{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:33:34Z","timestamp":1786116814708,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371610"],"award-info":[{"award-number":["82371610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.taap.2026.117939","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:41:17Z","timestamp":1783600877000},"page":"117939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Salicylate esters inhibit human and rat 11\u03b2-Hydroxysteroid dehydrogenase type 2: Mechanistic insights from enzyme kinetics, SPR, and molecular modeling"],"prefix":"10.1016","volume":"514","author":[{"given":"Yinwei","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiya","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renshan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.117939_bb0005","first-page":"335","article-title":"Apparent mineralocorticoid excess in the pediatric population: report of a novel pathogenic variant of the 11beta-HSD2 gene and Systematic review of the literature","volume":"16","author":"Adamidis","year":"2019","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.taap.2026.117939_bb0010","doi-asserted-by":"crossref","first-page":"25959","DOI":"10.1016\/S0021-9258(18)47142-6","article-title":"NAD (+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney","volume":"269","author":"Agarwal","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2026.117939_bb0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-291X(03)01359-7","article-title":"Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates","volume":"308","author":"Atanasov","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2026.117939_bb0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1203\/PDR.0b013e31818d6c24","article-title":"Prematurity is related to high placental cortisol in preeclampsia","volume":"65","author":"Aufdenblatten","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.taap.2026.117939_bb0025","doi-asserted-by":"crossref","first-page":"F1178","DOI":"10.1152\/ajprenal.00532.2009","article-title":"Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11{beta}-HSD activity","volume":"298","author":"Brem","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.taap.2026.117939_bb0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jsbmb.2008.12.006","article-title":"The (+)- and (\u2212)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2","volume":"113","author":"Chen","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2026.117939_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120444","article-title":"Species-specific inhibition of human and rat gonadal 3\u03b2-hydroxysteroid dehydrogenases by emerging organophosphate esters: a multiscale approach combining in vitro assays and computational modeling","volume":"321","author":"Dai","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117939_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141827","article-title":"Trihexyl phosphate exposure disrupts mitophagy and activates mtDNA-cGAS-STING signaling to drive pyroptosis and steroidogenic impairment in Leydig cells","volume":"507","author":"Dai","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117939_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137395","article-title":"Exploring the reproductive exposure risks of phthalates and organophosphates in atmospheric particulate matter based on quantitative structure-activity relationships and network toxicology models","volume":"488","author":"Gao","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117939_bb0050","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.steroids.2006.06.001","article-title":"Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram","volume":"71","author":"Garbrecht","year":"2006","journal-title":"Steroids"},{"key":"10.1016\/j.taap.2026.117939_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111210","article-title":"11beta-hydroxysteroid dehydrogenases: a growing multi-tasking family","volume":"526","author":"Gomez-Sanchez","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2026.117939_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108861","article-title":"Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: rational design, synthesis, and multi-level characterization","volume":"164","author":"G\u00fcle\u00e7","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.taap.2026.117939_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108689","article-title":"Fluorenyl-phthalimide hybrids as potent aldose reductase inhibitors with selective anticancer activity: rational design, synthesis, and molecular insights","volume":"163","author":"Gundogdu","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.taap.2026.117939_bb0070","first-page":"1306","article-title":"11Beta-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human placenta","volume":"85","author":"Hirasawa","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2026.117939_bb0075","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1523\/JNEUROSCI.4464-05.2006","article-title":"The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids","volume":"26","author":"Holmes","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2026.117939_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118416","article-title":"Phthalimide-benzoic acid hybrids as potent aldose reductase inhibitors: synthesis, enzymatic kinetics, and in silico characterization","volume":"131","author":"Hoti","year":"2025","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.taap.2026.117939_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115387","article-title":"Species-specific differences in the inhibition of 11beta-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole","volume":"412","author":"Inderbinen","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.117939_bb0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","article-title":"ZINC\u2014a free database of commercially available compounds for virtual screening","volume":"45","author":"Irwin","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.taap.2026.117939_bb0095","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.taap.2026.117939_bb0100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1210\/jc.2002-021378","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol\/cortisone shuttle in small preterm infants","volume":"88","author":"Kajantie","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2026.117939_bb0105","doi-asserted-by":"crossref","first-page":"24797","DOI":"10.1021\/acs.jafc.4c04265","article-title":"Endocrine-sisrupting effects of salicylate preservatives on neurosteroidogenesis: targeting 5alpha-reductase type 1","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.taap.2026.117939_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1631449","article-title":"Panoramic view of MDH1: driving cancer progression and shaping the tumor immune microenvironment","volume":"16","author":"Lou","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2026.117939_bb0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2011.04.007","article-title":"Environmental inhibitors of 11beta-hydroxysteroid dehydrogenase type 2","volume":"285","author":"Ma","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2026.117939_bb0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1289\/ehp.109-1240632","article-title":"Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay","volume":"109","author":"Miller","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2026.117939_bb0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.fct.2015.08.024","article-title":"Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues","volume":"86","author":"Ozaki","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2026.117939_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136999","article-title":"Integration of network toxicology and transcriptomics reveals the novel neurotoxic mechanisms of 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether","volume":"486","author":"Qu","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.117939_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2026.112032","article-title":"Hydrophobicity, 3D complexity, and steric feature affect salicylate inhibition of human and rat gonadal 3\u03b2-hydroxysteroid dehydrogenases: insights from experiments to 3D-QSAR and in silico docking analysis","volume":"432","author":"Ren","year":"2026","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2026.117939_bb0140","first-page":"1313","article-title":"Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia","volume":"86","author":"Schoof","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2026.117939_bb0145","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1210\/en.2009-0479","article-title":"The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability","volume":"150","author":"Sharma","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2026.117939_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113739","article-title":"Halogen atoms determine the inhibitory potency of halogenated bisphenol a derivatives on human and rat placental 11beta-hydroxysteroid dehydrogenase 2","volume":"175","author":"Shi","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2026.117939_bb0155","article-title":"Licorice induced pseudohyperaldosteronism, severe hypertension, and long QT","volume":"2019","author":"Smedegaard","year":"2019","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"10.1016\/j.taap.2026.117939_bb0160","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1172\/JCI113592","article-title":"Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle","volume":"82","author":"Stewart","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2026.117939_bb0165","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.taap.2026.117939_bb0170","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2026.117939_bb0175","first-page":"282","article-title":"Phenyl salicylates - a new group of potential antituberculotics","volume":"61","author":"Waisser","year":"2012","journal-title":"Ceska Slov. Farm."},{"key":"10.1016\/j.taap.2026.117939_bb0180","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2026.117939_bb0185","first-page":"135","article-title":"11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess","volume":"18","author":"White","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2026.117939_bb0190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.yrtph.2018.06.015","article-title":"Fragrance allergens in household detergents","volume":"97","author":"Wieck","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2026.117939_bb0195","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2026.117939_bb0200","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.reprotox.2016.04.004","article-title":"Structure-activity relationships of phthalates in inhibition of human placental 3beta-hydroxysteroid dehydrogenase 1 and aromatase","volume":"61","author":"Xu","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2026.117939_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111203","article-title":"Food additive salicylates inhibit human and rat placental 3\u03b2-hydroxysteroid dehydrogenase: 3D-QSAR and in silico analysis","volume":"402","author":"Yang","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2026.117939_bb0210","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.toxlet.2011.12.004","article-title":"The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics","volume":"209","author":"Zhang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2026.117939_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114715","article-title":"Direct inhibition of bisphenols on human and rat 11beta-hydroxysteroid dehydrogenase 2: structure-activity relationship and docking analysis","volume":"254","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.117939_bb0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00018-018-2918-5","article-title":"Mechanisms for establishment of the placental glucocorticoid barrier, a guard for life","volume":"76","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:33:43Z","timestamp":1786019623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26002358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"alternative-id":["S0041008X26002358"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117939","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salicylate esters inhibit human and rat 11\u03b2-Hydroxysteroid dehydrogenase type 2: Mechanistic insights from enzyme kinetics, SPR, and molecular modeling","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117939"}}