{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:24:52Z","timestamp":1793917492764,"version":"4.8.0"},"update-to":[{"DOI":"10.1016\/j.taap.2026.117864","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}}],"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.taap.2026.117864","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:21:58Z","timestamp":1778628118000},"page":"117864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["RETRACTED: Paroxetine attenuates doxorubicin-induced cardiotoxicity: Integrated network pharmacology, molecular modeling, and in vivo evidence consistent with modulation of GRK2\/iNOS-related pathways"],"prefix":"10.1016","volume":"513","author":[{"given":"Mahmoud","family":"Nabil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Abdel-Ghany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader E.","family":"Abo-Dya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud H.","family":"Elbatreek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117864_bb0005","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00280-017-3413-7","article-title":"Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis","volume":"80","author":"Abdel-Daim","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0010","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12012-021-09644-3","article-title":"Chia seed oil ameliorates doxorubicin-induced cardiotoxicity in female wistar rats: an electrocardiographic, biochemical and histopathological approach","volume":"21","author":"Ahmed","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.taap.2026.117864_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417270","article-title":"Cardioprotective effects of the GRK2 inhibitor paroxetine on isoproterenol-induced cardiac Remodeling by modulating NF-\u03baB mediated Prohypertrophic and Profibrotic gene expression","author":"Alonazi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117864_bb0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s40360-024-00824-9","article-title":"Potential cardioprotective effect of paroxetine against ventricular remodeling in an animal model of myocardial infarction: a comparative study","volume":"25","author":"Alonazi","year":"2024","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2026.117864_bb0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coemr.2020.09.004","article-title":"ScienceDirect G protein \u2013 coupled receptor kinase 2 at crossroads of metabolic and cardiovascular diseases","volume":"16","author":"Arcones","year":"2021","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"10.1016\/j.taap.2026.117864_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD014638.pub2","article-title":"Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines","author":"de Baat","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.taap.2026.117864_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176507","article-title":"Inhibition of both NOX and TNF-\u03b1 exerts substantial renoprotective effects in renal ischemia reperfusion injury rat model","volume":"970","author":"Bayoumi","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0040","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3390\/cells10020457","article-title":"Why do we not assess sympathetic nervous system activity in heart failure management: might GRK2 serve as a new biomarker?","volume":"10","author":"Bencivenga","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.taap.2026.117864_bb0045","article-title":"Anti-proliferative effects of paroxetine alone or in combination with sorafenib in HepG2 cells","volume":"58","author":"Cakil","year":"2022","journal-title":"Brazilian J. Pharm. Sci."},{"key":"10.1016\/j.taap.2026.117864_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113903","article-title":"Biomedicine & Pharmacotherapy Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy","volume":"156","author":"Chen","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117864_bb0055","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/934239","article-title":"Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats","volume":"2013","author":"Chennuru","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.taap.2026.117864_bb0060","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/ehf2.12706","article-title":"Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure","volume":"7","author":"Ciccarelli","year":"2020","journal-title":"ESC Hear. Fail."},{"key":"10.1016\/j.taap.2026.117864_bb0065","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00210-023-02382-z","article-title":"Doxorubicin-induced acute cardiotoxicity is associated with increased oxidative stress, autophagy, and inflammation in a murine model","volume":"396","author":"Dulf","year":"2023","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0070","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1007\/s10787-023-01285-y","article-title":"Thymus satureioides Coss. Combats oral ulcer via inhibition of inflammation, proteolysis, and apoptosis","volume":"31","author":"Elbatreek","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.taap.2026.117864_bb0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.etap.2017.12.020","article-title":"Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats","volume":"58","author":"El-kashef","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cbi.2018.05.015","article-title":"Venlafaxine mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats","volume":"290","author":"El-Kashef","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2026.117864_bb0085","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1139\/cjpp-2016-0115","article-title":"Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats","volume":"94","author":"Elshazly","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0090","first-page":"310","article-title":"Paroxetine-induced Ca2+ movement and death in OC2 human oral cancer cells","volume":"54","author":"Fang","year":"2011","journal-title":"Chin. J. Physiol"},{"key":"10.1016\/j.taap.2026.117864_bb0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yjmcc.2018.05.103","article-title":"GRK2 is a novel early marker of cardiotoxicity in response to doxorubicin","volume":"120","author":"Gambardella","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2026.117864_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1133423","article-title":"The beneficial role of exercise in preventing doxorubicin-induced cardiotoxicity","volume":"14","author":"Gaytan","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2026.117864_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ph18050681","article-title":"Doxorubicin-induced cardiotoxicity and the emerging role of SGLT2 inhibitors: from Glycemic control to cardio-oncology","author":"Goje","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.taap.2026.117864_bb0110","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3390\/cancers16050885","article-title":"Inhibition of TNBC cell growth by paroxetine: induction of apoptosis and blockage of autophagy flux","volume":"16","author":"Huang","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.taap.2026.117864_bb0115","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1080\/15548627.2015.1038016","article-title":"Identifying an essential role of nuclear LC3 for autophagy","volume":"11","author":"Huang","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2026.117864_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118315","article-title":"Cardioprotective strategies against doxorubicin-induced cardiotoxicity: a review from standard therapies to emerging mitochondrial transplantation","volume":"189","author":"Ito-Hagiwara","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117864_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117261","article-title":"Inhibition of GRK2 reduced doxorubicin-induced oxidative stress and apoptosis through upregulating ADH1","volume":"497","author":"Jiang","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00441-018-02987-4","article-title":"Nitric oxide signalling and antidepressant action revisited","volume":"377","author":"Joca","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.taap.2026.117864_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101394","article-title":"Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: have we been barking up the wrong tree?","volume":"29","author":"Kalyanaraman","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2026.117864_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112411","article-title":"Paroxetine mitigates cardiac remodelling by doxorubicin and increases survival","volume":"145","author":"Kosi\u0107","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117864_bb0145","doi-asserted-by":"crossref","first-page":"22","DOI":"10.31393\/morphology-journal-2020-26(4)-04","article-title":"Dynamics of morphological changes in the heart of rats after serial systemic administration of doxorubicin","volume":"26","author":"Kostiuk","year":"2020","journal-title":"Reports Morphol."},{"key":"10.1016\/j.taap.2026.117864_bb0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u00a0\u2212\u00a0\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.taap.2026.117864_bb0155","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"ESC scientific document group. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European society for therapeutic radiology and oncology (ESTRO) and the international cardio-oncology soci","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Hear. J"},{"key":"10.1016\/j.taap.2026.117864_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1322181","article-title":"Casuarina glauca branchlets' extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies","volume":"14","author":"Mohamed","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00395-024-01078-6","article-title":"Cardioprotection strategies for anthracycline cardiotoxicity","volume":"120","author":"Moreno-Arciniegas","year":"2025","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.taap.2026.117864_bb0170","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/jphp.12073","article-title":"Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts","volume":"65","author":"Nayak","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0175","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ddr.20339","article-title":"Effect of the antidepressant paroxetine on Ca2+ movement in PC3 human prostate cancer cells","volume":"71","author":"Pan","year":"2010","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.taap.2026.117864_bb0180","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ijc.33965","article-title":"Repurposing autophagy regulators in brain tumors","volume":"151","author":"Petrosyan","year":"2022","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2026.117864_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1242596","article-title":"Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention","volume":"10","author":"Qiu","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.taap.2026.117864_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117864_bb0195","first-page":"279","article-title":"Strain analysis in the assessment of a mouse model of cardiotoxicity due to chemotherapy: sample for preclinical research","volume":"30","author":"Rea","year":"2016","journal-title":"In Vivo"},{"key":"10.1016\/j.taap.2026.117864_bb0200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","article-title":"Molecular mechanism of doxorubicin-induced cardiomyopathy \u2013 an update","volume":"818","author":"Renu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0205","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00204-022-03262-w","article-title":"Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation","volume":"96","author":"Sangweni","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2026.117864_bb0210","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.yjmcc.2015.10.002","article-title":"Journal of molecular and cellular cardiology GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels","volume":"89","author":"Sato","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2026.117864_bb0215","series-title":"Restricting Mitochondrial GRK2 Post-Ischemia Confers Cardioprotection by Reducing Myocyte Death and Maintaining Glucose Oxidation 1\u201310","author":"Sato","year":"2018"},{"key":"10.1016\/j.taap.2026.117864_bb0220","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.lfs.2018.09.046","article-title":"Paroxetine and rivastigmine mitigates adjuvant-induced rheumatoid arthritis in rats: impact on oxidative stress, apoptosis and RANKL\/OPG signals","volume":"212","author":"Shafiey","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2026.117864_bb0225","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12012-022-09721-1","article-title":"Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches","volume":"22","author":"Sheibani","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.taap.2026.117864_bb0230","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.drudis.2021.10.019","article-title":"Repurposing antidepressants for anticancer drug discovery","volume":"27","author":"Song","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.taap.2026.117864_bb0235","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1001\/jama.1991.03470120074036","article-title":"Cardiac toxicity 4 to 20\u00a0years after completing anthracycline therapy","volume":"266","author":"Steinherz","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.taap.2026.117864_bb0240","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016364","article-title":"Paroxetine attenuates cardiac hypertrophy via blocking GRK2 and ADRB1 interaction in hypertension","volume":"10","author":"Sun","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.taap.2026.117864_bb0245","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1161\/CIRCULATIONAHA.117.032821","article-title":"Beclin-1-dependent autophagy protects the heart during sepsis","volume":"138","author":"Sun","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2026.117864_bb0250","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s12012-025-10030-6","article-title":"Statins: novel approaches for the Management of Doxorubicin-Induced Cardiotoxicity-a Literature Review","volume":"25","author":"TamehriZadeh","year":"2025","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.taap.2026.117864_bb0255","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.semcancer.2025.01.004","article-title":"The dual function of autophagy in doxorubicin-induced cardiotoxicity: mechanism and natural products","volume":"109","author":"Tan","year":"2025","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.taap.2026.117864_bb0260","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1021\/cb3003013","article-title":"Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility","volume":"7","author":"Thal","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.taap.2026.117864_bb0265","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jaccao.2024.02.004","article-title":"Dexrazoxane to prevent cardiotoxicity in adults treated with anthracyclines","volume":"6","author":"Upshaw","year":"2024","journal-title":"JACC CardioOncol."},{"key":"10.1016\/j.taap.2026.117864_bb0270","first-page":"13","article-title":"Sesamol: a treatment for diabetes-associated blood-brain barrier dysfunction","volume":"2","author":"VanGilder","year":"2014","journal-title":"Postdoc J. A J. Postdr. Res. Postdr. Aff."},{"key":"10.1016\/j.taap.2026.117864_bb0275","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fcell.2019.00397","article-title":"Blockage of autophagic flux and induction of mitochondria fragmentation by paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway","volume":"7","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2026.117864_bb0280","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2337\/db12-1530","article-title":"Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes","volume":"62","author":"Wheatcroft","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2026.117864_bb0285","first-page":"2165","article-title":"The true colors of autophagy in doxorubicin-induced cardiotoxicity (review)","volume":"18","author":"Xiao","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.taap.2026.117864_bb0290","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1124\/jpet.111.189589","article-title":"Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy","volume":"341","author":"Xu","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2026.117864_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117844","article-title":"Interleukin-9 aggravates doxorubicin-induced cardiotoxicity by promoting inflammation and apoptosis in mice","volume":"255","author":"Ye","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2026.117864_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2022.929302","article-title":"Danhong injection attenuates doxorubicin-induced cardiotoxicity in rats via suppression of apoptosis: network pharmacology analysis and experimental validation","volume":"13","author":"Yi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2026.117864_bb0305","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13020-024-01056-z","article-title":"Network pharmacology: a crucial approach in traditional Chinese medicine research","volume":"20","author":"Zhai","year":"2025","journal-title":"Chin. Med."},{"key":"10.1016\/j.taap.2026.117864_bb0310","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41418-019-0372-z","article-title":"FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.taap.2026.117864_bb0315","doi-asserted-by":"crossref","first-page":"44735","DOI":"10.1038\/srep44735","article-title":"Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2026.117864_bb0320","first-page":"558","article-title":"Network pharmacology for traditional Chinese medicine in era of artificial intelligence","volume":"16","author":"Zhao","year":"2024","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.taap.2026.117864_bb0325","first-page":"29","article-title":"Dexrazoxane makes doxorubicin-induced heart failure a rare event in sarcoma patients receiving high cumulative doses","volume":"11","author":"Zheng","year":"2025","journal-title":"Cardio-Oncol. (London, England)"}],"updated-by":[{"DOI":"10.1016\/j.taap.2026.117864","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}},{"DOI":"10.1016\/j.taap.2026.118032","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000}},{"DOI":"10.1016\/j.taap.2026.118032","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000}}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:01:16Z","timestamp":1788235276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":65,"alternative-id":["S0041008X26001602"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117864","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Paroxetine attenuates doxorubicin-induced cardiotoxicity: Integrated network pharmacology, molecular modeling, and in vivo evidence consistent with modulation of GRK2\/iNOS-related pathways","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117864"}}