{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:02:32Z","timestamp":1784768552336,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX24_2348"],"award-info":[{"award-number":["SJCX24_2348"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.taap.2026.117858","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:17:31Z","timestamp":1778577451000},"page":"117858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Shared inflammatory targets of phthalate plasticizers in MODS-related syndromes: An integrative network toxicology study with representative DEHP in vitro validation"],"prefix":"10.1016","volume":"512","author":[{"given":"Lin","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aifeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keran","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangquan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117858_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131153","article-title":"Therapeutic potential of proteases in acute lung injury and respiratory distress syndrome via TLR4\/Nrf2\/NF-kB signaling modulation","volume":"267","author":"Anwar","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2026.117858_bb0010","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.chemosphere.2019.05.280","article-title":"Metabolites of phosphate flame retardants and alternative plasticizers in urine from intensive care patients","volume":"233","author":"Bastiaensen","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2026.117858_bb0015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijpharm.2015.03.030","article-title":"Migrability of PVC plasticizers from medical devices into a simulant of infused solutions","volume":"485","author":"Bernard","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.taap.2026.117858_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192369","article-title":"Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices","volume":"13","author":"Bernard","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2026.117858_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11040252","article-title":"Association between urinary metabolites and the exposure of intensive care newborns to plasticizers of medical devices used for their care management","volume":"11","author":"Bernard","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.taap.2026.117858_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126978","article-title":"Quantification of bis (2-ethylhexyl) phthalate released by medical devices during respiratory assistance and estimation of patient exposure","volume":"255","author":"Bouattour","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2026.117858_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147371","article-title":"The effects of phthalate ester exposure on human health: a review","volume":"786","author":"Chang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.117858_bb0040","doi-asserted-by":"crossref","DOI":"10.5492\/wjccm.v13.i3.94020","article-title":"Reimagining critical care: trends and shifts in 21st century medicine","volume":"13","author":"Doppalapudi","year":"2024","journal-title":"World. J. Crit. Care. Med."},{"key":"10.1016\/j.taap.2026.117858_bb0045","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.70024","article-title":"Engineering bacterial biocatalysts for the degradation of phthalic acid esters","volume":"17","author":"Durante-Rodr\u00edguez","year":"2024","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.taap.2026.117858_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116866","article-title":"Elucidating the mechanism of plasticizers inducing breast cancer through network toxicology and molecular docking analysis","volume":"284","author":"He","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117858_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154143","article-title":"Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK\/NF-\u03baB and Keap1\/Nrf2\/HO-1 pathway","volume":"101","author":"Hong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117858_bb0060","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/toxics11060527","article-title":"Unveiling the hidden dangers of plasticizers: a call for immediate action","volume":"11","author":"Huang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2026.117858_bb0065","doi-asserted-by":"crossref","first-page":"37737","DOI":"10.1007\/s11356-022-18784-0","article-title":"PM2.5-bound phthalates and phthalate substitutes in a megacity of southern China: spatioseasonal variations, source apportionment, and risk assessment","volume":"29","author":"Huang","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.taap.2026.117858_bb0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10753-022-01715-z","article-title":"PCSK9 promotes endothelial dysfunction during Sepsis via the TLR4\/MyD88\/NF-\u03baB and NLRP3 pathways","volume":"46","author":"Huang","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.taap.2026.117858_bb0075","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.envint.2015.04.008","article-title":"Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-a in intensive care unit (ICU) patients","volume":"81","author":"Huygh","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.117858_bb0080","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.3906\/sag-2012-151","article-title":"Extracorporeal carbon dioxide removal (ECCO2R) in COPD and ARDS patients with severe hypercapnic respiratory failure. A retrospective case-control study","volume":"51","author":"\u0130nal","year":"2021","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.taap.2026.117858_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105739","article-title":"Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by limiting pyroptosis","volume":"116","author":"Ji","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.taap.2026.117858_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224931","article-title":"Exposure of patients to di (2-ethylhexy)phthalate (DEHP) and its metabolite MEHP during extracorporeal membrane oxygenation (ECMO) therapy","volume":"15","author":"Kaestner","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2026.117858_bb0095","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/metabo11020094","article-title":"Comparative effects of Di- (2-ethylhexyl)phthalate and Di- (2-ethylhexyl)terephthalate metabolites on thyroid receptors: in vitro and in silico studies","volume":"11","author":"Kambia","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.taap.2026.117858_bb0100","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.scitotenv.2018.04.158","article-title":"Concentration and factors affecting the distribution of phthalates in the air and dust: a global scenario","volume":"635","author":"Kashyap","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.117858_bb0105","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3109\/01902148.2015.1044137","article-title":"Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation","volume":"41","author":"Katsura","year":"2015","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.taap.2026.117858_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/936864","article-title":"Evaluation of central venous catheter associated blood stream infections: a microbiological observational study","volume":"2013","author":"Khanna","year":"2013","journal-title":"J. Pathog."},{"key":"10.1016\/j.taap.2026.117858_bb0115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00204-004-0642-4","article-title":"New metabolites of di (2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP","volume":"79","author":"Koch","year":"2005","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2026.117858_bb0120","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1681\/ASN.2013050528","article-title":"Toll-like receptor 4-induced IL-22 accelerates kidney regeneration","volume":"25","author":"Kulkarni","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2026.117858_bb0125","article-title":"Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-\u03baB\/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney","volume":"926","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.117858_bb0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13613-025-01513-4","article-title":"Crosstalk between lung and extrapulmonary organs in sepsis-related acute lung injury\/acute respiratory distress syndrome","volume":"15","author":"Li","year":"2025","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.taap.2026.117858_bb0135","article-title":"Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotype","author":"Lindell","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.taap.2026.117858_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110311","article-title":"Tirzepatide attenuates lipopolysaccharide-induced left ventricular remodeling and dysfunction by inhibiting the TLR4\/NF-kB\/NLRP3 pathway","volume":"120","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2026.117858_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116103","article-title":"An eNAMPT-neutralizing mAb reduces post-infarct myocardial fibrosis and left ventricular dysfunction","volume":"170","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117858_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111617","article-title":"Arsenic (III) induces oxidative stress and inflammation in the gills of common carp, which is ameliorated by zinc (II)","volume":"225","author":"Lu","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.taap.2026.117858_bb0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41392-025-02127-9","article-title":"Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies","volume":"10","author":"Ma","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.117858_bb0160","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1007\/s10238-023-01064-7","article-title":"Modulation of IRAK enzymes as a therapeutic strategy against SARS-CoV-2 induced cytokine storm","volume":"23","author":"Mahmoud","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.taap.2026.117858_bb0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jhazmat.2018.09.087","article-title":"Phthalate and alternative plasticizers in indwelling medical devices in pediatric intensive care units","volume":"363","author":"Malarvannan","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117858_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135583","article-title":"Recent advances in sustainable biopolymer-based nanocomposites for smart food packaging: a review","volume":"279","author":"Mishra","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2026.117858_bb0175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00134-016-4673-0","article-title":"Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure","volume":"43","author":"Morelli","year":"2017","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.taap.2026.117858_bb0180","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00134-025-07993-z","article-title":"Association of hospital-level continuous kidney replacement therapy use and mortality in critically ill patients with acute kidney injury","volume":"51","author":"Neyra","year":"2025","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.taap.2026.117858_bb0185","first-page":"173","article-title":"Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization","volume":"3","author":"Nolan","year":"2022","journal-title":"Nat. Can."},{"key":"10.1016\/j.taap.2026.117858_bb0190","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1021\/acs.est.0c02455","article-title":"Percutaneous penetration and metabolism of plasticizers by skin cells and its implication in dermal exposure to plasticizers by skin wipes","volume":"54","author":"Pan","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2026.117858_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108605","article-title":"Ongoing exposure to endocrine disrupting phthalates and alternative plasticizers in neonatal intensive care unit patients","volume":"186","author":"Panneel","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.117858_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116151","article-title":"Rosuvastatin and diosmetin inhibited the HSP70\/TLR4 \/NF-\u03baB p65\/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin","volume":"171","author":"Saad","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117858_bb0205","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1007\/s11356-017-1042-7","article-title":"Arsenic and\/or copper caused inflammatory response via activation of inducible nitric oxide synthase pathway and triggered heat shock protein responses in testis tissues of chicken","volume":"25","author":"Shao","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.taap.2026.117858_bb0215","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0002-9610(69)90011-7","article-title":"Respiratory failure, hypotension, sepsis, and jaundice. A clinical syndrome associated with lethal hemorrhage from acute stress ulceration of the stomach","volume":"117","author":"Skillman","year":"1969","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.taap.2026.117858_bb0220","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.xphs.2019.06.015","article-title":"DEHP Nanodroplets leached from polyvinyl chloride IV bags promote aggregation of IVIG and activate complement in human serum","volume":"109","author":"Snell","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.taap.2026.117858_bb0225","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.yrtph.2016.01.013","article-title":"The safety of medical devices containing DEHP plasticized PVC or other plasticizers on neonates and other groups possibly at risk (2015 update)","volume":"76","author":"Testai","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2026.117858_bb0230","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/tox.23686","article-title":"Phthalate derivative DEHP disturbs the antiproliferative effect of camptothecin in human lung cancer cells by attenuating DNA damage and activating Akt\/NF-\u03baB signaling pathway","volume":"38","author":"Urade","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2026.117858_bb0235","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jare.2023.08.006","article-title":"Forsythiaside a alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-\u03b3\/RXR-\u03b1 complex","volume":"60","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.taap.2026.117858_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157443","article-title":"Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites-a review","volume":"847","author":"Wen","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.117858_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108191","article-title":"Particle transfer mediates dermal exposure of consumers to plasticizers in eraser and pen accessories","volume":"180","author":"Wu","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.117858_bb0250","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13054-025-05329-3","article-title":"Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives","volume":"29","author":"Wu","year":"2025","journal-title":"Crit. Care"},{"key":"10.1016\/j.taap.2026.117858_bb0255","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/s12889-024-17801-w","article-title":"Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.taap.2026.117858_bb0260","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/rb\/rbw008","article-title":"Opportunities and challenges for the development of polymer-based biomaterials and medical devices","volume":"3","author":"Yin","year":"2016","journal-title":"Regener. Biomater."},{"key":"10.1016\/j.taap.2026.117858_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156733","article-title":"COX-2 optimizes cardiac mitochondrial biogenesis and exerts a cardioprotective effect during sepsis","volume":"182","author":"Yin","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2026.117858_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8877056","article-title":"Tofacitinib ameliorates lipopolysaccharide-induced acute kidney injury by blocking the JAK-STAT1\/STAT3 signaling pathway","volume":"2021","author":"Yun","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2026.117858_bb0275","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/jcsm.12867","article-title":"Sepsis induces interleukin 6, gp130\/JAK2\/STAT3, and muscle wasting","volume":"13","author":"Zanders","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.taap.2026.117858_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110086","article-title":"Dietary omega-3 alleviates copper-induced nephrotoxicity via suppression of NLRP3-mediated pyroptosis and lipid metabolism disorder in chickens","volume":"147","author":"Zhang","year":"2026","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.taap.2026.117858_bb0285","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13020-024-00946-6","article-title":"\u0392-Elemene promotes microglial M2-like polarization against ischemic stroke via AKT\/mTOR signaling axis-mediated autophagy","volume":"19","author":"Zhao","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.taap.2026.117858_bb0290","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molimm.2025.02.002","article-title":"Alleviation of sepsis-induced lung and liver injury by polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via suppression of TLR4\/NF-\u03baB\/COX-2 pathway and modulation of immune checkpoint molecules","volume":"179","author":"Zhao","year":"2025","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.taap.2026.117858_bb0295","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41419-023-05782-4","article-title":"Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization","volume":"14","author":"Zhou","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.117858_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115763","article-title":"Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4\/MyD88\/NF-\u03baB pathway","volume":"301","author":"Zhu","year":"2023","journal-title":"J. Ethnopharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:38:47Z","timestamp":1784767127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":59,"alternative-id":["S0041008X26001547"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117858","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shared inflammatory targets of phthalate plasticizers in MODS-related syndromes: An integrative network toxicology study with representative DEHP in vitro validation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117858"}}