{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:36Z","timestamp":1790816856199,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,24]],"date-time":"2027-09-24T00:00:00Z","timestamp":1821744000000},"content-version":"am","delay-in-days":327,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL171763"],"award-info":[{"award-number":["R01 HL171763"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL149351"],"award-info":[{"award-number":["R01 HL149351"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["T32ES011564"],"award-info":[{"award-number":["T32ES011564"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES023716"],"award-info":[{"award-number":["P42 ES023716"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES033531"],"award-info":[{"award-number":["R01 ES033531"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.taap.2026.118037","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:50:59Z","timestamp":1789721459000},"page":"118037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chronic inhalation of m-xylene disrupts vascular homeostasis through endothelial injury and impaired vascular repair"],"prefix":"10.1016","volume":"516","author":[{"given":"Marina V.","family":"Malovichko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha A.","family":"McFall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breandon S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalinie S.","family":"Wickramasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel D.","family":"Sithu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Conklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor N.","family":"Zelko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.taap.2026.118037_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183602","article-title":"Benzene exposure is associated with cardiovascular disease risk","volume":"12","author":"Abplanalp","year":"2017","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.taap.2026.118037_bb0010","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/toxsci\/kfy252","article-title":"Benzene exposure induces insulin resistance in mice","volume":"167","author":"Abplanalp","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2026.118037_bb0015","doi-asserted-by":"crossref","first-page":"H479","DOI":"10.1152\/ajpheart.00817.2003","article-title":"Cardiovascular pathophysiology of environmental pollutants","volume":"286","author":"Bhatnagar","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.taap.2026.118037_bb0020","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.0000243586.99701.cf","article-title":"Environmental cardiology - studying mechanistic links between pollution and heart disease","volume":"99","author":"Bhatnagar","year":"2006","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.taap.2026.118037_bb0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.thromres.2011.10.010","article-title":"Platelet-leukocyte interactions in thrombosis","volume":"129","author":"Cerletti","year":"2012","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.taap.2026.118037_bb0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/toxsci\/kfx095","article-title":"Biomarkers of chronic acrolein inhalation exposure in mice: implications for tobacco product-induced toxicity","volume":"158","author":"Conklin","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.taap.2026.118037_bb0035","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction - testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.taap.2026.118037_bb0040","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000934","article-title":"Acrolein exposure is associated with increased cardiovascular disease risk","volume":"3","author":"DeJarnett","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"13","key":"10.1016\/j.taap.2026.118037_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16132284","article-title":"Personal NO(2) and volatile organic compounds exposure levels are associated with markers of cardiovascular risk in women in the Cape Town region of South Africa","volume":"16","author":"Everson","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.taap.2026.118037_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170639","article-title":"Exposure to BTEX is associated with cardiovascular disease, dyslipidemia and leukocytosis in national US population","volume":"919","author":"He","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"22","key":"10.1016\/j.taap.2026.118037_bb0055","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1161\/hc4601.099485","article-title":"Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease","volume":"104","author":"Heitzer","year":"2001","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.taap.2026.118037_bb0060","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"Hill","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.taap.2026.118037_bb0065","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cmet.2007.10.005","article-title":"Metabolomics","volume":"6","author":"Idle","year":"2007","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.taap.2026.118037_bb0070","doi-asserted-by":"crossref","first-page":"H1510","DOI":"10.1152\/ajpheart.00878.2020","article-title":"Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: role of acetaldehyde and formaldehyde","volume":"320","author":"Jin","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.taap.2026.118037_bb0075","first-page":"687","article-title":"Activation of blood platelets in workers exposed to organic solvents","volume":"34","author":"Kyvik","year":"1992","journal-title":"J. Occup. Med."},{"issue":"4","key":"10.1016\/j.taap.2026.118037_bb0080","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/09537109409006046","article-title":"Hydrophobic organic-solvents activate human platelets in-vitro","volume":"5","author":"Kyvik","year":"1994","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.taap.2026.118037_bb0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/ntr\/ntx230","article-title":"Systemic toxicity of smokeless tobacco products in mice","volume":"21","author":"Malovichko","year":"2019","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.taap.2026.118037_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115742","article-title":"Subclinical markers of cardiovascular toxicity of benzene inhalation in mice","volume":"431","author":"Malovichko","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"50","key":"10.1016\/j.taap.2026.118037_bb0095","doi-asserted-by":"crossref","first-page":"27044","DOI":"10.1021\/acs.est.5c04941","article-title":"Detection and proinflammatory effects of BTEX within the human atherosclerotic plaque","volume":"59","author":"Marfella","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2026.118037_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.110903","article-title":"Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction","volume":"196","author":"McGraw","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2026.118037_bb0105","series-title":"Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan","first-page":"192","author":"Medicine Io","year":"2011"},{"key":"10.1016\/j.taap.2026.118037_bb0110","first-page":"1167","article-title":"A review of environmental and occupational exposure to xylene and its health concerns","volume":"14","author":"Niaz","year":"2015","journal-title":"EXCLI J."},{"issue":"12","key":"10.1016\/j.taap.2026.118037_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226744","article-title":"Electronic cigarettes and insulin resistance in animals and humans: results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016)","volume":"14","author":"Orimoloye","year":"2019","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.taap.2026.118037_bb0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCRESAHA.110.222679","article-title":"Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells","volume":"107","author":"O\u2019Toole","year":"2010","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.taap.2026.118037_bb0125","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1172\/JCI119009","article-title":"Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts","volume":"98","author":"Pan","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2026.118037_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115877","article-title":"Environmental exposure to volatile organic compounds is associated with endothelial injury","volume":"437","author":"Riggs","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2026.118037_bb0135","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/j.1538-7836.2006.01911.x","article-title":"Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome","volume":"4","author":"Simak","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.taap.2026.118037_bb0140","doi-asserted-by":"crossref","unstructured":"Sinning JM, Losch J, Walenta K, Bohm M, Nickenig G, Werner N. Circulating CD31+\/annexin V+ microparticles correlate with cardiovascular outcomes. Eur. Heart J. 2011;32(16):2034\u201341. doi:https:\/\/doi.org\/10.1093\/eurheartj\/ehq478. Epub 20101224. PubMed PMID: 21186238.","DOI":"10.1093\/eurheartj\/ehq478"},{"issue":"2","key":"10.1016\/j.taap.2026.118037_bb0145","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.taap.2010.07.013","article-title":"Exposure to acrolein by inhalation causes platelet activation","volume":"248","author":"Sithu","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.taap.2026.118037_bb0150","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86442","article-title":"Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats","volume":"2","author":"Sithu","year":"2017","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.taap.2026.118037_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.atherosclerosis.2011.01.001","article-title":"Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice","volume":"215","author":"Srivastava","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.taap.2026.118037_bb0160","series-title":"Toxicological Profile for Xylene, Atlanta GA","year":"2007"},{"issue":"5","key":"10.1016\/j.taap.2026.118037_bb0165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/09537109409006432","article-title":"Organic-solvents activate human platelets through the inositol lipid-linked signal-transduction system","volume":"5","author":"Tysnes","year":"1994","journal-title":"Platelets"},{"issue":"10","key":"10.1016\/j.taap.2026.118037_bb0170","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMoa043814","article-title":"Circulating endothelial progenitor cells and cardiovascular outcomes","volume":"353","author":"Werner","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.taap.2026.118037_bb0175","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/01.ATV.0000191634.13057.15","article-title":"Circulating CD31 annexin V apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease","volume":"26","author":"Werner","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.taap.2026.118037_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13121212","article-title":"Oxidative stress and genotoxicity of long-term occupational exposure to low levels of BTEX in gas station workers","volume":"13","author":"Xiong","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.taap.2026.118037_bb0185","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 47.: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","author":"Xylene","year":"1989"},{"issue":"1","key":"10.1016\/j.taap.2026.118037_bb0190","article-title":"Mediating effect of oxidative stress on blood pressure elevation in workers exposed to low concentrations of benzene, toluene, and xylene (BTX)","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:48:30Z","timestamp":1790815710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26003339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S0041008X26003339"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.118037","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic inhalation of m-xylene disrupts vascular homeostasis through endothelial injury and impaired vascular repair","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.118037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118037"}}