{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:07:21Z","timestamp":1790816841240,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000139","name":"United States Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.taap.2026.118046","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:20:12Z","timestamp":1790097612000},"page":"118046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acute or developmental exposure of primary rat cortical cells to Emamectin Benzoate disrupts gene expression"],"prefix":"10.1016","volume":"516","author":[{"given":"Thomas W.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Freeborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold M.","family":"Winnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Padgett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasada Rao S.","family":"Kodavanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.118046_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105771","article-title":"Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives","volume":"177","author":"Adla","year":"2024","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.taap.2026.118046_bb0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.dnarep.2018.08.019","article-title":"DNA double-strand breaks as drivers of neural genomic change, function, and disease","volume":"71","author":"Alt","year":"2018","journal-title":"DNA Repair"},{"key":"10.1016\/j.taap.2026.118046_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cotox.2018.03.004","article-title":"The adverse outcome pathway: a multifaceted framework supporting 21st century toxicology","volume":"9","author":"Ankley","year":"2018","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.taap.2026.118046_bb0020","series-title":"Ivermectin and Abamectin","year":"1989"},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12859-020-03910-x","article-title":"multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data","volume":"21","author":"Canzler","year":"2020","journal-title":"BMC Bioinform"},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/toxsci\/kfac018","article-title":"Integrating data from in vitro new approach methodologies for developmental neurotoxicity","volume":"187","author":"Carstens","year":"2022","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2026.118046_bb0035","series-title":"ToxCast Database: Invitrodb version 4.3 (p. 0 Bytes)","author":"Center for Computational Toxicology and Exposure, E","year":"2025"},{"issue":"3","key":"10.1016\/j.taap.2026.118046_bb0040","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.etap.2015.04.008","article-title":"Toxic effects of sub-chronic exposure of male albino rats to emamectin benzoate and possible ameliorative role of Foeniculum vulgare essential oil","volume":"39","author":"El-Sheikh","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005968","article-title":"Reactome graph database: efficient access to complex pathway data","volume":"14","author":"Fabregat","year":"2018","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13073-016-0384-y","article-title":"XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits","volume":"8","author":"Fang","year":"2016","journal-title":"Genome Med"},{"issue":"5","key":"10.1016\/j.taap.2026.118046_bb0055","first-page":"505","article-title":"The benchmark dose method\u2014review of available models, and recommendations for application in health risk assessment","volume":"33","author":"Filipsson","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"issue":"9553","key":"10.1016\/j.taap.2026.118046_bb0060","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.taap.2026.118046_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165787","article-title":"Potential adverse outcome pathway (AOP) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (Danio rerio)","volume":"900","author":"Gu","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.taap.2026.118046_bb0070","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.3390\/ijms24043757","article-title":"Neurodevelopmental toxicity of Emamectin Benzoate to the early life stage of zebrafish larvae (Danio rerio)","volume":"24","author":"Gu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0075","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ymthe.2025.10.039","article-title":"siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients","volume":"34","author":"Guida","year":"2026","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0080","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/toxsci\/kfab009","article-title":"High-throughput transcriptomics platform for screening environmental chemicals","volume":"181","author":"Harrill","year":"2021","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2026.118046_bb0085","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0168-0102(93)90076-3","article-title":"Formation and maturation of synapses in primary cultures of rat cerebral cortical cells: an electron microscopic study","volume":"16","author":"Ichikawa","year":"1993","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0090","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2012482118","article-title":"Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration","volume":"118","author":"Ishii","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.taap.2026.118046_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106202","article-title":"Emamectin benzoate and nanoplastics induce PANoptosis of common carp (Cyprinus carpio) gill through MAPK pathway","volume":"206","author":"Ju","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0100","first-page":"385","article-title":"Toxicity of Fipronil and Emamectin Benzoate and their mixtures against cotton Leafworm, Spodoptera littoralis (Lepidoptera: Noctuidae) with relation to GABA content","volume":"113","author":"Kandil","year":"2020","journal-title":"J. Econ. Entomol."},{"issue":"4","key":"10.1016\/j.taap.2026.118046_bb0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.autrev.2009.08.002","article-title":"The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis","volume":"9","author":"Kaushansky","year":"2010","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.taap.2026.118046_bb0110","first-page":"72","article-title":"Emamectin benzoate (Proclaim\u00ae) mediates biochemical changes and histopathological damage in the kidney of male Wistar rats (Rattus norvegicus)","volume":"27","author":"Khaldoun-Oularbi","year":"2015","journal-title":"Toxicol. Anal. Clin."},{"issue":"6","key":"10.1016\/j.taap.2026.118046_bb0115","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10646-021-02426-1","article-title":"Emamectin benzoate induced enzymatic and transcriptional alternation in detoxification mechanism of predatory beetle Paederus fuscipes (Coleoptera: Staphylinidae) at the sublethal concentration","volume":"30","author":"Khan","year":"2021","journal-title":"Ecotoxicology (London, England)"},{"issue":"6","key":"10.1016\/j.taap.2026.118046_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/toxics12060437","article-title":"Integrated approach for testing and assessment for developmental neurotoxicity (DNT) to prioritize aromatic organophosphorus flame retardants","volume":"12","author":"Kreutz","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2026.118046_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2024.1402630","article-title":"Stem cell-based approaches for developmental neurotoxicity testing","volume":"6","author":"Ku","year":"2024","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.taap.2026.118046_bb0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/bs.ctdb.2020.11.003","article-title":"The essential role of primary cilia in cerebral cortical development and disorders","volume":"142","author":"Liu","year":"2021","journal-title":"Curr. Top. Dev. Biol."},{"issue":"12","key":"10.1016\/j.taap.2026.118046_bb0135","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"8","key":"10.1016\/j.taap.2026.118046_bb0140","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/tox.23149","article-title":"Nigella sativa oil protects against emamectin benzoate-induced neurotoxicity in rats","volume":"36","author":"Madkour","year":"2021","journal-title":"Environ. Toxicol."},{"issue":"3","key":"10.1016\/j.taap.2026.118046_bb0145","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1021\/cn900029p","article-title":"Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism","volume":"1","author":"Mehta","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.taap.2026.118046_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113618","article-title":"Toxic effects of the Emamectin Benzoate exposure on cultured human bronchial epithelial (16HBE) cells","volume":"257","author":"Niu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2026.118046_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntt.2021.106981","article-title":"Neuroprotective effect of hesperidin against emamectin benzoate-induced neurobehavioral toxicity in rats","volume":"86","author":"Noshy","year":"2021","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.taap.2026.118046_bb0160","series-title":"NTP Research Report on National Toxicology Program Approach to Genomic Dose-Response Modeling: Research Report 5","author":"NTP","year":"2018"},{"issue":"2","key":"10.1016\/j.taap.2026.118046_bb0165","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/toxsci\/kfae145","article-title":"Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities","volume":"203","author":"O\u2019Brien","year":"2025","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2026.118046_bb0170","first-page":"101","article-title":"Review of Emamectin benzoate poisoning","volume":"14","author":"Pan","year":"2024","journal-title":"JACME"},{"key":"10.1016\/j.taap.2026.118046_bb0175","doi-asserted-by":"crossref","DOI":"10.1177\/09603271241249965","article-title":"Reassessing clinical presentations of emamectin benzoate poisoning: a comprehensive study","volume":"43","author":"Pan","year":"2024","journal-title":"Hum. Exp. Toxicol."},{"issue":"10","key":"10.1016\/j.taap.2026.118046_bb0180","first-page":"1780","article-title":"BMDExpress 2: enhanced transcriptomic dose-response analysis workflow","volume":"35","author":"Phillips","year":"2019","journal-title":"Bioinf. (Oxf.)"},{"issue":"2","key":"10.1016\/j.taap.2026.118046_bb0185","doi-asserted-by":"crossref","DOI":"10.1042\/NS20180207","article-title":"Culturing primary neurons from rat hippocampus and cortex","volume":"3","author":"Sahu","year":"2019","journal-title":"Neuronal. Signal"},{"key":"10.1016\/j.taap.2026.118046_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121660","article-title":"Combined exposure of emamectin benzoate and microplastics induces tight junction disorder, immune disorder and inflammation in carp midgut via lysosome\/ROS\/ferroptosis pathway","volume":"257","author":"Shi","year":"2024","journal-title":"Water Res."},{"issue":"12","key":"10.1016\/j.taap.2026.118046_bb0195","first-page":"1441","article-title":"The neural palette of heme: altered heme homeostasis underlies defective neurotransmission, increased oxidative stress, and disease pathogenesis","volume":"13","author":"Soladogun","year":"2024","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"21","key":"10.1016\/j.taap.2026.118046_bb0200","doi-asserted-by":"crossref","first-page":"11994","DOI":"10.1021\/acs.est.6b03456","article-title":"Whole-organism transcriptomic analysis provides mechanistic insight into the acute toxicity of Emamectin Benzoate in Daphnia magna","volume":"50","author":"Song","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.taap.2026.118046_bb0205","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1523\/JNEUROSCI.0124-22.2022","article-title":"Mllt11 regulates migration and neurite outgrowth of cortical projection neurons during development","volume":"42","author":"Stanton-Turcotte","year":"2022","journal-title":"J. Neurosci."},{"issue":"43","key":"10.1016\/j.taap.2026.118046_bb0210","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0215","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/toxsci\/kfm092","article-title":"A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure","volume":"98","author":"Thomas","year":"2007","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.taap.2026.118046_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105651","article-title":"GABA system as the cause and effect in early development","volume":"161","author":"Topchiy","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.taap.2026.118046_bb0225","unstructured":"U.S. EPA. (2025). ToxCast & Tox21 Summary Files from invitrodb_v4 (https:\/\/www.epa.gov\/comptox-Tools\/toxicity-Forecasting-Toxcast; version v4)."},{"key":"10.1016\/j.taap.2026.118046_bb0230","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.aquatox.2011.10.015","article-title":"Biological effects of the anti-parasitic chemotherapeutant emamectin benzoate on a non-target crustacean, the spot prawn (Pandalus platyceros Brandt, 1851) under laboratory conditions","volume":"108","author":"Veldhoen","year":"2012","journal-title":"Aquat. Toxicol. (Amsterdam, Neth.)"},{"issue":"2","key":"10.1016\/j.taap.2026.118046_bb0235","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S000748532300038X","article-title":"Molecular mechanisms of cytochrome P450-mediated detoxification of tetraniliprole, spinetoram, and emamectin benzoate in the fall armyworm, Spodoptera frugiperda (J.E. Smith)","volume":"114","author":"Wang","year":"2024","journal-title":"Bull. Entomol. Res."},{"issue":"3","key":"10.1016\/j.taap.2026.118046_bb0240","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/tox.23681","article-title":"The potential immunotoxicity of emamectin benzoate on the human THP-1 macrophages","volume":"38","author":"Wei","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"7","key":"10.1016\/j.taap.2026.118046_bb0245","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1021\/acs.jproteome.3c00172","article-title":"Proteome profiling of rat brain cortical changes during early postnatal brain development","volume":"22","author":"Winnik","year":"2023","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.taap.2026.118046_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2026.117824","article-title":"Proteome profiling of emamectin-treated primary rat cortical cells following up to twelve days in vitro exposure","volume":"511","author":"Winnik","year":"2026","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2026.118046_bb0255","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0892-0362(97)00002-0","article-title":"Developmental neurotoxicity evaluation of the avermectin pesticide, emamectin benzoate, in Sprague-Dawley rats","volume":"19","author":"Wise","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.taap.2026.118046_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106396","article-title":"Polystyrene-microplastics and Emamectin Benzoate co-exposure induced lipid remodeling by suppressing PPAR\u03b1 signals to drive ACSL4-dependent ferroptosis and carp splenic injury","volume":"210","author":"Wu","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"issue":"4","key":"10.1016\/j.taap.2026.118046_bb0265","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2016.03.097","article-title":"Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABAA\/C receptors","volume":"473","author":"Xu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.taap.2026.118046_bb0270","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1046\/j.1460-9568.1999.00490.x","article-title":"Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin","volume":"11","author":"Yamamoto","year":"1999","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.taap.2026.118046_bb0275","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/1471-2164-8-387","article-title":"BMDExpress: a software tool for the benchmark dose analyses of genomic data","volume":"8","author":"Yang","year":"2007","journal-title":"BMC Genomics"},{"issue":"5","key":"10.1016\/j.taap.2026.118046_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178302","article-title":"A trichostatin a expression signature identified by TempO-Seq targeted whole transcriptome profiling","volume":"12","author":"Yeakley","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2026.118046_bb0285","series-title":"clusterProfiler","author":"Yu","year":"2017"},{"key":"10.1016\/j.taap.2026.118046_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114827","article-title":"Emamectin benzoate-induced toxicity affects intestinal epithelial integrity involving apoptosis","volume":"190","author":"Yue","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"47","key":"10.1016\/j.taap.2026.118046_bb0295","doi-asserted-by":"crossref","first-page":"82185","DOI":"10.18632\/oncotarget.18988","article-title":"Potential genotoxic and cytotoxicity of emamectin benzoate in human normal liver cells","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2026.118046_bb0300","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.reprotox.2020.06.010","article-title":"A cross-platform approach to characterize and screen potential neurovascular unit toxicants","volume":"96","author":"Zurlinden","year":"2020","journal-title":"Reprod. Toxicol. (Elmsford, NY)"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2600342X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2600342X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:48:37Z","timestamp":1790815717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2600342X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":60,"alternative-id":["S0041008X2600342X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.118046","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute or developmental exposure of primary rat cortical cells to Emamectin Benzoate disrupts gene expression","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.118046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118046"}}