{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:08Z","timestamp":1790816828410,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2025SF-YBXM-005"],"award-info":[{"award-number":["2025SF-YBXM-005"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.taap.2026.118023","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:41:54Z","timestamp":1787848914000},"page":"118023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["RAB17 downregulation elicits antitumor impacts in prostate cancer by triggering ferroptotic cell death through the regulation of TfR1-mediated iron overload"],"prefix":"10.1016","volume":"516","author":[{"given":"Dongli","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanghui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.118023_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117293","article-title":"Evaluation of several farnesyloxycarbostyril derivatives as potential 15-LOX-1 inhibitors for prostate cancer treatment","volume":"498","author":"Aghasizadeh","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0010","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.eururo.2025.01.010","article-title":"Combination therapies in locally advanced and metastatic hormone-sensitive prostate cancer","volume":"87","author":"Azad","year":"2025","journal-title":"Eur. Urol."},{"key":"10.1016\/j.taap.2026.118023_bb0015","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.taap.2026.118023_bb0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41585-024-00869-9","article-title":"Unlocking ferroptosis in prostate cancer - the road to novel therapies and imaging markers","volume":"21","author":"Cao","year":"2024","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.taap.2026.118023_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134777","article-title":"Advancing glioblastoma treatment through iron metabolism: a focus on TfR1 and Ferroptosis innovations","volume":"278","author":"Caverzan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2026.118023_bb0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/09645284241302816","article-title":"Electroacupuncture improves postoperative cognitive dysfunction by inhibiting ferroptosis via the TFR1-DMT1-FPN pathway","volume":"43","author":"Chen","year":"2025","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.taap.2026.118023_bb0035","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2026.118023_bb0040","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.taap.2026.118023_bb0045","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad020","article-title":"Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers","volume":"11","author":"Du","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.taap.2026.118023_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117622","article-title":"The neonicotinoid Imidacloprid provokes Ferritinophagy\/Ferroptosis Axis disruption in rats\u2019 liver: the attenuation impact of Berberine chloride-loaded nano-liposomes","volume":"506","author":"Farag","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0055","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","article-title":"Epidemiology and prevention of prostate cancer","volume":"4","author":"Gandaglia","year":"2021","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.taap.2026.118023_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117233","article-title":"Cadmium-induced iron dysregulation contributes to functional impairment in brain endothelial cells via the ferroptosis pathway","volume":"495","author":"Gil","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41419-024-06464-5","article-title":"CYLD regulates cell ferroptosis through hippo\/YAP signaling in prostate cancer progression","volume":"15","author":"Gu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.118023_bb0070","doi-asserted-by":"crossref","first-page":"13211","DOI":"10.2147\/OTT.S285153","article-title":"Knockdown of circular RNA Hsa_circ_0000714 can regulate RAB17 by sponging miR-370-3p to reduce paclitaxel resistance of ovarian cancer through CDK6\/RB pathway","volume":"13","author":"Guo","year":"2020","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.taap.2026.118023_bb0075","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/cmi.12329","article-title":"Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion","volume":"16","author":"Haobam","year":"2014","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.taap.2026.118023_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2026.117732","article-title":"Potassium channel tetramerization domain-containing 10 exerts a tumor suppressive function in breast cancer by destabilizing SLC7A11 to induce ferroptosis","volume":"508","author":"He","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0085","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1039\/D3BM01894F","article-title":"Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer","volume":"12","author":"Huang","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.taap.2026.118023_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155835","article-title":"Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs","volume":"132","author":"Jia","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.taap.2026.118023_bb0095","article-title":"The role of RAB GTPases and its potential in predicting immunotherapy response and prognosis in colorectal cancer","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.taap.2026.118023_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116769","article-title":"Heavy metals, oxidative stress, and the role of AhR signaling","volume":"482","author":"Kou","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0105","article-title":"The role of transcription factors in prostate cancer progression","volume":"48","author":"Lee","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2026.118023_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2026.117912","article-title":"Targeting NFS1-mediated ferroptosis mitigates alveolar injury in experimental idiopathic pulmonary fibrosis","volume":"514","author":"Li","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107915","article-title":"Precision targeting of androgen receptor-ferroptosis crosstalk in prostate cancer: from mechanisms to therapeutic strategies","volume":"219","author":"Lv","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2026.118023_bb0120","doi-asserted-by":"crossref","first-page":"14347","DOI":"10.3390\/ijms241814347","article-title":"Emerging immunotherapy approaches for treating prostate cancer","volume":"24","author":"Meng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.118023_bb0125","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41580-025-00843-2","article-title":"Recommendations for robust and reproducible research on ferroptosis","volume":"26","author":"Mishima","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2026.118023_bb0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41392-025-02129-7","article-title":"Molecular principles underlying aggressive cancers","volume":"10","author":"Nussinov","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.118023_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.101032","article-title":"Epitranscriptomic mechanisms of androgen signalling and prostate cancer","volume":"56","author":"Patke","year":"2024","journal-title":"Neoplasia"},{"key":"10.1016\/j.taap.2026.118023_bb0140","first-page":"4963","article-title":"Down-regulation of Rab17 promotes tumourigenic properties of hepatocellular carcinoma cells via Erk pathway","volume":"8","author":"Qi","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.taap.2026.118023_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70126","article-title":"Hypoxic neural stem cells enhance spinal cord repair through HIF-1a\/RAB17-driven extracellular vesicle release","volume":"14","author":"Qin","year":"2025","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.taap.2026.118023_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117638","article-title":"Matairesinol regulates TGF-beta-induced EMT and TGF-beta associated crosstalk with Wnt Signaling in PC3 prostate cancer cells: an omics-guided therapeutic insight","volume":"506","author":"Rajadnya","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.taap.2026.118023_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.70037","article-title":"Optimizing treatment for metastatic castration-resistant prostate cancer: Food and Drug Administration-approved therapies, emerging strategies, and biomarker-driven approaches","volume":"131","author":"Saeed","year":"2025","journal-title":"Cancer"},{"key":"10.1016\/j.taap.2026.118023_bb0165","doi-asserted-by":"crossref","first-page":"T109","DOI":"10.1530\/ERC-21-0073","article-title":"Management of early-stage metastatic prostate cancer: appraisal of locoregional treatments and radiation therapy, with or without immunomodulation","volume":"28","author":"Sandoval","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"issue":"Pt 1","key":"10.1016\/j.taap.2026.118023_bb0170","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj3150021","article-title":"Benzyloxycarbonyl-Val-ala-asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32","volume":"315","author":"Slee","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2026.118023_bb0175","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2026.118023_bb0180","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.taap.2026.118023_bb0185","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1091\/mbc.E18-07-0433","article-title":"Rab17 regulates apical delivery of hepatic transcytotic vesicles","volume":"29","author":"Striz","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.taap.2026.118023_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.176","article-title":"Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models","volume":"3","author":"Takahashi","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.118023_bb0195","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-025-07809-4","article-title":"SLC7A11 upregulation via AR and NEDD4L ubiquitination contributes to ferroptosis inhibition and enzalutamide resistance in castration-resistant prostate cancer","volume":"16","author":"Tang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.118023_bb0200","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrurol.2016.89","article-title":"The role of the prostate in male fertility, health and disease","volume":"13","author":"Verze","year":"2016","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.taap.2026.118023_bb0205","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/1759-7714.13278","article-title":"Downregulation of Rab17 promotes cell proliferation and invasion in non-small cell lung cancer through STAT3\/HIF-1alpha\/VEGF signaling","volume":"11","author":"Wang","year":"2020","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.taap.2026.118023_bb0210","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12943-021-01307-9","article-title":"Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer","volume":"20","author":"Wu","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.taap.2026.118023_bb0215","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41419-025-07848-x","article-title":"CENPT prevents renal cell carcinoma against ferroptosis by enhancing the synthesis of glutathione","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.118023_bb0220","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12967-025-06180-4","article-title":"Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2026.118023_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.431","article-title":"Rab17 mediates differential antigen sorting following efferocytosis and phagocytosis","volume":"7","author":"Yin","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2026.118023_bb0230","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41420-025-02528-3","article-title":"Mitochondrial SLC25A10 promotes prostate cancer progression by inhibiting ferritinophagy","volume":"11","author":"Yu","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.taap.2026.118023_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110743","article-title":"Downregulation of RAB17 have a poor prognosis in kidney renal clear cell carcinoma and its expression correlates with DNA methylation and immune infiltration","volume":"109","author":"Zeng","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.taap.2026.118023_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2026.117720","article-title":"Nuclear protein 1 defends against acute pancreatitis by mitigating pancreatic acinar cell ferroptosis through the maintenance of cellular iron homeostasis","volume":"508","author":"Zeng","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117148","article-title":"Inhibition of CDGSH iron-sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2\/SLC7A11\/GPX4 pathway","volume":"493","author":"Zhang","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2026.118023_bb0250","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12915-025-02378-6","article-title":"Iron metabolism and ferroptosis in human health and disease","volume":"23","author":"Zhong","year":"2025","journal-title":"BMC Biol."},{"key":"10.1016\/j.taap.2026.118023_bb0255","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jcp.29845","article-title":"Analysis of carcinogenic signaling networks in endometrial cancer identifies RAB17 as a potential target","volume":"236","author":"Zhou","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2026.118023_bb0260","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41419-024-07013-w","article-title":"RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis","volume":"15","author":"Zhou","year":"2024","journal-title":"Cell Death Dis."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:47:19Z","timestamp":1790815639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26003194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":52,"alternative-id":["S0041008X26003194"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.118023","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RAB17 downregulation elicits antitumor impacts in prostate cancer by triggering ferroptotic cell death through the regulation of TfR1-mediated iron overload","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.118023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118023"}}