270","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1530-0277.1993.tb00745.x","article-title":"Screening for disulfiram-induced liver test dysfunction in an inpatient alcoholism program","volume":"17","author":"Wright","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2025.117499_bb0275","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.3748\/wjg.v10.i19.2901","article-title":"Effects of narcotic analgesic drugs on human Oddi\u2019s sphincter motility","volume":"10","author":"Wu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2025.117499_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114609","article-title":"FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation","volume":"43","author":"Xu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.taap.2025.117499_bb0285","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40360-022-00583-5","article-title":"Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability","volume":"23","author":"Yang","year":"2022","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2025.117499_bb0290","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/20494637221083837","article-title":"The 2021 NICE guidelines for assessment and management of chronic pain: a cross-sectional study mapping against a sample of 1,000* in the community","volume":"16","author":"Zambelli","year":"2022","journal-title":"Br. J. Pain"},{"key":"10.1016\/j.taap.2025.117499_bb0295","article-title":"Morphine suppresses liver cancer cell tumor properties in vitro and in vivo","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.taap.2025.117499_bb0300","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.gpb.2022.01.004","article-title":"SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets","volume":"20","author":"Zheng","year":"2022","journal-title":"Genom. Proteom. Bioinforma."},{"key":"10.1016\/j.taap.2025.117499_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024019","article-title":"Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung","volume":"6","author":"Zheng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2025.117499_bb0310","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/j.pain.0000000000002557","article-title":"A global study of pain prevalence across 52 countries: examining the role of country-level contextual factors","volume":"163","author":"Zimmer","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.taap.2025.117499_bb0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0028-3908(77)90042-9","article-title":"Constant rate infusion of deuterated phosphorylcholine to measure the effects of morphine on acetylcholine turnover rate in specific nuclei of rat brain","volume":"16","author":"Zsilla","year":"1977","journal-title":"Neuropharmacology"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25002753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25002753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:33:05Z","timestamp":1779942785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25002753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":63,"alternative-id":["S0041008X25002753"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117499","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The hepatic and developmental toxicity of chronic morphine and disulfiram co-treatment for pain relief - a comprehensive in vitro and in vivo assessment","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117499"}}