{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:01:37Z","timestamp":1784815297870,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023YFS0205"],"award-info":[{"award-number":["2023YFS0205"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.taap.2026.117782","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:53:13Z","timestamp":1772643193000},"page":"117782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lysine succinylation-mediated energy metabolism imbalance drives brain injury in acute diquat poisoning"],"prefix":"10.1016","volume":"511","author":[{"given":"Chaocheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117782_bb0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnagi.2014.00018","article-title":"Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink\u2013parkin pathway","volume":"6","author":"Amadoro","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.taap.2026.117782_bb0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.taap.2026.117782_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10040166","article-title":"Diquat poisoning: care management and medico-legal implications","volume":"10","author":"Basilicata","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2026.117782_bb0020","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1021\/acs.jmedchem.6b01817","article-title":"Interrogating the roles of post-translational modifications of non-histone proteins: miniperspective","volume":"61","author":"Buuh","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2026.117782_bb0025","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3390\/ijms17081208","article-title":"One-carbon metabolism in prostate cancer: the role of androgen signaling","volume":"17","author":"Corbin","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117782_bb0030","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.taap.2026.117782_bb0035","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.taap.2026.117782_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113765","article-title":"Metabolomics profile of plasma in acute diquat-poisoned patients using gas chromatography-mass spectrometry","volume":"176","author":"Dai","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2026.117782_bb0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12864-021-07567-5","article-title":"First comprehensive analysis of lysine succinylation in paper mulberry (Broussonetia papyrifera)","volume":"22","author":"Dong","year":"2021","journal-title":"BMC Genomics"},{"key":"10.1016\/j.taap.2026.117782_bb0050","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/nar\/gkn176","article-title":"High-throughput functional annotation and data mining with the Blast2GO suite","volume":"36","author":"G\u00f6tz","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2026.117782_bb0055","article-title":"Paraquat and diquat: recent updates on their pretreatment and analysis methods since 2010 in biological samples","volume":"28","author":"Guo","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2026.117782_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101336","article-title":"Post-translational modifications: regulators of neurodegenerative proteinopathies","volume":"68","author":"Gupta","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.taap.2026.117782_bb0065","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211026117","article-title":"High-dose diquat poisoning: a case report","volume":"49","author":"Huang","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.taap.2026.117782_bb0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"Pre-clinical models, techniques and protocols","volume":"1916","author":"Kraeuter","year":"2018","journal-title":"Methods. Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.taap.2026.117782_bb0075","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0960327118765330","article-title":"Human and experimental toxicology of diquat poisoning: toxicokinetics, mechanisms of toxicity, clinical features, and treatment","volume":"37","author":"Magalh\u00e3es","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.taap.2026.117782_bb0080","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications\u2014cause and consequence of genome function","volume":"23","author":"Mill\u00e1n-Zambrano","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.taap.2026.117782_bb0085","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1007\/s12035-024-04172-x","article-title":"Imaging findings and toxicological mechanisms of nervous system injury caused by diquat","volume":"61","author":"Ren","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.taap.2026.117782_bb0090","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2026.117782_bb0095","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gendis.2019.09.011","article-title":"Enzymatic and metabolic regulation of lysine succinylation","volume":"7","author":"Sreedhar","year":"2020","journal-title":"Genes Dis."},{"key":"10.1016\/j.taap.2026.117782_bb0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41540-025-00506-0","article-title":"A single-cell network approach to decode metabolic regulation in gynecologic and breast cancers","volume":"11","author":"Srivastava","year":"2025","journal-title":"npj Syst. Biol. Appl."},{"key":"10.1016\/j.taap.2026.117782_bb0105","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.048993","article-title":"Metabolism navigates neural cell fate in development, aging and neurodegeneration","volume":"14","author":"Traxler","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.taap.2026.117782_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102242","article-title":"Role of succinylation modification in central nervous system diseases","volume":"95","author":"Wang","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.taap.2026.117782_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117188","article-title":"Diquat exacerbates oxidative stress and neuroinflammation by blocking the autophagic flux of microglia in the hippocampus","volume":"286","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117782_bb0120","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1021\/acs.est.4c07783","article-title":"Diquat induces cell death and dopamine neuron loss via reactive oxygen species generation in Caenorhabditis elegans","volume":"59","author":"Wang","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2026.117782_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117161","article-title":"Study on the mechanism of brain injury caused by acute diquat poisoning based on metabolomics","volume":"494","author":"Wang","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.117782_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuro.2025.103327","article-title":"Toxicological effects of diquat on the central nervous system and associated treatment challenges","volume":"111","author":"Wang","year":"2025","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2026.117782_bb0135","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.taap.2026.117782_bb0140","series-title":"Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma","author":"Young","year":"2024"},{"key":"10.1016\/j.taap.2026.117782_bb0145","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/15563650.2021.2013495","article-title":"Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases","volume":"60","author":"Yu","year":"2022","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.taap.2026.117782_bb0150","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nchembio.495","article-title":"Identification of lysine succinylation as a new post-translational modification","volume":"7","author":"Zhang","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.taap.2026.117782_bb0155","article-title":"Chronic exposure to diquat causes reproductive toxicity in female mice","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2026.117782_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800001","article-title":"Quantitative global proteome and lysine succinylome analyses reveal the effects of energy metabolism in renal cell carcinoma","volume":"18","author":"Zhang","year":"2018","journal-title":"Proteomics"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26000785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26000785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:14:57Z","timestamp":1784812497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26000785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":32,"alternative-id":["S0041008X26000785"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117782","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysine succinylation-mediated energy metabolism imbalance drives brain injury in acute diquat poisoning","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117782"}}