{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:01:32Z","timestamp":1784815292405,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007924","name":"Bengbu Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.taap.2026.117773","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:13:24Z","timestamp":1771546404000},"page":"117773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dexmedetomidine regulates fatty acid oxidation through the AMPK\/PGC-1\u03b1\/CPT1A pathway to mitigate renal ischaemia-reperfusion injury"],"prefix":"10.1016","volume":"511","author":[{"given":"Cong-Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Chun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Feng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Rui","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Tian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117773_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117169","article-title":"T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks","volume":"286","author":"An","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3 Pt 2","key":"10.1016\/j.taap.2026.117773_bb0010","first-page":"F407","article-title":"Metabolic substrate utilization by rabbit proximal tubule. An NADH fluorescence study","volume":"254","author":"Balaban","year":"1988","journal-title":"Am. J. Phys."},{"issue":"4","key":"10.1016\/j.taap.2026.117773_bb0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MNH.0b013e32833aa4ac","article-title":"Renal lipid metabolism and lipotoxicity","volume":"19","author":"Bobulescu","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"9","key":"10.1016\/j.taap.2026.117773_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019718","article-title":"Long-term outcomes of acute kidney injury after different types of cardiac surgeries: a population-based study","volume":"10","author":"Chen","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.taap.2026.117773_bb0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4939-7598-3_12","article-title":"Compound C\/dorsomorphin: its use and misuse as an AMPK inhibitor","volume":"1732","author":"Dasgupta","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.taap.2026.117773_bb0030","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13098-024-01432-7","article-title":"Strategy for treating MAFLD: electroacupuncture alleviates hepatic steatosis and fibrosis by enhancing AMPK mediated glycolipid metabolism and autophagy in T2DM rats","volume":"16","author":"Duan","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"issue":"6","key":"10.1016\/j.taap.2026.117773_bb0035","doi-asserted-by":"crossref","first-page":"F1714","DOI":"10.1152\/ajprenal.00322.2018","article-title":"What we need to know about lipid-associated injury in case of renal ischemia-reperfusion","volume":"315","author":"Erpicum","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.taap.2026.117773_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.970292","article-title":"The AMPK pathway in fatty liver disease","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.taap.2026.117773_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020347","article-title":"The role of PGC-1\u03b1 and mitochondrial biogenesis in kidney diseases","volume":"10","author":"Fontecha-Barriuso","year":"2020","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.taap.2026.117773_bb0050","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tem.2016.05.002","article-title":"Mitochondria-power players in kidney function?","volume":"27","author":"Forbes","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.taap.2026.117773_bb0055","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","article-title":"Metformin: from mechanisms of action to therapies","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.taap.2026.117773_bb0060","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2209735","article-title":"Dexmedetomidine enables copper homeostasis in cerebral ischemia\/reperfusion via ferredoxin 1","volume":"55","author":"Guo","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.taap.2026.117773_bb0065","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.2147\/DDDT.S428024","article-title":"Dexmedetomidine ameliorates cardiac ischemia\/reperfusion injury by enhancing autophagy through activation of the AMPK\/SIRT3 pathway","volume":"17","author":"He","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.taap.2026.117773_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176090","article-title":"Dexmedetomidine against intestinal ischemia\/reperfusion injury: A systematic review and meta-analysis of preclinical studies","volume":"959","author":"Hou","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.taap.2026.117773_bb0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10545-010-9061-2","article-title":"A general introduction to the biochemistry of mitochondrial fatty acid \u03b2-oxidation","volume":"33","author":"Houten","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.taap.2026.117773_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.747911","article-title":"The protective effect of dexmedetomidine against ischemia-reperfusion injury after hepatectomy: a meta-analysis of randomized controlled trials","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.taap.2026.117773_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.semnephrol.2018.01.003","article-title":"The role of peroxisome proliferator-activated receptor \u03b3 coactivator 1\u03b1 (PGC-1\u03b1) in kidney disease","volume":"38","author":"Li","year":"2018","journal-title":"Semin. Nephrol."},{"issue":"15","key":"10.1016\/j.taap.2026.117773_bb0090","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1007\/s00018-021-03892-w","article-title":"The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury","volume":"78","author":"Li","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.117773_bb0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1158\/1535-7163.MCT-13-0579","article-title":"The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent","volume":"13","author":"Liu","year":"2014","journal-title":"Mol. Cancer Ther."},{"issue":"8","key":"10.1016\/j.taap.2026.117773_bb0100","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/abbs\/gmw061","article-title":"Cathelicidin PR-39 peptide inhibits hypoxia\/reperfusion-induced kidney cell apoptosis by suppression of the endoplasmic reticulum-stress pathway","volume":"48","author":"Liu","year":"2016","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"3","key":"10.1016\/j.taap.2026.117773_bb0105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1213\/ANE.0000000000005804","article-title":"Remote ischemic preconditioning reduces acute kidney injury after cardiac surgery: a systematic review and meta-analysis of randomized controlled trials","volume":"134","author":"Long","year":"2022","journal-title":"Anesth. Analg."},{"issue":"5","key":"10.1016\/j.taap.2026.117773_bb0110","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140695","article-title":"Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis","volume":"131","author":"Miguel","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.taap.2026.117773_bb0115","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI111524","article-title":"Oxygen free radicals in ischemic acute renal failure in the rat","volume":"74","author":"Paller","year":"1984","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.taap.2026.117773_bb0120","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00467-022-05748-2","article-title":"Transcriptional regulation of proximal tubular metabolism in acute kidney injury","volume":"38","author":"Piret","year":"2023","journal-title":"Pediatr. Nephrol."},{"issue":"6","key":"10.1016\/j.taap.2026.117773_bb0125","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.kint.2021.08.031","article-title":"Loss of proximal tubular transcription factor Kr\u00fcppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation","volume":"100","author":"Piret","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2026.117773_bb0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jconrel.2022.07.013","article-title":"Targeted delivery via albumin corona nanocomplex to renal tubules to alleviate acute kidney injury","volume":"349","author":"Qin","year":"2022","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.taap.2026.117773_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.132","article-title":"Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer","volume":"7","author":"Qu","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.117773_bb0140","article-title":"Berberine reduces lipid accumulation by promoting fatty acid oxidation in renal tubular epithelial cells of the diabetic kidney","volume":"12","author":"Rong","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.taap.2026.117773_bb0145","doi-asserted-by":"crossref","first-page":"8311","DOI":"10.1002\/jcb.28114","article-title":"MicroRNA-194 overexpression protects against hypoxia\/reperfusion-induced HK-2 cell injury through direct targeting Rheb","volume":"120","author":"Shen","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2026.117773_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117860","article-title":"Renal ischemia\/reperfusion injury: an insight on in vitro and in vivo models","volume":"256","author":"Shiva","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2026.117773_bb0155","first-page":"52","article-title":"Alteration of fatty acid oxidation in tubular epithelial cells: from acute kidney injury to renal fibrogenesis","volume":"2","author":"Simon","year":"2015","journal-title":"Front. Med. (Lausanne)"},{"issue":"4","key":"10.1016\/j.taap.2026.117773_bb0160","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bja.2019.12.036","article-title":"Effect of dexmedetomidine on acute kidney injury after aortic surgery: a single-Centre, placebo-controlled, randomised controlled trial","volume":"124","author":"Soh","year":"2020","journal-title":"Br. J. Anaesth."},{"issue":"12","key":"10.1016\/j.taap.2026.117773_bb0165","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1194\/jlr.M700378-JLR200","article-title":"Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome","volume":"48","author":"Watkins","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2026.117773_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.615424","article-title":"Dexmedetomidine protects human cardiomyocytes against ischemia-reperfusion injury through \u03b12-adrenergic receptor\/AMPK-dependent autophagy","volume":"12","author":"Xiao","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.taap.2026.117773_bb0175","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.kint.2022.01.029","article-title":"Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation","volume":"101","author":"Xu","year":"2022","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.taap.2026.117773_bb0180","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.3748\/wjg.v21.i12.3492","article-title":"Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: an update","volume":"21","author":"Yan","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2026.117773_bb0185","article-title":"Dexmedetomidine enhances autophagy via \u03b12-AR\/AMPK\/mTOR pathway to inhibit the activation of NLRP3 inflammasome and subsequently alleviates lipopolysaccharide-induced acute kidney injury","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2026.117773_bb0190","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.18632\/aging.202653","article-title":"PGC-1\u03b1 alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury","volume":"13","author":"Yuan","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.taap.2026.117773_bb0195","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1523-1755.2005.00061.x","article-title":"Renal tubular triglyercide accumulation following endotoxic, toxic, and ischemic injury","volume":"67","author":"Zager","year":"2005","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.taap.2026.117773_bb0200","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00134-023-07169-7","article-title":"Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study","volume":"49","author":"Zarbock","year":"2023","journal-title":"Intensive Care Med."},{"issue":"6","key":"10.1016\/j.taap.2026.117773_bb0205","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/SHK.0000000000002011","article-title":"Dexmedetomidine prevents PDIA3 decrease by activating \u03b12-adrenergic receptor to alleviate intestinal I\/r in mice","volume":"58","author":"Zhan","year":"2022","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.taap.2026.117773_bb0210","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10787-022-01117-5","article-title":"Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK\/SIRT1 pathway","volume":"31","author":"Zhang","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"8","key":"10.1016\/j.taap.2026.117773_bb0215","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.recesp.2024.02.004","article-title":"Dexmedetomidine mitigates acute kidney injury after coronary artery bypass grafting: a prospective clinical trial","volume":"77","author":"Zhang","year":"2024","journal-title":"Rev. Esp. Cardiol. (Engl. Ed.)"},{"key":"10.1016\/j.taap.2026.117773_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120241","article-title":"Corrigendum to \u201cPolyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity\u201d [Life Sci. 204 (2018) 55\u201364]","volume":"295","author":"Zhou","year":"2022","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.taap.2026.117773_bb0225","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.7150\/thno.92848","article-title":"MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity","volume":"14","author":"Zhou","year":"2024","journal-title":"Theranostics"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26000694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26000694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:14:25Z","timestamp":1784812465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26000694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":45,"alternative-id":["S0041008X26000694"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117773","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexmedetomidine regulates fatty acid oxidation through the AMPK\/PGC-1\u03b1\/CPT1A pathway to mitigate renal ischaemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117773"}}