{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:45:29Z","timestamp":1792629929443,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1P01ES028942-01"],"award-info":[{"award-number":["1P01ES028942-01"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.taap.2025.117527","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:54:34Z","timestamp":1755737674000},"page":"117527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Peroxynitrite is key to Cylindrospermopsin-mediated MASLD to MASH progression via triggering TXNIP binding to NLRP3 and subsequent inflammasome activation"],"prefix":"10.1016","volume":"504","author":[{"given":"Punnag","family":"Saha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipro","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhajit","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"More","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan W.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Kin","family":"Syn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mae","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117527_bb0005","doi-asserted-by":"crossref","first-page":"G408","DOI":"10.1152\/ajpgi.00061.2019","article-title":"Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21","volume":"317","author":"Albadrani","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2025.117527_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2018.04.002","article-title":"High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease","volume":"17","author":"Alhasson","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2025.117527_bb0015","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.redox.2017.09.009","article-title":"Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration","volume":"14","author":"Bartesaghi","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2025.117527_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102795","article-title":"Unlocking the power of NOX2: a comprehensive review on its role in immune regulation","volume":"64","author":"Bode","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2025.117527_bb0025","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.taap.2025.117527_bb0030","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1515\/hsz-2020-0181","article-title":"Redox-dependent and independent effects of thioredoxin interacting protein","volume":"401","author":"Cao","year":"2020","journal-title":"Biol. Chem."},{"key":"10.1016\/j.taap.2025.117527_bb0035","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-024-01542-6","article-title":"Metabolic dysfunction-associated steatotic liver disease and atherosclerosis","author":"Castillo-Nunez","year":"2024","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.taap.2025.117527_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.05.005","article-title":"HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease","volume":"13","author":"Chandrashekaran","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2025.117527_bb0045","article-title":"Protocol for primary mouse hepatocyte isolation","volume":"1","author":"Charni-Natan","year":"2020","journal-title":"STAR Protoc."},{"key":"10.1016\/j.taap.2025.117527_bb0050","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jhep.2012.11.035","article-title":"Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis","volume":"58","author":"Chatterjee","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2025.117527_bb0055","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","article-title":"TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target","volume":"55","author":"Choi","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.taap.2025.117527_bb0060","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3389\/fphys.2020.00767","article-title":"The emerging role of hepatocellular eNOS in non-alcoholic fatty liver disease development","volume":"11","author":"Cunningham","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2025.117527_bb0065","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.2337\/db20-1228","article-title":"Critical role for hepatocyte-specific eNOS in NAFLD and NASH","volume":"70","author":"Cunningham","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2025.117527_bb0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.taap.2013.02.003","article-title":"Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity","volume":"269","author":"Das","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2025.117527_bb0075","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.ajpath.2015.03.024","article-title":"NADPH oxidase-derived Peroxynitrite drives inflammation in mice and human nonalcoholic steatohepatitis via TLR4-lipid raft recruitment","volume":"185","author":"Das","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2025.117527_bb0080","doi-asserted-by":"crossref","first-page":"G298","DOI":"10.1152\/ajpgi.00346.2014","article-title":"Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis","volume":"308","author":"Dattaroy","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2025.117527_bb0085","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2478\/10004-1254-64-2013-2320","article-title":"Human exposure to cyanotoxins and their effects on health","volume":"64","author":"Drobac","year":"2013","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"10.1016\/j.taap.2025.117527_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031797","article-title":"Radiolysis studies of oxidation and nitration of tyrosine and some other biological targets by Peroxynitrite-derived radicals","volume":"23","author":"Folkes","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117527_bb0095","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.2010.01196.x","article-title":"Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling","volume":"164","author":"Forstermann","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2025.117527_bb0100","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/hep.30093","article-title":"High mobility group Box-1 drives fibrosis progression Signaling via the receptor for advanced glycation end products in mice","volume":"68","author":"Ge","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117527_bb0105","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/10715769900301171","article-title":"Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications","volume":"31","author":"Goss","year":"1999","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.taap.2025.117527_bb0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0041-0101(94)90023-X","article-title":"Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method","volume":"32","author":"Harada","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.taap.2025.117527_bb0115","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species","volume":"44","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2025.117527_bb0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.hal.2008.08.006","article-title":"Eutrophication and harmful algal blooms: a scientific consensus","volume":"8","author":"Heisler","year":"2008","journal-title":"Harmful Algae"},{"key":"10.1016\/j.taap.2025.117527_bb0125","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.scitotenv.2019.02.426","article-title":"Neurotoxicity induced by microcystins and cylindrospermopsin: a review","volume":"668","author":"Hinojosa","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117527_bb0130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/tox.10104","article-title":"Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male Swiss albino mice: determination of no observed adverse effect level for deriving a drinking water guideline value","volume":"18","author":"Humpage","year":"2003","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2025.117527_bb0135","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/15287390590925465","article-title":"Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress","volume":"68","author":"Humpage","year":"2005","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.taap.2025.117527_bb0140","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117527_bb0145","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.chemosphere.2018.12.157","article-title":"Effects of cylindrospermopsin on cultured immortalized human airway epithelial cells","volume":"220","author":"Kubickova","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2025.117527_bb0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.taap.2025.117527_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated mechanisms of MASLD pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.taap.2025.117527_bb0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2025.117527_bb0165","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jhep.2014.11.034","article-title":"Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management","volume":"62","author":"McPherson","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2025.117527_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/biom14040476","article-title":"Innate Immunity and MASLD","volume":"14","author":"Meyer","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.taap.2025.117527_bb0175","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chemosphere.2019.03.143","article-title":"Immunomodulatory effects of cyanobacterial toxin cylindrospermopsin on innate immune cells","volume":"226","author":"Moosova","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2025.117527_bb0180","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/jam.12048","article-title":"Cylindrospermopsin: occurrence, methods of detection and toxicology","volume":"114","author":"Moreira","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.taap.2025.117527_bb0185","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s13205-019-1976-1","article-title":"Harmful algal blooms under changing climate and constantly increasing anthropogenic actions: the review of management implications","volume":"9","author":"Nwankwegu","year":"2019","journal-title":"3 Biotech"},{"key":"10.1016\/j.taap.2025.117527_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1221669","article-title":"Cellular heterogeneity and plasticity during NAFLD progression","volume":"10","author":"Park","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.taap.2025.117527_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9120402","article-title":"In vitro toxicological assessment of Cylindrospermopsin: a review","volume":"9","author":"Pichardo","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.taap.2025.117527_bb0200","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/toxsci\/kfh267","article-title":"The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice","volume":"82","author":"Reisner","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2025.117527_bb0205","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2025.117527_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216354","article-title":"Hepatic NLRP3-derived Hsp70 binding to TLR4 mediates MASLD to MASH progression upon inhibition of PP2A by harmful algal bloom toxin microcystin, a second hit","volume":"24","author":"Roy","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117527_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11070905","article-title":"Andrographolide attenuates gut-brain-Axis associated pathology in gulf war illness by modulating bacteriome-Virome associated inflammation and microglia-neuron proinflammatory crosstalk","volume":"11","author":"Saha","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.taap.2025.117527_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14120835","article-title":"Subchronic Oral Cylindrospermopsin exposure alters the host gut microbiome and is associated with progressive hepatic inflammation, stellate cell activation, and mild fibrosis in a preclinical study","volume":"14","author":"Saha","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.taap.2025.117527_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103281","article-title":"Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis","volume":"73","author":"Sarkar","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2025.117527_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139807","article-title":"Global scanning of cylindrospermopsin: critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards","volume":"738","author":"Scarlett","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117527_bb0235","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/toxsci\/kft104","article-title":"Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice","volume":"134","author":"Seth","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2025.117527_bb0240","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/tx100439a","article-title":"Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC analyses, and quantum mechanical study of the free radical pathway","volume":"24","author":"Sikora","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2025.117527_bb0245","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrgastro.2015.94","article-title":"Inflammasome activation and function in liver disease","volume":"12","author":"Szabo","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2025.117527_bb0250","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.toxrep.2015.12.008","article-title":"Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: potential implications for neurodegenerative diseases","volume":"3","author":"Takser","year":"2016","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.taap.2025.117527_bb0255","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0041-0101(94)90008-6","article-title":"Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans","volume":"32","author":"Terao","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.taap.2025.117527_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.04.016","article-title":"New and emerging treatments for metabolic dysfunction-associated steatohepatitis","author":"Tincopa","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2025.117527_bb0265","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2025.117527_bb0270","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s40572-019-00232-w","article-title":"Mechanisms of environmental contributions to fatty liver disease","volume":"6","author":"Wahlang","year":"2019","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.taap.2025.117527_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124653","article-title":"Four decades of progress in cylindrospermopsin research: the ins and outs of a potent cyanotoxin","volume":"406","author":"Yang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2025.117527_bb0280","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/apt.12046","article-title":"Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions?","volume":"36","author":"Yilmaz","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.taap.2025.117527_bb0285","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117527_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106555","article-title":"Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease","volume":"154","author":"Zheng","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2025.117527_bb0295","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25003035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25003035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:30:13Z","timestamp":1779942613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25003035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":59,"alternative-id":["S0041008X25003035"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117527","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peroxynitrite is key to Cylindrospermopsin-mediated MASLD to MASH progression via triggering TXNIP binding to NLRP3 and subsequent inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117527"}}