{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:20:43Z","timestamp":1788236443247,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Shanghai Municipality Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762074"],"award-info":[{"award-number":["2024M762074"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["24YF2735900"],"award-info":[{"award-number":["24YF2735900"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.taap.2026.117836","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:17:17Z","timestamp":1777439837000},"page":"117836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-\u03baB-mediated pyroptosis"],"prefix":"10.1016","volume":"513","author":[{"given":"Yunzhi","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoju","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.taap.2026.117836_bb0005","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"13","key":"10.1016\/j.taap.2026.117836_bb0010","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCULATIONAHA.114.012669","article-title":"Knockout of adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice","volume":"131","author":"Bauer","year":"2015","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.taap.2026.117836_bb0015","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American heart association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.taap.2026.117836_bb0020","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0008-6363(01)00220-6","article-title":"Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, \u22123 and \u22129 production by vascular smooth muscle cells","volume":"50","author":"Bond","year":"2001","journal-title":"Cardiovasc. Res."},{"issue":"17","key":"10.1016\/j.taap.2026.117836_bb0025","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: An ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.taap.2026.117836_bb0030","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCULATIONAHA.118.033700","article-title":"RhoE fine-Tunes inflammatory response in myocardial infarction","volume":"139","author":"Dai","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2026.117836_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110222","article-title":"Panaxynol ameliorates cardiac ischemia\/reperfusion injury by suppressing NLRP3-induced pyroptosis and apoptosis via HMGB1\/TLR4\/NF-\u03baB axis","volume":"121","author":"Ding","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.taap.2026.117836_bb0040","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2174\/1389203723666220817085941","article-title":"The role of NF-\u03baB in myocardial ischemia\/reperfusion injury","volume":"23","author":"Dong","year":"2022","journal-title":"Curr. Protein Peptide Sci."},{"issue":"11","key":"10.1016\/j.taap.2026.117836_bb0045","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1096\/fj.05-5133fje","article-title":"Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction","volume":"20","author":"Frantz","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2026.117836_bb0050","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.taap.2026.117836_bb0055","first-page":"735","article-title":"Innate immune receptors, key actors in cardiovascular diseases","volume":"5","author":"Ja\u00e9n","year":"2020","journal-title":"JACC: Basic to Translational Science"},{"issue":"1","key":"10.1016\/j.taap.2026.117836_bb0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13059-015-0676-3","article-title":"The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family","volume":"16","author":"Kelwick","year":"2015","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.taap.2026.117836_bb0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"10","key":"10.1016\/j.taap.2026.117836_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.430","article-title":"MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.taap.2026.117836_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04143-3","article-title":"Pyroptosis inhibition improves the symptom of acute myocardial infarction","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.117836_bb0080","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.matbio.2018.06.002","article-title":"ADAMTS proteins in human disorders","volume":"71-72","author":"Mead","year":"2018","journal-title":"Matrix Biol."},{"issue":"4","key":"10.1016\/j.taap.2026.117836_bb0085","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1021\/acs.jmedchem.3c02036","article-title":"BAY-9835: discovery of the first orally bioavailable ADAMTS7 inhibitor","volume":"67","author":"Meibom","year":"2024","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.taap.2026.117836_bb0090","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/CIRCRESAHA.121.319163","article-title":"Coronary disease association with ADAMTS7 is due to protease activity","volume":"129","author":"Mizoguchi","year":"2021","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.taap.2026.117836_bb0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jacbts.2021.08.006","article-title":"Targeting the inflammasome in cardiovascular disease","volume":"7","author":"Olsen","year":"2022","journal-title":"JACC Basic Transl Sci"},{"issue":"3","key":"10.1016\/j.taap.2026.117836_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0301133","article-title":"Piperine alleviates nonalcoholic steatohepatitis by inhibiting NF-\u03baB-mediated hepatocyte pyroptosis","volume":"19","author":"Ran","year":"2024","journal-title":"PloS One"},{"issue":"25","key":"10.1016\/j.taap.2026.117836_bb0105","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.taap.2026.117836_bb0110","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.123.322737","article-title":"ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1","volume":"133","author":"Sharifi","year":"2023","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.taap.2026.117836_bb0115","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2026.117836_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.prerep.2024.100020","article-title":"Refinement by gentle handling of mice affects oral-dosing pharmacokinetic end points and response to stress under drug administration and sampling","volume":"2","author":"Swan","year":"2024","journal-title":"Pharmacological Research - Reports"},{"issue":"4","key":"10.1016\/j.taap.2026.117836_bb0125","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","article-title":"The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases","volume":"21","author":"Toldo","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.taap.2026.117836_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108053","article-title":"Targeting the NLRP3 inflammasome in cardiovascular diseases","volume":"236","author":"Toldo","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2026.117836_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113803","article-title":"Inhibition of CCR2 attenuates NLRP3-dependent pyroptosis after myocardial ischaemia-reperfusion in rats via the NF-kB pathway","volume":"145","author":"Wang","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.taap.2026.117836_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40001-015-0118-4","article-title":"Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction","volume":"20","author":"Wu","year":"2015","journal-title":"Eur. J. Med. Res."},{"issue":"3","key":"10.1016\/j.taap.2026.117836_bb0145","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1159\/000443047","article-title":"Association of ADAMTS-7 levels with cardiac function in a rat model of acute myocardial infarction","volume":"38","author":"Wu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2026.117836_bb0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40001-018-0305-1","article-title":"Association of serum ADAMTS-7 levels with left ventricular reverse remodeling after ST-elevation myocardial infarction","volume":"23","author":"Wu","year":"2018","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.taap.2026.117836_bb0155","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.117836_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117367","article-title":"Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-\u03baB pathway in heart failure","volume":"179","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.taap.2026.117836_bb0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.gendis.2020.06.005","article-title":"The nuclear factor kappa b (NF-kB) signaling in cancer development and immune diseases","volume":"8","author":"Zinatizadeh","year":"2021","journal-title":"Genes Dis"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:02:25Z","timestamp":1788235345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"alternative-id":["S0041008X26001328"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117836","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-\u03baB-mediated pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117836"}}