{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:09:09Z","timestamp":1786997349435,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017600","name":"Instytut Zootechniki \u2013 Pa\u0144stwowy Instytut Badawczy","doi-asserted-by":"publisher","award":["501\\u2013181-921"],"award-info":[{"award-number":["501\\u2013181-921"]}],"id":[{"id":"10.13039\/100017600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.taap.2026.117826","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T14:49:08Z","timestamp":1776610148000},"page":"117826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Analysis of the effect of high doses of vitamin D on gene and protein expression in the intestine of pigs (Sus scrofa)"],"prefix":"10.1016","volume":"511","author":[{"given":"Maria","family":"Oczkowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Wierzbicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"\u015awi\u0105tkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Szmato\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Steg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Smo\u0142ucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.taap.2026.117826_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102213","article-title":"Genomic analysis of 1,25-dihydroxyvitamin d3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects","volume":"298","author":"Aita","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.taap.2026.117826_bb0010","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.3390\/nu5093605","article-title":"Vitamin D: deficiency, sufficiency and toxicity","volume":"5","author":"Alshahrani","year":"2013","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.taap.2026.117826_bb0015","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S2213-8587(17)30357-1","article-title":"Effect of vitamin d supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials","volume":"5","author":"Autier","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.taap.2026.117826_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105501","article-title":"Vitamin D and the intestine: Review and update","volume":"196","author":"Christakos","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"16","key":"10.1016\/j.taap.2026.117826_bb0025","article-title":"Analysis of 1,25-dihydroxyvitamin d genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin d in human intestinal physiology","volume":"4","author":"Criss","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.taap.2026.117826_bb0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/01635581.2024.2328378","article-title":"Association between pretreatment blood 25-hydroxyvitamin D level and survival outcomes in patients with clinically localized prostate cancer: an updated meta-analysis","volume":"76","author":"Cui","year":"2024","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.taap.2026.117826_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105600","article-title":"VDR in salivary gland homeostasis and cancer","volume":"199","author":"DeSantis","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.taap.2026.117826_bb0040","first-page":"1085","article-title":"Effects of IFN-beta and 1,25-dihydroxyvitamin d3 on cellular proliferation, induction of 2\u2032,5\u2032-oligoadenylate (2-5A) synthetase and changes in immunoreactive pRB\/p53 in human prostatic JCA-1 cells","volume":"39","author":"Faiella","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"issue":"13","key":"10.1016\/j.taap.2026.117826_bb0045","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1242\/dev.066381","article-title":"P\u00e9rez de Castro I, malumbres M. genetic disruption of aurora b uncovers an essential role for aurora C during early mammalian development","volume":"138","author":"Fern\u00e1ndez-Miranda","year":"2011","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.taap.2026.117826_bb0050","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/15476286.2015.1044194","article-title":"Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition","volume":"12","author":"Fontemaggi","year":"2015","journal-title":"RNA Biol."},{"issue":"5","key":"10.1016\/j.taap.2026.117826_bb0055","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1158\/1940-6207.CAPR-12-0253","article-title":"Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue","volume":"6","author":"Giangreco","year":"2013","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"5","key":"10.1016\/j.taap.2026.117826_bb0060","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1210\/endrev\/bnae009","article-title":"Consensus statement on vitamin d status assessment and supplementation: whys, whens, and hows","volume":"45","author":"Giustina","year":"2024","journal-title":"Endocr. Rev."},{"issue":"10","key":"10.1016\/j.taap.2026.117826_bb0065","first-page":"3458","article-title":"Inhibition of AURKB, regulated by pseudogene MTND4P12, confers synthetic lethality to PARP inhibition in skin cutaneous melanoma","volume":"10","author":"Guo","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.taap.2026.117826_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117001","article-title":"Advances in biomedical applications of vitamin d for VDR targeted management of obesity and cancer","volume":"177","author":"Gupta","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.taap.2026.117826_bb0075","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/ibd\/izaa087","article-title":"Vitamin d therapy in adults with inflammatory bowel disease: a systematic review and Meta-analysis","volume":"26","author":"Guzman-Prado","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0080","doi-asserted-by":"crossref","first-page":"17778","DOI":"10.1038\/s41598-022-22307-9","article-title":"Vitamin d enhances type i IFN signaling in COVID-19 patients","volume":"12","author":"Hafezi","year":"2022","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.taap.2026.117826_bb0085","article-title":"Emerging insights into keratin 7 roles in tumor progression and metastasis of cancers","volume":"8","author":"Hosseinalizadeh","year":"2024","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058725","article-title":"Influence of vitamin d status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial","volume":"8","author":"Hossein-nezhad","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2026.117826_bb0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.intimp.2018.07.019","article-title":"Immunomodulatory effect of 1, 25 dihydroxy vitamin d3 on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages","volume":"62","author":"Jadhav","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.taap.2026.117826_bb0105","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1016\/j.psj.2020.06.006","article-title":"Differential immunomodulatory effect of vitamin D (1,25 (OH)2 D3) on the innate immune response in different types of cells infected in vitro with infectious bursal disease virus","volume":"99","author":"Jaime","year":"2020","journal-title":"Poult. Sci."},{"issue":"8","key":"10.1016\/j.taap.2026.117826_bb0110","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.28886","article-title":"Effect of vitamin d supplements on relapse or death in a p53-immunoreactive subgroup with digestive tract cancer: post hoc analysis of the AMATERASU randomized clinical trial","volume":"6","author":"Kanno","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"2","key":"10.1016\/j.taap.2026.117826_bb0115","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.abb.2004.09.004","article-title":"Gene expression profiles in rat intestine identify pathways for 1, 25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties","volume":"432","author":"Kutuzova","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.taap.2006.10.005","article-title":"1,25-Dihydroxyvitamin d3 regulates genes responsible for detoxification in intestine","volume":"218","author":"Kutuzova","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000937","article-title":"Active vitamin D3 treatment attenuated bacterial translocation via improving intestinal barriers in cirrhotic rats","volume":"65","author":"Lee","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"issue":"7","key":"10.1016\/j.taap.2026.117826_bb0130","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.3390\/app10072554","article-title":"Regulation of a SOD1-to-SOD2 antioxidative switch to prevent bone cancer","volume":"10","author":"Lisse","year":"2020","journal-title":"Appl. Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the dependency of cellular protein levels on mRNA abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.taap.2026.117826_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2023.110557","article-title":"Influence of vitamin D metabolites on vitamin d status, immunity and gut health of piglets","volume":"257","author":"Madsen","year":"2023","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.taap.2026.117826_bb0150","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1042\/BST20220839","article-title":"ISG15 driven cellular responses to virus infection","volume":"50","author":"Munnur","year":"2022","journal-title":"Biochem. Soc. Trans."},{"issue":"2","key":"10.1016\/j.taap.2026.117826_bb0155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S2213-8587(21)00345-4","article-title":"The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality","volume":"10","author":"Neale","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.taap.2026.117826_bb0160","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/gene.2011.21","article-title":"IRF7: activation, regulation, modification and function","volume":"12","author":"Ning","year":"2011","journal-title":"Genes Immun."},{"issue":"7597","key":"10.1016\/j.taap.2026.117826_bb0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature17406","article-title":"Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia","volume":"532","author":"Okumura","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12967-024-04889-2","article-title":"Circulating vitamin D level before initiating chemotherapy impacts on the time-to-outcome in metastatic colorectal cancer patients: systematic review and meta-analysis","volume":"22","author":"Ottaiano","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2026.117826_bb0175","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10572","article-title":"Vitamin d modulation of mitochondrial oxidative metabolism and mTOR enforces stress adaptations and anticancer responses","volume":"6","author":"Quigley","year":"2021","journal-title":"JBMR Plus."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0185","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.2101054","article-title":"A vitamin D-RelB\/NF-\u03baB pathway limits chandipura virus multiplication by rewiring the homeostatic state of autoregulatory type 1 IFN-IRF7 signaling","volume":"209","author":"Ratra","year":"2022","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.taap.2026.117826_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/8756-3282(94)90707-2","article-title":"Hypercalcemia and hyperosteolysis in vitamin d intoxication: effects of clodronate therapy","volume":"15","author":"Rizzoli","year":"1994","journal-title":"Bone"},{"issue":"14","key":"10.1016\/j.taap.2026.117826_bb0195","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3390\/nu16142195","article-title":"The \u201csunshine vitamin\u201d and its antioxidant benefits for enhancing muscle function","volume":"16","author":"Russo","year":"2024","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.taap.2026.117826_bb0200","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/jir.2023.0098","article-title":"The Many Faces of Oligoadenylate Synthetases","volume":"43","author":"Sarkar","year":"2023","journal-title":"J. Interf. Cytokine Res."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0205","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00394-023-03302-w","article-title":"The association between circulating 25-hydroxyvitamin D and pancreatic cancer: a systematic review and meta-analysis of observational studies","volume":"63","author":"Shen","year":"2024","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0210","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53864-1","article-title":"Disassociation of vitamin D\u2019s calcemic activity and non-calcemic genomic activity and individual responsiveness: a randomized controlled double-blind clinical trial","volume":"9","author":"Shirvani","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0215","doi-asserted-by":"crossref","first-page":"535","DOI":"10.21873\/anticanres.13982","article-title":"Variable genomic and Metabolomic responses to varying doses of vitamin D supplementation","volume":"40","author":"Shirvani","year":"2020","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0220","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cgh.2020.02.013","article-title":"No association between vitamin d supplementation and risk of colorectal adenomas or serrated polyps in a randomized trial","author":"Song","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.taap.2026.117826_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/nu5125127","article-title":"Does vitamin d sufficiency equate to a single serum 25-hydroxyvitamin d level or are different levels required for non-skeletal diseases?","volume":"5","author":"Spedding","year":"2013","journal-title":"Nutrients"},{"issue":"1\u20132","key":"10.1016\/j.taap.2026.117826_bb0230","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jsbmb.2005.06.003","article-title":"Colon cancer and solar ultraviolet b radiation and prevention and treatment of colon cancer in mice with vitamin D and its gemini analogs","volume":"97","author":"Spina","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2026.117826_bb0235","article-title":"Effects of high-dose vitamin d3 supplementation on pig performance, vitamin D content in meat, and muscle transcriptome in pigs","author":"Steg","year":"2024","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)."},{"key":"10.1016\/j.taap.2026.117826_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2025.106835","article-title":"Very high-dose vitamin d\u2083 supplementation reduces the expression of genes and proteins engaged in \u03b2-oxidation in healthy pigs","volume":"254","author":"Steg","year":"2025","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.taap.2026.117826_bb0245","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00018-021-04081-5","article-title":"Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon","volume":"79","author":"Stenvall","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2026.117826_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101332","article-title":"PLK1 inhibition-based combination therapies for cancer management","volume":"16","author":"Su","year":"2022","journal-title":"Transl. Oncol."},{"issue":"10","key":"10.1016\/j.taap.2026.117826_bb0255","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/jn\/135.10.2350","article-title":"Vitamin d deficiency enhances the growth of MC-26 colon cancer xenografts in Balb\/c mice","volume":"135","author":"Tangpricha","year":"2005","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.taap.2026.117826_bb0260","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ibd\/izac253","article-title":"Effectiveness of vitamin d supplementation on disease course in inflammatory bowel disease patients: systematic review with Meta-analysis","volume":"30","author":"Valvano","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"issue":"5","key":"10.1016\/j.taap.2026.117826_bb0265","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/ajcn\/nqab419","article-title":"Vitamin d supplementation and prevention of cardiovascular disease and cancer in the finnish vitamin D trial: a randomized controlled trial","volume":"115","author":"Virtanen","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"issue":"9","key":"10.1016\/j.taap.2026.117826_bb0270","first-page":"2114","article-title":"Comprehensive analysis of microRNA\/mRNA signature in colon adenocarcinoma","volume":"21","author":"Wang","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"14","key":"10.1016\/j.taap.2026.117826_bb0275","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1158\/1078-0432.CCR-23-0447","article-title":"Plasma 25-hydroxyvitamin d levels and survival in stage III colon cancer: Findings from CALGB\/SWOG 80702 (alliance)","volume":"29","author":"Wang","year":"2023","journal-title":"Clin. Cancer Res."},{"issue":"14","key":"10.1016\/j.taap.2026.117826_bb0280","article-title":"Vitamin d3 promotes gastric cancer cell autophagy by mediating p53\/AMPK\/mTOR signaling","volume":"8","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"30","key":"10.1016\/j.taap.2026.117826_bb0285","doi-asserted-by":"crossref","first-page":"48656","DOI":"10.18632\/oncotarget.8799","article-title":"KIFC1: a promising chemotherapy target for cancer treatment?","volume":"7","author":"Xiao","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.taap.2026.117826_bb0290","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12032-020-01362-0","article-title":"Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer","volume":"37","author":"Yang","year":"2020","journal-title":"Med. Oncol."},{"issue":"18","key":"10.1016\/j.taap.2026.117826_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810603","article-title":"1,25-Dihydroxyvitamin d3 negatively regulates the inflammatory response to porcine epidemic diarrhea virus infection by inhibiting NF-\u03baB and JAK\/STAT signaling pathway in IPEC-J2 porcine epithelial cells","volume":"23","author":"Yang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2026.117826_bb0300","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/jsfa.11388","article-title":"Effects of 25-hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus","volume":"102","author":"Zhang","year":"2022","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.taap.2026.117826_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1095509","article-title":"Dietary 25-hydroxycholecalciferol modulates gut microbiota and improves the growth, meat quality, and antioxidant status of growing-finishing pigs","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.taap.2026.117826_bb0310","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/cbdd.14153","article-title":"KIF4A knockdown inhibits tumor progression and promotes chemo-sensitivity via induction of p21 in lung cancer cells","volume":"101","author":"Zhang","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0315","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1017\/S000711451400097X","article-title":"Dietary vitamin d supplementation attenuates immune responses of pigs challenged with rotavirus potentially through the retinoic acid-inducible gene I signalling pathway","volume":"112","author":"Zhao","year":"2014","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.taap.2026.117826_bb0320","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/1745039X.2015.1034522","article-title":"Effect of 25-hydroxyvitamin d3 on rotavirus replication and gene expressions of RIG-I signalling molecule in porcine rotavirus-infected IPEC-J2 cells","volume":"69","author":"Zhao","year":"2015","journal-title":"Arch. Anim. Nutr."},{"issue":"4","key":"10.1016\/j.taap.2026.117826_bb0325","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41419-023-05802-3","article-title":"The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:13:44Z","timestamp":1784812424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":64,"alternative-id":["S0041008X26001225"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117826","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the effect of high doses of vitamin D on gene and protein expression in the intestine of pigs (Sus scrofa)","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117826","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117826"}}