{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:24:00Z","timestamp":1787304240268,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.taap.2026.117938","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:41:05Z","timestamp":1783467665000},"page":"117938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bisphenol a exposure induces low back pain associated with intervertebral disc degeneration via BIRC3-mediated nucleus pulposus cell senescence"],"prefix":"10.1016","volume":"515","author":[{"given":"Tao","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Database issue","key":"10.1016\/j.taap.2026.117938_bb0005","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets \u2013 update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"40","key":"10.1016\/j.taap.2026.117938_bb0010","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1021\/j100142a004","article-title":"A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model","volume":"97","author":"Bayly","year":"1993","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.taap.2026.117938_bb0015","first-page":"1","article-title":"National health and nutrition examination survey: national youth fitness survey plan, operations, and analysis, 2012","volume":"163","author":"Borrud","year":"2014","journal-title":"Vital Health Stat. 2"},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2026.117938_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142103","article-title":"Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka","volume":"357","author":"Chen","year":"2024","journal-title":"Chemosphere"},{"issue":"10","key":"10.1016\/j.taap.2026.117938_bb0030","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.7150\/ijms.25634","article-title":"A review on the effects of bisphenol a and its derivatives on skeletal health","volume":"15","author":"Chin","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.taap.2026.117938_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106260","article-title":"Systems toxicogenomics of prenatal low-dose BPA exposure on liver metabolic pathways, gut microbiota, and metabolic health in mice","volume":"146","author":"Diamante","year":"2021","journal-title":"Environ. Int."},{"issue":"20","key":"10.1016\/j.taap.2026.117938_bb0040","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.taap.2026.117938_bb0045","series-title":"Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining","first-page":"785","article-title":"XGBoost: a scalable tree boosting system","author":"Ester","year":"2016"},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13578-020-00521-0","article-title":"BIRC3 and BIRC5: multi-faceted inhibitors in cancer","volume":"11","author":"Frazzi","year":"2021","journal-title":"Cell Biosci."},{"issue":"4","key":"10.1016\/j.taap.2026.117938_bb0055","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.taap.2026.117938_bb0060","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrc2889","article-title":"IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer","volume":"10","author":"Gyrd-Hansen","year":"2010","journal-title":"Nat. Rev. Cancer"},{"issue":"10137","key":"10.1016\/j.taap.2026.117938_bb0065","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0070","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"issue":"11","key":"10.1016\/j.taap.2026.117938_bb0075","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nrd1549","article-title":"Docking and scoring in virtual screening for drug discovery: methods and applications","volume":"3","author":"Kitchen","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2026.117938_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v028.i05","article-title":"Building predictive models in R using the caret package","volume":"28","author":"Kuhn","year":"2008","journal-title":"J. Stat. Softw."},{"issue":"4","key":"10.1016\/j.taap.2026.117938_bb0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1186\/s13075-014-0416-1","article-title":"Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration","volume":"16","author":"La Binch","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.taap.2026.117938_bb0090","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2665-9913(23)00098-X","article-title":"Global, regional, and national burden of low back pain, 1990-2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"5","year":"2023","journal-title":"Lancet Rheumatol."},{"issue":"3","key":"10.1016\/j.taap.2026.117938_bb0095","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar2198","article-title":"Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration","volume":"9","author":"Le Maitre","year":"2007","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.taap.2026.117938_bb0100","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.taap.2026.117938_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0109298673358689250711005445","article-title":"Investigating the causal role of neurotrophic factors in low back pain and sciatica: a mendelian randomization study","volume":"32","author":"Lin","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.taap.2026.117938_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117434","article-title":"Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology","volume":"289","author":"Lin","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117938_bb0115","series-title":"International Conference on Information Computing and Applications","first-page":"246","article-title":"New machine learning algorithm: random forest","volume":"vol. 2012","author":"Liu","year":"2012"},{"key":"10.1016\/j.taap.2026.117938_bb0120","series-title":"A unified approach to interpreting model predictions","author":"Lundberg","year":"2017"},{"issue":"33","key":"10.1016\/j.taap.2026.117938_bb0125","doi-asserted-by":"crossref","first-page":"11778","DOI":"10.1073\/pnas.0711122105","article-title":"Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation","volume":"105","author":"Mahoney","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010208","article-title":"Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0135","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.taap.2026.117938_bb0140","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol a and human health: a review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.taap.2026.117938_bb0145","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.taap.2026.117938_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040686","article-title":"Cellular senescence in intervertebral disc aging and degeneration: molecular mechanisms and potential therapeutic opportunities","volume":"13","author":"Silwal","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.taap.2026.117938_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114711","article-title":"Cellular senescence\u2013molecular mechanisms of intervertebral disc degeneration from an immune perspective","volume":"162","author":"Song","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"43","key":"10.1016\/j.taap.2026.117938_bb0160","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J. R. Stat. Soc. Series B Stat. Methodology"},{"issue":"3","key":"10.1016\/j.taap.2026.117938_bb0170","article-title":"Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression","volume":"9","author":"Tu","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"10.1016\/j.taap.2026.117938_bb0175","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"issue":"9","key":"10.1016\/j.taap.2026.117938_bb0180","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general amber force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.taap.2026.117938_bb0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41420-023-01730-5","article-title":"Emerging role and therapeutic implications of p53 in intervertebral disc degeneration","volume":"9","author":"Wang","year":"2023","journal-title":"Cell Death Discovery"},{"issue":"4","key":"10.1016\/j.taap.2026.117938_bb0190","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s00216-005-0019-4","article-title":"Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4-methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometry","volume":"383","author":"Ye","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.taap.2026.117938_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109934","article-title":"Deciphering the toxicological mechanisms of per- and polyfluoroalkyl substances (PFAS) in musculoskeletal disorders via integrated network toxicology and molecular docking","volume":"206","author":"Yu","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.117938_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114082","article-title":"Long-term BPA exposure leads to bone malformation and abnormal expression of MAPK\/Wnt\/FoxO signaling pathway genes in zebrafish offspring","volume":"245","author":"Zhu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:29:45Z","timestamp":1787300985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26002346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S0041008X26002346"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117938","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphenol a exposure induces low back pain associated with intervertebral disc degeneration via BIRC3-mediated nucleus pulposus cell senescence","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117938"}}