{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:45:40Z","timestamp":1785876340522,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2308085MH299"],"award-info":[{"award-number":["2308085MH299"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015016","name":"State Key Laboratory of Tea Plant Biology and Utilization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.taap.2026.117907","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:05:42Z","timestamp":1781049942000},"page":"117907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Matrine ameliorated myocardial ischemia-reperfusion injury through lipid accumulation reduction by activating JAK2-STAT3-CPT1 signaling pathway"],"prefix":"10.1016","volume":"514","author":[{"given":"Mengyan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuncan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.taap.2026.117907_bb0005","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","article-title":"Myocardial ischemia-reperfusion injury and the influence of inflammation","volume":"33","author":"Algoet","year":"2023","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.taap.2026.117907_bb0010","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41569-021-00536-1","article-title":"Ceramides and other sphingolipids as drivers of cardiovascular disease","volume":"18","author":"Choi","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"12","key":"10.1016\/j.taap.2026.117907_bb0015","first-page":"795","article-title":"Metabolic reprogramming unlocks the regenerative potential of the heart","volume":"20","author":"Fern\u00e1ndez-Ruiz","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"22","key":"10.1016\/j.taap.2026.117907_bb0020","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1161\/CIRCULATIONAHA.124.072194","article-title":"XBP1s-EDEM2 prevents the onset and development of HFpEF by ameliorating cardiac lipotoxicity","volume":"151","author":"Fonseka","year":"2025","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.taap.2026.117907_bb0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0163-7827(01)00014-5","article-title":"Alterations in myocardial lipid metabolism during myocardial ischemia and reperfusion","volume":"41","author":"Ford","year":"2002","journal-title":"Prog. Lipid Res."},{"issue":"3","key":"10.1016\/j.taap.2026.117907_bb0030","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0008-6363(99)00239-4","article-title":"The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice","volume":"44","author":"Hayek","year":"1999","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.taap.2026.117907_bb0035","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.apsb.2019.03.003","article-title":"Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPK\u03b1\/UCP2 pathway","volume":"9","author":"Hu","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.taap.2026.117907_bb0040","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jacbts.2024.12.008","article-title":"Metabolic adaptations and therapies in cardiac hypoxia: mechanisms and clinical implications\/potential strategies","volume":"10","author":"Li","year":"2025","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.taap.2026.117907_bb0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/DDDT.S349678","article-title":"Matrine exerts pharmacological effects through multiple signaling pathways: a comprehensive review","volume":"16","author":"Lin","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.taap.2026.117907_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156389","article-title":"Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2\/SIRT3 signaling pathway","volume":"138","author":"Lu","year":"2025","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.taap.2026.117907_bb0055","article-title":"American Heart Association Council on epidemiology and prevention statistics committee and stroke statistics committee. Heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.taap.2026.117907_bb0060","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0735-1097(91)90852-Z","article-title":"Immediate and short-term cardiovascular effects of fosinopril, a new angiotensin-converting enzyme inhibitor, in patients with essential hypertension","volume":"17","author":"Oren","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.taap.2026.117907_bb0065","first-page":"1","article-title":"Mitochondrial Oxidative Stress, Calcium and Dynamics in Cardiac Ischaemia-Reperfusion Injury","author":"Rozich","year":"2025","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.taap.2026.117907_bb0070","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ccell.2020.06.007","article-title":"IL6\/STAT3 Signaling hijacks Estrogen receptor \u03b1 enhancers to drive breast Cancer metastasis","volume":"38","author":"Siersb\u00e6k","year":"2020","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.taap.2026.117907_bb0075","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.cdd.4400656","article-title":"Opposing actions of STAT-1 and STAT3 on the Bcl-2 and Bcl-x promoters","volume":"7","author":"Stephanou","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.taap.2026.117907_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.981766","article-title":"Xin-Ji-Er-Kang protects heart from ischemia-reperfusion injury by rebalancing lipid metabolism","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.taap.2026.117907_bb0085","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1161\/HYPERTENSIONAHA.123.20481","article-title":"Hypertension-driven regulatory T-cell perturbations accelerate myocardial ischemia-reperfusion injury","volume":"80","author":"Sun","year":"2023","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.taap.2026.117907_bb0090","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s12967-023-04715-1","article-title":"WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis","volume":"21","author":"Tai","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.taap.2026.117907_bb0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cmet.2017.11.001","article-title":"JAK\/STAT3-regulated fatty acid \u03b2-oxidation is critical for breast cancer stem cell self-renewal and chemoresistance","volume":"27","author":"Wang","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2026.117907_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177153","article-title":"Potential diagnostic biomarkers in heart failure: suppressed immune-associated genes identified by bioinformatic analysis and machine learning","volume":"986","author":"Wang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.taap.2026.117907_bb0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/jcdd10020079","article-title":"Expression pattern and molecular mechanism of oxidative stress-related genes in myocardial ischemia-reperfusion injury","volume":"10","author":"Wu","year":"2023","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"1","key":"10.1016\/j.taap.2026.117907_bb0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s11658-025-00766-y","article-title":"Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis","volume":"30","author":"Xu","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.taap.2026.117907_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1558484","article-title":"Immune in myocardial ischemia\/reperfusion injury: potential mechanisms and therapeutic strategies","volume":"16","author":"Xuan","year":"2025","journal-title":"Front. Immunol."},{"issue":"22","key":"10.1016\/j.taap.2026.117907_bb0120","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1158\/0008-5472.CAN-21-0646","article-title":"Oxidized low-density lipoprotein links hypercholesterolemia and bladder Cancer aggressiveness by promoting Cancer stemness","volume":"81","author":"Yang","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.taap.2026.117907_bb0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cmet.2023.12.003","article-title":"Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer","volume":"36","author":"Zhang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2026.117907_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155649","article-title":"The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.taap.2026.117907_bb0135","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1038\/s41467-025-61875-y","article-title":"Inhibiting CD36 palmitoylation improves cardiac function post-infarction by regulating lipid metabolic homeostasis and autophagy","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.taap.2026.117907_bb0140","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00019501-200608000-00010","article-title":"Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion","volume":"17","author":"Zhao","year":"2006","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.taap.2026.117907_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114024","article-title":"Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3\/CPT1 pathway","volume":"157","author":"Zheng","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2026.117907_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113792","article-title":"Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury","volume":"155","author":"Zhou","year":"2022","journal-title":"Biomed. Pharmacother."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:56:47Z","timestamp":1785873407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26002036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S0041008X26002036"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117907","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrine ameliorated myocardial ischemia-reperfusion injury through lipid accumulation reduction by activating JAK2-STAT3-CPT1 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117907"}}