{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:13:28Z","timestamp":1791810808114,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202301ZYTS337"],"award-info":[{"award-number":["YDZJ202301ZYTS337"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20230955KJ"],"award-info":[{"award-number":["JJKH20230955KJ"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104902"],"award-info":[{"award-number":["82104902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.taap.2025.117562","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:01:53Z","timestamp":1758020513000},"page":"117562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Tetrahydroxy stilbene glucoside for alleviating osteoporosis: Elevating autophagy to attenuate osteoblast dysfunction mediated by the AMPK\/mTOR\/ULK1 pathway"],"prefix":"10.1016","volume":"505","author":[{"given":"Wenqi","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117562_bb0005","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1089\/scd.2014.0484","article-title":"The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review","volume":"24","author":"Atashi","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.taap.2025.117562_bb0010","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/1756-185X.14436","article-title":"Lin28A alleviates ovariectomy-induced osteoporosis through activation of the AMP-activated protein kinase pathway in rats","volume":"25","author":"Cai","year":"2022","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.taap.2025.117562_bb0015","doi-asserted-by":"crossref","first-page":"66416","DOI":"10.18632\/oncotarget.12013","article-title":"Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female","volume":"7","author":"Camuzard","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2025.117562_bb0020","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.3390\/ijms22073553","article-title":"Skeletal aging and osteoporosis: mechanisms and therapeutics","volume":"22","author":"Chandra","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0025","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/63.6.547","article-title":"Calorie restriction and aging: the ultimate \u201ccleansing diet\u201d","volume":"63","author":"Cuervo","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2023.101782","article-title":"Bone health and menopause: osteoporosis prevention and treatment","volume":"38","author":"de Villiers","year":"2024","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2025.117562_bb0035","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2025.117562_bb0040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.11138\/ccmbm\/2017.14.1.209","article-title":"Oxidative stress in bone remodeling: role of antioxidants","volume":"14","author":"Domazetovic","year":"2017","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"10.1016\/j.taap.2025.117562_bb0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/antiox10040533","article-title":"The relationship between mitochondrial reactive oxygen species production and mitochondrial energetics in rat tissues with different contents of reduced coenzyme Q","volume":"10","author":"Dominiak","year":"2021","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.taap.2025.117562_bb0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7326\/AITC201708010","article-title":"Osteoporosis","volume":"167","author":"Ensrud","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.taap.2025.117562_bb0055","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3390\/molecules23092306","article-title":"Tetrahydroxystilbene glucoside regulates proliferation, differentiation, and OPG\/RANKL\/M-CSF expression in MC3T3-E1 cells via the PI3K\/Akt pathway","volume":"23","author":"Fan","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2025.117562_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113997","article-title":"Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1\/Parkin signaling pathway","volume":"177","author":"Gao","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2025.117562_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175809","article-title":"Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer\u2019s disease via cGAS-STING","volume":"953","author":"Gao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2025.117562_bb0070","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biochi.2021.11.008","article-title":"Role of AMPK mediated pathways in autophagy and aging","volume":"195","author":"Ge","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.taap.2025.117562_bb0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12906-023-04332-x","article-title":"Biochanin A abrogates osteoclastogenesis in type 2 diabetic osteoporosis via regulating ROS\/MAPK signaling pathway based on integrating molecular docking and experimental validation","volume":"24","author":"He","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.taap.2025.117562_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109676","article-title":"Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2\/HO-1 signaling pathway","volume":"121","author":"Jin","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2025.117562_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40520-018-1109-4","article-title":"Executive summary of European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"31","author":"Kanis","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.taap.2025.117562_bb0090","article-title":"The biology of normal bone remodelling","volume":"26","author":"Katsimbri","year":"2017","journal-title":"Eur. J. Cancer Care (Engl.)."},{"key":"10.1016\/j.taap.2025.117562_bb0095","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.3390\/ijms21145169","article-title":"Osteocyte-related cytokines regulate osteoclast formation and bone resorption","volume":"21","author":"Kitaura","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/er.2017-00064","article-title":"Energy metabolism of the osteoblast: implications for osteoporosis","volume":"38","author":"Lee","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2025.117562_bb0105","first-page":"5548","article-title":"Autophagy attenuates the oxidative stress-induced apoptosis of Mc3T3-E1 osteoblasts","volume":"21","author":"Li","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0110","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1080\/15548627.2018.1483807","article-title":"Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss","volume":"14","author":"Li","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2025.117562_bb0115","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/toxins12110729","article-title":"Overview of pharmacokinetics and liver toxicities of radix polygoni multiflori","volume":"12","author":"Li","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.taap.2025.117562_bb0120","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.3390\/ijms22094312","article-title":"Metallothionein 3 promotes osteoblast differentiation in C2C12 cells via reduction of oxidative stress","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116338","article-title":"Anti-atherosclerotic effect of tetrahydroxy stilbene glucoside via dual-targeting of hepatic lipid metabolisms and aortic M2 macrophage polarization in ApoE(\u2212\/\u2212) mice","volume":"248","author":"Li","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.taap.2025.117562_bb0130","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1002\/jbmr.1971","article-title":"Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation","volume":"28","author":"Liu","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.taap.2025.117562_bb0135","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.yexcr.2008.01.011","article-title":"Free radicals and senescence","volume":"314","author":"Lu","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2025.117562_bb0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","article-title":"What old means to bone","volume":"21","author":"Manolagas","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.taap.2025.117562_bb0145","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2025.117562_bb0150","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.3390\/ijms21207623","article-title":"Molecular mechanisms and emerging therapeutics for osteoporosis","volume":"21","author":"Noh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0155","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.4161\/auto.36182","article-title":"Autophagy in osteoblasts is involved in mineralization and bone homeostasis","volume":"10","author":"Nollet","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2025.117562_bb0160","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1089\/scd.2012.0124","article-title":"Basal autophagy decreased during the differentiation of human adult mesenchymal stem cells","volume":"21","author":"Oliver","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.taap.2025.117562_bb0165","doi-asserted-by":"crossref","first-page":"24262","DOI":"10.1038\/srep24262","article-title":"Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage","volume":"6","author":"Piemontese","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117562_bb0170","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.7150\/thno.17949","article-title":"Autophagy maintains the function of bone marrow mesenchymal stem cells to prevent estrogen deficiency-induced osteoporosis","volume":"7","author":"Qi","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.taap.2025.117562_bb0175","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrm2234","article-title":"Endocrine regulation of ageing","volume":"8","author":"Russell","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2025.117562_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/105135","article-title":"Controlling redox status for stem cell survival, expansion, and differentiation","volume":"2015","author":"Sart","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"2024","key":"10.1016\/j.taap.2025.117562_bb0185","article-title":"Dual regulation of phaseol on osteoclast formation and osteoblast differentiation by targeting TAK1 kinase for osteoporosis treatment","volume":"S2090-1232","author":"Tan","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.taap.2025.117562_bb0190","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00223-019-00593-2","article-title":"Autophagy regulates craniofacial bone acquisition","volume":"105","author":"Thomas","year":"2019","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.taap.2025.117562_bb0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/ars.2013.5777","article-title":"Calcium signaling alterations, oxidative stress, and autophagy in aging","volume":"21","author":"Ureshino","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2025.117562_bb0200","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.ijbiomac.2020.10.077","article-title":"ASP2-1, a polysaccharide from Acorus tatarinowii Schott, inhibits osteoclastogenesis via modulation of NFATc1 and attenuates LPS-induced bone loss in mice","volume":"165","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2025.117562_bb0205","article-title":"A review of pharmacology, toxicity and pharmacokinetics of 2,3,5,4\u2019-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2025.117562_bb0210","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.3390\/nu14193955","article-title":"Trimethylamine-N-oxide promotes osteoclast differentiation and bone loss via activating ROS-dependent NF-kappaB signaling pathway","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2025.117562_bb0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11657-021-00969-8","article-title":"Osteoporosis in Europe: a compendium of country-specific reports","volume":"17","author":"Willers","year":"2022","journal-title":"Arch. Osteoporos."},{"key":"10.1016\/j.taap.2025.117562_bb0220","doi-asserted-by":"crossref","first-page":"16511","DOI":"10.1038\/s41598-017-16688-5","article-title":"2,3,4\u2032,5-tetrahydroxystilbene-2-O-\u03b2-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117562_bb0225","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jep.2011.07.055","article-title":"Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata","volume":"137","author":"Yu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2025.117562_bb0230","first-page":"25","article-title":"Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis","volume":"9","author":"Zeng","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.taap.2025.117562_bb0235","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejphar.2012.05.045","article-title":"Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells","volume":"689","author":"Zhang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2025.117562_bb0240","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00198-015-3348-y","article-title":"Renin inhibitor aliskiren exerts beneficial effect on trabecular bone by regulating skeletal renin-angiotensin system and kallikrein-kinin system in ovariectomized mice","volume":"27","author":"Zhang","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.taap.2025.117562_bb0245","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/1756-185X.13357","article-title":"Protective effects of 2,3,5,4-tetrahydroxystilbene-2-o-\u03b2-D-glucoside against osteoporosis: current knowledge and proposed mechanisms","volume":"21","author":"Zhang","year":"2018","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.taap.2025.117562_bb0250","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jssc.201200668","article-title":"Pharmacokinetics of 2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-glucoside in rat using ultra-performance LC-quadrupole TOF-MS","volume":"36","author":"Zhao","year":"2013","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.taap.2025.117562_bb0255","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.3892\/etm.2017.4915","article-title":"Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. Demonstrates osteoblast differentiation promoting activity","volume":"14","author":"Zheng","year":"2017","journal-title":"Exp. Ther. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25003382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25003382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:09:13Z","timestamp":1780722553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25003382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":51,"alternative-id":["S0041008X25003382"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117562","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetrahydroxy stilbene glucoside for alleviating osteoporosis: Elevating autophagy to attenuate osteoblast dysfunction mediated by the AMPK\/mTOR\/ULK1 pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117562"}}