{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:44:05Z","timestamp":1792086245753,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["BYKY2024005"],"award-info":[{"award-number":["BYKY2024005"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.taap.2026.117870","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:50:36Z","timestamp":1778712636000},"page":"117870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Irisin alleviates ferroptosis in LPS-induced acute kidney injury via regulating FGL2"],"prefix":"10.1016","volume":"513","author":[{"given":"Supei","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.taap.2026.117870_bb0005","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.14202\/vetworld.2020.2191-2196","article-title":"The optimal therapeutic irisin dose intervention in animal model: A systematic review","volume":"13","author":"Alzoughool","year":"2020","journal-title":"Vet. World"},{"issue":"4","key":"10.1016\/j.taap.2026.117870_bb0010","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.chembiol.2020.03.016","article-title":"Ferroptosis and necroptosis in the kidney","volume":"27","author":"Belavgeni","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.taap.2026.117870_bib167","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2018.10.019","article-title":"Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress","volume":"20","author":"Bi","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2026.117870_bb0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1479-5876-9-51","article-title":"Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction","volume":"9","author":"Chen","year":"2011","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.taap.2026.117870_bb0020","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.tcb.2022.03.012","article-title":"The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development","volume":"32","author":"Doke","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.taap.2026.117870_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109799","article-title":"Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target","volume":"116","author":"Fu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2026.117870_bb0030","first-page":"1","article-title":"Emerging role of ferroptosis in acute kidney injury","volume":"2019","author":"Hu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.taap.2026.117870_bib166","doi-asserted-by":"crossref","first-page":"109452","DOI":"10.1016\/j.biopha.2019.109452","article-title":"Neuroprotective effects of irisin against cerebral ischemia\/reperfusion injury via Notch signaling pathway","volume":"120","author":"Jin","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.taap.2026.117870_bb0035","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s00134-017-4832-y","article-title":"Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017: expert opinion of the working group on prevention, AKI section, European Society of Intensive Care Medicine","volume":"43","author":"Joannidis","year":"2017","journal-title":"Intensive Care Med."},{"issue":"21","key":"10.1016\/j.taap.2026.117870_bb0040","doi-asserted-by":"crossref","first-page":"14764","DOI":"10.1021\/acs.jmedchem.2c01276","article-title":"First-in-class dual mechanism ferroptosis-HDAC inhibitor hybrids","volume":"65","author":"Karaj","year":"2022","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.taap.2026.117870_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.taap.2026.117870_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.796724","article-title":"The programmed cell death of macrophages, endothelial cells, and tubular epithelial cells in sepsis-AKI","volume":"8","author":"Li","year":"2021","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.taap.2026.117870_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41420-022-00859-z","article-title":"Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.117870_bb0060","article-title":"The role of irisin in kidney diseases","author":"Li","year":"2024","journal-title":"Clin. Chim. Acta"},{"issue":"17","key":"10.1016\/j.taap.2026.117870_bb0065","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.7150\/thno.115661","article-title":"The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma","volume":"15","author":"Liu","year":"2025","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.taap.2026.117870_bb0070","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/cbin.11198","article-title":"MAPK-mediated upregulation of fibrinogen-like protein 2 promotes proliferation, migration, and invasion of colorectal cancer cells","volume":"43","author":"Liu","year":"2019","journal-title":"Cell Biol. Int."},{"issue":"2","key":"10.1016\/j.taap.2026.117870_bb0075","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.kint.2021.10.028","article-title":"Dephosphorylation of AMP-activated protein kinase exacerbates ischemia\/reperfusion-induced acute kidney injury via mitochondrial dysfunction","volume":"101","author":"Ma","year":"2022","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.taap.2026.117870_bb0080","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2015121376","article-title":"Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid\u2013induced AKI","volume":"28","author":"Martin-Sanchez","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"9","key":"10.1016\/j.taap.2026.117870_bb0085","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/biom9090394","article-title":"Superiority of the non-glycosylated form over the glycosylated form of irisin in the attenuation of adipocytic meta-inflammation: A potential factor in the fight against insulin resistance","volume":"9","author":"Mazur-Bialy","year":"2019","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.taap.2026.117870_bb0090","first-page":"88","article-title":"The time-course of antioxidant irisin activity: role of the Nrf2\/HO-1\/HMGB1 axis","volume":"10","author":"Mazur-Bialy","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"2","key":"10.1016\/j.taap.2026.117870_bib170","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41419-022-04628-9","article-title":"Targeting ferroptosis in acute kidney injury","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.117870_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5537330","article-title":"Ferroptosis in different pathological contexts seen through the eyes of mitochondria","volume":"2021","author":"Otasevic","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.taap.2026.117870_bb0100","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.3390\/ijms25115924","article-title":"Acute kidney injury in sepsis","volume":"25","author":"Pais","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117870_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.k4891","article-title":"Sepsis associated acute kidney injury","author":"Poston","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.taap.2026.117870_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.857067","article-title":"Post-treatment with irisin attenuates acute kidney injury in sepsis mice through anti-ferroptosis via the SIRT1\/Nrf2 pathway","volume":"13","author":"Qiongyue","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2026.117870_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1106529","article-title":"Irisin: an anti-inflammatory exerkine in aging and redox-mediated comorbidities","volume":"14","author":"Trettel","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.taap.2026.117870_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41581-019-0197-5","article-title":"The multifaceted role of iron in renal health and disease","volume":"16","author":"Van Swelm","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.taap.2026.117870_bib168","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/FJC.0000000000000608","article-title":"Irisin protects heart against ischemia-reperfusion injury through a SOD2-dependent mitochondria mechanism","volume":"72","author":"Wang","year":"2018","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.taap.2026.117870_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110468","article-title":"Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization","volume":"130","author":"Wu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117870_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113199","article-title":"Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism","volume":"152","author":"Xiong","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117870_bb0135","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cca.2020.07.022","article-title":"Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis","volume":"510","author":"Yang","year":"2020","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"issue":"12","key":"10.1016\/j.taap.2026.117870_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202408845","article-title":"Lactylation of HDAC1 confers resistance to ferroptosis in colorectal cancer","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.taap.2026.117870_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2393262","article-title":"Mitochondrial dysfunction in acute kidney injury","volume":"46","author":"Yao","year":"2024","journal-title":"Ren. Fail."},{"issue":"1","key":"10.1016\/j.taap.2026.117870_bb0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/ndt\/gfad142","article-title":"Sepsis-associated acute kidney injury\u2014treatment standard","volume":"39","author":"Zarbock","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"23","key":"10.1016\/j.taap.2026.117870_bb0155","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1158\/1078-0432.CCR-24-0796","article-title":"Combinations of HDAC inhibitor and PPAR agonist induce ferroptosis of leukemic stem cell-like cells in acute myeloid leukemia","volume":"30","author":"Zhou","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.taap.2026.117870_bib169","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcp.29903","article-title":"Involvement of GPX4 in irisin\u2019s protection against ischemia reperfusion-induced acute kidney injury","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell Physiol."},{"issue":"11","key":"10.1016\/j.taap.2026.117870_bb0160","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax0629","article-title":"Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5","volume":"5","author":"Zhou","year":"2019","journal-title":"Sci. Adv."},{"issue":"13","key":"10.1016\/j.taap.2026.117870_bb0165","first-page":"1467","article-title":"Role of Fgl2 in macrophage polarization during acute kidney injury in mice","volume":"46","author":"Zhu","year":"2024","journal-title":"J. Army Med. Univ."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26001663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:03:13Z","timestamp":1788235393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":38,"alternative-id":["S0041008X26001663"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117870","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Irisin alleviates ferroptosis in LPS-induced acute kidney injury via regulating FGL2","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117870"}}