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Dis."},{"issue":"8","key":"10.1016\/j.taap.2026.118035_bb0475","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","article-title":"Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification","volume":"32","author":"Shen","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.taap.2026.118035_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117085","article-title":"Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells","volume":"285","author":"Shi","year":"2024","journal-title":"Ecotoxicol. Environ. 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