{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:09Z","timestamp":1787169669190,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360652"],"award-info":[{"award-number":["82360652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.taap.2026.117710","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:48:11Z","timestamp":1767890891000},"page":"117710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Synergistic assault of DEHP and MPs: Unmasking the ER stress-triggered autophagic injury male fertility"],"prefix":"10.1016","volume":"507","author":[{"given":"Jiajun","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.taap.2026.117710_bb0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00217-019-03412-y","article-title":"Phthalate ester migration into food: effect of packaging material and time","volume":"246","author":"Alp","year":"2020","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.taap.2026.117710_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152665","article-title":"Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats","volume":"449","author":"An","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2026.117710_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138415","article-title":"Spatial distribution and characteristics of microplastics and associated contaminants from mid-altitude lake in NW Himalaya","volume":"326","author":"Bulbul","year":"2023","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.taap.2026.117710_bb0020","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrendo.2010.71","article-title":"A local autocrine axis in the testes that regulates spermatogenesis","volume":"6","author":"Cheng","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"issue":"12","key":"10.1016\/j.taap.2026.117710_bb0030","article-title":"Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials","volume":"17","author":"Efsa Panel on Food Contact Materials, E., Processing, A","year":"2019","journal-title":"EFSA J."},{"key":"10.1016\/j.taap.2026.117710_bb0035","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.foodcont.2016.10.050","article-title":"Migration of di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) from polypropylene food containers","volume":"73","author":"Fang","year":"2017","journal-title":"Food Control"},{"key":"10.1016\/j.taap.2026.117710_bb0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsbmb.2016.03.031","article-title":"Impact on CYP19A1 activity by mutations in NADPH cytochrome P450 oxidoreductase","volume":"165","author":"Fl\u00fcck","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.taap.2026.117710_bb0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3892\/or.2021.7933","article-title":"Endoplasmic reticulum stress, cell death and tumor: association between endoplasmic reticulum stress and the apoptosis pathway in tumors (review)","volume":"45","author":"Fu","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.taap.2026.117710_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129740","article-title":"Exposure to phthalates DEHP and DINP may lead to oxidative damage and lipidomic disruptions in mouse kidney","volume":"271","author":"Gu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2026.117710_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116679","article-title":"Impact of DEHP on mitochondria-associated endoplasmic reticulum membranes and reproductive toxicity in ovary","volume":"282","author":"Guo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117710_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140068","article-title":"Iron's silent betrayal: Ferritinophagy-driven mitochondrial damage mediates polylactic acid nanoplastics and Cr(VI)-induced cardiac injury","volume":"499","author":"Guo","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"6632","key":"10.1016\/j.taap.2026.117710_bb0065","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.adf6098","article-title":"Soil microplastics pollution in agriculture","volume":"379","author":"He","year":"2023","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.taap.2026.117710_bb0070","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2026.117710_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112889","article-title":"Exposure to DEHP induces testis toxicity and injury through the ROS\/mTOR\/NLRP3 signaling pathway in immature rats","volume":"227","author":"Hong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.taap.2026.117710_bb0080","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.gendis.2023.02.030","article-title":"X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity","volume":"11","author":"Hong","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.taap.2026.117710_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: in vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117710_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129652","article-title":"Trojan horse in the intestine: a review on the biotoxicity of microplastics combined environmental contaminants","volume":"439","author":"Hu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117710_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107459","article-title":"Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks","volume":"168","author":"Hu","year":"2022","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.taap.2026.117710_bb0100","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/s41418-019-0444-0","article-title":"ER-phagy and human diseases","volume":"27","author":"H\u00fcbner","year":"2020","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.taap.2026.117710_bb0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.taap.2026.117710_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124543","article-title":"Chronic exposure to polystyrene microplastics induced LHR reduction and decreased testosterone levels through NF-\u03baB pathway","volume":"358","author":"Jin","year":"2024","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.taap.2026.117710_bb0115","first-page":"2","article-title":"Testicular biopsy score count \u2013 a method for registration of spermatogenesis in human testes: Normal values and results in 335 Hypogonadal males","volume":"1","author":"Johnsen","year":"2008","journal-title":"Hormones"},{"issue":"8","key":"10.1016\/j.taap.2026.117710_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084368","article-title":"Mechanism of decision making between autophagy and apoptosis induction upon endoplasmic reticulum stress","volume":"25","author":"Kapuy","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"S1","key":"10.1016\/j.taap.2026.117710_bb0125","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2022.36.S1.R4705","article-title":"Effect of di-ethylhexyl phthalate (DEHP) on androgen related proteins in JEG-3 placental cells","volume":"36","author":"Kruger","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2026.117710_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103958","article-title":"Di(2-ethylhexyl) phthalate disturbs cholesterol metabolism through oxidative stress in rat liver","volume":"95","author":"Li","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2026.117710_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-016-0031-z","article-title":"p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation","volume":"21","author":"Liu","year":"2016","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"4","key":"10.1016\/j.taap.2026.117710_bb0145","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10937400903094091","article-title":"Reproductive and developmental toxicity of phthalates","volume":"12","author":"Lyche","year":"2009","journal-title":"J. Toxicol. Environ. Health Part B"},{"key":"10.1016\/j.taap.2026.117710_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159834","article-title":"Microplastics in human food chains: food becoming a threat to health safety","volume":"858","author":"Mamun","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"18","key":"10.1016\/j.taap.2026.117710_bb0155","doi-asserted-by":"crossref","first-page":"R988","DOI":"10.1016\/j.cub.2017.07.067","article-title":"Spermatogenesis","volume":"27","author":"Nishimura","year":"2017","journal-title":"Curr. Biol."},{"issue":"Pt B","key":"10.1016\/j.taap.2026.117710_bb0160","article-title":"Estimation of the mass of microplastics ingested - a pivotal first step towards human health risk assessment","volume":"404","author":"Senathirajah","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.taap.2026.117710_bb0165","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/jcp.26137","article-title":"Crosstalk of ER stress-mediated autophagy and ER-phagy: involvement of UPR and the core autophagy machinery","volume":"233","author":"Song","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2026.117710_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109479","article-title":"Evaluation of trace metals in thyroid tissues: comparative analysis with benign and malignant thyroid diseases","volume":"183","author":"Stojsavljevic","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117710_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117232","article-title":"Effect of endoplasmic reticulum stress-mediated excessive autophagy on apoptosis and formation of kidney stones","volume":"244","author":"Sun","year":"2020","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.taap.2026.117710_bb0180","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.jafc.3c00798","article-title":"Heat stress-induced intestinal barrier impairment: current insights into the aspects of oxidative stress and endoplasmic reticulum stress","volume":"71","author":"Tang","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"13","key":"10.1016\/j.taap.2026.117710_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26136156","article-title":"Micro- and Nanoplastics as disruptors of the endocrine system-a review of the threats and consequences associated with plastic exposure","volume":"26","author":"Tyc","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.117710_bb0190","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/eesa.2000.1930","article-title":"Environmental risk limits for two phthalates, with special emphasis on endocrine disruptive properties","volume":"46","author":"van Wezel","year":"2000","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117710_bb0195","series-title":"Molecules","article-title":"Sorption behavior and mechanisms of organic contaminants to nano and microplastics","volume":"25","author":"Wang","year":"2020"},{"issue":"1","key":"10.1016\/j.taap.2026.117710_bb0200","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1080\/13880209.2022.2110126","article-title":"Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels","volume":"60","author":"Wang","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.taap.2026.117710_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170962","article-title":"Microplastic-mediated new mechanism of liver damage: from the perspective of the gut-liver axis","volume":"919","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.117710_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117904","article-title":"Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-mediated imbalance of mTORC1 and mTORC2","volume":"289","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.117710_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119789","article-title":"Microplastics-perturbed gut microbiota triggered the testicular disorder in male mice: via fecal microbiota transplantation","volume":"309","author":"Wen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.117710_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113577","article-title":"Male reproductive toxicity of polystyrene microplastics: study on the endoplasmic reticulum stress signaling pathway","volume":"172","author":"Wen","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.taap.2026.117710_bb0225","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/19393210.2019.1574909","article-title":"Migration of phthalates from plastic packages to convenience foods and its cumulative health risk assessments","volume":"12","author":"Yang","year":"2019","journal-title":"Food Addit. Contam., Part B"},{"key":"10.1016\/j.taap.2026.117710_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122406","article-title":"Early clues and molecular mechanism involved in neurodegenerative diseases induced in immature mice by combined exposure to polypropylene microplastics and DEHP","volume":"336","author":"Yang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.117710_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109766","article-title":"FAM134B-induced endoplasmic reticulum (ER)-phagy exacerbates cisplatin-insulted hair cell apoptosis: possible relation to excessive ER stress","volume":"748","author":"Yang","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.taap.2026.117710_bb0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.gendis.2018.06.004","article-title":"DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy","volume":"5","author":"Yi","year":"2018","journal-title":"Genes Dis."},{"key":"10.1016\/j.taap.2026.117710_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102886","article-title":"Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice","volume":"67","author":"Zeng","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2026.117710_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156727","article-title":"Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-\u03baB-NLRP3-GSDMD and AMPK-PGC-1\u03b1 axes","volume":"840","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.117710_bb0255","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.envpol.2018.07.080","article-title":"Crosstalk between unfolded protein response and Nrf2-mediated antioxidant defense in Di-(2-ethylhexyl) phthalate-induced renal injury in quail (Coturnix japonica)","volume":"242","author":"Zhao","year":"2018","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.taap.2026.117710_bb0260","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1080\/15548627.2020.1827780","article-title":"ATF4 links ER stress with reticulophagy in glioblastoma cells","volume":"17","author":"Zielke","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.taap.2026.117710_bb0265","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26000062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26000062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:21:25Z","timestamp":1773955285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26000062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":51,"alternative-id":["S0041008X26000062"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117710","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic assault of DEHP and MPs: Unmasking the ER stress-triggered autophagic injury male fertility","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117710"}}