{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:19:10Z","timestamp":1790291950103,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.taap.2025.117655","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:51:49Z","timestamp":1763765509000},"page":"117655","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Capsaicin alleviates DEHP-induced testicular dysfunction by suppressing oxidative stress in mice"],"prefix":"10.1016","volume":"506","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjie","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117655_bb0005","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1007\/s11064-023-03983-z","article-title":"Capsaicin, the Vanilloid receptor TRPV1 agonist in neuroprotection: mechanisms involved and significance","volume":"48","author":"Abdel-Salam","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2025.117655_bb0010","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2018.10.102","article-title":"Effects of DEHP on post-embryonic development, nuclear receptor expression, metabolite and ecdysteroid concentrations of the moth Spodoptera littoralis","volume":"215","author":"Aviles","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2025.117655_bb0015","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/tox.24029","article-title":"Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K\/AKT pathway","volume":"39","author":"Chen","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2025.117655_bb0020","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s12272-014-0332-6","article-title":"Down-regulation of oxidative stress and COX-2 and iNOS expressions by dimethyl lithospermate in aged rat kidney","volume":"37","author":"Choi","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2025.117655_bb0025","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1039\/D1FO03054J","article-title":"Lycopene regulates the mitochondrial unfolded protein response to prevent DEHP-induced cardiac mitochondrial damage in mice","volume":"13","author":"Cui","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2025.117655_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/nu14204334","article-title":"Capsaicin ameliorates high-fat diet-induced atherosclerosis in ApoE(\u2212\/\u2212) mice via remodeling gut microbiota","volume":"14","author":"Dai","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2025.117655_bb0035","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/tox.22866","article-title":"Di-2-ethylhexyl phthalate (DEHP) induces apoptosis and autophagy of mouse GC-1 spg cells","volume":"35","author":"Gan","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2025.117655_bb0040","doi-asserted-by":"crossref","first-page":"10665","DOI":"10.1039\/D2FO02209E","article-title":"Capsaicin regulates dyslipidemia by altering the composition of bile acids in germ-free mice","volume":"13","author":"Gong","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2025.117655_bb0045","doi-asserted-by":"crossref","first-page":"H225","DOI":"10.1152\/ajpheart.00548.2003","article-title":"Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries","volume":"287","author":"Hernanz","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2025.117655_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119742","article-title":"Rosa roxburghii juice alleviates DEHP-induced reproductive system damage in male mice via the PI3K\/AKT signaling pathway","volume":"347","author":"Huang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2025.117655_bb0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcsm.13120","article-title":"Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo","volume":"14","author":"Huang","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.taap.2025.117655_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900608","article-title":"Capsaicin improves glucose tolerance and insulin sensitivity through modulation of the gut microbiota-bile acid-FXR Axis in type 2 diabetic db\/db mice","volume":"63","author":"Hui","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2025.117655_bb0065","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/humrep\/deab034","article-title":"Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts","volume":"36","author":"Istvan","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2025.117655_bb0070","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1039\/D2FO03523E","article-title":"Capsaicin ameliorates diet-induced disturbances of glucose homeostasis and gut microbiota in mice associated with the circadian clock","volume":"14","author":"Liang","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2025.117655_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110575","article-title":"Mechanism of testicular injury induced by Di-ethylhexyl phthalate and its protective agents","volume":"381","author":"Lin","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2025.117655_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154067","article-title":"Capsaicin ameliorates renal fibrosis by inhibiting TGF-\u03b21-Smad2\/3 signaling","volume":"100","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2025.117655_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2024.102870","article-title":"TRPV1: receptor structure, activation, modulation and role in neuro-immune interactions and pain","volume":"119","author":"Maximiano","year":"2024","journal-title":"Cell Calcium"},{"key":"10.1016\/j.taap.2025.117655_bb0090","article-title":"TRP channels in Tumoral processes mediated by oxidative stress and inflammation","volume":"12","author":"Piciu","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.taap.2025.117655_bb0095","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.envint.2018.07.029","article-title":"Phthalate exposure and male reproductive outcomes: a systematic review of the human epidemiological evidence","volume":"121","author":"Radke","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2025.117655_bb0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2025.117655_bb0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.reprotox.2019.05.065","article-title":"Prenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels","volume":"87","author":"Sunman","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2025.117655_bb0110","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1139\/apnm-2018-0622","article-title":"Effect of dietary curcumin and capsaicin on testicular and hepatic oxidant-antioxidant status in rats fed a high-fat diet","volume":"44","author":"Tanr\u0131kulu-K\u00fc\u00e7\u00fck","year":"2019","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.taap.2025.117655_bb0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/19396368.2024.2306403","article-title":"Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation","volume":"70","author":"Uddandrao","year":"2024","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.taap.2025.117655_bb0120","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.18632\/aging.205138","article-title":"Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway","volume":"15","author":"Wang","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.taap.2025.117655_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137216","article-title":"Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice","volume":"312","author":"XueXia","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2025.117655_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137241","article-title":"Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2\/SLC7A11\/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice","volume":"282","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2025.117655_bb0135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.gendis.2018.06.004","article-title":"DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy","volume":"5","author":"Yi","year":"2018","journal-title":"Genes Dis"},{"key":"10.1016\/j.taap.2025.117655_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102584","article-title":"Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor","volume":"59","author":"Zhao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2025.117655_bb0145","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jare.2024.05.026","article-title":"SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice","volume":"71","author":"Zhao","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.taap.2025.117655_bb0150","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1021\/acs.jafc.2c01635","article-title":"Gap junction protein Connexin 43 as a target is internalized in astrocyte neurotoxicity caused by Di-(2-ethylhexyl) phthalate","volume":"70","author":"Zhao","year":"2022","journal-title":"J. Agric. Food Chem."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25004314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25004314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:53:46Z","timestamp":1780908826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25004314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":30,"alternative-id":["S0041008X25004314"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117655","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Capsaicin alleviates DEHP-induced testicular dysfunction by suppressing oxidative stress in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117655","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117655"}}