{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:02:40Z","timestamp":1784768560204,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.taap.2026.117838","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:49:09Z","timestamp":1777564149000},"page":"117838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Scoparone inhibits the progression of gastric cancer by regulating the PIN1\/STING\/TBK1\/IRF3 signaling pathway"],"prefix":"10.1016","volume":"512","author":[{"given":"Na","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117838_bb0005","first-page":"717","article-title":"Phenolic analysis and antimicrobial potential of Glycyrrhiza glabra L. plant root extract","volume":"10","author":"Aktepe","year":"2025","journal-title":"MAS J. Appl. Sci."},{"issue":"2","key":"10.1016\/j.taap.2026.117838_bb0010","first-page":"559","article-title":"Cytotoxic and antimicrobial analysis of biosynthesized selenium nanoparticles from Solanum tuberosum peels","volume":"9","author":"Aktepe","year":"2025","journal-title":"Int. J. Agric. Environ. Food Sci."},{"key":"10.1016\/j.taap.2026.117838_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156221","article-title":"Peptidyl-prolyl isomerase PIN1 as a pivotal regulator of cancer progression and therapy","volume":"275","author":"Bajinka","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.taap.2026.117838_bb0020","first-page":"1300","article-title":"Influence of antioxidant concentration, temperature, and saturated lipid content on \u03b1-tocopherol stability in oil blends","volume":"9","author":"Bayram","year":"2025","journal-title":"Int. J. Agric. Environ. Food Sci."},{"key":"10.1016\/j.taap.2026.117838_bb0025","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.7150\/ijbs.115073","article-title":"Glycolysis drives STING signaling to promote M1-macrophage polarization and aggravate liver fibrosis","volume":"21","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2026.117838_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063381","article-title":"Gastric Cancer in the era of epigenetics","volume":"25","author":"Christodoulidis","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117838_bb0035","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ccell.2025.12.002","article-title":"Targeting STING to generate therapeutic anti-tumor immunity","volume":"44","author":"Fahey","year":"2026","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2026.117838_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.02.061","article-title":"STING pathway activation with cisplatin polyprodrug nanoparticles for chemo-immunotherapy in ovarian cancer","volume":"381","author":"Fu","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.taap.2026.117838_bb0045","article-title":"Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer: a focus on the ferroptosis regulation","volume":"16","author":"Gao","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2026.117838_bb0050","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.21037\/tcr-24-1771","article-title":"Scoparone suppresses proliferation and cell cycle of hepatocellular carcinoma cells via inhibiting AKT\/GSK-3\u03b2\/cyclin D1 signaling pathway","volume":"14","author":"Hong","year":"2025","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.taap.2026.117838_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176091","article-title":"Scoparone induces autophagic cell death via the PAK1\/AKT axis in colorectal cancer","volume":"959","author":"Huang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2026.117838_bb0060","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70688","article-title":"Brazilin inhibits the proliferation of non-small cell lung Cancer by regulating the STING\/TBK1\/IRF3 pathway","volume":"29","author":"Kang","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2026.117838_bb0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/19768354.2024.2315950","article-title":"Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation","volume":"28","author":"Kim","year":"2024","journal-title":"Anim. Cells Syst. (Seoul)"},{"key":"10.1016\/j.taap.2026.117838_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113968","article-title":"USP34 regulates PIN1-cGAS-STING axis-dependent ferroptosis in cervical cancer via SUMOylation","volume":"147","author":"Liao","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2026.117838_bb0075","article-title":"The mechanisms of Pin1 as targets for cancer therapy","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2026.117838_bb0080","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1186\/s12967-025-07318-0","article-title":"Ginsenoside Rh2 as a novel PIN1 inhibitor disrupting the cancer stem cell-like phenotype in non-small cell lung cancer","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2026.117838_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2026.108136","article-title":"Cytokine epigenetics network for gastric cancer progression and chemoresistance","volume":"225","author":"Nagaraju","year":"2026","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2026.117838_bb0090","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s13046-025-03513-5","article-title":"TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity","volume":"44","author":"Niu","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.taap.2026.117838_bb0095","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1186\/s12964-024-01893-3","article-title":"Immunomodulatory effects of trastuzumab deruxtecan through the cGAS-STING pathway in gastric cancer cells","volume":"22","author":"Oh","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.taap.2026.117838_bb0100","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2026.5863","article-title":"RNA-binding protein DAZAP1 promotes gastric cancer metastasis by enhancing NOTCH1 and JAG1 mRNA stability","volume":"68","author":"Peng","year":"2026","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.taap.2026.117838_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27031256","article-title":"Mechanisms of antiproliferative effects of nobiletin, Scoparone, and Tangeretin isolated from Citrus reticulata Peel dichloromethane extract in acute myeloid Leukemia cells","volume":"27","author":"Russo","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117838_bb0110","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ncb0901-793","article-title":"Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC","volume":"3","author":"Ryo","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2026.117838_bb0115","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10555-020-09925-3","article-title":"Gastric cancer: a comprehensive review of current and future treatment strategies","volume":"39","author":"Sexton","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.taap.2026.117838_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2026.1746425","article-title":"TRIM26 deficiency drives gastric cancer lymph node metastasis via TGF-\u03b2 signaling activation and modulates gemcitabine response","volume":"14","author":"Shen","year":"2026","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2026.117838_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157912","article-title":"YTHDF2-orchestrated m(6)a methylation of BECN1 induces Scoparone-mediated hepatic stellate cell ferroptosis to attenuate liver fibrosis","volume":"153","author":"Sun","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117838_bb0130","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.taap.2026.117838_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107314","article-title":"Tetrandrine activates STING\/TBK1\/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer","volume":"207","author":"Tan","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2026.117838_bb0140","first-page":"630","article-title":"Investigation of the functional properties of some Origanum species and their bioactive components","volume":"9","author":"Tek\u0130N","year":"2025","journal-title":"ISPEC J. Agric. Sci."},{"key":"10.1016\/j.taap.2026.117838_bb0145","article-title":"Impact of juglone, a PIN1 \u0130nhibitor, on Oral carcinogenesis induced by 4-Nitroquinoline-1-oxide (4NQO) in rat model","volume":"60","author":"Topal","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.taap.2026.117838_bb0150","article-title":"PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1","volume":"28","author":"Wang","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2026.117838_bb0155","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41419-025-07960-y","article-title":"Tumor-derived PRMT1 suppresses macrophage antitumor activity by inhibiting cGAS\/STING signaling in gastric cancer cells","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.117838_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2026.100281","article-title":"Scoparone induces mitophagy and apoptosis via ROS accumulation in pancreatic cancer cells","volume":"10","author":"Weng","year":"2026","journal-title":"Curr. Res. Toxicol."},{"key":"10.1016\/j.taap.2026.117838_bb0165","article-title":"Multiple-pathway cGAS-STING activation with enhanced mild photothermal therapy through glycolysis regulation for boosting gastric cancer immunotherapy","volume":"37","author":"Xu","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.taap.2026.117838_bb0170","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1093\/nar\/gku1145","article-title":"Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis","volume":"42","author":"Yang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2026.117838_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-025-07463-6","article-title":"The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression","volume":"24","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2026.117838_bb0180","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41420-022-01030-4","article-title":"Hyperglycemia induces gastric carcinoma proliferation and migration via the Pin1\/BRD4 pathway","volume":"8","author":"Yu","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.taap.2026.117838_bb0185","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/mc.23027","article-title":"Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K\/AKT and Wnt\/\u03b2-catenin oncogenic pathways","volume":"58","author":"Zhang","year":"2019","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.taap.2026.117838_bb0190","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1158\/1535-7163.MCT-19-0656","article-title":"PIN1 inhibition sensitizes chemotherapy in gastric Cancer cells by targeting stem cell-like traits and multiple biomarkers","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2026.117838_bb0195","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41420-025-02850-w","article-title":"Effect of OASL on oxaliplatin-induced immunogenic cell death in gastric cancer via the cGAS-STING signaling pathway","volume":"12","author":"Zhang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.taap.2026.117838_bb0200","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10565-025-10118-3","article-title":"DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer","volume":"42","author":"Zhang","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.taap.2026.117838_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115618","article-title":"STING activation in macrophages by vanillic acid exhibits antineoplastic potential","volume":"213","author":"Zhu","year":"2023","journal-title":"Biochem. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:40:06Z","timestamp":1784767206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":41,"alternative-id":["S0041008X26001341"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117838","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scoparone inhibits the progression of gastric cancer by regulating the PIN1\/STING\/TBK1\/IRF3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117838"}}