{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:04Z","timestamp":1790816824389,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103857"],"award-info":[{"award-number":["82103857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300645"],"award-info":[{"award-number":["82300645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085Y039"],"award-info":[{"award-number":["2408085Y039"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.taap.2026.118022","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:50:26Z","timestamp":1787813426000},"page":"118022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Polystyrene nanoplastics exposure induces reproductive toxicity in male mice associated with the gut\u2013liver\/testis axis"],"prefix":"10.1016","volume":"516","author":[{"given":"Fahao","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yile","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maozhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40364-024-00601-0","article-title":"FGL1 and FGL2: emerging regulators of liver health and disease","volume":"12","author":"Chen","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.taap.2026.118022_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173458","article-title":"Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-\u03baB\/NLRP3 pathways and related gut-liver axis in mice","volume":"935","author":"Chen","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12944-025-02613-7","article-title":"Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver","volume":"24","author":"Chen","year":"2025","journal-title":"Lipids Health Dis."},{"issue":"4","key":"10.1016\/j.taap.2026.118022_bb0020","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5009\/gnl240539","article-title":"Gut-liver axis: the role of intestinal microbiota and their metabolites in the progression of metabolic dysfunction-associated steatotic liver disease","volume":"19","author":"Cui","year":"2025","journal-title":"Gut Liver"},{"issue":"19","key":"10.1016\/j.taap.2026.118022_bb0025","first-page":"2372","article-title":"Liver gene transfer for metabolite detoxification in inherited metabolic diseases","volume":"598","author":"D\u2019Alessio","year":"2024","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2026.118022_bb0030","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2026.118022_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126009","article-title":"Exposure to polystyrene microplastics with different functional groups: implications for blood pressure and heart","volume":"372","author":"Du","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.118022_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108732","article-title":"Exploring the hypothetical links between environmental pollutants, diet, and the gut-testis axis: the potential role of microbes in male reproductive health","volume":"130","author":"Dubey","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2026.118022_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111043","article-title":"Polystyrene microplastics induce male reproductive toxicity in mice by activating spermatogonium mitochondrial oxidative stress and apoptosis","volume":"396","author":"Fang","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12989-025-00642-9","article-title":"Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice","volume":"22","author":"Feng","year":"2025","journal-title":"Part. Fibre Toxicol."},{"issue":"6","key":"10.1016\/j.taap.2026.118022_bb0055","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/tox.23763","article-title":"Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice","volume":"38","author":"Fu","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2026.118022_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115618","article-title":"The male reproductive toxicity after nanoplastics and microplastics exposure: sperm quality and changes of different cells in testis","volume":"267","author":"Gao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.118022_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171299","article-title":"Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system","volume":"922","author":"Gao","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.taap.2026.118022_bb0070","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.200303026","article-title":"FoxO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons","volume":"162","author":"Gilley","year":"2003","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jat.4510","article-title":"The reproductive and transgenerational toxicity of microplastics and nanoplastics: a threat to mammalian fertility in both sexes","volume":"44","author":"He","year":"2024","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2026.118022_bb0080","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/jat.4696","article-title":"Long-term nanoplastics exposure contributes to impaired steroidogenesis by disrupting the hypothalamic-testis axis: evidence from integrated transcriptome and metabolome analysis","volume":"45","author":"He","year":"2025","journal-title":"J. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12951-025-03650-1","article-title":"Gut microbiota contributes to polystyrene nanoplastics-induced fetal growth restriction by disturbing placental nicotinamide metabolism","volume":"23","author":"He","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.taap.2026.118022_bb0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.taap.2026.118022_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: in vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.118022_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114332","article-title":"Polystyrene nanoplastics promote CHIP-mediated degradation of tight junction proteins by activating the IRE1\u03b1\/XBP1s pathway in mouse Sertoli cells","volume":"248","author":"Hu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-18550-5","article-title":"Probiotics as a therapeutic approach to alleviate reproductive harm from polystyrene microplastics in male rats","volume":"15","author":"Hwang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2026.118022_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2026.110165","article-title":"Perinatal exposure to polystyrene microplastics induces multigenerational impairment of male reproduction via disrupted steroidogenesis and proteostasis","volume":"209","author":"Jiang","year":"2026","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.118022_bb0115","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.scitotenv.2018.08.353","article-title":"Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice","volume":"649","author":"Jin","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.118022_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.118022_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2024.100531","article-title":"Gut-lung microbiota dynamics in mice exposed to nanoplastics","volume":"36","author":"Kalu\u00e7","year":"2024","journal-title":"NanoImpact"},{"issue":"6","key":"10.1016\/j.taap.2026.118022_bb0130","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1007\/s43032-021-00624-0","article-title":"The interplay between androgen and gut microbiota: is there a microbiota-gut-testis axis?","volume":"29","author":"Li","year":"2022","journal-title":"Reprod. Sci."},{"issue":"5","key":"10.1016\/j.taap.2026.118022_bb0135","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaf535","article-title":"Quantifying antibiotic resistome risks across environmental niches: the L-ARRAP for long-read metagenomic profiling","volume":"26","author":"Li","year":"2025","journal-title":"Brief. Bioinform."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0140","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/s41598-025-86810-5","article-title":"Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by RNA-seq","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.taap.2026.118022_bb0145","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1039\/D5NH00024F","article-title":"Toxicity of nanoplastics: machine learning combined with meta-analysis","volume":"10","author":"Li","year":"2025","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.taap.2026.118022_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153834","article-title":"Size-dependent deleterious effects of nano- and microplastics on sperm motility","volume":"506","author":"Lin","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2026.118022_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.122867","article-title":"Quantitative evaluation of microplastic interference with gut microbiota: identifying sensitive indicators and key factors","volume":"286","author":"Liu","year":"2025","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.taap.2026.118022_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/biology14050523","article-title":"Synergistic toxicity of combined exposure to acrylamide and polystyrene nanoplastics on the gut-liver axis in mice","volume":"14","author":"Liu","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.taap.2026.118022_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123086","article-title":"Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupting spermatogenesis in mice","volume":"342","author":"Ma","year":"2024","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.taap.2026.118022_bb0170","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/hep4.1292","article-title":"Intestine-specific overexpression of carboxylesterase 2c protects mice from diet-induced liver steatosis and obesity","volume":"3","author":"Maresch","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.taap.2026.118022_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164687","article-title":"Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: the insights in physiological, histological, and oxidative damages","volume":"892","author":"Meng","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.118022_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2021.100302","article-title":"Unintended human ingestion of nanoplastics and small microplastics through drinking water, beverages, and food sources","volume":"21","author":"Mortensen","year":"2021","journal-title":"NanoImpact"},{"issue":"2","key":"10.1016\/j.taap.2026.118022_bb0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.taap.2026.118022_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121947","article-title":"Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney","volume":"333","author":"Qiu","year":"2023","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.taap.2026.118022_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304686","article-title":"The impact of microplastics polystyrene on the microscopic structure of mouse intestine, tight junction genes and gut microbiota","volume":"19","author":"Su","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2026.118022_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115586","article-title":"SCD1 is the critical signaling hub to mediate metabolic diseases: mechanism and the development of its inhibitors","volume":"170","author":"Sun","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.taap.2026.118022_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26104870","article-title":"Adverse effect of polystyrene nanoplastics in impairing glucose metabolism in liver injury","volume":"26","author":"Susilo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.taap.2026.118022_bb0210","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/tox.23618","article-title":"Polystyrene nanoplastics exacerbated lipopolysaccharide-induced necroptosis and inflammation via the ROS\/MAPK pathway in mice spleen","volume":"37","author":"Tang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2026.118022_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117235","article-title":"Assessing the impact of sub-chronic polyethylene terephthalate nanoplastic exposure on male reproductive health in mice","volume":"495","author":"Tombul","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"13","key":"10.1016\/j.taap.2026.118022_bb0220","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.3390\/ijms26136156","article-title":"Micro- and nanoplastics as disruptors of the endocrine system\u2014a review of the threats and consequences associated with plastic exposure","volume":"26","author":"Tyc","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.118022_bb0225","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0230","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s10020-019-0075-4","article-title":"Silencing of SAA1 inhibits palmitate- or high-fat diet-induced insulin resistance through suppression of the NF-\u03baB pathway","volume":"25","author":"Wang","year":"2019","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0235","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12989-024-00582-w","article-title":"Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes","volume":"21","author":"Wang","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.taap.2026.118022_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133583","article-title":"Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE\u2212\/\u2212 mice","volume":"466","author":"Wen","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.taap.2026.118022_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12081714","article-title":"The potential mechanisms involved in the disruption of spermatogenesis in mice by nanoplastics and microplastics","volume":"12","author":"Wen","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.taap.2026.118022_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2026.118022_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131470","article-title":"Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice","volume":"454","author":"Xu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.taap.2026.118022_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141197","article-title":"Surface-charge-dependent ovarian toxicity of polystyrene microplastics: insights into accumulation, mitochondrial damage, and macrophage polarization","volume":"503","author":"Xu","year":"2026","journal-title":"J. Hazard. Mater."},{"issue":"27","key":"10.1016\/j.taap.2026.118022_bb0265","doi-asserted-by":"crossref","first-page":"34524","DOI":"10.1021\/acsami.4c04416","article-title":"Polystyrene nanoplastics induce lipid metabolism disorder by activating the PERK-ATF4 signaling pathway in mice","volume":"16","author":"Yu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.taap.2026.118022_bb0270","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12989-023-00557-3","article-title":"Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics","volume":"20","author":"Zhang","year":"2023","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.taap.2026.118022_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108353","article-title":"Continuous oral exposure to micro- and nanoplastics induced gut microbiota dysbiosis, intestinal barrier and immune dysfunction in adult mice","volume":"182","author":"Zhang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2026.118022_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117166","article-title":"Potential toxicity of microplastics on vertebrate liver: a systematic review and meta-analysis","volume":"286","author":"Zhang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.taap.2026.118022_bb0285","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00965-25","article-title":"Multi-omics analysis reveals the mechanism of Lactobacillus plantarum in alleviating metabolic disorders in type 2 diabetic mice through the gut-liver axis","volume":"10","author":"Zhang","year":"2025","journal-title":"mSystems"},{"issue":"4","key":"10.1016\/j.taap.2026.118022_bb0290","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/03602532.2025.2568231","article-title":"Research on the content and activity of CYP450 enzymes in human liver","volume":"57","author":"Zhang","year":"2025","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.taap.2026.118022_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172795","article-title":"Polystyrene nanoplastics cause reproductive toxicity in zebrafish: PPAR mediated lipid metabolism disorder","volume":"931","author":"Zheng","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2026.118022_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120438","article-title":"sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes","volume":"296","author":"Zhu","year":"2022","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.118022_bb0305","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acs.chemrestox.1c00374","article-title":"Polystyrene nanoplastics induce neutrophil extracellular traps in mice neutrophils","volume":"35","author":"Zhu","year":"2022","journal-title":"Chem. Res. Toxicol."},{"issue":"8","key":"10.1016\/j.taap.2026.118022_bb0310","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.3390\/ijms24087382","article-title":"Polystyrene microplastics induce oxidative stress in mouse hepatocytes in relation to their size","volume":"24","author":"Zou","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:49:21Z","timestamp":1790815761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26003182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":62,"alternative-id":["S0041008X26003182"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.118022","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene nanoplastics exposure induces reproductive toxicity in male mice associated with the gut\u2013liver\/testis axis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.118022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118022"}}