{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:53:08Z","timestamp":1785912788595,"version":"3.56.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.taap.2026.117925","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:28:59Z","timestamp":1782257339000},"page":"117925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Asiaticoside alleviates metabolic associated fatty liver disease via PI3K\/AKT\/mTOR signaling pathway"],"prefix":"10.1016","volume":"514","author":[{"given":"Manman","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.taap.2026.117925_bb0005","doi-asserted-by":"crossref","DOI":"10.1177\/03000605251370323","article-title":"Total cholesterol\/high-density lipoprotein cholesterol ratio is a significant predictor of metabolic syndrome among people on dolutegravir-based antiretroviral therapy: a cross-sectional study in southwestern Uganda","volume":"53","author":"Bagenda","year":"2025","journal-title":"J. Int. Med. Res."},{"issue":"3","key":"10.1016\/j.taap.2026.117925_bb0010","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/MOL.0b013e328352dd03","article-title":"Connecting mTORC1 signaling to SREBP-1 activation","volume":"23","author":"Bakan","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"issue":"5","key":"10.1016\/j.taap.2026.117925_bb0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/jcmm.17635","article-title":"Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: a review","volume":"27","author":"Bandopadhyay","year":"2023","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"10.1016\/j.taap.2026.117925_bb0020","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hep4.1041","article-title":"Hepatic natural killer T-cell and CD8+ T-cell signatures in mice with nonalcoholic steatohepatitis","volume":"1","author":"Bhattacharjee","year":"2017","journal-title":"Hepatol. Commun."},{"issue":"42","key":"10.1016\/j.taap.2026.117925_bb0025","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.3748\/wjg.v16.i42.5286","article-title":"Histopathology of nonalcoholic fatty liver disease","volume":"16","author":"Brunt","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2026.117925_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117371","article-title":"Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia\/reperfusion injury by directing mitochondrial quality control via the VDAC1-beta-tubulin signaling axis","volume":"320","author":"Chang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.taap.2026.117925_bb0035","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-0032-1306423","article-title":"Dyslipidemia in patients with nonalcoholic fatty liver disease","volume":"32","author":"Chatrath","year":"2012","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2026.117925_bb0040","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1038\/srep12333","article-title":"Yindanxinnaotong, a Chinese compound medicine, synergistically attenuates atherosclerosis progress","volume":"5","author":"Cheng","year":"2015","journal-title":"Sci. Rep."},{"issue":"18","key":"10.1016\/j.taap.2026.117925_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101034","article-title":"Apolipoprotein A4 restricts diet-induced hepatic steatosis via SREBF1-mediated lipogenesis and enhances IRS-PI3K-Akt signaling","volume":"66","author":"Cheng","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.taap.2026.117925_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113634","article-title":"Scutellariae Radix and Coptidis Rhizoma improve glucose and lipid metabolism in T2DM rats via regulation of the metabolic profiling and MAPK\/PI3K\/Akt signaling pathway","volume":"19","author":"Cui","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"7170","key":"10.1016\/j.taap.2026.117925_bb0055","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"Cunningham","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0060","first-page":"215","article-title":"Mitochondrial alterations in nonalcoholic fatty liver disease. Pediatric case description of three submitted sequential biopsies","volume":"18","author":"Da Silva","year":"2009","journal-title":"J. Gastrointestin. Liver Dis."},{"issue":"9","key":"10.1016\/j.taap.2026.117925_bb0065","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.cmet.2024.07.024","article-title":"Mitochondrial membrane lipids in the regulation of bioenergetic flux","volume":"36","author":"Decker","year":"2024","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/metabo2020303","article-title":"A historical overview of natural products in drug discovery","volume":"2","author":"Dias","year":"2012","journal-title":"Metabolites"},{"issue":"Pt 3","key":"10.1016\/j.taap.2026.117925_bb0075","article-title":"A new target for curcumin in the treatment of non-alcoholic fatty liver disease: the FTO protein","volume":"319","author":"Fan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.taap.2026.117925_bb0080","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/ptr.5404","article-title":"Asiaticoside inhibits TNF-alpha-induced endothelial hyperpermeability of human aortic endothelial cells","volume":"29","author":"Fong","year":"2015","journal-title":"Phytother. Res."},{"issue":"7","key":"10.1016\/j.taap.2026.117925_bb0085","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0090","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2026.117925_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.771459","article-title":"The potential application of Chinese medicine in liver diseases: a new opportunity","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.taap.2026.117925_bb0100","article-title":"Effects of dietary inclusion of Asiaticoside on growth performance, lipid metabolism, and gut microbiota in yellow-feathered chickens","volume":"13","author":"Fu","year":"2023","journal-title":"Animals (Basel)"},{"issue":"3","key":"10.1016\/j.taap.2026.117925_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165621","article-title":"Protective effect of metformin against palmitate-induced hepatic cell death","volume":"1866","author":"Geng","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.taap.2026.117925_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155921","article-title":"Asiaticoside modulates human NK cell functional fate by mediating metabolic flexibility in the tumor microenvironment","volume":"133","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.taap.2026.117925_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18889","article-title":"A herb mixture to ameliorate non-alcoholic fatty liver in rats fed a high-fat diet","volume":"9","author":"Ha","year":"2023","journal-title":"Heliyon"},{"issue":"Pt A","key":"10.1016\/j.taap.2026.117925_bb0120","article-title":"A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb","volume":"302","author":"He","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2026.117925_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155494","article-title":"Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation","volume":"127","author":"He","year":"2024","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.taap.2026.117925_bb0130","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.taap.2026.117925_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.716783","article-title":"Dietary interventions in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"8","author":"Houttu","year":"2021","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.taap.2026.117925_bb0140","doi-asserted-by":"crossref","DOI":"10.1080\/01443615.2024.2350761","article-title":"Effects of asiaticoside on the model of gestational diabetes mellitus in HTR-8\/svneo cells via PI3K\/AKT pathway","volume":"44","author":"Hu","year":"2024","journal-title":"J. Obstet. Gynaecol."},{"issue":"4","key":"10.1016\/j.taap.2026.117925_bb0145","article-title":"Cisd2 protects the liver from oxidative stress and ameliorates Western diet-induced nonalcoholic fatty liver disease","volume":"10","author":"Huang","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"18","key":"10.1016\/j.taap.2026.117925_bb0150","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.taap.2026.117925_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.22242","article-title":"Asiaticoside enhances the effect of propofol on the invasion, ferroptosis and immune escape of bladder cancer","volume":"85","author":"Jin","year":"2024","journal-title":"Drug Dev. Res."},{"issue":"4","key":"10.1016\/j.taap.2026.117925_bb0160","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00535-013-0758-5","article-title":"Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease","volume":"48","author":"Kawano","year":"2013","journal-title":"J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.taap.2026.117925_bb0165","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2026.117925_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157197","article-title":"Baicalin ameliorates high-fat diet induced MAFLD by inhibiting ERK\/PPARgamma\/CD36 pathway","volume":"147","author":"Lei","year":"2025","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0175","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.taap.2026.117925_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102187","article-title":"The sex steroid precursor dehydroepiandrosterone prevents nonalcoholic steatohepatitis by activating the AMPK pathway mediated by GPR30","volume":"48","author":"Li","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2026.117925_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156098","article-title":"The processing mechanism of vinegar-processed Curcumae rhizome enhances anti hepatic fibrotic effects through regulation of PI3K\/Akt\/mTOR signaling pathway","volume":"135","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117925_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156316","article-title":"Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K\/Akt\/mTOR signaling pathway","volume":"136","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.taap.2026.117925_bb0195","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1038\/s41467-018-06931-6","article-title":"Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling","volume":"9","author":"Liang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2026.117925_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144406","article-title":"Hemp seed protein exerts its hypoglycemic and hypolipidemic effects through degradation into short peptides","volume":"484","author":"Liu","year":"2025","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12551-016-0247-1","article-title":"Software for molecular docking: a review","volume":"9","author":"Pagadala","year":"2017","journal-title":"Biophys. Rev."},{"issue":"39","key":"10.1016\/j.taap.2026.117925_bb0210","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.3748\/wjg.v20.i39.14205","article-title":"Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease","volume":"20","author":"Paradies","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0215","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/jpet.123.001639","article-title":"Pharmacology of a potent and novel inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) Inflammasome that attenuates development of nonalcoholic steatohepatitis and liver fibrosis","volume":"386","author":"Povero","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2026.117925_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1563561","article-title":"Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6\/PPARgamma signaling pathway","volume":"16","author":"Qiu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2026.117925_bb0225","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12944-015-0087-1","article-title":"Effect of a high fat, high sucrose diet on the promotion of non-alcoholic fatty liver disease in male rats: the ameliorative role of three natural compounds","volume":"14","author":"Ragab","year":"2015","journal-title":"Lipids Health Dis."},{"issue":"5","key":"10.1016\/j.taap.2026.117925_bb0230","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease","volume":"77","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.taap.2026.117925_bb0235","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1002\/ptr.8238","article-title":"The therapeutic potential of typical plant-derived compounds for the management of metabolic disorders","volume":"38","author":"Roy","year":"2024","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0240","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"169","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.taap.2026.117925_bb0245","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.180147","article-title":"Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression","volume":"8","author":"Sefried","year":"2018","journal-title":"Open Biol."},{"issue":"1","key":"10.1016\/j.taap.2026.117925_bb0250","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12986-023-00748-x","article-title":"Pharmacotherapies of NAFLD: updated opportunities based on metabolic intervention","volume":"20","author":"Shao","year":"2023","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.taap.2026.117925_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104614","article-title":"Anti-inflammatory action and associated intracellular signaling of Centella asiatica extract on lipopolysaccharide-stimulated RAW 264.7 macrophage","volume":"61","author":"Shin","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.taap.2026.117925_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114005","article-title":"Induction of autophagy via the PI3K\/Akt\/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice","volume":"157","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0265","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.31518","article-title":"Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade","volume":"73","author":"Tilg","year":"2021","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.taap.2026.117925_bb0270","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1007\/s00210-024-02959-2","article-title":"Therapeutic potential of oleanolic acid in liver diseases","volume":"397","author":"Wang","year":"2024","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.taap.2026.117925_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156953","article-title":"Integrated metabolomics and network pharmacology reveal the PI3K\/Akt-mediated therapeutic mechanism of Abrus cantoniensis in lipid metabolism disorders","volume":"145","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117925_bb0280","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jare.2025.05.014","article-title":"Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease","volume":"80","author":"Wang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.taap.2026.117925_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157137","article-title":"Asiaticoside alleviates atherosclerosis progression by suppressing RhoF-NF-kappaB\/MAPK signaling and inflammation in macrophages","volume":"146","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117925_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156317","article-title":"Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-kappaB pathway","volume":"136","author":"Wei","year":"2025","journal-title":"Phytomedicine"},{"issue":"Pt 2","key":"10.1016\/j.taap.2026.117925_bb0300","article-title":"Caveolin-1 ameliorates hepatic injury in non-alcoholic fatty liver disease by inhibiting ferroptosis via the NOX4\/ROS\/GPX4 pathway","volume":"230","author":"Wu","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2026.117925_bb0305","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.7150\/ijbs.92337","article-title":"NUP85 alleviates lipid metabolism and inflammation by regulating PI3K\/AKT signaling pathway in nonalcoholic fatty liver disease","volume":"20","author":"Wu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2026.117925_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156375","article-title":"Shouhui Tongbian capsule ameliorates obesity by enhancing energy consumption and promoting lipolysis via cAMP-PKA pathway","volume":"138","author":"Wu","year":"2025","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.taap.2026.117925_bb0315","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.tjnut.2023.05.026","article-title":"Stigmasterol protects against steatohepatitis induced by high-fat and high-cholesterol diet in mice by enhancing the alternative bile acid synthesis pathway","volume":"153","author":"Xin","year":"2023","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.taap.2026.117925_bb0320","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12147","article-title":"LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K\/AKT\/HIF-1alpha pathway","volume":"24","author":"Xu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2026.117925_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115692","article-title":"The role of hepatocyte mitochondrial DNA in liver injury","volume":"168","author":"Xu","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.taap.2026.117925_bb0330","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18055","article-title":"Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: activation of the AMPK\/Nrf2 pathway","volume":"28","author":"Xu","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2026.117925_bb0335","article-title":"Elevated ALT\/AST ratio as a marker for NAFLD risk and severity: insights from a cross-sectional analysis in the United States","volume":"15","author":"Xuan","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.taap.2026.117925_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119376","article-title":"Total saponins from Panax japonicus reduced lipid deposition and inflammation in hepatocyte via PHD2 and hepatic macrophage-derived exosomal miR-463-5p","volume":"342","author":"Yang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.taap.2026.117925_bb0345","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2468-1253(20)30077-7","article-title":"Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"5","author":"Ye","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.taap.2026.117925_bb0350","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.taap.2026.117925_bb0355","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.phymed.2010.01.008","article-title":"Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide\/D-galactosamine in mice","volume":"17","author":"Zhang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.117925_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122505","article-title":"Dimethyl fumarate restores Ca(2+) dyshomeostasis through activation of the SIRT1 signal to treat nonalcoholic fatty liver disease","volume":"341","author":"Zhang","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2026.117925_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105761","article-title":"Assessing and mitigating foodborne acetochlor exposure induced ileum toxicity in broiler chicks: the role of omega-3 polyunsaturated fatty acids supplementation and molecular pathways analysis","volume":"199","author":"Zhang","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"10","key":"10.1016\/j.taap.2026.117925_bb0370","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1007\/s00210-024-03091-x","article-title":"Asiaticoside alleviates lipopolysaccharide-induced acute lung injury by blocking Sema4D\/CD72 and inhibiting mitochondrial dysfunction in RAW264.7 cell and mice","volume":"397","author":"Zhang","year":"2024","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.taap.2026.117925_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136928","article-title":"GPR120 exacerbates the immune-inflammatory response in chicken liver by mediating acetochlor induced macrophage M1 polarization","volume":"485","author":"Zhang","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117925_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110086","article-title":"Dietary omega-3 alleviates copper-induced nephrotoxicity via suppression of NLRP3-mediated pyroptosis and lipid metabolism disorder in chickens","volume":"147","author":"Zhang","year":"2026","journal-title":"J. Nutr. Biochem."},{"issue":"8","key":"10.1016\/j.taap.2026.117925_bb0385","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.4049\/jimmunol.2000649","article-title":"AKT regulates NLRP3 Inflammasome activation by phosphorylating NLRP3 serine 5","volume":"205","author":"Zhao","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2026.117925_bb0390","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.freeradbiomed.2026.01.057","article-title":"Growth arrest-specific 6 rejuvenates senescent HUCMSCs through upregulating Nrf2 for diabetic wound therapy","volume":"247","author":"Zhao","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2026.117925_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173976","article-title":"Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease","volume":"898","author":"Zhou","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2026.117925_bb0400","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41420-022-01022-4","article-title":"HtrA2\/Omi mitigates NAFLD in high-fat-fed mice by ameliorating mitochondrial dysfunction and restoring autophagic flux","volume":"8","author":"Zhou","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.taap.2026.117925_bb0405","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2147\/DDDT.S509208","article-title":"Asiaticoside attenuates chronic restraint stress-induced hippocampal CA1 neuronal Ferroptosis via activating BDNF\/Nrf2\/GPX4 signaling pathway","volume":"19","author":"Zhou","year":"2025","journal-title":"Drug Des. Devel. Ther."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:34:08Z","timestamp":1785911648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26002218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":80,"alternative-id":["S0041008X26002218"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117925","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asiaticoside alleviates metabolic associated fatty liver disease via PI3K\/AKT\/mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117925"}}