{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:21Z","timestamp":1790816841208,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018996","name":"Hellenic Academic Libraries Link","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.taap.2026.118027","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:42:29Z","timestamp":1788565349000},"page":"118027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sodasulphanecobalamin provides rapid cyanide detoxification and hemodynamic rescue in a rat model of acute cyanide poisoning"],"prefix":"10.1016","volume":"516","author":[{"given":"Olatunji Nozeem","family":"Salako","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Sarris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Anayo","family":"Orji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chukuemaka","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaliyapillai","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Kenar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.taap.2026.118027_bb0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2174\/138955707780619581","article-title":"Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction","volume":"7","author":"Bajgar","year":"2007","journal-title":"Mini-Rev. Med. Chem."},{"issue":"7022","key":"10.1016\/j.taap.2026.118027_bb0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/bmj.312.7022.26","article-title":"Relation between plasma lactate and blood cyanide concentrations in acute cyanide poisoning","volume":"312","author":"Baud","year":"1996","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.taap.2026.118027_bb0025","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.annemergmed.2016.09.034","article-title":"Sodium nitrite and sodium thiosulfate are effective against acute cyanide poisoning when administered by intramuscular injection","volume":"69","author":"Bebarta","year":"2017","journal-title":"Ann. Emerg. Med."},{"issue":"19","key":"10.1016\/j.taap.2026.118027_bb0035","article-title":"Oxidative neutralisation of sulfur-based chemical warfare agents mediated by a lipase: from batch to flow reactor","volume":"31","author":"Boddaert","year":"2025","journal-title":"Chemistry"},{"key":"10.1016\/j.taap.2026.118027_bb0040","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.12409","article-title":"The determination of thiocyanate in the blood plasma and holding water of Amphiprion clarkii after exposure to cyanide","volume":"9","author":"Bonanno","year":"2021","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.taap.2026.118027_bb0050","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.annemergmed.2007.01.026","article-title":"Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation","volume":"49","author":"Borron","year":"2007","journal-title":"Ann. Emerg. Med."},{"issue":"6","key":"10.1016\/j.taap.2026.118027_bb0060","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.chemosphere.2005.09.048","article-title":"Cyanide detoxification by recombinant bacterial rhodanese","volume":"63","author":"Cipollone","year":"2006","journal-title":"Chemosphere"},{"issue":"11","key":"10.1016\/j.taap.2026.118027_bb0065","doi-asserted-by":"crossref","first-page":"850","DOI":"10.7205\/MILMED.169.11.850","article-title":"A review of multi-threat medical countermeasures against chemical warfare and terrorism","volume":"169","author":"Cowan","year":"2004","journal-title":"Mil. Med."},{"issue":"7","key":"10.1016\/j.taap.2026.118027_bb0085","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/10408440802304944","article-title":"Which cyanide antidote?","volume":"39","author":"Hall","year":"2009","journal-title":"Crit. Rev. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2026.118027_bb0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s43188-022-00156-y","article-title":"Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats","volume":"39","author":"Han","year":"2022","journal-title":"Toxicol. Res."},{"issue":"3","key":"10.1016\/j.taap.2026.118027_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010220","article-title":"The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infections","volume":"16","author":"Hickman","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"15","key":"10.1016\/j.taap.2026.118027_bb0105","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1002\/cbic.201500348","article-title":"Discovery of new classes of compounds that reactivate acetylcholinesterase inhibited by organophosphates","volume":"16","author":"Katz","year":"2015","journal-title":"Chembiochem"},{"issue":"8","key":"10.1016\/j.taap.2026.118027_bb0125","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1074\/jbc.RA117.000826","article-title":"Thiosulfate sulfurtransferase-like domain\u2013containing 1 protein interacts with thioredoxin","volume":"293","author":"Libiad","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.taap.2026.118027_bb0130","first-page":"305","article-title":"Comparison of antidotal efficacy of chelating agents upon acute toxicity of co(II) in mice","volume":"50","author":"Llobet","year":"1985","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.taap.2026.118027_bb0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/inorganics12030091","article-title":"Fluorescent vitamin B12\u2013platinum(II) derivatives as potential metallotheranostic agents for the treatment and imaging of tumors","volume":"12","author":"Mehder","year":"2024","journal-title":"Inorganics"},{"issue":"3","key":"10.1016\/j.taap.2026.118027_bb0150","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5731\/pdajpst.2014.00974","article-title":"Advice on degradation products in pharmaceuticals: a toxicological evaluation","volume":"68","author":"Melo","year":"2014","journal-title":"PDA J. Pharm. Sci. Technol."},{"issue":"12","key":"10.1016\/j.taap.2026.118027_bb0155","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1289\/ehp.99107933","article-title":"The sources, fate, and toxicity of chemical warfare agent degradation products","volume":"107","author":"Munro","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2026.118027_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.923432","article-title":"Correlating biodegradation kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the dynamics of microbial communities originating from soil in Vietnam contaminated with herbicides and dioxins","volume":"13","author":"Nguyen","year":"2022","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.taap.2026.118027_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072342","article-title":"Novel aspects of toxicity mechanisms of dioxins and related compounds","volume":"21","author":"Pohjanvirta","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.118027_bb0180","first-page":"241","article-title":"Therapeutic options to treat mustard gas poisoning - review","volume":"10","author":"Rafati-Rahimzadeh","year":"2019","journal-title":"Casp. J. Intern. Med."},{"key":"10.1016\/j.taap.2026.118027_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2019.00289","article-title":"Enzymatic bioremediation of organophosphate compounds\u2014progress and remaining challenges","volume":"7","author":"Thakur","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.taap.2026.118027_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.05.001","article-title":"Effect of sub-acute oral cyanide administration in rats: protective efficacy of alpha-ketoglutarate and sodium thiosulfate","volume":"156","author":"Tulsawani","year":"2005","journal-title":"Chem. Biol. Interact."},{"issue":"49","key":"10.1016\/j.taap.2026.118027_bb0205","doi-asserted-by":"crossref","first-page":"58291","DOI":"10.1021\/acsami.1c15890","article-title":"Detoxification of the toxic Sulfur mustard simulant by a supramolecular antidote in vitro and in vivo","volume":"13","author":"Zhou","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:48:51Z","timestamp":1790815731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26003236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":23,"alternative-id":["S0041008X26003236"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.118027","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodasulphanecobalamin provides rapid cyanide detoxification and hemodynamic rescue in a rat model of acute cyanide poisoning","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.118027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118027"}}