{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:05Z","timestamp":1790816825806,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K17845"],"award-info":[{"award-number":["JP22K17845"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K21273"],"award-info":[{"award-number":["JP21K21273"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.taap.2026.117997","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:58:17Z","timestamp":1787155097000},"page":"117997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mitochondrial sensitivity to Ca2+-induced permeability transition in mouse liver exhibits time-of-day dependence"],"prefix":"10.1016","volume":"516","author":[{"given":"Tomoyuki","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taira","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Shimba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutaka","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2008.09.029","article-title":"Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo","volume":"46","author":"Abe","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.taap.2026.117997_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/foods12101947","article-title":"Sudachitin and Nobiletin stimulate lipolysis via activation of the cAMP\/PKA\/HSL pathway in 3T3-L1 adipocytes","volume":"12","author":"Abe","year":"2023","journal-title":"Foods"},{"issue":"10","key":"10.1016\/j.taap.2026.117997_bb0015","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1096\/fj.02-0097fje","article-title":"Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells","volume":"16","author":"Armstrong","year":"2002","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.taap.2026.117997_bb0020","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202254978","article-title":"TMBIM5 is the ca(2+) \/H(+) antiporter of mammalian mitochondria","volume":"23","author":"Austin","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.taap.2026.117997_bb0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ceca.2018.05.003","article-title":"The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore","volume":"73","author":"Baines","year":"2018","journal-title":"Cell Calcium"},{"issue":"7033","key":"10.1016\/j.taap.2026.117997_bb0030","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0035","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0003-2697(90)90208-Q","article-title":"Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples","volume":"190","author":"Baker","year":"1990","journal-title":"Anal. Biochem."},{"issue":"8","key":"10.1016\/j.taap.2026.117997_bb0040","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.taap.2026.117997_bb0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/08941939.2010.496036","article-title":"Intracellular calcium signaling pathways during liver ischemia and reperfusion","volume":"23","author":"Chang","year":"2010","journal-title":"J. Investig. Surg."},{"issue":"7527","key":"10.1016\/j.taap.2026.117997_bb0050","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.taap.2026.117997_bb0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-4682-11-16","article-title":"Cosinor-based rhythmometry","volume":"11","author":"Cornelissen","year":"2014","journal-title":"Theor. Biol. Med. Model."},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0060","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1432-1033.1977.tb11839.x","article-title":"The calcium-induced and sodium-induced effluxes of calcium from heart mitochondria. Evidence for a sodium-calcium carrier","volume":"79","author":"Crompton","year":"1977","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(80)80986-0","article-title":"On the role of the calcium transport cycle in heart and other mammalian mitochondria","volume":"119","author":"Denton","year":"1980","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0070","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neurobiolaging.2009.03.003","article-title":"Cyclophilin D deficiency improves mitochondrial function and learning\/memory in aging Alzheimer disease mouse model","volume":"32","author":"Du","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.taap.2026.117997_bb0075","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1097\/LVT.0000000000000252","article-title":"Liver ischemia-reperfusion injury: from trigger loading to shot firing","volume":"29","author":"Felli","year":"2023","journal-title":"Liver Transpl."},{"issue":"10","key":"10.1016\/j.taap.2026.117997_bb0080","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1007\/s11064-019-02769-6","article-title":"Sex differences in ischemia\/reperfusion injury: the role of mitochondrial permeability transition","volume":"44","author":"Fels","year":"2019","journal-title":"Neurochem. Res."},{"issue":"8","key":"10.1016\/j.taap.2026.117997_bb0085","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-2952(01)00745-6","article-title":"Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition","volume":"62","author":"Furuno","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2026.117997_bb0090","doi-asserted-by":"crossref","unstructured":"Greenwell B J, Trott A J, Beytebiere J R, Pao S, Bosley A, Beach E, Finegan P, Hernandez C, Menet J S. 2019. Rhythmic food intake drives rhythmic gene expression more potently than the hepatic circadian clock in mice. Cell Rep. 27(3): 649\u2013657 e645. doi:https:\/\/doi.org\/10.1016\/j.celrep.2019.03.064.","DOI":"10.1016\/j.celrep.2019.03.064"},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2008.04.021","article-title":"Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition","volume":"45","author":"Hansson","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0100","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0022-4804(03)00091-X","article-title":"Mitochondrial permeability transition and cytochrome c release in ischemia-reperfusion injury of the rat liver","volume":"111","author":"Hirakawa","year":"2003","journal-title":"J. Surg. Res."},{"issue":"Pt 3","key":"10.1016\/j.taap.2026.117997_bb0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1042\/bj20021342","article-title":"Protection from inactivation of the adenine nucleotide translocator during hypoglycaemia-induced apoptosis by mitochondrial phospholipid hydroperoxide glutathione peroxidase","volume":"371","author":"Imai","year":"2003","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0110","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/ajt.16219","article-title":"Ischemia-reperfusion injury and its relationship with early allograft dysfunction in liver transplant patients","volume":"21","author":"Ito","year":"2021","journal-title":"Am. J. Transplant."},{"issue":"4","key":"10.1016\/j.taap.2026.117997_bb0115","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cmet.2015.08.006","article-title":"Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness","volume":"22","author":"Jacobi","year":"2015","journal-title":"Cell Metab."},{"issue":"52","key":"10.1016\/j.taap.2026.117997_bb0120","doi-asserted-by":"crossref","first-page":"18757","DOI":"10.1073\/pnas.1421708111","article-title":"Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase","volume":"111","author":"Johnson","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0125","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1124\/jpet.107.119545","article-title":"Role of Ca2+\u2212independent phospholipase A2gamma in Ca2+\u2212induced mitochondrial permeability transition","volume":"321","author":"Kinsey","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0130","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.apsb.2021.05.029","article-title":"The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia\/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.taap.2026.117997_bb0135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2022.01.059","article-title":"Liver cyclophilin D deficiency inhibits the progression of early NASH by ameliorating steatosis and inflammation","volume":"594","author":"Li","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0140","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.taap.2006.09.012","article-title":"Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes","volume":"217","author":"Lim","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2026.117997_bb0145","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.bbrc.2020.06.152","article-title":"Rev-erbalpha regulates hepatic ischemia-reperfusion injury in mice","volume":"529","author":"Lin","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1\u20132","key":"10.1016\/j.taap.2026.117997_bb0150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.abb.2009.09.002","article-title":"Redox characterization of human cyclophilin D: identification of a new mammalian mitochondrial redox sensor","volume":"491","author":"Linard","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.taap.2026.117997_bb0155","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmgh.2023.03.003","article-title":"Mechanistic insight and clinical implications of ischemia\/reperfusion injury post liver transplantation","volume":"15","author":"Liu","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.taap.2026.117997_bb0160","article-title":"Circadian control of ConA-induced acute liver injury and inflammatory response via Bmal1 regulation of Junb","volume":"5","author":"Liu","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.taap.2026.117997_bb0165","article-title":"Cyclophilin D (PPIF) and MPTP in hepatic ischemia-reperfusion injury: insights into mechanisms","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.taap.2026.117997_bb0170","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1073\/pnas.1601786113","article-title":"Circadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome","volume":"113","author":"Manoogian","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0175","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2002.31871","article-title":"Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats","volume":"35","author":"Masubuchi","year":"2002","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0180","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2004.09.015","article-title":"Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice","volume":"42","author":"Masubuchi","year":"2005","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.taap.2026.117997_bb0185","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/CIRCRESAHA.123.323882","article-title":"Inhibition of the mPTP and lipid peroxidation is additively protective against I\/R injury","volume":"134","author":"Mendoza","year":"2024","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.taap.2026.117997_bb0190","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1194\/jlr.M046961","article-title":"Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver","volume":"55","author":"Moffat","year":"2014","journal-title":"J. Lipid Res."},{"issue":"35","key":"10.1016\/j.taap.2026.117997_bb0195","doi-asserted-by":"crossref","first-page":"29837","DOI":"10.1074\/jbc.M112.373654","article-title":"Genetic ablation of calcium-independent phospholipase a(2)gamma (iPLA(2)gamma) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release","volume":"287","author":"Moon","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2026.117997_bb0200","article-title":"Modulation of mitochondrial permeability transition pores in reperfusion injury: mechanisms and therapeutic approaches","author":"Morciano","year":"2024","journal-title":"Eur. J. Clin. Investig."},{"issue":"7033","key":"10.1016\/j.taap.2026.117997_bb0205","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell deat","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.taap.2026.117997_bb0210","doi-asserted-by":"crossref","first-page":"E1673","DOI":"10.1073\/pnas.1519650113","article-title":"Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins","volume":"113","author":"Neufeld-Cohen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"46","key":"10.1016\/j.taap.2026.117997_bb0215","doi-asserted-by":"crossref","first-page":"40184","DOI":"10.1074\/jbc.M111.243469","article-title":"Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore","volume":"286","author":"Nguyen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0220","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.taap.2010.08.007","article-title":"Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition","volume":"248","author":"Okuda","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2026.117997_bb0225","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ceca.2009.03.012","article-title":"Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease","volume":"45","author":"Paradies","year":"2009","journal-title":"Cell Calcium"},{"issue":"15","key":"10.1016\/j.taap.2026.117997_bb0230","doi-asserted-by":"crossref","first-page":"10750","DOI":"10.1074\/jbc.R112.420752","article-title":"The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles","volume":"288","author":"Patron","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"6158","key":"10.1016\/j.taap.2026.117997_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/science.1243417","article-title":"Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice","volume":"342","author":"Peek","year":"2013","journal-title":"Science"},{"issue":"27","key":"10.1016\/j.taap.2026.117997_bb0240","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1016\/j.febslet.2006.10.036","article-title":"Interaction of peroxidized cardiolipin with rat-heart mitochondrial membranes: induction of permeability transition and cytochrome c release","volume":"580","author":"Petrosillo","year":"2006","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.taap.2026.117997_bb0245","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0250","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/10715762.2010.520319","article-title":"Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury","volume":"45","author":"Ramachandran","year":"2011","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.taap.2026.117997_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115659","article-title":"Role of respiratory uncoupling in drug-induced mitochondrial permeability transition","volume":"427","author":"Sato","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0260","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2018.01.011","article-title":"Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics","volume":"27","author":"Schmitt","year":"2018","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0265","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.102.1.97","article-title":"Molecular architecture of the inner membrane of mitochondria from rat liver: a combined biochemical and stereological study","volume":"102","author":"Schwerzmann","year":"1986","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.taap.2026.117997_bb0270","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.molcel.2023.12.008","article-title":"Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis","volume":"84","author":"Shi","year":"2024","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.taap.2026.117997_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025231","article-title":"Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation","volume":"6","author":"Shimba","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0280","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.yjmcc.2012.05.012","article-title":"Ischemia-reperfusion induces myocardial infarction through mitochondrial ca(2)(+) overload","volume":"53","author":"Shintani-Ishida","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"11","key":"10.1016\/j.taap.2026.117997_bb0285","doi-asserted-by":"crossref","first-page":"eabj4716","DOI":"10.1126\/sciadv.abj4716","article-title":"Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients","volume":"8","author":"Singh","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0290","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/abbi.2000.2195","article-title":"Free fatty acid effects on mitochondrial permeability: an overview","volume":"386","author":"Sultan","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0295","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00769537","article-title":"The mitochondrial megachannel is the permeability transition pore","volume":"24","author":"Szabo","year":"1992","journal-title":"J. Bioenerg. Biomembr."},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0300","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/hep.21912","article-title":"Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage\/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition","volume":"47","author":"Theruvath","year":"2008","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.taap.2026.117997_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149630","article-title":"Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia\/reperfusion","volume":"11","author":"Vasques","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.taap.2026.117997_bb0310","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/s41467-018-03898-2","article-title":"A proteomics landscape of circadian clock in mouse liver","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"issue":"7883","key":"10.1016\/j.taap.2026.117997_bb0315","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41586-021-04025-w","article-title":"SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells","volume":"599","author":"Wang","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0320","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jhep.2025.02.029","article-title":"Circadian control of hepatic ischemia\/reperfusion injury via HSD17B13-mediated autophagy in hepatocytes","volume":"83","author":"Wang","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2026.117997_bb0325","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-026-04480-2","article-title":"Circadian regulation of hepatic detoxification: implications for drug-induced liver injury","author":"Wen","year":"2026","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.taap.2026.117997_bb0330","first-page":"238","article-title":"Cyclophilin D as a potential therapeutic target of liver ischemia\/reperfusion injury by mediating crosstalk between apoptosis and autophagy","volume":"9","author":"Yang","year":"2023","journal-title":"Chronic Dis. Transl. Med."},{"issue":"5","key":"10.1016\/j.taap.2026.117997_bb0335","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.metabol.2016.02.003","article-title":"Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice","volume":"65","author":"Yasumoto","year":"2016","journal-title":"Metabolism"},{"issue":"1\u20132","key":"10.1016\/j.taap.2026.117997_bb0340","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mam.2008.08.003","article-title":"Glutathione in liver diseases and hepatotoxicity","volume":"30","author":"Yuan","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.taap.2026.117997_bb0345","first-page":"066","article-title":"Research progress on the role of mitochondria in the process of hepatic ischemia-reperfusion injury","volume":"12","author":"Zhou","year":"2024","journal-title":"Gastroenterol Rep (Oxf)."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26002930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:45:42Z","timestamp":1790815542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26002930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":69,"alternative-id":["S0041008X26002930"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.117997","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial sensitivity to Ca2+-induced permeability transition in mouse liver exhibits time-of-day dependence","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.117997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117997"}}