{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:02:37Z","timestamp":1784768557835,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230458"],"award-info":[{"award-number":["BK20230458"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018538","name":"National Ten Thousand Talent Program","doi-asserted-by":"publisher","award":["2024ZD0530800"],"award-info":[{"award-number":["2024ZD0530800"]}],"id":[{"id":"10.13039\/501100018538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173874"],"award-info":[{"award-number":["82173874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073914"],"award-info":[{"award-number":["82073914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374124"],"award-info":[{"award-number":["82374124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["23KJB310017"],"award-info":[{"award-number":["23KJB310017"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.taap.2026.117859","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:17:55Z","timestamp":1778577475000},"page":"117859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Curcumol induces autophagy-dependent hepatic stellate cell death through methionine metabolism disruption"],"prefix":"10.1016","volume":"512","author":[{"given":"Yi-jie","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-ru","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-qi","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-zhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117859_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111350","article-title":"Terpenoids from Curcumae Rhizoma: their anticancer effects and clinical uses on combination and versus drug therapies","volume":"138","author":"Chen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117859_bb0010","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jhep.2022.10.028","article-title":"Hepatocyte-specific mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice","volume":"78","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2026.117859_bb0015","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jhep.2017.06.001","article-title":"Hepatic stellate cell activation and pro-fibrogenic signals","volume":"67","author":"Gandhi","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2026.117859_bb0020","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jhep.2020.04.044","article-title":"Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis","volume":"73","author":"Gao","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2026.117859_bb0025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jhep.2019.08.026","article-title":"Autophagy in hepatic adaptation to stress","volume":"72","author":"Hazari","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2026.117859_bb0030","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1053\/j.gastro.2011.12.044","article-title":"Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues","volume":"142","author":"Hern\u00e1ndez-Gea","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2026.117859_bb0035","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.cmet.2024.05.003","article-title":"Metabolic reprogramming in liver fibrosis","volume":"36","author":"Horn","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2026.117859_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108117","article-title":"The regulatory role and mechanism of autophagy in energy metabolism-related hepatic fibrosis","volume":"234","author":"Hou","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2026.117859_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173424","article-title":"Curcumin reduces methionine adenosyltransferase 2B expression by interrupting phosphorylation of p38 MAPK in hepatic stellate cells","volume":"886","author":"Hu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2026.117859_bb0050","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/HEP.0000000000001133","article-title":"The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis","volume":"82","author":"Kim","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2026.117859_bb0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2026.117859_bb0060","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cmet.2023.01.011","article-title":"Exercise-activated hepatic autophagy via the FN1-\u03b15\u03b21 integrin pathway drives metabolic benefits of exercise","volume":"35","author":"Kuramoto","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2026.117859_bb0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41420-025-02367-2","article-title":"Discoidin domain receptor inhibitor DDR1-IN-1 induces autophagy and necroptotic cell death in malignant peripheral nerve sheath tumor","volume":"11","author":"Lai","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.taap.2026.117859_bb0070","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1042\/CS20180177","article-title":"HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis","volume":"132","author":"Li","year":"2018","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.taap.2026.117859_bb0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-020-00349-7","article-title":"Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.117859_bb0080","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3390\/ph18030287","article-title":"Micheliolide alleviates hepatic fibrosis by inhibiting autophagy in hepatic stellate cells via the TrxR1\/2-mediated ROS\/MEK\/ERK pathway","volume":"18","author":"Liu","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.taap.2026.117859_bb0085","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1053\/gast.2003.50151","article-title":"Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma","volume":"124","author":"Mart\u00ednez-Chantar","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2026.117859_bb0090","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/hep.21650","article-title":"Role of S-adenosyl-L-methionine in liver health and injury","volume":"45","author":"Mato","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2026.117859_bb0095","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/j.ejmech.2011.07.057","article-title":"Natural products: an evolving role in future drug discovery","volume":"46","author":"Mishra","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2026.117859_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12891","article-title":"S-adenosylmethionine: a metabolite critical to the regulation of autophagy","volume":"53","author":"Ouyang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.taap.2026.117859_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100973","article-title":"Autophagy in liver diseases: a review","volume":"82","author":"Qian","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.taap.2026.117859_bb0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.livres.2017.07.002","article-title":"Methionine adenosyltransferases in liver health and diseases","volume":"1","author":"Ramani","year":"2017","journal-title":"Liver. Res."},{"key":"10.1016\/j.taap.2026.117859_bb0115","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/hep.23411","article-title":"Changes in the expression of methionine Adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation","volume":"51","author":"Ramani","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2026.117859_bb0120","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/jcp.24839","article-title":"Role of methionine adenosyltransferase \u03b12 and \u03b2 phosphorylation and stabilization in human hepatic stellate cell trans-differentiation","volume":"230","author":"Ramani","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2026.117859_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101322","article-title":"Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling","volume":"28","author":"Shen","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2026.117859_bb0130","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1002\/ptr.7483","article-title":"Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells","volume":"36","author":"Sun","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2026.117859_bb0135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2013.06.041","article-title":"Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A","volume":"154","author":"Sutter","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.taap.2026.117859_bb0140","article-title":"Upregulation of ATG9b by propranolol promotes autophagic cell death of hepatic stellate cells to improve liver fibrosis","volume":"28","author":"Wang","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2026.117859_bb0145","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.7150\/ijbs.34716","article-title":"Curcumol: from plant roots to Cancer roots","volume":"15","author":"Wei","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2026.117859_bb0150","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1080\/15384101.2020.1814044","article-title":"Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37","volume":"19","author":"Xin","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.taap.2026.117859_bb0155","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.7150\/thno.106597","article-title":"Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions","volume":"15","author":"Yan","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.taap.2026.117859_bb0160","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ncb0910-814","article-title":"Eaten alive: a history of macroautophagy","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2026.117859_bb0165","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1038\/s41467-024-52527-8","article-title":"The role of forkhead box M1-methionine adenosyltransferase 2a\/2B axis in liver inflammation and fibrosis","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2026.117859_bb0170","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200933RR","article-title":"Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells","volume":"36","author":"Zheng","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2026.117859_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154721","article-title":"Small-molecule natural plants for reversing liver fibrosis based on modulation of hepatic stellate cells activation: an update","volume":"113","author":"Zheng","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117859_bb0180","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/path.5536","article-title":"C-Jun acts downstream of PI3K\/AKT signaling to mediate the effect of leptin on methionine adenosyltransferase 2B in hepatic stellate cells in vitro and in vivo","volume":"252","author":"Zhu","year":"2020","journal-title":"J. Pathol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:39:48Z","timestamp":1784767188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"alternative-id":["S0041008X26001559"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117859","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumol induces autophagy-dependent hepatic stellate cell death through methionine metabolism disruption","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117859"}}