{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:16:23Z","timestamp":1769159783829,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.taap.2025.117687","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T02:55:28Z","timestamp":1765421728000},"page":"117687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mechanistic insights into trimetazidine's protection against bladder ischemia-reperfusion injury via mirR-211\/CHOP modulation and SIRT1\/AMPK\/PGC1\u03b1-mediated mitochondrial biogenesis"],"prefix":"10.1016","volume":"507","author":[{"given":"Sultan","family":"Alrashdi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimaa K.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Elbaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed K.","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2025.117687_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123747","article-title":"Trimetazidine improves dexamethasone-induced insulin resistance and associated hepatic abnormalities in rats","volume":"375","author":"Abdelaziz","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2025.117687_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.01.029","article-title":"The renoprotective effects of naringin and trimetazidine on renal ischemia\/reperfusion injury in rats through inhibition of apoptosis and downregulation of micoRNA-10a","volume":"112","author":"Amini","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2025.117687_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1756287216675778","article-title":"The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction","volume":"9","author":"Andersson","year":"2017","journal-title":"Ther. Adv. Urol."},{"key":"10.1016\/j.taap.2025.117687_bb0020","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.taap.2025.117687_bb0025","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.3390\/ijms12107199","article-title":"Roles of oxidative stress, apoptosis, PGC-1\u03b1 and mitochondrial biogenesis in cerebral ischemia","volume":"12","author":"Chen","year":"2011","journal-title":"IJMS"},{"key":"10.1016\/j.taap.2025.117687_bb0030","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.2147\/DDDT.S360283","article-title":"Trimetazidine reduces cardiac fibrosis in rats by inhibiting NOX2-mediated endothelial-to-mesenchymal transition","volume":"16","author":"Chen","year":"2022","journal-title":"DDDT"},{"key":"10.1016\/j.taap.2025.117687_bb0035","doi-asserted-by":"crossref","DOI":"10.1155\/ijcp\/8164243","article-title":"The protective role of PGC-1\u03b1 in cystitis Glandularis: mitigating mitochondrial injury and inflammation","volume":"2024","author":"Chen","year":"2024","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.taap.2025.117687_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.70009","article-title":"SIRT1 alleviates oxidative stress-induced mitochondrial dysfunction and mitochondria-associated membrane dysregulation in stress urinary incontinence","volume":"58","author":"Chen","year":"2025","journal-title":"Cell Prolif."},{"key":"10.1016\/j.taap.2025.117687_bb0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molcel.2012.08.025","article-title":"mirR-211 is a Prosurvival MicroRNA that regulates chop expression in a PERK-dependent manner","volume":"48","author":"Chitnis","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2025.117687_bb0050","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/biomedicines12102299","article-title":"Protective effects of trimetazidine and dexmedetomidine on liver injury in a mesenteric artery ischemia\u2013reperfusion rat model via endoplasmic reticulum stress","volume":"12","author":"Ciftel","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.taap.2025.117687_bb0055","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190595","article-title":"Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3\/TXNIP aix","volume":"39","author":"Cui","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.taap.2025.117687_bb0060","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s40256-025-00724-1","article-title":"Trimetazidine in cardiovascular disease and beyond: a comprehensive review","volume":"25","author":"Goel","year":"2025","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.taap.2025.117687_bb0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/JME-19-0066","article-title":"The miRNAs mirR-211-5p and miR-204-5p modulate ER stress in human beta cells","volume":"63","author":"Grieco","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.taap.2025.117687_bb0070","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/jcmm.16236","article-title":"PGC-1\u03b1 protects from myocardial ischaemia-reperfusion injury by regulating mitonuclear communication","volume":"26","author":"Li","year":"2022","journal-title":"J Cellular Molecular Medi"},{"key":"10.1016\/j.taap.2025.117687_bb0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.metabol.2015.10.022","article-title":"The protective effect of trimetazidine on myocardial ischemia\/reperfusion injury through activating AMPK and ERK signaling pathway","volume":"65","author":"Liu","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.taap.2025.117687_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109114","article-title":"The role of AMPK-SIRT1-autophagy pathway in the intestinal protection process by propofol against regional ischemia\/reperfusion injury in rats","volume":"111","author":"Liu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2025.117687_bb0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/antiox10020283","article-title":"Dietary anti-aging polyphenols and potential mechanisms","volume":"10","author":"Luo","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.taap.2025.117687_bb0090","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.3892\/mmr.2016.5773","article-title":"Trimetazidine protects against cardiac ischemia\/reperfusion injury via effects on cardiac miRNA-21 expression, Akt and the Bcl-2\/Bax pathway","volume":"14","author":"Ma","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2025.117687_bb0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1423-0127-19-71","article-title":"Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment","volume":"19","author":"Mahfoudh-Boussaid","year":"2012","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.taap.2025.117687_bb0100","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/iju.12652","article-title":"Chronic bladder ischemia and oxidative stress: new pharmacotherapeutic targets for lower urinary tract symptoms","volume":"22","author":"Nomiya","year":"2015","journal-title":"Int J of Urology"},{"key":"10.1016\/j.taap.2025.117687_bb0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5213\/inj.2142206.103","article-title":"Metformin and sildenafil attenuate inflammation and suppress apoptosis after ischemia\/reperfusion injuries in rat urinary bladder","volume":"25","author":"Park","year":"2021","journal-title":"Int. Neurourol. J."},{"key":"10.1016\/j.taap.2025.117687_bb0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.eururo.2006.01.031","article-title":"The association between vascular risk factors and lower urinary tract symptoms in both sexes","volume":"50","author":"Ponholzer","year":"2006","journal-title":"Eur. Urol."},{"key":"10.1016\/j.taap.2025.117687_bb0115","doi-asserted-by":"crossref","DOI":"10.31083\/FBL25565","article-title":"Trimetazidine: activating AMPK signal to ameliorate coronary microcirculation dysfunction after myocardial infarction","volume":"30","author":"Qu","year":"2025","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.taap.2025.117687_bb0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1681.2007.04810.x","article-title":"\u03b1-Lipoic acid protects against renal ischaemia\u2013reperfusion injury in rats","volume":"35","author":"\u015eehirli","year":"2008","journal-title":"Clin Exp Pharma Physio"},{"key":"10.1016\/j.taap.2025.117687_bb0125","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.atherosclerosis.2014.10.091","article-title":"Effective inhibition of cardiomyocyte apoptosis through the combination of trimetazidine and N-acetylcysteine in a rat model of myocardial ischemia and reperfusion injury","volume":"237","author":"\u015eent\u00fcrk","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.taap.2025.117687_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/906787","article-title":"Allopurinol protects against ischemia\/reperfusion-induced injury in rat urinary bladders","volume":"2015","author":"Shin","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.taap.2025.117687_bb0135","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.3390\/ijms20205034","article-title":"Ischemia\/reperfusion injury revisited: an overview of the latest pharmacological strategies","volume":"20","author":"Soares","year":"2019","journal-title":"IJMS"},{"key":"10.1016\/j.taap.2025.117687_bb0140","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00345-014-1298-1","article-title":"Urinary bladder mucosal responses to ischemia","volume":"33","author":"Sunagawa","year":"2015","journal-title":"World J. Urol."},{"key":"10.1016\/j.taap.2025.117687_bb0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.fjc.0000164091.81198.a3","article-title":"The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury","volume":"46","author":"Tritto","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.taap.2025.117687_bb0150","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00109-018-1664-3","article-title":"Trimetazidine protects against myocardial ischemia\/reperfusion injury by inhibiting excessive autophagy","volume":"96","author":"Wu","year":"2018","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.taap.2025.117687_bb0155","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2025.117687_bb0160","article-title":"Cellular stress and molecular responses in bladder ischemia","volume":"22","author":"Yang","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.taap.2025.117687_bb0165","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fnmol.2017.00443","article-title":"SIRT1\/PGC-1\u03b1 Signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral Hemorrhage in rats","volume":"10","author":"Zhou","year":"2018","journal-title":"Front. Mol. Neurosci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25004636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X25004636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:38:01Z","timestamp":1769103481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X25004636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":33,"alternative-id":["S0041008X25004636"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2025.117687","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into trimetazidine's protection against bladder ischemia-reperfusion injury via mirR-211\/CHOP modulation and SIRT1\/AMPK\/PGC1\u03b1-mediated mitochondrial biogenesis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2025.117687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117687"}}