{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:24:44Z","timestamp":1793917484466,"version":"4.8.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2023QH1127"],"award-info":[{"award-number":["2023QH1127"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.taap.2026.118082","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:17:03Z","timestamp":1791818223000},"page":"118082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Auriculasin induces LACTB expression to regulate colorectal cancer cell apoptosis, ferroptosis, invasion, and in vivo tumor growth"],"prefix":"10.1016","volume":"517","author":[{"given":"Jia-sheng","family":"Ke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ze","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-bin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-shi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2026.118082_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.fct.2019.02.030","article-title":"Auriculasin sensitizes primary prostate cancer cells to TRAIL-mediated apoptosis through up-regulation of the DR5-dependent pathway","volume":"126","author":"Cho","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2026.118082_bb0005","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.fct.2017.12.007","article-title":"Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis","volume":"111","author":"Cho","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2026.118082_bb0010","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.fct.2018.09.025","article-title":"Effects of auriculasin on vascular endothelial growth factor (VEGF)-induced angiogenesis via regulation of VEGF receptor 2 signaling pathways in vitro and in vivo","volume":"121","author":"Cho","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2026.118082_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176013","article-title":"Cancer chemotherapy resistance: mechanisms and recent breakthrough in targeted drug delivery","volume":"958","author":"Davodabadi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2026.118082_bb0025","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.taap.2026.118082_bb0030","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/1735-5362.288425","article-title":"Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies","volume":"15","author":"Hashemi","year":"2020","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.taap.2026.118082_bb0035","first-page":"527","article-title":"Pinocembrin inhibits the proliferation, migration, invasiveness, and epithelial-mesenchymal transition of colorectal cancer cells by regulating LACTB","volume":"37","author":"Jiang","year":"2022","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.taap.2026.118082_bb0045","article-title":"LACTB, a metabolic therapeutic target in clinical cancer application","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.taap.2026.118082_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/cas.13134","article-title":"Activation of MMP-9 by membrane type-1 MMP\/MMP-2 axis stimulates tumor metastasis","volume":"108","author":"Li","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.taap.2026.118082_bb0050","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.2147\/IJN.S331519","article-title":"Targeted nanotherapeutics using LACTB gene therapy against melanoma","volume":"16","author":"Liu","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.taap.2026.118082_bb0055","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/mc.23533","article-title":"PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation","volume":"62","author":"Luo","year":"2023","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.taap.2026.118082_bb0060","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.molcel.2023.11.042","article-title":"OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB","volume":"84","author":"Ma","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2026.118082_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27238367","article-title":"Natural products as anticancer agents: current status and future perspectives","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2026.118082_bb0070","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.taap.2026.118082_bb0085","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2026.118082_bb0075","doi-asserted-by":"crossref","first-page":"12185","DOI":"10.2147\/CMAR.S278566","article-title":"MicroRNA-1276 promotes colon cancer cell proliferation by negatively regulating LACTB","volume":"12","author":"Wang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.taap.2026.118082_bb0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbrc.2021.11.101","article-title":"Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation","volume":"587","author":"Wang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2026.118082_bb0090","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00210-024-03328-9","article-title":"Auriculasin induces mitochondrial oxidative stress and drives ferroptosis by inhibiting PI3K\/Akt pathway in non-small cell lung cancer","volume":"398","author":"Wang","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.taap.2026.118082_bb0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4103\/apjon.apjon-2130","article-title":"Review of the effects and safety of traditional Chinese medicine in the treatment of cancer cachexia","volume":"8","author":"Xu","year":"2021","journal-title":"Asia-Pac. J. Oncol. Nurs."},{"key":"10.1016\/j.taap.2026.118082_bb0095","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.2147\/CMAR.S250661","article-title":"LACTB regulates PIK3R3 to promote autophagy and inhibit EMT and proliferation through the PI3K\/AKT\/mTOR signaling pathway in colorectal cancer","volume":"12","author":"Xu","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.taap.2026.118082_bb0105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3892\/etm.2022.11172","article-title":"LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway","volume":"23","author":"Xu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.taap.2026.118082_bb0110","first-page":"601","article-title":"LACTB induced apoptosis of oxaliplatin-resistant gastric cancer through regulating autophagy-mediated mitochondrial apoptosis pathway","volume":"13","author":"Yang","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.taap.2026.118082_bb0115","article-title":"The pivotal role of LACTB in the process of cancer development","volume":"26","author":"Zhang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2026.118082_bb0120","first-page":"939","article-title":"Clinical significance of \u03b2-lactamase expression in colorectal cancer","volume":"37","author":"Zhou","year":"2022","journal-title":"Cancer Biother. Radiopharm."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X26003789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:48:10Z","timestamp":1793915290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X26003789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":24,"alternative-id":["S0041008X26003789"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2026.118082","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Auriculasin induces LACTB expression to regulate colorectal cancer cell apoptosis, ferroptosis, invasion, and in vivo tumor growth","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2026.118082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118082"}}