{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:51:49Z","timestamp":1785909109611,"version":"3.56.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241089"],"award-info":[{"award-number":["82241089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.taap.2026.117929","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:07:30Z","timestamp":1782572850000},"page":"117929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Human-relevant exposure to mixtures of rare earth elements disrupts T3 homeostasis through impaired synthesis and conversion in human Thyrocytes"],"prefix":"10.1016","volume":"514","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. James C.","family":"Crabbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117929_bb0005","article-title":"Recent advances in functional materials for rare earth recovery: a review","volume":"37","author":"Artiushenko","year":"2023","journal-title":"Sustain. Mater. Technol."},{"key":"10.1016\/j.taap.2026.117929_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1168663","article-title":"A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins","volume":"14","author":"Bagga","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.taap.2026.117929_bb0015","first-page":"99","article-title":"An investigation of lanthanum and other metals levels in blood, urine and hair among residents in the rare earth mining area of a city in China","volume":"36","author":"Bao","year":"2018","journal-title":"Zhonghua Laodong Weisheng Zhiyebing Zazhi"},{"key":"10.1016\/j.taap.2026.117929_bb0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0083-6729(05)71004-9","article-title":"Thyroid hormones and brain development","volume":"71","author":"Bernal","year":"2005","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.taap.2026.117929_bb0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.23907\/2016.024","article-title":"An overview of the thyroid gland and thyroid-related deaths for the forensic pathologist","volume":"6","author":"Beynon","year":"2016","journal-title":"Acad. Forensic Pathol."},{"key":"10.1016\/j.taap.2026.117929_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1210\/edrv.23.1.0455","article-title":"Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases","volume":"23","author":"Bianco","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2026.117929_bb0035","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1007\/s00204-021-03155-4","article-title":"Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety","volume":"95","author":"Borgert","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2026.117929_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122583","article-title":"Thyroid disrupting chemicals","volume":"18","author":"Calsolaro","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117929_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17041399","article-title":"The accumulation and metabolism characteristics of rare earth elements in Sprague-Dawley rats","volume":"17","author":"Cao","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.taap.2026.117929_bb0050","first-page":"1128","article-title":"Mito-TEMPO ameliorates sodium palmitate induced ferroptosis in MIN6 cells through PINK1\/Parkin-mediated mitophagy","volume":"37","author":"Chang","year":"2024","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.taap.2026.117929_bb0055","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1172\/JCI116510","article-title":"The thyroid gland is a major source of circulating T3 in the rat","volume":"91","author":"Chanoine","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2026.117929_bb0060","article-title":"Toxicological effects of Caco-2 cells following short-term and long-term exposure to Ag nanoparticles","volume":"17","author":"Chen","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117929_bb0065","article-title":"U-shaped relationship of rare earth element lanthanum and oral cancer risk: a propensity score-based study in the southeast of China","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.taap.2026.117929_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123499","article-title":"What are exposure biomarkers of rare earth elements for the ionic rare earth occupational population?","volume":"345","author":"Chen","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.117929_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106685","article-title":"Toxicokinetics in rats and modeling to support the interpretation of biomonitoring data for rare-earth elements","volume":"155","author":"Desrosiers","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.117929_bib367","doi-asserted-by":"crossref","first-page":"154261","DOI":"10.1016\/j.tox.2025.154261","article-title":"Gadolinium impairs male steroidogenesis: in vivo and in vitro evidence","volume":"518","author":"Falvo","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2026.117929_bib368","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.toxlet.2006.02.003","article-title":"Neurotoxicological consequence of long-term exposure to lanthanum","volume":"165","author":"Feng","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2026.117929_bb0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1210\/clinem\/dgac525","article-title":"Evaluating the progression to hypothyroidism in preconception euthyroid thyroid peroxidase antibody-positive women","volume":"108","author":"Gill","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2026.117929_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jbbm.2005.10.003","article-title":"Fluorescence probes used for detection of reactive oxygen species","volume":"65","author":"Gomes","year":"2005","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.taap.2026.117929_bb0090","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1007\/s12011-024-04297-z","article-title":"Levels of rare earth elements in food and human dietary exposure: a review","volume":"203","author":"Gonz\u00e1lez","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0095","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1038\/nprot.2007.304","article-title":"Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research","volume":"2","author":"Graham","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.taap.2026.117929_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126488","article-title":"Rare earth elements exposure and the alteration of the hormones in the hypothalamic-pituitary-thyroid (HPT) axis of the residents in an e-waste site: a cross-sectional study","volume":"252","author":"Guo","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2026.117929_bb0105","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1385\/BTER:114:1:225","article-title":"Urinary yttrium excretion and effects of yttrium chloride on renal function in rats","volume":"114","author":"Hayashi","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120121","article-title":"Urine is better for rare earth elements bimonitoring in long-term exposed population: an exposure-response relationship study","volume":"263","author":"He","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jes.2024.01.054","article-title":"Health risks of rare earth elements exposure: impact on mitochondrial DNA copy number and micronucleus frequency","volume":"151","author":"Hong","year":"2025","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.taap.2026.117929_bb0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.redox.2015.06.004","article-title":"Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor \u03b2-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells","volume":"5","author":"Hrabe","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2026.117929_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119649","article-title":"Toxicity of tetrabromobisphenol A to human thyroid follicular epithelial cells through oxidative stress: a combined analysis at the cellular and molecular levels","volume":"309","author":"Huang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117929_bb0130","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0039-9140(97)00017-9","article-title":"A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability","volume":"44","author":"Ishiyama","year":"1997","journal-title":"Talanta"},{"key":"10.1016\/j.taap.2026.117929_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.992883","article-title":"Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion","volume":"13","author":"Jing","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.taap.2026.117929_bb0140","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxlet.2021.04.003","article-title":"Effect of the dose on the toxicokinetics of a quaternary mixture of rare earth elements administered to rats","volume":"345","author":"Jomaa","year":"2021","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2026.117929_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140895","article-title":"Toxicokinetics of rare earth element oxides administered intravenously to rats","volume":"349","author":"Jomaa","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2026.117929_bb0150","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1557\/s43577-022-00289-3","article-title":"Mineral economics of the rare-earth elements","volume":"47","author":"Jowitt","year":"2022","journal-title":"MRS Bull."},{"key":"10.1016\/j.taap.2026.117929_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM198201073060107","article-title":"Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones","volume":"306","author":"Larsen","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2026.117929_bb0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.nu.15.070195.001543","article-title":"Nutritional and hormonal regulation of thyroid hormone deiodinases","volume":"15","author":"Larsen","year":"1995","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.taap.2026.117929_bb0165","article-title":"Redox regulation: mechanisms, biology and therapeutic targets in diseases","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.117929_bb0170","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012717","article-title":"Investigation of rare earth elements in urine and drinking water of children in mining area","volume":"97","author":"Liang","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.taap.2026.117929_bb0175","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12011-015-0312-9","article-title":"Serum proteomic analysis based on iTRAQ in miners exposed to soil containing rare earth elements","volume":"167","author":"Liu","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105222","article-title":"Prenatal exposure of rare earth elements cerium and ytterbium and neonatal thyroid stimulating hormone levels: findings from a birth cohort study","volume":"133","author":"Liu","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.117929_bb0185","article-title":"Effect of preeclampsia on ultrastructure of thyroid gland, hepatic type 1 iodothyronine deiodinase, and thyroid hormone levels in rats","volume":"2021","author":"Liu","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2026.117929_bb0190","doi-asserted-by":"crossref","first-page":"38751","DOI":"10.1007\/s11356-022-24958-7","article-title":"Association between rare earth element exposure during pregnancy and newborn telomere length","volume":"30","author":"Liu","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.taap.2026.117929_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142321","article-title":"Occurrence of rare earth elements in umbilical cord serum and association with thyroid hormones and birth outcomes in newborns","volume":"359","author":"Liu","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2026.117929_bb0200","article-title":"Energy metabolism in health and diseases","volume":"10","author":"Liu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.117929_bb0205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.taap.2026.117929_bb0210","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1021\/ar4001229","article-title":"Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action","volume":"46","author":"Manna","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0215","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF03347465","article-title":"Physiological role and regulation of iodothyronine deiodinases: a 2011 update","volume":"34","author":"Marsili","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.taap.2026.117929_bb0220","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1210\/endo.142.7.8280","article-title":"Expression and regulation of type II iodothyronine deiodinase in human thyroid gland","volume":"142","author":"Murakami","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2026.117929_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082164","article-title":"Molecular markers guiding thyroid cancer management","volume":"12","author":"Nyl\u00e9n","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.taap.2026.117929_bb0230","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0022-2275(20)40690-X","article-title":"Reaction of linoleic acid hydroperoxide with thiobarbituric acid","volume":"19","author":"Ohkawa","year":"1978","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2026.117929_bb0235","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.envres.2015.06.039","article-title":"Rare earth elements in human and animal health: state of art and research priorities","volume":"142","author":"Pagano","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0240","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1080\/15548627.2018.1474992","article-title":"Transcription factor NFE2L2\/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A","volume":"14","author":"Pajares","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2026.117929_bb0245","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0014-4827(03)00341-0","article-title":"Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide","volume":"290","author":"Pi","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.taap.2026.117929_bb0250","doi-asserted-by":"crossref","unstructured":"Pilo, A., Iervasi, G., Vitek, F., Ferdeghini, M., Cazzuola, F., Bianchi, R., 1990. Thyroidal and peripheral production of 3,5,3\u2032-triiodothyronine in humans by multicompartmental analysis. Am. J. Phys. 258, E715\u2013726.","DOI":"10.1152\/ajpendo.1990.258.4.E715"},{"key":"10.1016\/j.taap.2026.117929_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119801","article-title":"Occupational exposure to rare earth elements: assessment of external and internal exposure","volume":"309","author":"Qiao","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.117929_bb0260","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/acs.est.4c09710","article-title":"Cytotoxicity and oxidative stress induced by technology-critical elements versus traditional metal contaminants: an in vitro bioassay study","volume":"59","author":"Qvarforth","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2026.117929_bb0265","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.taap.2026.117929_bb0270","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3803\/EnM.2021.1198","article-title":"Deiodinases and the three types of thyroid hormone deiodination reactions","volume":"36","author":"Sabatino","year":"2021","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.taap.2026.117929_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.995503","article-title":"Perchlorate, nitrate, and thiocyanate: environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health","volume":"13","author":"Serrano-Nascimento","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.taap.2026.117929_bb0280","first-page":"881","article-title":"Effects of Nd(2)O(3) exposure of rare earth particles on C57 BL\/6J male mice sex hormone secretion and CYP11A1\/PLZF\/STRA8 protein expression","volume":"40","author":"Song","year":"2022","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"},{"key":"10.1016\/j.taap.2026.117929_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8050126","article-title":"H2O2 metabolism in normal thyroid cells and in thyroid tumorigenesis: focus on NADPH oxidases","volume":"8","author":"Szanto","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.taap.2026.117929_bb0290","series-title":"Werner and Ingbar's the Thyroid","author":"Taurog","year":"1996"},{"key":"10.1016\/j.taap.2026.117929_bb0295","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1081\/ESE-200026332","article-title":"Distribution characteristics of rare earth elements in children's scalp hair from a rare earths mining area in southern China","volume":"39","author":"Tong","year":"2004","journal-title":"J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.taap.2026.117929_bb0300","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1271\/bbb.63.485","article-title":"Spectrophotometric assay for superoxide dismutase based on the reduction of highly water-soluble tetrazolium salts by xanthine-xanthine oxidase","volume":"63","author":"Ukeda","year":"1999","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.taap.2026.117929_bb0305","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mce.2017.03.001","article-title":"The actions of thyroid hormone signaling in the nucleus","volume":"458","author":"Vella","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2026.117929_bb0310","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1021\/es305133k","article-title":"Organic extract contaminants from drinking water activate Nrf2-mediated antioxidant response in a human cell line","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2026.117929_bb0315","first-page":"876","article-title":"Association between exposure of rare earth elements and outcomes of in vitro fertilization-embryo transfer in Beijing","volume":"37","author":"Wang","year":"2024","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.taap.2026.117929_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119464","article-title":"Associations between rare earth element exposure and blood lipids in southern China: mediation analysis of oxidative stress and inflammation","volume":"307","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117929_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125507","article-title":"Modifying effects of prenatal exposure to rare earth elements on birth outcomes through maternal thyroid function in early pregnancy","volume":"366","author":"Wang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.117929_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054840","article-title":"The role of selected trace elements in oxidoreductive homeostasis in patients with thyroid diseases","volume":"24","author":"Wr\u00f3blewski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.117929_bib366","doi-asserted-by":"crossref","first-page":"104474","DOI":"10.1016\/j.yrtph.2019.104474","article-title":"Subchronic toxicity of cerium nitrate by 90-day oral exposure in wistar rats","volume":"108","author":"Wu","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2026.117929_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11110795","article-title":"Thyroid hormones, peripheral white blood count, and dose of basal insulin are associated with changes in nerve conduction studies in adolescents with type 1 diabetes","volume":"11","author":"Wysocka-Mincewicz","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.taap.2026.117929_bb0340","doi-asserted-by":"crossref","first-page":"12356","DOI":"10.1021\/acs.est.3c11009","article-title":"Disinfection byproducts of haloacetaldehydes disrupt hepatic lipid metabolism and induce lipotoxicity in high-fat culture conditions","volume":"58","author":"Yang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2026.117929_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136146","article-title":"Rare earth elements unintentionally released from global industrial activities","volume":"480","author":"Yun","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117929_bib369","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12011-013-9661-4","article-title":"Chemical elements of human bone tissue investigated by nuclear analytical and related methods","volume":"153","author":"Zaichick","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.taap.2026.117929_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115727","article-title":"The role of estrogen receptors (ERs)-Notch pathway in thyroid toxicity induced by Di-2-ethylhexyl phthalate (DEHP) exposure: population data and in vitro studies","volume":"269","author":"Zhang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117929_bb0355","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1007\/s12598-025-03459-9","article-title":"A comprehensive review on rare earth elements: resources, technologies, applications, and prospects","volume":"44","author":"Zhao","year":"2025","journal-title":"Rare Metals"},{"key":"10.1016\/j.taap.2026.117929_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.127084","article-title":"Hypertension risk is associated with elevated concentrations of rare earth elements in serum","volume":"74","author":"Zhong","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.taap.2026.117929_bb0365","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1021\/acs.est.2c08627","article-title":"Thyroid-disrupting effects of exposure to fipronil and its metabolites from drinking water based on human thyroid follicular epithelial Nthy-ori 3\u20131 cell lines","volume":"57","author":"Zhuang","year":"2023","journal-title":"Environ. Sci. Technol."}],"updated-by":[{"DOI":"10.1016\/j.taap.2026.117935","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000}},{"DOI":"10.1016\/j.taap.2026.117935","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:37:04Z","timestamp":1785908224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26002255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":77,"alternative-id":["S0041008X26002255"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117929","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human-relevant exposure to mixtures of rare earth elements disrupts T3 homeostasis through impaired synthesis and conversion in human Thyrocytes","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117929","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117929"}}