{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:15:04Z","timestamp":1780910104151,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903357"],"award-info":[{"award-number":["81903357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.taap.2025.117660","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:27:45Z","timestamp":1764030465000},"page":"117660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nomilin ameliorates perfluorooctanoic acid (PFOA)-induced impairment of zebrafish (Danio rerio) ocular development and visual function through PIK3CA activation"],"prefix":"10.1016","volume":"506","author":[{"given":"Xing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"D1","key":"10.1016\/j.taap.2025.117660_bb0005","doi-asserted-by":"crossref","first-page":"D1038","DOI":"10.1093\/nar\/gky1151","article-title":"Omim.org: leveraging knowledge across phenotype\u2013gene relationships","volume":"47","author":"Amberger","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2025.117660_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108053","article-title":"Mechanistic insight into the adverse outcome of tire wear and road particle leachate exposure in zebrafish (Danio rerio) larvae","volume":"178","author":"Chang","year":"2023","journal-title":"Environ. Int."},{"issue":"14","key":"10.1016\/j.taap.2025.117660_bb0025","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.2174\/1386207326666230418112827","article-title":"Nomilin Attenuates Lipopolysaccharide-Induced Inflammatory Response by Binding with Myeloid Differentiation Protein-2","volume":"26","author":"Chen","year":"2023","journal-title":"Comb. Chem. High Throughput Screen."},{"issue":"Pt 2","key":"10.1016\/j.taap.2025.117660_bb0030","article-title":"Neonatal per- and polyfluoroalkyl substance exposure in relation to retinoblastoma","volume":"240","author":"Chen","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2025.117660_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109324","article-title":"Exploring the mechanism of PPCPs on human metabolic diseases based on network toxicology and molecular docking","volume":"196","author":"Cheng","year":"2025","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.taap.2025.117660_bb0040","article-title":"Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the Pka\/Creb Signaling Pathway","volume":"11","author":"Choi","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"23","key":"10.1016\/j.taap.2025.117660_bb0045","doi-asserted-by":"crossref","first-page":"63522","DOI":"10.1007\/s11356-023-26797-6","article-title":"Pfoa, PFHxA and C6O4 differently modulate the expression of CXCL8 in normal thyroid cells and in thyroid cancer cell lines","volume":"30","author":"Coperchini","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"W1","key":"10.1016\/j.taap.2025.117660_bb0050","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.taap.2025.117660_bb0055","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4103\/ijo.IJO_1862_21","article-title":"Clinical patterns of congenital ocular anomalies in the pediatric age group (0 to 5 years) and its association with various demographic parameters","volume":"70","author":"Dash","year":"2022","journal-title":"Indian J. Ophthalmol."},{"issue":"D1","key":"10.1016\/j.taap.2025.117660_bb0060","doi-asserted-by":"crossref","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative Toxicogenomics Database (Ctd): update 2021","volume":"49","author":"Davis","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.taap.2025.117660_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/bdr2.2414","article-title":"Prevalence of congenital ocular anomalies in 15 countries of europe: results from the medikeye study","volume":"116","author":"Dubucs","year":"2024","journal-title":"Birth Defects Res."},{"issue":"8","key":"10.1016\/j.taap.2025.117660_bb0070","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1074\/jbc.M807745200","article-title":"Cdc42-mtor signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation","volume":"284","author":"Endo","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0075","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1038\/s41467-023-39118-9","article-title":"Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions","volume":"14","author":"Fan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2025.117660_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153641","article-title":"Deficiency of spns1 exacerbates per- and polyfluoroalkyl substances mediated hepatic toxicity and steatosis in zebrafish (Danio rerio)","volume":"499","author":"Gadi","year":"2023","journal-title":"Toxicology"},{"issue":"13","key":"10.1016\/j.taap.2025.117660_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32007","article-title":"Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K\/Akt\/mtor signaling pathway in a type 2 diabetes zebrafish model","volume":"10","author":"Gao","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.taap.2025.117660_bb0090","doi-asserted-by":"crossref","first-page":"120022","DOI":"10.1016\/j.envpol.2022.120022","article-title":"Perfluorooctanoic acid-induced developmental cardiotoxicity in chicken embryo: Roles of miR-490-5p","volume":"312","author":"Guo","year":"2022","journal-title":"Environ. Pollut. (Barking, Essex: 1987)"},{"key":"10.1016\/j.taap.2025.117660_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123912","article-title":"Effects of developmental exposure to individual and combined Pfas on development and behavioral stress responses in larval zebrafish","volume":"349","author":"Hamed","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2025.117660_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155081","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/Akt\/NF\u03baB and Mapk pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.taap.2025.117660_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ph14080716","article-title":"Zebrafish Model in Ophthalmology to Study Disease Mechanism and Drug Discovery","volume":"14","author":"Hong","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"7446","key":"10.1016\/j.taap.2025.117660_bb0110","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.taap.2025.117660_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167904","article-title":"Efficient analysis of toxicity and mechanisms of environmental pollutants with network toxicology and molecular docking strategy: Acetyl tributyl citrate as an example","volume":"905","author":"Huang","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jat.4506","article-title":"A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4'-sulfonyldiphenol based on network toxicology analysis","volume":"44","author":"Huang","year":"2024","journal-title":"J. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using David bioinformatics resources","volume":"4","author":"Huang Da","year":"2009","journal-title":"Nat. Protoc."},{"issue":"29","key":"10.1016\/j.taap.2025.117660_bb0130","doi-asserted-by":"crossref","first-page":"73018","DOI":"10.1007\/s11356-023-27629-3","article-title":"Fish to learn: insights into the effects of environmental chemicals on eye development and visual function in zebrafish","volume":"30","author":"Huang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.taap.2025.117660_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2025.149338","article-title":"Crosstalk between signaling pathways (Rho\/Rock, Tgf-\u03b2 and Wnt\/\u03b2-Catenin Pathways\/ PI3K-Akt-mtor) in Cataract: A Mechanistic Exploration and therapeutic strategy","volume":"947","author":"Khan","year":"2025","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.59249\/RRMM8911","article-title":"External Disruption of Ocular Development in Utero","volume":"97","author":"Kim","year":"2024","journal-title":"Yale J. Biol. Med."},{"issue":"Pt 2","key":"10.1016\/j.taap.2025.117660_bb0145","article-title":"Immunotoxicity mechanisms of perfluorinated compounds Pfoa and Pfos","volume":"291","author":"Liang","year":"2022","journal-title":"Chemosphere"},{"issue":"Pt 2","key":"10.1016\/j.taap.2025.117660_bb0150","article-title":"Impacts of Pfoa(C8), GenX(C6), and their mixtures on zebrafish developmental toxicity and gene expression provide insight about tumor-related disease","volume":"858","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2025.117660_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117098","article-title":"Perfluorooctanoic acid (Pfoa) induces cardiotoxicity by activating the Keap1\/Nrf2 pathway in zebrafish (Danio rerio) embryos","volume":"285","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2025.117660_bb0160","doi-asserted-by":"crossref","DOI":"10.1007\/s11130-024-01228-0","article-title":"Nomilin Reversed Cardiotoxicity Caused by Co-exposure to Zearalenone and Deoxynivalenol via the Keap1\/Nrf2 Signaling Pathway in Zebrafish","author":"Liu","year":"2024","journal-title":"Plant Foods Hum. Nutr."},{"issue":"16","key":"10.1016\/j.taap.2025.117660_bb0165","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.taap.2025.117660_bb0170","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/bs.mcb.2016.10.006","article-title":"Zebrafish models of human eye and inner ear diseases","volume":"138","author":"Phillips","year":"2017","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.taap.2025.117660_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107746","article-title":"High-content analysis shows synergistic effects of low perfluorooctanoic acid (Pfos) and perfluorooctane sulfonic acid (Pfoa) mixture concentrations on human breast epithelial cell carcinogenesis","volume":"172","author":"Pierozan","year":"2023","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0180","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/eye.2016.198","article-title":"The zebrafish eye-a paradigm for investigating human ocular genetics","volume":"31","author":"Richardson","year":"2017","journal-title":"Eye (London, England)"},{"issue":"6","key":"10.1016\/j.taap.2025.117660_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065387","article-title":"An Overview towards Zebrafish Larvae as a Model for Ocular Diseases","volume":"24","author":"Rosa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"W1","key":"10.1016\/j.taap.2025.117660_bb0190","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"David: a web server for functional enrichment analysis and functional annotation of gene lists (2021\u00a0update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2025.117660_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118485","article-title":"Reproductive toxicity of Pfoa, Pfos and their substitutes: A review based on epidemiological and toxicological evidence","volume":"250","author":"Shi","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2025.117660_bb0200","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The gene cards suite: from gene data mining to disease genome sequence analyses","volume":"54,","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.taap.2025.117660_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2023.104892","article-title":"Associated anomalies in anophthalmia and microphthalmia","volume":"67","author":"Stoll","year":"2024","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.taap.2025.117660_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/qua.27359","article-title":"Exploring the co-activity of Fda approved drug gemcitabine and docetaxel for enhanced anti-breast cancer activity: Dft, docking, molecular dynamics simulation and pharmacophore studies","author":"Sukumaran","year":"2024","journal-title":"Int. J. Quantum Chem."},{"key":"10.1016\/j.taap.2025.117660_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115020","article-title":"Exposure to Pfoa and its novel analogs disrupts lipid metabolism in zebrafish","volume":"259","author":"Sun","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2025.117660_bb0220","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jes.2023.05.009","article-title":"Hexafluoropropylene oxide trimer acid, a perfluorooctanoic acid alternative, induces cardiovascular toxicity in zebrafish embryos","volume":"139","author":"Sun","year":"2024","journal-title":"J. Environ. Sci. (China)"},{"issue":"D1","key":"10.1016\/j.taap.2025.117660_bb0225","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The String database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2012.09.051","article-title":"Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease","volume":"145","author":"Tao","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.taap.2025.117660_bb0235","doi-asserted-by":"crossref","first-page":"15702","DOI":"10.1038\/s41598-020-72600-8","article-title":"Perfluorooctanoic acid in indoor particulate matter triggers oxidative stress and inflammation in corneal and retinal cells","volume":"10","author":"Tien","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2025.117660_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115663","article-title":"Environmental impacts, exposure pathways, and health effects of Pfoa and Pfos","volume":"267","author":"Wee","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.taap.2025.117660_bb0245","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2024.13207","article-title":"Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)","volume":"29","author":"Xia","year":"2024","journal-title":"Mol. Med. Rep."},{"issue":"15","key":"10.1016\/j.taap.2025.117660_bb0250","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1111\/jcmm.15484","article-title":"Nomilin targets the Keap1-Nrf2 signalling and ameliorates the development of osteoarthritis","volume":"24","author":"Xue","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2025.117660_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127888","article-title":"Toxicity of perfluorooctanoic acid on zebrafish early embryonic development determined by single-cell Rna sequencing","volume":"427","author":"Yu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2025.117660_bb0260","article-title":"Promoted Translocation of Perfluorooctanoic Acid across the Blood-Retinal Barrier due to its Inhibition of Tight Junction Assembly by Antagonizing LPAR1","author":"Yuan","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2025.117660_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.123028","article-title":"Comparison of the combined toxicity of Pfoa and emerging alternatives: A comprehensive evaluation of oxidative damage, apoptosis and immunotoxicity in embryonic and adult zebrafish","volume":"273","author":"Zhang","year":"2025","journal-title":"Water Res."},{"issue":"D1","key":"10.1016\/j.taap.2025.117660_bb0270","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"Ttd: Therapeutic Target Database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25004363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25004363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:54:46Z","timestamp":1780908886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25004363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"alternative-id":["S0041008X25004363"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117660","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nomilin ameliorates perfluorooctanoic acid (PFOA)-induced impairment of zebrafish (Danio rerio) ocular development and visual function through PIK3CA activation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117660"}}